Item | Information |
---|---|
CAS RN | 999-61-1 |
Chemical Name | 2-Hydroxypropyl acrylate |
Substance ID | H27-B-031/C-067B_P |
Classification year (FY) | FY2015 |
Ministry who conducted the classification | Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE) |
New/Revised | Revised |
Classification result in other fiscal year | FY2006 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
UN GHS document (External link) | UN GHS document |
Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
Model Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | eChemPortal |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Explosives | Not applicable |
- |
- | - | There are no chemical groups present in the molecule associated with explosive properties. |
2 | Flammable gases (including chemically unstable gases) | Not applicable |
- |
- | - | "Liquids" according to GHS definition. |
3 | Aerosols | Not applicable |
- |
- | - | Not an aerosol product. |
4 | Oxidizing gases | Not applicable |
- |
- | - | "Liquids" according to GHS definition. |
5 | Gases under pressure | Not applicable |
- |
- | - | "Liquids" according to GHS definition. |
6 | Flammable liquids | Not classified |
- |
- | - | A flash point is 97 degrees C (closed cup) (ACGIH (7th, 2001)). |
7 | Flammable solids | Not applicable |
- |
- | - | "Liquids" according to GHS definition. |
8 | Self-reactive substances and mixtures | Classification not possible |
- |
- | - | There is an unsaturated bond (olefins) in the chemical structure, but the classification is not possible due to no data. |
9 | Pyrophoric liquids | Not classified |
- |
- | - | It is estimated that it does not ignite at normal temperatures from an ignition point of 210 degrees C (GESTIS (Access on July 2015)). |
10 | Pyrophoric solids | Not applicable |
- |
- | - | "Liquids" according to GHS definition. |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | No established test method suitable for liquid substances. |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable |
- |
- | - | Not containing metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
13 | Oxidizing liquids | Not applicable |
- |
- | - | It is an organic compound which does not contain fluorine or chlorine but contains oxygen, and the oxygen is not chemically bonded to the elements other than carbon or hydrogen. |
14 | Oxidizing solids | Not applicable |
- |
- | - | "Liquids" according to GHS definition. |
15 | Organic peroxides | Not applicable |
- |
- | - | It is an organic compound that does not contain bivalent -O-O- structure in the molecule. |
16 | Corrosive to metals | Classification not possible |
- |
- | - | Due to no data, the classification is not possible. |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Category 4 |
Warning |
H302 | P301+P312 P264 P270 P330 P501 |
Two LD50 values of 250 to 500 mg/kg, 590 to 1,300 mg/kg (ACGIH (7th, 2001)) for rats were reported for a mixture of this substance and its isomer. Because one corresponds to Category 3 or 4, and the other corresponds to Category 4, it was classified in Category 4 to which most of the data correspond. |
1 | Acute toxicity (Dermal) | Category 2 |
Danger |
H310 | P302+P352 P361+P364 P262 P264 P270 P280 P310 P321 P405 P501 |
Two LD50 values of 170mg/kg and 250 mg/kg (ACGIH (7th, 2001)) were reported for rabbits. They correspond to Category 2 and 3, and it was classified in Category 2 to which lower LD50 value corresponds. |
1 | Acute toxicity (Inhalation: Gases) | Not applicable |
- |
- | - | "Liquids" according to GHS definition. |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible |
- |
- | - | The classification is not possible due to lack of data. It is reported that 7 to 8-hour inhalation in rats to the saturated vapour (room temperature) of this substance (supposing that the saturated vapour concentration is 9.8x10-4 ppm, converted to a 4-hour equivalent: 1.3-1.4x10-3 ppm) resulted in no death, and deaths were observed after 4-hour inhalation to the saturated vapour of this substance (650 ppm) generated at 100 degrees C (ACGIH (7th, 2001)), but the category cannot be determined. Besides, a vapour is assumed from the information "tested on the saturated vapour." |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | Due to lack of data, the classification is not possible. |
2 | Skin corrosion/irritation | Category 1 |
Danger |
H314 | P301+P330+P331 P303+P361+P353 P305+P351+P338 P304+P340 P260 P264 P280 P310 P321 P363 P405 P501 |
It is reported that in a skin irritation test using rabbits, moderate edema and moderate to severe necrosis were observed after this substance (170 to 250 mg/kg) was locally applied, and moderate chemical burns were found after application of a 10% aqueous solution (ACGIH (7th, 2001)). Moreover, it is reported that moderate irritation was found after open application of an isomer mixture containing 75% this substance (25% 1-hydroxy-2-propyl acrylate) to rabbit skin (DFGOT vol. 16 (2001)). Furthermore, it is reported that severe deep-seated necrosis was observed after 15-minute or 4-hour occlusive application of an isomer mixture containing 66% this substance (33% 1-hydroxy-2-propyl acrylate, 1% free acrylic acid or 1-hydroxy-3-propyl acrylate) (animal species: unknown) (DFGOT vol. 16 (2001)). From the above reports, the substance was classified in Category 1. Besides, it is classified in "Skin. Corr. 1B H314" in EU CLP classification (ECHA CL Inventory (Access on September 2015)). |
3 | Serious eye damage/eye irritation | Category 1 |
Danger |
H318 | P305+P351+P338 P280 P310 |
It is reported that severe eye irritation and corneal damage were observed after application of this substance (0.1 mL) into rabbit eyes (ACGIH (7th, 2001)), and that marked eye irritation was found after exposure to the vapour of this substance in rats (HSDB (Access on August 2015)). Moreover, this substance was classified in Category 1 in Skin Corrosion/Irritation. From the above, it was classified in Category 1. |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | Due to lack of data, the classification is not possible. |
4 | Skin sensitization | Category 1 |
Warning |
H317 | P302+P352 P333+P313 P362+P364 P261 P272 P280 P321 P501 |
It is reported that it was sensitizing in a sensitization test using guinea pigs (ACGIH (7th, 2001)), and it was only weakly sensitizing in the other sensitization test using guinea pigs (ACGIH (7th, 2001)). Moreover, there are multiple reports from human patch tests using an isomer mixture of hydroxypropyl acrylate reporting that it is sensitizing (DFGOT vol. 16 (2001)). ACGIH (7th, 2001) classified this substance as a sensitizer. As above, due to positive reports from sensitization tests using this substance as well as multiple positive reactions reported in human patch tests using an isomer mixture, this substance was classified in Category 1. Besides, it is classified in "Skin Sens. 1 H317" in EU CLP classification (ECHA CL Inventory (Access on September 2015)). |
5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | The classification is not possible due to lack of data. There are no in vivo data, and as for in vitro, negative and positive results were reported in a bacterial reverse mutation test (DFGOT vol. 16 (2001); PATTY (6th, 2012)). |
6 | Carcinogenicity | Classification not possible |
- |
- | - | Due to lack of data, the classification is not possible. |
7 | Reproductive toxicity | Classification not possible |
- |
- | - | Due to lack of data, the classification is not possible. |
8 | Specific target organ toxicity - Single exposure | Category 3 (Respiratory tract irritation) |
Warning |
H335 | P304+P340 P403+P233 P261 P271 P312 P405 P501 |
From the information that this substance is irritating to the respiratory tract (ACGIH (7th, 2001), DFGOT vol. 16 (2001), PATTY (6th, 2012)), it was classified in Category 3 (respiratory tract irritation). The previous classification was revised. |
9 | Specific target organ toxicity - Repeated exposure | Category 1 (respiratory organs) |
Danger |
H372 | P260 P264 P270 P314 P501 |
There is no information for this substance alone. As information for an isomer mixture of propyl acrylate (this substance = 74%, 1-hydroxy-2-propyl acrylate = 25%, acrylic acid = 0.73%), in a 1-month (20 to 21 administration) inhalation toxicity test using dogs, rats, rabbits, and mice, effects on the respiratory system such as squamous epithelial metaplasia and ulceration in the mucous membranes of the nasal concha, mucopurulent rhinitis, nasal mucosa inflammation, laryngitis, tracheitis, bronchitis, and pneumonia were observed at 5 ppm (converted to a Guidance value equivalent: 0.006 mg/m3) within a range of Category 1 or higher in dogs, rats, and rabbits (DFGOT vol. 16 (2001)). As above, because effects on respiratory organs were found within a range of Category 1, the substance was classified in Category 1 (respiratory system). |
10 | Aspiration hazard | Classification not possible |
- |
- | - | Due to lack of data, the classification is not possible. |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment (Acute) | Category 2 |
- |
H401 | P273 P501 |
From 96-hour LC50 = 3100 micro g/L for fish (Pimephales promelas) (HSDB, 2012; AQUIRE, 2016), it was classified in Category 2. |
11 | Hazardous to the aquatic environment (Long-term) | Not classified |
- |
- | - | Reliable chronic toxicity data were not obtained. Due to rapid degradability (readily degradable: a degradation rate by 28-day BOD = 83%, a degradation rate by TOC = 93%, a degradation rate by HPLC = 100% (Official Bulletin of Economy, Trade and Industry, 2001)), a low bioaccumulation estimate (LogPow = 0.35 (PHYSPROP Database, 2009)) although acute toxicity Category 2, it was classified as "Not classified." |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | No data. |
* A blank or "-" in a cell of classification denotes that the classification of the hazard class was not conducted. * Hazard_statement_and/or_Precautionary_statement will show when hovering the mouse over a code of Hazard_statement_and/or_Precautionary_statement. Hazard_statement_and/or_Precautionary_statement are also provided in the Excel file. * Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. * Codes assigned to each of the hazard statements and codes for each of the precautionary statement are based on the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) in United Nations. |