GHS Classification Result
GENERAL INFORMATION
REFERENCE INFORMATION
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
GENERAL INFORMATION
| Item | Information |
|---|---|
| CAS RN | 7085-85-0 |
| Chemical Name | Ethyl 2-cyanoacrylate |
| Substance ID | H27-B-055/C-091B_P |
| Classification year (FY) | FY2015 |
| Ministry who conducted the classification | Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE) |
| New/Revised | Revised |
| Classification result in other fiscal year | FY2009 FY2006 |
| Download of Excel format | Excel file |
REFERENCE INFORMATION
| Item | Information |
|---|---|
| Guidance used for the classification (External link) | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
| UN GHS document (External link) | UN GHS document |
| Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
| Model Label by MHLW (External link) | MHLW Website (in Japanese Only) |
| Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
| OECD/eChemPortal (External link) | eChemPortal |
| Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. |
| 2 | Flammable gases (including chemically unstable gases) | Not applicable |
- |
- | - | Liquid (GHS definition) |
| 3 | Aerosols | Not applicable |
- |
- | - | Not aerosol products. |
| 4 | Oxidizing gases | Not applicable |
- |
- | - | Liquid (GHS definition) |
| 5 | Gases under pressure | Not applicable |
- |
- | - | Liquid (GHS definition) |
| 6 | Flammable liquids | Category 4 |
Warning |
H227 | P370+P378 P403+P235 P210 P280 P501 |
Based on flash points of 75 deg C (closed cup) (ICSC (2001)), and 82.78 deg C (closed cup) (HSDB (Access on August 2015)), it was classified in Category 4. |
| 7 | Flammable solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
| 8 | Self-reactive substances and mixtures | Classification not possible |
- |
- | - | There is an unsaturated bond (olefins) in chemical structure, but the classification is not possible due to no data. |
| 9 | Pyrophoric liquids | Not classified |
- |
- | - | It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 485 deg C (Dictionary of Organic Compounds (Kodansha Scientific, Ltd., 2004)) |
| 10 | Pyrophoric solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
| 11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Test methods applicable to liquid substances are not available. |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable |
- |
- | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
| 13 | Oxidizing liquids | Not applicable |
- |
- | - | The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen. |
| 14 | Oxidizing solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
| 15 | Organic peroxides | Not applicable |
- |
- | - | Organic compounds containing no bivalent -O-O- structure in the molecule |
| 16 | Corrosive to metals | Classification not possible |
- |
- | - | Test methods applicable to liquid with lower boiling point are not available. |
| Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Acute toxicity (Oral) | Not classified |
- |
- | - | It is estimated that an LD50 value for rats is > 5,000 mg/kg based on a report of 1/6 death by administration of 5,000 mg/kg to rats (CICAD 36 (2001)). And there is a report of an LD50 value of 5,000 mg/kg (HSDB (Access on August 2015)) for rats. Therefore, this substance was classified as "Not classified." |
| 1 | Acute toxicity (Dermal) | Not classified |
- |
- | - | Based on a report that there was no death by administration of 2,000 mg/kg to rabbits (CICAD 36 (2001)), this substance was classified as "Not classified." Besides, there is a report of an LD50 value of 2,000 mg/kg (HSDB (Access on August 2015)) for rabbits, and it corresponds to Category 4. However, the data in a higher priority information source (CICAD 36 (2001)) was adopted according to the GHS Classification Guidance for the Japanese Government. |
| 1 | Acute toxicity (Inhalation: Gases) | Not applicable |
- |
- | - | Liquid (GHS definition) |
| 1 | Acute toxicity (Inhalation: Vapours) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. There is a report of an LC50 value (1 hour) of < 21.11 mg/L (converted 4-hour equivalent value: < 5.278 mg/L) (ACGIH (7th, 2001)) for rats, but it was not possible to identify the category from this value alone. Besides, the reference value of mist was applied because the LC50 value is higher than the saturated vapor pressure concentration (13.7 mg/L). |
| 2 | Skin corrosion/irritation | Not classified |
- |
- | - | There is a report that in a skin irritation test with rabbits, as the result of application of liquid of this substance for 24 hours, slight erythema and edema (mean sore 0.83) were observed (CICAD 36 (2001)). In addition, there is a description that no skin irritation was observed in a single-exposure in humans (CICAD 36 (2001)). Besides, there is a description that this substance has a severe irritating potential (ACGIH (7th, 2001)), but it is determined that it is not a sufficient data to be used for classification since details of exposure time etc. were unknown in the information. From the above, this substance was classified as "Not classified." Besides, this substance was classified as "Skin. Irrit. 2 H315" in the EU CLP classification (ECHA CL Inventory (Access on September 2015)). |
| 3 | Serious eye damage/eye irritation | Category 2 |
 Warning |
H319 | P305+P351+P338 P337+P313 P264 P280 |
There is a report that in an eye irritation test with rabbits, as the result of application of this substance, mean scores for irritation were redness, 1.75; conjunctival edema, 0.5; corneal opacity, 0.75; and iris response, 0.5, and all symptoms resolved within 7 days (CICAD 36 (2001)). In addition, there is a description that this substance is severely irritating to the eyes (ACGIH (7th, 2001)), but details of recovery etc. were unknown. From the above results, this substance was classified in Category 2. This substance was classified as "Eye. Irrit. 2 H319" in the EU CLP classification (ECHA CL Inventory (Access on September 2015)). |
| 4 | Respiratory sensitization | Classification not possible |
- |
- | - | Asthma symptoms are reported in occupational exposure on handling this substance (ACGIH (7th, 2001), CICAD 36 (2001), DFGOT Vol.13 (1999)), but any assessment report does not conclude that they were due to this substance because there is a possibility of combined exposures. In addition, it was described in CICAD 36 (2001) that it was not possible to conclude regarding whether asthma was induced by an allergenic or an irritation mechanism (CICAD 36 (2001)). From the above, it was classified as "Classification not possible." |
| 4 | Skin sensitization | Classification not possible |
- |
- | - | In patch tests with workers who showed skin reactions in occupational exposure during handling this substance, positive reaction was reported (ACGIH (2001), CICAD 36 (2001), DFGOT Vol.13 (1999)), but it is described in all the evaluation reports that it is not sufficient information to conclude sensitization, and this substance was not regarded as a sensitizer (ACGIH (2001), CICAD 36 (2001), DFGOT Vol.13 (1999)). From the above, this substance was classified as "Classification not possible." |
| 5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | The substance was classified as "Classification not possible" because it became impossible to classify a substance as "Not classified" according to the revised GHS classification guidance for the Japanese Government. As for in vivo, the micronucleus assay in rat and mouse bone marrow cells was negative (NTP DB (Access on September 2015)). As for in vitro, bacterial reverse mutation tests were negative (CICAD 36 (2001), ACGIH (7th, 2001), DFGOT Vol. 1 (1990), NTP DB (Access on September 2015)). |
| 6 | Carcinogenicity | Classification not possible |
- |
- | - | There are no classification results by other organizations, therefore, it was not possible to classify due to lack of data. |
| 7 | Reproductive toxicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 8 | Specific target organ toxicity - Single exposure | Category 3 (Respiratory tract irritation) |
Warning |
H335 | P304+P340 P403+P233 P261 P271 P312 P405 P501 |
This substance is irritating to the respiratory tract (ACGIH (7th, 2001), CICAD 36 (2001), DFGOT Vol. 1 (1990)). There was no other data in humans and experimental animals. From the above, this substance was classified in Category 3 (respiratory tract irritation). Besides, as for data in CICAD in the previous classification, the findings on humans were the information of repeated exposure, and the findings on rats were observed at the dose (21,000 mg/m3=21 mg/L) exceeding Category 2. Therefore, they were not adopted. |
| 9 | Specific target organ toxicity - Repeated exposure | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 10 | Aspiration hazard | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment (Acute) | Classification not possible |
- |
- | - | No data available. |
| 11 | Hazardous to the aquatic environment (Long-term) | Classification not possible |
- |
- | - | No data available. |
| 12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | No data available. |
NOTE:
| * A blank or "-" in a cell of classification denotes that the classification of the hazard class was not conducted. * Hazard_statement_and/or_Precautionary_statement will show when hovering the mouse over a code of Hazard_statement_and/or_Precautionary_statement. Hazard_statement_and/or_Precautionary_statement are also provided in the Excel file. * Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. * Codes assigned to each of the hazard statements and codes for each of the precautionary statement are based on the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) in United Nations. |