GHS Classification Result
GENERAL INFORMATION
REFERENCE INFORMATION
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
GENERAL INFORMATION
| Item | Information |
|---|---|
| CAS RN | 116-15-4 |
| Chemical Name | Hexafluoropropene [hexafluoropropylene] |
| Substance ID | H27-B-009/C-030B_P |
| Classification year (FY) | FY2015 |
| Ministry who conducted the classification | Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE) |
| New/Revised | Revised |
| Classification result in other fiscal year | FY2008 |
| Download of Excel format | Excel file |
REFERENCE INFORMATION
| Item | Information |
|---|---|
| Guidance used for the classification (External link) | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
| UN GHS document (External link) | UN GHS document |
| Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
| Model Label by MHLW (External link) | MHLW Website (in Japanese Only) |
| Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
| OECD/eChemPortal (External link) | eChemPortal |
| Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable |
- |
- | - | "Gases" according to GHS definition. |
| 2 | Flammable gases (including chemically unstable gases) | Classification not possible |
- |
- | - | There are data of upper explosion limit of 28.3% (estimate) (NITE Chemical Risk Information Platform (Access on June 2015)), however, no data of lower explosion limit. Due to being unable to judge Category 1 or 2, the classification is not possible. |
| 3 | Aerosols | Not applicable |
- |
- | - | Not an aerosol product. |
| 4 | Oxidizing gases | Not classified |
- |
- | - | Because it is estimated to be combustible from upper explosion limit data of 28.3% (estimate) (NITE Chemical Risk Information Platform (Access on June 2015)), it was classified as "Not classified." |
| 5 | Gases under pressure | Liquefied gas |
 Warning |
H280 | P410+P403 | From a critical temperature (86.2 degrees C (GESTIS (Access on June 2015))) above 65 degrees C, it was classified in liquefied gas (low pressure liquefied gas). |
| 6 | Flammable liquids | Not applicable |
- |
- | - | "Gases" according to GHS definition. |
| 7 | Flammable solids | Not applicable |
- |
- | - | "Gases" according to GHS definition. |
| 8 | Self-reactive substances and mixtures | Not applicable |
- |
- | - | "Gases" according to GHS definition. |
| 9 | Pyrophoric liquids | Not applicable |
- |
- | - | "Gases" according to GHS definition. |
| 10 | Pyrophoric solids | Not applicable |
- |
- | - | "Gases" according to GHS definition. |
| 11 | Self-heating substances and mixtures | Not applicable |
- |
- | - | "Gases" according to GHS definition. |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable |
- |
- | - | "Gases" according to GHS definition. |
| 13 | Oxidizing liquids | Not applicable |
- |
- | - | "Gases" according to GHS definition. |
| 14 | Oxidizing solids | Not applicable |
- |
- | - | "Gases" according to GHS definition. |
| 15 | Organic peroxides | Not applicable |
- |
- | - | "Gases" according to GHS definition. |
| 16 | Corrosive to metals | Classification not possible |
- |
- | - | No established test method suitable for gaseous substances. |
| Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Acute toxicity (Oral) | Not applicable |
- |
- | - | "Gases" according to GHS definition. |
| 1 | Acute toxicity (Dermal) | Not applicable |
- |
- | - | "Gases" according to GHS definition. |
| 1 | Acute toxicity (Inhalation: Gases) | Category 4 |
 Warning |
H332 | P304+P340 P261 P271 P312 |
From a reported LC50 value (4 hours) of 3,060 ppm for rats (ECETOC JACC 48 (2005)), it was classified in Category 4. |
| 1 | Acute toxicity (Inhalation: Vapours) | Not applicable |
- |
- | - | "Gases" according to GHS definition. |
| 1 | Acute toxicity (Inhalation: Dusts and mists) | Not applicable |
- |
- | - | "Gases" according to GHS definition. |
| 2 | Skin corrosion/irritation | Classification not possible |
- |
- | - | Due to lack of data, the classification is not possible. |
| 3 | Serious eye damage/eye irritation | Classification not possible |
- |
- | - | Due to lack of data, the classification is not possible. |
| 4 | Respiratory sensitization | Classification not possible |
- |
- | - | Due to lack of data, the classification is not possible. |
| 4 | Skin sensitization | Classification not possible |
- |
- | - | Due to lack of data, the classification is not possible. |
| 5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | Because it was not possible to classify a substance as "Not classified" according to the revised GHS classification guidance for the Japanese government, it was classified as "Classification not possible." As for in vivo, a dominant lethal test in rats, a micronucleus test in mouse bone marrow cells, and an unscheduled DNA synthesis test in rat hepatocytes were negative (ECETOC JACC 48 (2005)). On the other hand, there is a positive result in a micronucleus test in mouse bone marrow cells (ECETOC JACC 48 (2005)). However, it is written in ECETOC JACC 48 (2005) that there is little concern of mutagenicity for this substance due to slight statistical significance in the frequency of micronucleus formation observed only in males at the highest dose of 1200 ppm. As for in vitro, there are data of a negative bacterial reverse mutation test (ACGIH (7th, 2010), ECETOC JACC 48 (2005)) and one positive gene mutation test (hprt) in cultured mammalian cells (ACGIH (7th, 2010)), but other 3 data were negative (ECETOC JACC 48 (2005)). A chromosomal aberration test in cultured mammalian cells was positive (ECETOC JACC 48 (2005)), but a positive result was observed only at the highest dose, and it was evaluated as weak clastogenic in ECETOC JACC 48 (2005). |
| 6 | Carcinogenicity | Classification not possible |
- |
- | - | Due to lack of data, the classification is not possible. |
| 7 | Reproductive toxicity | Classification not possible |
- |
- | - | Due to lack of data, the classification is not possible. |
| 8 | Specific target organ toxicity - Single exposure | Category 1 (central nervous system, respiratory organs, kidney) |
 Danger |
H370 | P308+P311 P260 P264 P270 P321 P405 P501 |
There is no human information. As for experimental animals, this substance is irritating to the respiratory tract (ACGIH (7th, 2010)). In inhalation exposure in rats at 380-1,200 ppm, renal dysfunction and necrosis of proximal tubules were observed, but reversibility was reported. At these doses, there were no effects on other organs. In inhalation exposure in mice, guinea pigs, and rabbits at 2,000 ppm or higher, nephrosis was observed. In rabbits at 2,000-5,000 ppm, degeneration of kidney cells was reported (above ACGIH (7th, 2010), ECETOC JACC 48 (2005)). Pulmonary edema in rats in inhalation exposure at 500 ppm (LC50), central nervous signs such as loss of coordination and clonic convulsion, and necrosis of kidney cells in rats in inhalation exposure at 1,830 ppm (LC50) were reported (ECETOC JACC 48 (2005)). All of the above findings were observed at doses corresponding to Category 1. From the above, the substance was classified in Category 1 (central nervous system, respiratory system, kidney). The previous classification was revised by reviewing information. |
| 9 | Specific target organ toxicity - Repeated exposure | Category 1 (kidney) |
Danger |
H372 | P260 P264 P270 P314 P501 |
There is no human information. As for experimental animals, in a 2-week inhalation toxicity test using rats, mild nephropathy characterized by diffuse degeneration of the inner cortical tubules in the kidney was observed at 200 ppm (converted to a Guidance value equivalent: 20.3 ppm). Moreover, in a 90-day inhalation toxicity test using mice, regeneration of the inner cortical tubules, and cytomegaly and necrosis of the tubular epithelium in the kidney were found at 50 ppm (ECETOC JACC 48 (2005), ACGIH (7th, 2010)). Therefore, it was classified in Category 1 (kidney). |
| 10 | Aspiration hazard | Not applicable |
- |
- | - | "Gases" according to GHS definition. |
| Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment (Acute) | Classification not possible |
- |
- | - | No data. |
| 11 | Hazardous to the aquatic environment (Long-term) | Classification not possible |
- |
- | - | No data. |
| 12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | No data. |
NOTE:
| * A blank or "-" in a cell of classification denotes that the classification of the hazard class was not conducted. * Hazard_statement_and/or_Precautionary_statement will show when hovering the mouse over a code of Hazard_statement_and/or_Precautionary_statement. Hazard_statement_and/or_Precautionary_statement are also provided in the Excel file. * Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. * Codes assigned to each of the hazard statements and codes for each of the precautionary statement are based on the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) in United Nations. |