Item | Information |
---|---|
CAS RN | 156-59-2 |
Chemical Name | cis-1,2-Dichloroethylene |
Substance ID | H26-B-146, R-099 |
Classification year (FY) | FY2014 |
Ministry who conducted the classification | Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE) |
New/Revised | Revised |
Classification result in other fiscal year | FY2006 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | GHS Classification Guidance for the Japanese Government (FY2013 revised edition) |
UN GHS document (External link) | UN GHS document |
Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
Model Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | eChemPortal |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Explosives | Not applicable |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. |
2 | Flammable gases (including chemically unstable gases) | Not applicable |
- |
- | - | Liquid (GHS definition) |
3 | Aerosols | Not applicable |
- |
- | - | Not aerosol products. |
4 | Oxidizing gases | Not applicable |
- |
- | - | Liquid (GHS definition) |
5 | Gases under pressure | Not applicable |
- |
- | - | Liquid (GHS definition) |
6 | Flammable liquids | Category 2 |
Danger |
H225 |
P303+P361+P353
P370+P378 P403+P235 P210 P233 P240 P241 P242 P243 P280 P501 |
It was classified in Category 2 based on a flash point of 2.2-3.9 deg C (closed cup) and a boiling point of 60.1 deg C (HSDB (Access on December 2014)). Besides, it is classified in Class 3, PG II (UN1150) in UNRTDG. |
7 | Flammable solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
8 | Self-reactive substances and mixtures | Type G |
- |
- | - | There is a chemical group associated with self-reactive properties (unsaturated bond) present in the molecule. However, it is classified in Class 3, PG II (UN1150) in UNRTDG, not corresponding to self-reactive substances and mixtures, which is the higher precedence. |
9 | Pyrophoric liquids | Not classified |
- |
- | - | It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 460 deg C (GESTIS (Access on December 2014)). |
10 | Pyrophoric solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Test methods applicable to liquid substances are not available. |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable |
- |
- | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
13 | Oxidizing liquids | Not applicable |
- |
- | - | The substance is an organic compound containing chlorine (but not fluorine or oxygen) which is chemically bonded only to carbon or hydrogen. |
14 | Oxidizing solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
15 | Organic peroxides | Not applicable |
- |
- | - | Organic compounds containing no bivalent -O-O- structure in the molecule |
16 | Corrosive to metals | Classification not possible |
- |
- | - | No data available. |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
1 | Acute toxicity (Dermal) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
1 | Acute toxicity (Inhalation: Gases) | Not applicable |
- |
- | - | Liquid (GHS definition) |
1 | Acute toxicity (Inhalation: Vapours) | Category 4 |
Warning |
H332 |
P304+P340
P261 P271 P312 |
Based on a report of an LC50 value (4 hours) of 13,700 ppm for rats (IRIS TR (2010), Initial Risk Assessment Report (NITE, CERI, NEDO, 2008), Environmental Risk Assessment for Chemical Substances Vol. 2, Tentative Hazard Assessment Sheet (Ministry of the Environment, 2003)), it was classified in Category 4. Besides, the LC50 value was lower than 90% of the saturated vapor concentration (263,000 ppm), the reference value in units of ppm was applied as a vapour without a mist. Since new information sources (IRIS TR (2010), Initial Risk Assessment Report (NITE, CERI, NEDO, 2008)) were added and the criteria for Category 4 was changed from 2,500-5,000 ppm in the previous classification to 2,500-20,000 ppm, the category was changed. |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
2 | Skin corrosion/irritation | Category 2 |
Warning |
H315 |
P302+P352
P332+P313 P362+P364 P264 P280 P321 |
Since there are descriptions that an aqueous solution of this substance was irritating to human skin (Environmental Risk Assessment for Chemical Substances Vol. 2, Tentative Hazard Assessment Sheet (Ministry of the Environment, 2003)) and that this substance showed primary irritation to the skin and caused dermatitis (HSDB (Access on December 2014)), it was classified in Category 2. |
3 | Serious eye damage/eye irritation | Category 2 |
Warning |
H319 |
P305+P351+P338
P337+P313 P264 P280 |
There is a description that an aqueous solution of this substance was irritating to human eyes (Environmental Risk Assessment for Chemical Substances Vol. 2, Tentative Hazard Assessment Sheet (Ministry of the Environment, 2003)), and there is a description that 1,2-dichloroethylene, an isomer mixture containing this substance was irritating to the eyes (HSDB (Access on December 2014)). Besides, there is information that an isomer of this substance was corrosive to human eyes (ACGIH (7th, 2001)). From the above results, it was classified in Category 2. |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
4 | Skin sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | As for in vivo, it was negative or positive in mouse bone marrow chromosomal aberration tests, and it was negative in a sister chromatid exchange test with mice bone marrow cells (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008), ATSDR (1996), IRIS TR (2010), NTP DB (Access on Dec 2014)). As for in vitro, it was negative in a bacterial reverse mutation test, a chromosome aberration test and a sister chromatid exchange test with cultured mammalian cells (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008), ATSDR (1996), IRIS TR (2010), NTP DB (Access on Dec 2014)). A positive result in in vivo chromosomal aberration test was observed in only one test, which was conducted under a somewhat special condition in which a 1/6 amount of an LD50 value was administered 10 times. Therefore, IRIS TR (2010) described that although it was generally nonpositive, it was impossible to conclude the mutagenicity of this substance. From the above, it was classified as "Classification not possible." |
6 | Carcinogenicity | Classification not possible |
- |
- | - | Since it was classified as "I" by EPA (IRIS TR (2010)), it was classified as "Classification not possible." |
7 | Reproductive toxicity | Classification not possible |
- |
- | - |
Classification not possible due to lack of data. There was no information on this substance. In a dose-finding study of a teratogenicity test with mice given a mixture with the trans-isomer by the oral route, though limited test items, no abnormalities were observed in the examination of fetuses at doses where maternal toxicities were observed. Additionally, in a teratogenicity test with rats given the trans-isomer by the inhalation route, no significant fetal effects were observed at doses where maternal toxicities were observed (increased fetal resorption (within the range of historical data) was observed) (IRIS TR (2010)). |
8 | Specific target organ toxicity - Single exposure | Category 3 (Narcotic effects) |
Warning |
H336 |
P304+P340
P403+P233 P261 P271 P312 P405 P501 |
There is a description that this substance was narcotic to humans at high doses (ACGIH (7th, 2001)). As for experimental animals, it is described that inhalation exposure to rats caused narcotic effects but no death for 4 hours at 8,000 ppm (31.72 mg/L) and narcotic effects in 8 minutes and death in 4 hours at 16,000 ppm (63.44 mg/L) (PATTY (6th, 2012)). In addition, extension of sleeping time by hexobarbital and extension of anesthesia time by zoxazolamine were observed in an 8-hour inhalation exposure at 0.79 mg/L with rats (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008)). Besides, nausea, vomiting, weakness, tremor, central nervous system depression, vertigo and narcotic effects were observed by inhalation exposure to humans to 1,2-dichloroethylene (the isomer mixed ratio was unknown) (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008), Environmental Risk Assessment for Chemical Substances Vol. 2, Tentative Hazard Assessment Sheet (Ministry of the Environment, 2003), OEL Documentations (Japan Society For Occupational Health (JSOH), 1970)). As for trans-1,2-dichloroethylene, there were reports by oral administration to rats at 1,275 mg/kg, of decreased activity, ataxia, loss of righting reflex and depressed respiration, and of hyperemia in the pulmonary capillary and alveolar septal distention by a histopathological test (ACGIH (7th, 2001), ATSDR (1996)). Since there is also a description that there are differences in toxicities between the cis- and trans- isomers (details unknown) (OEL Documentations (Japan Society For Occupational Health (JSOH), 1970)), the toxicity data of a mixture and the trans-isomer was not used. From the above, since the main effects were narcotic effects based on the data of this substance, it was classified in Category 3 (narcotic effects). |
9 | Specific target organ toxicity - Repeated exposure | Classification not possible |
- |
- | - |
There was no knowledge of hazard on exposure of humans to this substance. As for experimental animals, in a test in which rats were administered this substance by gavage for 90 days, although an increase in the relative liver weight was observed, no histopathological findings were observed at a dose (97 mg/kg/day) of the upper limit of Category 2 (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008), IRIS TR (2010)). In addition, a decreased hematocrit value and reduced hemoglobin were observed. However, since both were the findings observed at a dose at the upper limit of Category 2 or at high doses exceeding Category 2 (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008), IRIS TR (2010)), it was considered inadequate to use them for classification. Moreover, no inhalation exposure tests of this substance were conducted. From the above, although it was considered to correspond to "Not classified" by the oral route based on the oral administration test results with rats, since there was no toxicity information by other routes and hazardous knowledge in humans, it was classified as "Classification not possible" due to lack of data. In this regard, although this substance was classified in Category 2 (blood) in the previous classification, the blood was excluded from the target organs by considering the onset doses as described above. Besides, the trans-isomer (CAS RN: 156-60-5), an isomer of this substance, was also classified as "Classification not possible" due to lack of data. |
10 | Aspiration hazard | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment (Acute) | Category 3 |
- |
H402 |
P273
P501 |
It was classified in Category 3 from 48-hour EC50 = 40.2 mg/L for crustacea (Daphnia magna) (Results of Aquatic Toxicity Tests of Chemicals conducted by Ministry of the Environment in Japan (Ministry of the Environment, 2003), Environmental Risk Assessment for Chemical Substances Vol. 5 (Ministry of the Environment, 2006), Initial Risk Assessment (NITE, CERI, NEDO, 2008)). |
11 | Hazardous to the aquatic environment (Long-term) | Category 3 |
- |
H412 |
P273
P501 |
If chronic toxicity data are used, then it is classified as "Not classified" due to 21-day NOEC = 4.51 mg/L for crustacea (Daphnia magna) (Results of Aquatic Toxicity Tests of Chemicals conducted by Ministry of the Environment in Japan (Ministry of the Environment, 2003), Environmental Risk Assessment for Chemical Substances Vol. 5 (Ministry of the Environment, 2006), Initial Risk Assessment (NITE, CERI, NEDO, 2008)), although it is not rapidly degradable (a degradation rate by BOD: 0% (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 1990)). If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified in Category 3 due to being not rapidly degradable (a degradation rate by BOD: 0% (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 1990)), and 96-hour LC50 = 67.2 mg/L for fish (Oryzias latipes) (Results of Aquatic Toxicity Tests of Chemicals conducted by Ministry of the Environment in Japan (Ministry of the Environment, 2003), Environmental Risk Assessment for Chemical Substances Vol. 5 (Ministry of the Environment, 2006), Initial Risk Assessment (NITE, CERI, NEDO, 2008)). By drawing a comparison between the above results, it was classified in Category 3. |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | This substance is not listed in the Annexes to the Montreal Protocol. |
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