GHS Classification Result
GENERAL INFORMATION
REFERENCE INFORMATION
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
GENERAL INFORMATION
| Item | Information |
|---|---|
| CAS RN | 91-22-5 |
| Chemical Name | Quinoline |
| Substance ID | H27-B-05-METI/M-026B_P |
| Classification year (FY) | FY2015 |
| Ministry who conducted the classification | Ministry of Economy, Trade and Industry (METI)/Ministry of the Environment (MOE) |
| New/Revised | Revised |
| Classification result in other fiscal year | FY2006 |
| Download of Excel format | Excel file |
REFERENCE INFORMATION
| Item | Information |
|---|---|
| Guidance used for the classification (External link) | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
| UN GHS document (External link) | UN GHS document |
| Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
| Model Label by MHLW (External link) | MHLW Website (in Japanese Only) |
| Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
| OECD/eChemPortal (External link) | eChemPortal |
| Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. |
| 2 | Flammable gases (including chemically unstable gases) | Not applicable |
- |
- | - | Liquid (GHS definition) |
| 3 | Aerosols | Not applicable |
- |
- | - | Not aerosol products. |
| 4 | Oxidizing gases | Not applicable |
- |
- | - | Liquid (GHS definition) |
| 5 | Gases under pressure | Not applicable |
- |
- | - | Liquid (GHS definition) |
| 6 | Flammable liquids | Not classified |
- |
- | - | Based on flash point information of 99 deg C (closed cup) (HSDB (Access on November 2015)), 101 deg C (closed cup) (ICSC (2008)), it was classified as "Not classified." |
| 7 | Flammable solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
| 8 | Self-reactive substances and mixtures | Not applicable |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. |
| 9 | Pyrophoric liquids | Not classified |
- |
- | - | It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 480 deg C (HSDB (Access on November 2015)). |
| 10 | Pyrophoric solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
| 11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Test methods applicable to liquid substances are not available. |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable |
- |
- | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
| 13 | Oxidizing liquids | Not applicable |
- |
- | - | Organic compounds containing no oxygen, fluorine or chlorine |
| 14 | Oxidizing solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
| 15 | Organic peroxides | Not applicable |
- |
- | - | Organic compounds containing no bivalent -O-O- structure in the molecule |
| 16 | Corrosive to metals | Classification not possible |
- |
- | - | No data available. |
| Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Acute toxicity (Oral) | Category 4 |
 Warning |
H302 | P301+P312 P264 P270 P330 P501 |
Based on reports of LD50 values of 331 mg/kg (Environmental Risk Assessment for Chemical Substances Vol.11 (Ministry of the Environment, 2013)) and 331-460 mg/kg (PATTY (6th, 2012)) for rats, this substance was classified in Category 4. |
| 1 | Acute toxicity (Dermal) | Category 3 |
 Danger |
H311 | P302+P352 P361+P364 P280 P312 P321 P405 P501 |
Based on a report of an LD50 value of 0.54 mL/kg (593 mg/kg) for rabbits (Environmental Risk Assessment for Chemical Substances Vol.11 (Ministry of the Environment, 2013)), PATTY (6th, 2012), this substance was classified in Category 3. |
| 1 | Acute toxicity (Inhalation: Gases) | Not applicable |
- |
- | - | Liquid (GHS definition) |
| 1 | Acute toxicity (Inhalation: Vapours) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 2 | Skin corrosion/irritation | Category 2 |
Warning |
H315 | P302+P352 P332+P313 P362+P364 P264 P280 P321 |
There are descriptions that this substance irritates the skin (Environmental Risk Assessment for Chemical Substances Vol.11 (Ministry of the Environment, 2013), HSDB (Access on October 2015)) and that exposure in rabbit skin causes moderate to severe irritation (PATTY (6th, 2012)). From the above, it was classified in Category 2. Besides, this substance is classified as "Skin. Irrit. 2 H315" in the EU CLP classification (ECHA CL Inventory (Access on September 2015)). |
| 3 | Serious eye damage/eye irritation | Category 2A |
Warning |
H319 | P305+P351+P338 P337+P313 P264 P280 |
There is a description that eye exposure to this substance in rabbit eyes caused moderate to severe irritation (PATTY (6th, 2012)). In addition, there are descriptions that this substance irritates eyes (Environmental Risk Assessment for Chemical Substances Vol.11 (Ministry of the Environment, 2013)) and that it may cause irreversible damage to human eyes (HSDB (Access on October 2015)). Therefore, this substance was classified in Category 2A. Besides, this substance is classified as "Eye. Irrit. 2 H319" in the EU CLP classification (ECHA CL Inventory (Access on September 2015)). |
| 4 | Respiratory sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 4 | Skin sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 5 | Germ cell mutagenicity | Category 2 |
 Warning |
H341 | P308+P313 P201 P202 P280 P405 P501 |
As for in vivo, this substance was positive only in the liver but was negative in the bone marrow, testis, lung, kidney and spleen in the lac Z transgenic mouse gene mutation test, positive and negative in the rat bone marrow cell micronucleus test, negative in the rat liver micronucleus test, positive in the mouse bone marrow cell micronucleus test, negative in the mouse liver micronucleus test, positive in the chromosome aberration test and the sister chromatid exchanger test with rat liver, negative in the chromosome aberration test and the sister chromatid exchange test with mouse bone marrow, and equivocal in the rat liver unscheduled DNA synthesis test (IRIS Summary (2001), Environmental Risk Assessment for Chemical Substances Vol.11 (Ministry of the Environment, 2013), PATTY (6th, 2012), NTP DB (Access on November 2015)). As for in vitro, it was positive in a bacterial reverse mutation test, a mammalian cell gene mutation test, a mouse lymphoma test, a chromosomal aberration test and a sister chromatid exchange test (IRIS Summary (2001), Environmental Risk Assessment for Chemical Substances Vol.11 (Ministry of the Environment, 2013), PATTY (6th, 2012), NTP DB (Access on November 2015)). Based on the above, the substance was classified in Category 2 because positive results were observed in in-vivo somatic cell mutagenicity tests, and negative results in in-vivo germ cell mutagenicity tests. |
| 6 | Carcinogenicity | Category 1B |
Danger |
H350 | P308+P313 P201 P202 P280 P405 P501 |
There is no epidemiological data available for human carcinogenicity. As for experimental animals, in carcinogenicity tests in which rats or mice were dosed for two years in drinking water, a dose-dependent increase in incidences of liver tumor (hepatocellular adenoma, hepatocellular carcinoma, angiosarcoma) in males and females at or above 200 ppm, and a mild increase in incidences of neuroepithelioma in the nasal cavity in males at or above 400 ppm were observed in rats, and increased incidences of hemangioma in the subcutaneous tissue, etc. or hemangiosarcoma in the retroperitoneum, mesentery, liver and subcutaneous tissue, etc. in male and female mice at 150 ppm or more, were observed and in particular, hemangiosarcoma was observed in most animals in both males and females (Environmental Risk Assessment for Chemical Substances Vol.11 (Ministry of the Environment, 2013), Results from Carcinogenicity Studies (Ministry of Health, Labour and Welfare, 1999)). In addition, in either of two carcinogenicity tests, in which male rats were dosed in their diet at a dose of 500 ppm or more, or 750 ppm for 40 weeks or 30 weeks respectively, and another test in which male and female rats or male and female mice were dosed in their diet at 200 ppm for 30 weeks, an increased incidence of liver tumors (liver nodules, hemangiosarcoma, hepatocellular carcinoma etc.) was observed (Environmental Risk Assessment for Chemical Substances Vol.11 (Ministry of the Environment, 2013), IRIS Summary (2001)). Based on the experimental animal data of the diet administration, the EPA considered that this substance corresponded to "B2 (probable human carcinogen)" according to the 1986 criteria and "L (likely to be carcinogenic in humans)" according to the 1996 criteria for the classification of carcinogenicity (IRIS Summary (2001)), and similarly the EU classified it as "Carc. 1B" in the CLP classification (ECHA CL Inventory (Access on November 2015)). Based on the above, this substance was classified in Category 1B according to the GHS classification guidance for the Japanese government. The category was changed from the previous classification. |
| 7 | Reproductive toxicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 8 | Specific target organ toxicity - Single exposure | Category 1 (nervous system), Category 3 (respiratory tract irritation) |
Danger Warning |
H370 H335 |
P308+P311 P260 P264 P270 P321 P405 P501 P304+P340 P403+P233 P261 P271 P312 |
This substance is an irritant and in humans, cough or sore throat by inhalation exposure and sore throat also by oral ingestion (Environmental Risk Assessment for Chemical Substances Vol.11 (Ministry of the Environment, 2013)), nausea, fever, vomiting, gastrointestinal spasm, dizziness and irregular tachycardia (PATTY (6th, 2012), HSDB (Access on November 2015)), and dyspnea due to respiratory muscle paralysis (HSDB (Access on November 2015)) are reported. As for experimental animals, there are descriptions of lethargy, inhibition of respiration, weakness and coma by oral administration (details unknown) (PATTY (6th, 2012), HSDB (Access on November 2015)) and a description that quinoline and its many derivatives show toxicity in the retina and optic nerve (HSDB (Access on November 2015)), although the details are unknown. Based on the above, since this substance causes respiratory tract irritation and shows respiratory muscle paralysis and respiratory inhibition, it affects the nervous system. Therefore, this substance was classified in Category 1 (nervous system) and Category 3 (respiratory tract irritation). The information source listed as List 3 which was described in the previous classification was not adopted. |
| 9 | Specific target organ toxicity - Repeated exposure | Category 2 (liver) |
Warning |
H373 | P260 P314 P501 |
No information on humans is available. In a 40-week feeding toxicity study with rats, suppression of body weight gain, increase in liver relative weight, mild to moderate oval cellular infiltration, hyperplasia of the bile duct and fatty degeneration in the liver were observed at 0.05% (corresponding to 25 mg/kg/day) within the range for Category 2 (Environmental Risk Assessment for Chemical Substances Vol.11 (Ministry of the Environment, 2013), IRIS Tox. Review (2001)). As described above, the liver was affected in the range for Category 2 for experimental animals. Beside, although there is a description in the previous classification that "effects on rat liver (vascular tumor, increase in liver weight, and hyperplasia of bile duct in the liver) were reported in PATTY (5th, 2001)," there is no corresponding description in PATTY (6th, 2012). In addition, as for humans, there was a description that it is reported that this substance was toxic to the retina and the optic nerve in humans (HSDB (Access on November 2015)). The original literature of this result is PATTY (3th, 1981-1982), however, since there is no corresponding description in PATTY (6th, 2012) at present, it was not adopted as evidence for classification. Therefore, this substance was classified in Category 2 (liver). |
| 10 | Aspiration hazard | Classification not possible |
- |
- | - | Classification not possible due to lack of data. Besides, kinematic viscosity is calculated to be 2.75 mm2/sec (30/25 deg C) from the numerical data (viscosity: 2.997 mPa*s (30 deg C), density (specific gravity): 1.09 (25 deg C)) listed on HSDB (Access on November 2015). |
| Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment (Acute) | Category 1 |
 Warning |
H400 | P273 P391 P501 |
From 96-hour LC50 = 0.44 mg/L for fish (Pimephales promelas) (Environmental Risk Assessment for Chemical Substances vol. 11 (Ministry of the Environment, 2013)), it was classified in Category 1. |
| 11 | Hazardous to the aquatic environment (Long-term) | Category 1 |
Warning |
H410 | P273 P391 P501 |
If chronic toxicity data are used, then it is classified in Category 2 due to being not rapidly degradable (non-biodegradable, a degradation rate by 14-day BOD = 0.2%, a degradation rate by TOC = 1.7%, a degradation rate by GC = 5.2%, a degradation rate by UV-VIS = 2.4% (Official Bulletin of Ministry of International Trade and Industry, 1978)), and 21-day NOEC = 0.8 mg/L for crustacea (Daphnia magna) (ECETOC TR91, 2003, Environmental Risk Assessment for Chemical Substances vol. 11 (Ministry of the Environment, 2013)). If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified in Category 1 due to being not rapidly degradable, and 96-hour LC50 = 0.44 mg/L for fish (Pimephales promelas) (Environmental Risk Assessment for Chemical Substances vol. 11 (Ministry of the Environment, 2013)). By drawing a comparison between the above results, it was classified in Category 1. |
| 12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | No data available. |
NOTE:
| * A blank or "-" in a cell of classification denotes that the classification of the hazard class was not conducted. * Hazard_statement_and/or_Precautionary_statement will show when hovering the mouse over a code of Hazard_statement_and/or_Precautionary_statement. Hazard_statement_and/or_Precautionary_statement are also provided in the Excel file. * Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. * Codes assigned to each of the hazard statements and codes for each of the precautionary statement are based on the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) in United Nations. |