NITE - Chemical Management Field

GHS Classification Result

GENERAL INFORMATION

Item	Information
CAS RN	7783-70-2
Chemical Name	Antimony(V) fluoride
Substance ID	H27-B-037/C-073B_P
Classification year (FY)	FY2015
Ministry who conducted the classification	Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised	Revised
Classification result in other fiscal year	FY2006
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
UN GHS document (External link)	UN GHS document
Definitions/Abbreviations (Excel file)	Definitions/Abbreviations
Model Label by MHLW (External link)	MHLW Website (in Japanese Only)
Model SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	eChemPortal

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Explosives	Not applicable	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.
2	Flammable gases (including chemically unstable gases)	Not applicable	- -	-	-	Liquid (GHS definition)
3	Aerosols	Not applicable	- -	-	-	Not aerosol products.
4	Oxidizing gases	Not applicable	- -	-	-	Liquid (GHS definition)
5	Gases under pressure	Not applicable	- -	-	-	Liquid (GHS definition)
6	Flammable liquids	Not classified	- -	-	-	It is not combustible (GESTIS (Access on July 2015)).
7	Flammable solids	Not applicable	- -	-	-	Liquid (GHS definition)
8	Self-reactive substances and mixtures	Not applicable	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9	Pyrophoric liquids	Not classified	- -	-	-	It is not combustible (GESTIS (Access on July 2015)).
10	Pyrophoric solids	Not applicable	- -	-	-	Liquid (GHS definition)
11	Self-heating substances and mixtures	Not classified	- -	-	-	It is not combustible (GESTIS (Access on July 2015)).
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified	- -	-	-	It contains metalloids (Sb) and reacts with water (NITE Chemical Risk Information Platform (NITE-CHRIP) (Access on July 2015)), however, gas produced is hydrogen fluoride, which is not combustible.
13	Oxidizing liquids	Classification not possible	- -	-	-	It is an inorganic compound containing fluorine (but not oxygen), but the classification is not possible due to no data.
14	Oxidizing solids	Not applicable	- -	-	-	Liquid (GHS definition)
15	Organic peroxides	Not applicable	- -	-	-	It is an inorganic compound.
16	Corrosive to metals	Classification not possible	- -	-	-	It is described that it attacks many metals (ICSC (2011)), but the classification is not possible due to no data.

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Acute toxicity (Oral)	Classification not possible	- -	-	-	Classification not possible due to lack of data. Besides, the estimated lethal doses of 5-50 mg/kg as antimony salt for humans were reported (Sittig's (5th, 2008)), but they were not adopted for classification because of unreliable information.
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	Classification not possible due to lack of data.
1	Acute toxicity (Inhalation: Gases)	Not applicable	- -	-	-	Liquid (GHS definition)
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	Classification not possible due to lack of data. The LC50 value of 152 mg Sb/kg (2hours) (SbF5 converted value: 270 mg/kg) for mice was reported (DFGOT vol. 23 (2007)), but it was not adopted for classification because adequate unit was not used. Moreover, the LC50 value of 270 mg/m3 (30.5 ppm) for mice was reported (RTECS (Access on August 2015)), but it was not adopted for classification because exposure time is unknown. The reference values in the unit of ppm was applied as vapour without mist because the LC50 values are lower than the saturated vapor pressure concentration (12,833 ppm). The classification was revised by taking into account the exposure times.
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	Classification not possible due to lack of data.
2	Skin corrosion/irritation	Category 2	Warning	H315	P302+P352 P332+P313 P362+P364 P264 P280 P321	There is a description that this substance is severely irritating to the skin to the skin (HSDB (Access on August 2015)), and that it causes skin burns (HSDB (Access on August 2015)). The classification was changed to Category 2 due to no description of the recovery.
3	Serious eye damage/eye irritation	Category 2A	Warning	H319	P305+P351+P338 P337+P313 P264 P280	Although there is no detailed information, it is described that this substance is severely irritating to the eye (HSDB (Access on August 2015)). The classification was changed to Category 2A due to no description of the recovery.
4	Respiratory sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.
4	Skin sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.
5	Germ cell mutagenicity	Classification not possible	- -	-	-	Classification not possible due to lack of data.
6	Carcinogenicity	Classification not possible	- -	-	-	There is no information regarding carcinogenicity of this substance for either humans or experimental animals. Among antimony compounds, as for antimony trioxide, it was reported that many deaths due to lung cancer occurred among factory workers in the Great Britain who were mainly exposed to dust of antimony trioxide in the antimony manufacturing process for not less than 8 years. After that, in the expanded investigation, the expected rate of deaths from lung cancer (5.7) was slightly higher than the expected rate of deaths from lung cancer of the same age (4.5). However, this excess risk of carcinogenicity was not necessarily of consequence statistically because of the relatively small numbers involved, and it was concluded as an "equivocal result" (ACGIH (7th, 2001)). Additionally, it is described that as for the workers exposed to antimony and arsenic in the antimony ore smelting factory in the United States, the lung cancer by exposing to antimony trioxide dust was concerned about, but there was no record of death due to lung cancer, etc., therefore, it could not be analyzed due to lack of information (ACGIH (7th, 2001)). In the inhalation test in which rats were exposed to antimony trioxide dust (45mg/m3) or antimony ore concentrate (40mg/m3) for 1 year, lung tumors were found at the incidence of 32% in both exposed groups, and it was revealed that tumor types included squamous cell carcinomas, bronchoalveolar adenomas, bronchoalveolar carcinomas, and scirrhous carcinomas (ACGIH (7th, 2001)). Based on these findings in the experimental animals in addition to the limited epidemiological findings in humans, "production of antimony trioxide" was given an A2 designation by ACGIH, but antimony and its compounds were not classified for the carcinogenicity (ACGIH (7th, 2001)). As for the carcinogenicity of antimony compounds, the Japan Society for Occupational Health classified only antimony trioxide in Group 2B (OEL Documentations (Japan Society For Occupational Health (JSOH), 2013)). From the above, as for carcinogenicity, it was considered antimony trioxide was equivalent to Category 2 or Category 1B, but no other data were available for other antimony compounds. Therefore, this substance was also classified as "Classification not possible" due to lack of data.
7	Reproductive toxicity	Classification not possible	- -	-	-	Classification not possible due to lack of data.
8	Specific target organ toxicity - Single exposure	Category 1 (respiratory organs, cardiovascular system, liver, kidney)	Danger	H370	P308+P311 P260 P264 P270 P321 P405 P501	This substance is irritating to the respiratory tract (DFGOT vol. 23 (2007), HSDB (Access on August 2015)). Although the details of the data are unknown, it is described that the acute effects of this substance due to human poisoning are cough, wheezing, dyspnea, chest tightness and pulmonary edema by inhalation and dermal exposure; severe burns of oral cavity and throat, nausea, vomiting, abdominal cramp, and bloody diarrhea by oral ingestion; and bradycardia, hypotension, coma, seizures, cardiac arrest, jaundice, glomerular nephritis, albuminuria, severe hypocalcemia, hyperkalemia and hypomagnesemia which are lead to by systemic absorption via any route (HSDB (Access on August 2015)). As described above, this substance is irritating to the respiratory tract, and as for other target organs, effects on the respiratory organs, cardiovascular system, liver, and kidney were adopted based on the information source in List 2. Therefore, this substance was classified in Category 1 (respiratory organs, cardiovascular system, liver, kidney). Since new information was added, the previous classification was revised.
9	Specific target organ toxicity - Repeated exposure	Classification not possible	- -	-	-	There is no data available for this substance itself, therefore, classification was not possible due to lack of data. Besides, in ACGIH's "ANTIMONY and COMPOUNDS," it was described that pneumonia, cardiac and hematological disorders are predicted with acute and chronic exposure to high concentrations (ACGIH (7th, 2001)). Moreover, in ACGIH's "FLUORIDES," bone lesions related to fluorosis due to occupational exposure to inorganic fluorides was reported (ACGIH (7th, 2001)). In the previous classification, based mainly on a description in ACGIH, the effect on the bone as fluoride and effect on the lung, cardiovascular system and liver as antimony compound were used for classification, but these data were used only as references because these were not the data of this substance.
10	Aspiration hazard	Classification not possible	- -	-	-	Classification not possible due to lack of data. Besides, based on the numeric in HSDB (Access on August 2015) (viscosity: 0.768 mPa*s (24.4 deg C), density (specific gravity): 3.097 (25.8 deg C)), kinematic viscosity was calculated to 0.248 mm2/sec (25/26 deg C).

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
11	Hazardous to the aquatic environment (Acute)	Classification not possible	- -	-	-	No data available.
11	Hazardous to the aquatic environment (Long-term)	Classification not possible	- -	-	-	No data available.
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	No data available.

NOTE:

* A blank or "-" in a cell of classification denotes that the classification of the hazard class was not conducted.
* Hazard_statement_and/or_Precautionary_statement will show when hovering the mouse over a code of Hazard_statement_and/or_Precautionary_statement.
Hazard_statement_and/or_Precautionary_statement are also provided in the Excel file.
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government,
and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.
* Codes assigned to each of the hazard statements and codes for each of the precautionary statement are
based on the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) in United Nations.

To GHS Information