NITE - Chemical Management Field

GHS Classification Result

GENERAL INFORMATION

Item	Information
CAS RN	7789-06-2
Chemical Name	Strontium chromate
Substance ID	H26-B-142, R-088
Classification year (FY)	FY2014
Ministry who conducted the classification	Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised	Revised
Classification result in other fiscal year	FY2006
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	GHS Classification Guidance for the Japanese Government (FY2013 revised edition)
UN GHS document (External link)	UN GHS document
Definitions/Abbreviations (Excel file)	Definitions/Abbreviations
Model Label by MHLW (External link)	MHLW Website (in Japanese Only)
Model SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	eChemPortal

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Explosives	Not applicable	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.
2	Flammable gases (including chemically unstable gases)	Not applicable	- -	-	-	Solid (GHS definition).
3	Aerosols	Not applicable	- -	-	-	Not aerosol products.
4	Oxidizing gases	Not applicable	- -	-	-	Solid (GHS definition).
5	Gases under pressure	Not applicable	- -	-	-	Solid (GHS definition).
6	Flammable liquids	Not applicable	- -	-	-	Solid (GHS definition).
7	Flammable solids	Not classified	- -	-	-	It is not combustible (ICSC (2013)).
8	Self-reactive substances and mixtures	Not applicable	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9	Pyrophoric liquids	Not applicable	- -	-	-	Solid (GHS definition).
10	Pyrophoric solids	Not classified	- -	-	-	It is not combustible (ICSC (2013)).
11	Self-heating substances and mixtures	Not classified	- -	-	-	It is not combustible (ICSC (2013)).
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified	- -	-	-	Because data of water solubility: 0.12 g/100 mL (15 deg C) (ICSC (2013)) were obtained, it is estimated that it does not react vigorously with water.
13	Oxidizing liquids	Not applicable	- -	-	-	Solid (GHS definition).
14	Oxidizing solids	Classification not possible	- -	-	-	It is an inorganic compound containing oxygen (but not halogen). Because it is a chromate, it is estimated to be oxidizing, but the classification is not possible due to no data.
15	Organic peroxides	Not applicable	- -	-	-	It is an inorganic compound.
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to solid substances are not available.

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Acute toxicity (Oral)	Category 4	Warning	H302	P301+P312 P362+P364 P264 P270 P330 P501	Based on a report of an LD50 value for rats of 811 mg/kg (CICAD 78 (2013), ATSDR (2000)), it was classified in Category 4.
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	Classification not possible due to lack of data.
1	Acute toxicity (Inhalation: Gases)	Not applicable	- -	-	-	Solid (GHS definition)
1	Acute toxicity (Inhalation: Vapours)	Not applicable	- -	-	-	Solid (GHS definition)
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	Classification not possible due to lack of data.
2	Skin corrosion/irritation	Category 1	Danger	H314	P301+P330+P331 P303+P361+P353 P305+P351+P338 P304+P340 P260 P264 P280 P310 P321 P363 P405 P501	There is a description that this substance was corrosive (HSDB (Access on December 2014)). In addition, there are many reports describing that hexavalent chromium compounds were corrosive (EU-RAR (2005), DFG vol. 3 (1992), OEL Documentations (Japan Society For Occupational Health (JSOH), 1989)). From the above, it was classified in Category 1. Because of adding a description of HSDB and description of hexavalent chromium, the category was changed.
3	Serious eye damage/eye irritation	Category 1	Danger	H318	P305+P351+P338 P280 P310	There is a description that this substance was corrosive (HSDB (Access on December 2014)). In addition, there are many reports describing that hexavalent chromium compounds were corrosive (EU-RAR (2005), DFG vol. 3 (1992), OEL Documentations (Japan Society For Occupational Health (JSOH), 1989)). From the above, according to the GHS Classification Guidance for the Japanese Government, it was classified in Category 1.
4	Respiratory sensitization	Category 1	Danger	H334	P304+P340 P342+P311 P261 P284 P501	The Japan Society for Occupational Health (JSOH) classified chromium compounds in occupational sensitizers to the airway Group 2. Although this substance is not specified in this classification, there is a description in OEL Documentations (Japan Society For Occupational Health (JSOH), 1989) that hexavalent chromium compounds are more toxic than divalent and trivalent compounds. In addition, there is a description that chromium compounds caused asthma (ATSDR (2012), EU-RAR (2005)). From the above, it was classified in Category 1.
4	Skin sensitization	Category 1	Warning	H317	P302+P352 P333+P313 P362+P364 P261 P272 P280 P321 P501	Although it is not information limited to this substance, there is a description that hexavalent chromium compounds were sensitizing to the skin (EU-RAR (2005), ATSDR (2012), PATTY (6th, 2012)). In addition, there is a report that sensitization was observed in a human patch test with hexavalent chromium compounds (ATSDR (2012)). Moreover, chromium compounds including this substance were classified in occupational skin sensitizers Group 1 by Japan Society For Occupational Health (JSOH) (Recommendation of Occupational Exposure Limits (Japan Society For Occupational Health (JSOH), 2014)). Although this substance is not specified in this classification, there is a description that hexavalent chromium compounds are more toxic than divalent or trivalent compounds in the OEL Documentations (Japan Society For Occupational Health (JSOH), 1989). From the above, it was classified in Category 1.
5	Germ cell mutagenicity	Classification not possible	- -	-	-	Classification not possible due to lack of data. There are no in vivo data. As for in vitro, it was positive in bacterial reverse mutation tests and a sister chromatid exchange test with cultured mammalian cells (IARC 49 (1990)). This substance is poorly water-soluble Cr (VI).
6	Carcinogenicity	Category 1A	Danger	H350	P308+P313 P201 P202 P280 P405 P501	Since it was classified in Group 1 (as chromium (VI)) by IARC (IARC (1990)), in A1 (as chromium VI compound) by ACGIH (ACGIH (7th, 2001)), as K (as hexavalent chromium compound) by NTP (NTP RoC (2014)) and in 1 by Japan Society for Occupational Health (JSOH) (OEL Documentations (1989)), it was classified in Category 1A. Besides, it was classified in 2 by EU (EU (Access on Dec. 2014)).
7	Reproductive toxicity	Category 2	Warning	H361	P308+P313 P201 P202 P280 P405 P501	There are no data on this substance. As for reproductive toxicity of chromium (VI), potassium dichromate (CAS: 7778-50-9) and potassium chromate (CAS: 7789-00-6), water-soluble substances, were classified in Category 1B. Because this substance has a low water solubility of 0.12 g/100 mL (15 deg C), it was hard to say that it caused obvious reproductive effects on experimental animals. Therefore, it was classified in Category 2. Besides, chromium and its compounds were classified in reproductive toxicants Group 3 (provisional) (correspond to Category 2) in Recommendation of Occupational Exposure Limits (2014) by Japan Society For Occupational Health (JSOH). However, because the classification of Recommendation of Occupational Exposure Limits was in a provisional period, it was not adopted.
8	Specific target organ toxicity - Single exposure	Category 1 (central nervous system, respiratory organs, cardiovascular system, haemal system, liver, kidney)	Danger	H370	P308+P311 P260 P264 P270 P321 P405 P501	There are no data on this substance in either humans or experimental animals. There are reports that respiratory tract irritation, respiratory tract inflammation, nose and chest pain, cough, dyspnea, cyanosis and kidney damage were observed in human inhalation exposure to hexavalent chromium compounds, that vomiting, diarrhea, gastrointestinal tract bleeding, liver necrosis and renal tubular necrosis in the kidney were observed by human oral exposure, and that severe respiratory, cardiovascular, gastrointestinal, hematological, hepatic, renal, and neurological effects were reported in an accidental or intentional human ingestion at high-doses (ACGIH (7th, 2001), CICAD 78 (2013), EHC 61 (1988), EU-RAR (2005), ATSDR (2012)). Although there are no data on this substance, this substance is a hexavalent chromium compound and it was considered possible to use the toxicity findings of hexavalent chromium compounds for classification of this substance. The findings on the gastrointestinal tract were not adopted because of being effects of local irritation. From the above, it was classified in Category 1 (central nervous system, respiratory organs, cardiovascular system, hemal system, liver, kidney).
9	Specific target organ toxicity - Repeated exposure	Category 1 (respiratory organs)	Danger	H372	P260 P264 P270 P314 P501	There are no reports of clear effects by repeated exposure to this substance in either humans or experimental animals. However, in the Hazard Assessment Report of a series of hexavalent chromium compounds including this substance, there is a description that in humans who were exposed occupationally to hexavalent chromium compounds, irritation of the respiratory tract and eyes were observed, which may cause ulcer/perforations in the nasal septum (CICAD 78 (2013)). Therefore, this substance was also classified in Category 1 (respiratory organs) like other hexavalent chromium compounds.
10	Aspiration hazard	Classification not possible	- -	-	-	Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
11	Hazardous to the aquatic environment (Acute)	Classification not possible	- -	-	-	No data available.
11	Hazardous to the aquatic environment (Long-term)	Classification not possible	- -	-	-	No data available.
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in the Annexes to the Montreal Protocol.

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

To GHS Information