GHS Classification Result

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GENERAL INFORMATION
Item Information
CAS RN 25973-55-1
Chemical Name 2-(2H-Benzotriazol-2-yl)-4,6-di-tert-pentylphenol [UV-328]
Substance ID H27-A-028/C-058A_P
Classification year (FY) FY2015
Ministry who conducted the classification Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised New
Classification result in other fiscal year  
Download of Excel format Excel file

REFERENCE INFORMATION
Item Information
Guidance used for the classification (External link) GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
UN GHS document (External link) UN GHS document
Definitions/Abbreviations (Excel file) Definitions/Abbreviations
Model Label by MHLW (External link) MHLW Website (in Japanese Only)
Model SDS by MHLW (External link) MHLW Website (in Japanese Only)
OECD/eChemPortal (External link) eChemPortal

PHYSICAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Explosives Not applicable
-
-
- - There are no chemical groups present in the molecule associated with explosive properties.
2 Flammable gases (including chemically unstable gases) Not applicable
-
-
- - "Solids" according to GHS definition.
3 Aerosols Not applicable
-
-
- - Not an aerosol product.
4 Oxidizing gases Not applicable
-
-
- - "Solids" according to GHS definition.
5 Gases under pressure Not applicable
-
-
- - "Solids" according to GHS definition.
6 Flammable liquids Not applicable
-
-
- - "Solids" according to GHS definition.
7 Flammable solids Classification not possible
-
-
- - Due to no data, the classification is not possible.
8 Self-reactive substances and mixtures Not applicable
-
-
- - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not applicable
-
-
- - "Solids" according to GHS definition.
10 Pyrophoric solids Not classified
-
-
- - It is estimated that it does not ignite at normal temperatures from an ignition point of 390 degrees C (GESTIS (Access on July 2015)).
11 Self-heating substances and mixtures Classification not possible
-
-
- - No established test method suitable for solid substances with a melting point of 140 degrees C or lower.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable
-
-
- - Not containing metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable
-
-
- - "Solids" according to GHS definition.
14 Oxidizing solids Not applicable
-
-
- - It is an organic compound which does not contain fluorine or chlorine but contains oxygen, and the oxygen is not chemically bonded to the elements other than carbon or hydrogen.
15 Organic peroxides Not applicable
-
-
- - It is an organic compound that does not contain bivalent -O-O- structure in the molecule.
16 Corrosive to metals Classification not possible
-
-
- - No established test method suitable for solid substances.

HEALTH HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Acute toxicity (Oral) Classification not possible
-
-
- - Due to lack of data, the classification is not possible.
1 Acute toxicity (Dermal) Classification not possible
-
-
- - Due to lack of data, the classification is not possible.
1 Acute toxicity (Inhalation: Gases) Not applicable
-
-
- - "Solids" according to GHS definition.
1 Acute toxicity (Inhalation: Vapours) Not applicable
-
-
- - "Solids" according to GHS definition.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible
-
-
- - Due to lack of data, the classification is not possible.
2 Skin corrosion/irritation Classification not possible
-
-
- - Due to lack of data, the classification is not possible.
3 Serious eye damage/eye irritation Classification not possible
-
-
- - Due to lack of data, the classification is not possible.
4 Respiratory sensitization Classification not possible
-
-
- - Due to lack of data, the classification is not possible.
4 Skin sensitization Classification not possible
-
-
- - Due to lack of data, the classification is not possible.
5 Germ cell mutagenicity Classification not possible
-
-
- - The classification is not possible due to lack of data.
There are no in vivo data, and as for in vitro, a chromosomal aberration test in cultured mammalian cells was negative (Japan Existing Chemical Data Base, Ministry of Health, Labour and Welfare (Access on July 2015)).
6 Carcinogenicity Classification not possible
-
-
- - Due to lack of data, the classification is not possible.
7 Reproductive toxicity Classification not possible
-
-
- - Due to lack of data, the classification is not possible.
8 Specific target organ toxicity - Single exposure Classification not possible
-
-
- - Due to lack of data, the classification is not possible.
9 Specific target organ toxicity - Repeated exposure Category 1 (liver), Category 2 (kidney)


Danger
Warning
H372
H373
P260
P264
P270
P314
P501
There are no human data.
As for experimental animals, in a 90-day diet administration toxicity test using rats, hepatic damage (necrosis of hepatocytes, hypertrophy of parenchyma cells with nuclei of different size, shape, and chromatin content, an increase of hepatocytes having two nuclei, overgrowth of bile duct) was observed at 100 ppm (males: 5.8 to 13.2 mg/kg/day, females: 6.8 to 13.1 mg/kg/day) or higher, and tubulonephrosis in the kidney was found at 800 ppm (males: 52.7 to 98.7 mg/kg/day) or above (ECHA RAC OPINION (2013)).
In a 90-day diet administration toxicity test using dogs, fatty degeneration of hepatocytes in the liver and fibrosis of the liver (males) were observed at 60 mg/kg/day or higher (ECHA RAC OPINION (2013)).
As above, effects on the liver were found from Category 1, and effects on kidney were observed within a range of Category 2.
Therefore, the substance was classified in Category 1 (liver), Category 2 (kidney).

10 Aspiration hazard Classification not possible
-
-
- - Due to lack of data, the classification is not possible.

ENVIRONMENTAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Not classified
-
-
- - From 72-hour ErC50 > 0.016 mg/L for algae (Pseudokirchneriella subcapitata), and 48-hour EC50 > 0.083 mg/L for crustacea (Daphnia magna), and 96-hour LC50 > 0.078 mg/L for fish (Oryzias latipes) (all Results of Eco-toxicity tests of chemicals conducted by Ministry of the Environment in Japan, 2006), it was classified as "Not classified."
11 Hazardous to the aquatic environment (Long-term) Category 1


Warning
H410 P273
P391
P501
If chronic toxicity data are used, then it is classified in Category 1 because it is regarded as hardly degradable (Official Bulletin of Economy, Trade and Industry, 2008) and 72-hour NOEC (r) = 0.016 mg/L for algae (Pseudokirchneriella subcapitata) (Results of Eco-toxicity tests of chemicals conducted by Ministry of the Environment in Japan, 2006) although rapid degradability data are not obtained.
If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, it was classified in Category 4 because it is regarded as hardly degradable (Official Bulletin of Economy, Trade and Industry, 2008) and high bioaccumulation is estimated (LogPow = 7.25 (PHYSPROP Database, 2009)) although it corresponds to "Not classified" in acute toxicity for both crustacea and fish and rapid degradability data are not obtained.
It was classified in Category 1 by drawing a comparison between the above results.
12 Hazardous to the ozone layer Classification not possible
-
-
- - No data.


NOTE:
* A blank or "-" in a cell of classification denotes that the classification of the hazard class was not conducted.
* Hazard_statement_and/or_Precautionary_statement will show when hovering the mouse over a code of Hazard_statement_and/or_Precautionary_statement.
Hazard_statement_and/or_Precautionary_statement are also provided in the Excel file.
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government,
and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.
* Codes assigned to each of the hazard statements and codes for each of the precautionary statement are
based on the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) in United Nations.

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