Item | Information |
---|---|
CAS RN | 541-73-1 |
Chemical Name | m-Dichlorobenzene |
Substance ID | H27-B-045/C-081B_P |
Classification year (FY) | FY2015 |
Ministry who conducted the classification | Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE) |
New/Revised | Revised |
Classification result in other fiscal year | FY2008 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
UN GHS document (External link) | UN GHS document |
Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
Model Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | eChemPortal |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Explosives | Not applicable |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. |
2 | Flammable gases (including chemically unstable gases) | Not applicable |
- |
- | - | Liquid (GHS definition) |
3 | Aerosols | Not applicable |
- |
- | - | Not aerosol products. |
4 | Oxidizing gases | Not applicable |
- |
- | - | Liquid (GHS definition) |
5 | Gases under pressure | Not applicable |
- |
- | - | Liquid (GHS definition) |
6 | Flammable liquids | Category 4 |
Warning |
H227 | P370+P378 P403+P235 P210 P280 P501 |
Based on a flash point of 63 deg C (closed cup) (GESTIS (Access on August 2015)), it was classified in Category 4. |
7 | Flammable solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
8 | Self-reactive substances and mixtures | Not applicable |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. |
9 | Pyrophoric liquids | Not classified |
- |
- | - | It is estimated that it does not ignite at normal temperatures from an autoignition temperature of > 500 deg C (HSDB (Access on August 2015)). |
10 | Pyrophoric solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Test methods applicable to liquid substances are not available. |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable |
- |
- | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
13 | Oxidizing liquids | Not applicable |
- |
- | - | The substance is an organic compound containing chlorine (but not fluorine or oxygen) which is chemically bonded only to carbon or hydrogen. |
14 | Oxidizing solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
15 | Organic peroxides | Not applicable |
- |
- | - | Organic compounds containing no bivalent -O-O- structure in the molecule |
16 | Corrosive to metals | Classification not possible |
- |
- | - | No data available. |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Category 4 |
Warning |
H302 | P301+P312 P264 P270 P330 P501 |
The following three reports are available as LD50 values for rats: 580 mg/kg (Environmental Risk Assessment for Chemical Substances Vol.6 (Ministry of the Environment, 2008)), 1,200 mg/kg (males), 1,000 mg/kg (females) (Environmental Risk Assessment for Chemical Substances Vol.6 (Ministry of the Environment, 2008), ATSDR (2006)), and 2,300 mg/kg (Environmental Risk Assessment for Chemical Substances Vol.6 (Ministry of the Environment, 2008), DFGOT vol. 1 (1990)). As two of these correspond to Category 4 and one corresponds to "Not classified" (Category 5 in UN GHS classification), this substance was classified in Category 4. |
1 | Acute toxicity (Dermal) | Not classified |
- |
- | - | Based on a report of an LD50 value of > 2,000 mg/kg (Environmental Risk Assessment for Chemical Substances Vol.6 (Ministry of the Environment, 2008)) for rats, this substance was classified as "Not classified." The previous classification result was revised. |
1 | Acute toxicity (Inhalation: Gases) | Not applicable |
- |
- | - | Liquid (GHS definition) |
1 | Acute toxicity (Inhalation: Vapours) | Category 3 |
Danger |
H331 | P304+P340 P403+P233 P261 P271 P311 P321 P405 P501 |
Based on a report of an LC50 value (7 hours) of 8,200 mg/m3 (converted 4-hour equivalent value: 1,779 ppm) (Environmental Risk Assessment for Chemical Substances Vol.6 (Ministry of the Environment, 2008)) for rats, this substance was classified in Category 3. Besides, a reference value in the unit of ppm was applied as vapour without mist, as the LC50 value is less than 90% of the saturated vapor concentration (1,974 ppm (12,081 mg/m3)). |
1 | Acute toxicity (Inhalation: Dusts and mists) | Not classified |
- |
- | - | Based on a report of an LC50 value (4 hours) of 17.6 mg/L for rats (Environmental Risk Assessment for Chemical Substances Vol.6 (Ministry of the Environment, 2008)), this substance was classified as "Not classified." Besides, the reference value for mist was applied as the LC50 value is greater than the saturated vapor concentration (1,974 ppm (12,081 mg/m3)). The category was revised by adding the new information obtained for this investigation. |
2 | Skin corrosion/irritation | Category 2 |
Warning |
H315 | P302+P352 P332+P313 P362+P364 P264 P280 P321 |
There are descriptions that this substance is irritating to the skin and causes erythema and pain on contact with the skin (Environmental Risk Assessment for Chemical Substances Vol.6 (Ministry of the Environment, 2008)). From the above, this substance was classified in Category 2. Besides, it is reported that strong irritation occurred after 24-hour occlusive application of this substance in a skin irritation test with rabbits (DFGOT vol. 1(1991)). However, it was not used for this classification as it is the result of 24-hour application. |
3 | Serious eye damage/eye irritation | Category 2A |
Warning |
H319 | P305+P351+P338 P337+P313 P264 P280 |
It was reported that in an eye irritation test with rabbits, 24-hour application of 0.1 mL of this substance resulted in slight to severe chemosis and slight corneal opacity (DFGOT vol. 1 (1991), BUA 8 (1987)). In addition, there are descriptions that this substance is irritating to the eye and causes pain on contact with the eye (Environmental Risk Assessment for Chemical Substances Vol.6 (Ministry of the Environment, 2008)). As above, based on reports of severe symptoms, this substance was classified in Category 2A. |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
4 | Skin sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | As for in vivo, this substance was positive in a micronucleus test with bone marrow cells of mice dosed intraperitoneally (Environmental Risk Assessment for Chemical Substances Vol.6 (Ministry of the Environment, 2008), DFGOT Vol. 1 (1990), EHC 128 (1991), IARC 73 (1999)) and negative in a chromosome aberration test with the bone marrow cells of Chinese hamsters dosed orally (BUA 133 (1996)). As for in vitro, this substance was negative in bacterial reverse mutation tests (Environmental Risk Assessment for Chemical Substances Vol.6 (Ministry of the Environment, 2008), ATSDR (2006), DFGOT Vol. 1 (1990), IARC 73 (1999), EHC 128 (1991)). From the above, the positive finding in the in-vivo bone marrow micronucleus test was considered unsuitable for use in evaluation (DFGOT Vol. 1 (1990)), and this substance was classified as "Classification not possible" according to the GHS Classification Guidance for the Japanese Government. |
6 | Carcinogenicity | Classification not possible |
- |
- | - | There is no information available for the classification in terms of carcinogenicity of this substance, in either humans or experimental animals. The IARC classified this substance in Group 3 (IARC vol. 73 (1999)). In terms of other carcinogenicity classifications, the EPA classified this substance as "D (Not classifiable as to human carcinogenicity)" (IRIS Summary (Access on August 2015)) in 1990. From the above, this substance was classified as "Classification not possible" for this hazard class. Besides, because of the revision of the GHS Classification Guidance for the Japanese Government, which was used as a classification criteria, the classification result was changed from the previous one ("Not classified"). |
7 | Reproductive toxicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. Besides, while there is a description that no effects of either maternal toxicity or fetal developmental toxicity were observed at up to 200 mg/kg/day in a developmental toxicity study with pregnant rats given this substance by gavage during organogenesis (gestation days 6 to 15), this report is considered inadequate as it consists only of a summary without details of the method and results of the study (ATSDR (2006), DFGOT MAK Value Documentation (2013), HSDB (Access on August 2015)). |
8 | Specific target organ toxicity - Single exposure | Category 1 (liver), Category 3 (respiratory tract irritation, narcotic effects) |
Danger Warning |
H370 H335 H336 |
P308+P311 P260 P264 P270 P321 P405 P501 P304+P340 P403+P233 P261 P271 P312 |
This substance causes respiratory tract irritation (Environmental Risk Assessment for Chemical Substances Vol.6 (Ministry of the Environment, 2008), EHC 128 (1991)). It is reported that this substance causes cough, lethargy, and sore throat through inhalational exposure and causes diarrhea, nausea, and vomiting through ingestion (Environmental Risk Assessment for Chemical Substances Vol.6 (Ministry of the Environment, 2008)), although there are no details specifying whether this pertains to humans or experimental animals. It is also reported that oral administration of this substance to mice at 300 mg/kg (equivalent to Category 1) caused liver damage with significantly increased liver weights and serum ALT activity and extensive centrilobular hepatocyte necrosis (IARC 73 (1999)). It is described that oral administration of this substance to mice at doses of not less than 1,000 mg/kg (equivalent to Category 2) caused ataxia, labored breathing (EHC 128 (1991)), and depression of the central nervous system (narcotic effects) (EHC 128 (1991)). From the above, this substance causes respiratory tract irritation, narcotic effects, and effects on the liver, therefore, was classified in Category 1 (liver) and in Category 3 (respiratory tract irritation, narcotic effects). |
9 | Specific target organ toxicity - Repeated exposure | Category 2 (liver) |
Warning |
H373 | P260 P314 P501 |
There is no information on humans. In experimental animals, a 10-day oral toxicity test with rats dosed by gavage revealed increased liver weights, hepatic degeneration (vacuolization and swelling) at 368 mg/kg/day (converted guidance value: 40.9 mg/kg/day), which is within the range of Category 2; a 90-day oral toxicity test (gavage) revealed increased liver weights, hepatocellular alterations, and hepatocellular necrosis at 147-588 mg/kg/day, which exceeds the range of Category 2 (Environmental Risk Assessment for Chemical Substances Vol.6 (Ministry of the Environment, 2008), ATSDR (2006)). Besides, this 90-day test also revealed increased GOT (AST) and cholesterol levels (males), reduced LDH levels (males), decreased thyroid follicular colloid density, and vacuolization of the cells of the adenohypophysis (in males) at 9 mg/kg/day, which is within the range of Category 1, however, these findings were not adopted for this classification as they were considered to be secondary findings associated with hepatic enzyme induction. In addition, a 28-day oral toxicity test with rats dosed by gavage revealed increased liver weights and enzyme induction in the liver (without histopathological alterations) at 100 mg/kg/day (converted guidance value: 31.1 mg/kg/day), which is within the range of Category 2, and hepatocellular hypertrophy and slightly raised serum enzyme activity at 500 mg/kg/day (converted guidance value: 155.6 mg/kg/day), which exceeds Category 2 (BUA 133 (1996), Environmental Risk Assessment for Chemical Substances Vol.6 (Ministry of the Environment, 2008)). Therefore, this substance was classified in Category 2 (liver). |
10 | Aspiration hazard | Classification not possible |
- |
- | - | Classification not possible due to lack of data. Besides, the kinematic viscosity of this substance is calculated to be 0.810 mm2/sec (25 deg C) from numerical data (viscosity: 1.044 mPa*s (25 deg C), density (specific gravity): 1.2884) listed on the HSDB (Access on August 2015). |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment (Acute) | Category 2 |
- |
H401 | P273 P501 |
From 96-hour LC50/EC50 = 2.85 mg/L for crustacea (Mysidopsis bahia) (EHC 128, 1991), it was classified in Category 2. |
11 | Hazardous to the aquatic environment (Long-term) | Category 1 |
Warning |
H410 | P273 P391 P501 |
Due to being not rapidly degradable (a degradation rate by BOD = 0%, a degradation rate by GC = 0% (Official Bulletin of Ministry of International Trade and Industry, 1983)), and 21-day NOEC (reproduction) < 0.1 mg/L for crustacea (Daphnia magna) (Results of Aquatic Toxicity Tests of Chemicals conducted by Environment Agency in Japan (Environment Agency, 1995), Environmental Risk Assessment for Chemical Substances vol. 6 (Ministry of the Environment, 2008)), it was classified in Category 1. |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | No data available. |
* A blank or "-" in a cell of classification denotes that the classification of the hazard class was not conducted. * Hazard_statement_and/or_Precautionary_statement will show when hovering the mouse over a code of Hazard_statement_and/or_Precautionary_statement. Hazard_statement_and/or_Precautionary_statement are also provided in the Excel file. * Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. * Codes assigned to each of the hazard statements and codes for each of the precautionary statement are based on the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) in United Nations. |