GHS Classification Result

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GENERAL INFORMATION
Item Information
CAS RN 9002-86-2
Chemical Name Chloroethene polymer [polyvinyl chloride or PVC]
Substance ID H27-A-019/C-019A_P
Classification year (FY) FY2015
Ministry who conducted the classification Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised New
Classification result in other fiscal year  
Download of Excel format Excel file

REFERENCE INFORMATION
Item Information
Guidance used for the classification (External link) GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
UN GHS document (External link) UN GHS document
Definitions/Abbreviations (Excel file) Definitions/Abbreviations
Model Label by MHLW (External link) MHLW Website (in Japanese Only)
Model SDS by MHLW (External link) MHLW Website (in Japanese Only)
OECD/eChemPortal (External link) eChemPortal

PHYSICAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Explosives Not applicable
-
-
- - There are no chemical groups present in the molecule associated with explosive properties.
2 Flammable gases (including chemically unstable gases) Not applicable
-
-
- - "Solids" according to GHS definition.
3 Aerosols Not applicable
-
-
- - Not an aerosol product.
4 Oxidizing gases Not applicable
-
-
- - "Solids" according to GHS definition.
5 Gases under pressure Not applicable
-
-
- - "Solids" according to GHS definition.
6 Flammable liquids Not applicable
-
-
- - "Solids" according to GHS definition.
7 Flammable solids Classification not possible
-
-
- - It is combustible, but the classification is not possible due to no data.
8 Self-reactive substances and mixtures Not applicable
-
-
- - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not applicable
-
-
- - "Solids" according to GHS definition.
10 Pyrophoric solids Not classified
-
-
- - It is estimated that it does not ignite at normal temperatures from an ignition point of 600 degrees C (GESTIS (Access on June 2015)).
11 Self-heating substances and mixtures Classification not possible
-
-
- - Due to no data, the classification is not possible.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable
-
-
- - Not containing metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable
-
-
- - "Solids" according to GHS definition.
14 Oxidizing solids Not applicable
-
-
- - It is an organic compound which does not contain oxygen or fluorine but contains chlorine, and the chlorine is not chemically bonded to the elements other than carbon or hydrogen.
15 Organic peroxides Not applicable
-
-
- - It is an organic compound that does not contain bivalent -O-O- structure in the molecule.
16 Corrosive to metals Classification not possible
-
-
- - No established test method suitable for solid substances.

HEALTH HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Acute toxicity (Oral) Classification not possible
-
-
- - Due to lack of data, the classification is not possible.
1 Acute toxicity (Dermal) Classification not possible
-
-
- - Due to lack of data, the classification is not possible.
1 Acute toxicity (Inhalation: Gases) Not applicable
-
-
- - "Solids" according to GHS definition.
1 Acute toxicity (Inhalation: Vapours) Not applicable
-
-
- - "Solids" according to GHS definition.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible
-
-
- - Due to lack of data, the classification is not possible.
2 Skin corrosion/irritation Classification not possible
-
-
- - Due to lack of data, the classification is not possible.
Besides, it is reported that mild irritation was observed in a skin irritation test using rats (PATTY (6th, 2012)).
However, it was judged as insufficient data to be used for the classification due to unknown details such as application time.
3 Serious eye damage/eye irritation Classification not possible
-
-
- - Due to lack of data, the classification is not possible.
4 Respiratory sensitization Classification not possible
-
-
- - Due to lack of data, the classification is not possible.
4 Skin sensitization Classification not possible
-
-
- - Due to lack of data, the classification is not possible.
5 Germ cell mutagenicity Classification not possible
-
-
- - Due to lack of data, the classification is not possible.
There are no in vivo data, and as for in vitro, a bacterial reverse mutation test was negative (NTP DB (Access on July 2015)).
6 Carcinogenicity Classification not possible
-
-
- - Many epidemiological studies in workers in inhalation exposure to dust of this substance were reported.
It is written that workers exposed for over five years to the environment where levels measured as total dust (particles of 1 to 6 micro m constitute 4.5 to 30%) exceeded 10 mg/m3 more than 60% time to measure a work environment concentration were diagnosed of benign pneumoconiosis in X-ray examination, and mild pneumoconiosis (diagnosed by X-ray examination), respiratory symptoms, and slightly decreased pulmonary function were observed in workers exposed to particles of this substance as respirable dust at a 10 (mg/m3 x-years) concentration (ACGIH (7th, 2008)). However, there is no report clearly showing an increase of respiratory system tumors in exposure to this substance.
Also in experimental animals, inhalation exposure (six hours/day, five days/week) to this substance (90% of particles were not larger than 1.5 micro m in diameter) in rats, guinea pigs, or monkeys at a 13 mg/m3 concentration for 22 months resulted in no lung tumor formation in any species. What found was the only existence of particles of this substance in alveolar macrophages (ACGIH (7th, 2008)).
From the above, ACGIH classified in A4. Besides, IARC classified in Group 3 (IARC vol. 19, Suppl. 7 (1987)).
Therefore, also in this evaluation, the substance was classified as "Classification not possible" in this hazard class.
7 Reproductive toxicity Classification not possible
-
-
- - It is reported in ACGIH (7th, 2008) that Finnish female workers in occupational exposure to this substance did not show increased risk of spontaneous abortions, and that an increased odds ratio (2.3, 95% confidence interval: 1.0 to 5.1) for stillbirths or cases having infants with deaths after birth, malformations, or low birth weight was observed in a case-control study in Norwegian and Swedish female workers who were engaged in work handling this substance. However, other than these, there is neither report on reproductive effects in human by exposure to this substance nor reproductive/developmental toxicity information in experimental animals (ACGIH (7th, 2008), DFGOT vol. 2 (1991), PATTY (6th, 2012), HSDB (Access on June 2015)). Therefore, the classification is not possible due to lack of data.
8 Specific target organ toxicity - Single exposure Category 3 (Respiratory tract irritation)


Warning
H335 P304+P340
P403+P233
P261
P271
P312
P405
P501
Because this substance (dust) is irritating to the respiratory tract (HSDB (Access on June 2015)), it was classified in Category 3 (respiratory tract irritation).
9 Specific target organ toxicity - Repeated exposure Category 1 (respiratory organs)


Danger
H372 P260
P264
P270
P314
P501
As for humans, it is written that in epidemiological studies in workers in inhalation exposure to dust of this substance, workers exposed for over five years to the environment where levels measured as total dust (particles of 1 to 6 micro m constitute 4.5 to 30%) exceeded 10 mg/m3 more than 60% time to measure a work environment concentration were diagnosed of benign pneumoconiosis in X-ray examination, and mild pneumoconiosis (diagnosed by X-ray examination), respiratory symptoms, and slightly decreased pulmonary function were observed in workers exposed to particles of this substance as respirable dust at a 10 (mg/m3 x-years) concentration as cumulative exposure (ACGIH (7th, 2008)).
As for experimental animals, in a 22-month inhalation exposure test (an average diameter: 1.2 micro m) using rats, guinea pigs, or monkeys, phagocytosis of PVC by macrophages and benign pneumoconiosis (fibrosis, inflammation, deficits in pulmonary function, no cancer observed) were reported at 13 mg/m3 (0.013 mg/L). In a 15-week to 8-month inhalation toxicity test using rats (an average diameter: 1.31 micro m, 1.7 micro m), phagocytosis of PVC by macrophages, alveolar septal thickening, interstitial inflammation including the proliferation of connective tissue, and granulomatous foci characterized by the small nodular formation in the lung lymph nodes were reported at 8 to 12 mg/m3 (0.008 to 0.012 mg/L). On an oral route, it is reported that significant effects were not observed in a 2-year repeated oral administration toxicity test using rats did. Besides, it is reported that hyperplasia of the gastric mucosa was observed in a drinking water administration toxicity test using rats after ten months, but a period and amount of administration and so on were not described (ACGIH (7th, 2008)). Findings in the lung in animal tests were within the range of Category 1.
As above, as effects of inhalation exposure to dust of this substance, there is the report of benign pneumoconiosis, respiratory symptoms, and slightly decreased pulmonary function in humans.
On top of that, because effects on the lung were reported within the range of Category 1 in experimental animals using respirable-sized dust, ACGIH (7th, 2008) recommended a threshold limit value (TLV) of 1 mg/m3 for the respirable-sized fraction. Therefore, the substance was classified in Category 1 (respiratory organs).
10 Aspiration hazard Classification not possible
-
-
- - Due to lack of data, the classification is not possible.

ENVIRONMENTAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Classification not possible
-
-
- - No data.
11 Hazardous to the aquatic environment (Long-term) Classification not possible
-
-
- - No data.
12 Hazardous to the ozone layer Classification not possible
-
-
- - No data.


NOTE:
* A blank or "-" in a cell of classification denotes that the classification of the hazard class was not conducted.
* Hazard_statement_and/or_Precautionary_statement will show when hovering the mouse over a code of Hazard_statement_and/or_Precautionary_statement.
Hazard_statement_and/or_Precautionary_statement are also provided in the Excel file.
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government,
and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.
* Codes assigned to each of the hazard statements and codes for each of the precautionary statement are
based on the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) in United Nations.

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