GHS Classification Result
GENERAL INFORMATION
REFERENCE INFORMATION
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
GENERAL INFORMATION
| Item | Information |
|---|---|
| CAS RN | 137-05-3 |
| Chemical Name | Methyl 2-cyanoacrylate |
| Substance ID | H27-B-056/C-092B_P |
| Classification year (FY) | FY2015 |
| Ministry who conducted the classification | Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE) |
| New/Revised | Revised |
| Classification result in other fiscal year | FY2006 |
| Download of Excel format | Excel file |
REFERENCE INFORMATION
| Item | Information |
|---|---|
| Guidance used for the classification (External link) | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
| UN GHS document (External link) | UN GHS document |
| Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
| Model Label by MHLW (External link) | MHLW Website (in Japanese Only) |
| Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
| OECD/eChemPortal (External link) | eChemPortal |
| Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. |
| 2 | Flammable gases (including chemically unstable gases) | Not applicable |
- |
- | - | Liquid (GHS definition) |
| 3 | Aerosols | Not applicable |
- |
- | - | Not aerosol products. |
| 4 | Oxidizing gases | Not applicable |
- |
- | - | Liquid (GHS definition) |
| 5 | Gases under pressure | Not applicable |
- |
- | - | Liquid (GHS definition) |
| 6 | Flammable liquids | Category 4 |
Warning |
H227 | P370+P378 P403+P235 P210 P280 P501 |
Based on a flash point of 82.78 deg C (closed cup) (ACGIH (7th, 2001)), it was classified in Category 4. |
| 7 | Flammable solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
| 8 | Self-reactive substances and mixtures | Classification not possible |
- |
- | - | There is an unsaturated bond (olefins) in chemical structure, but the classification is not possible due to no data. |
| 9 | Pyrophoric liquids | Not classified |
- |
- | - | It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 485 deg C (Dictionary of Organic Compounds (Kodansha Scientific, Ltd., 2004)) |
| 10 | Pyrophoric solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
| 11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Test methods applicable to liquid substances are not available. |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable |
- |
- | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
| 13 | Oxidizing liquids | Not applicable |
- |
- | - | The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen. |
| 14 | Oxidizing solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
| 15 | Organic peroxides | Not applicable |
- |
- | - | Organic compounds containing no bivalent -O-O- structure in the molecule |
| 16 | Corrosive to metals | Not classified |
- |
- | - | Steel and aluminum may be used as a container (HSDB (Access on August 2015)). |
| Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Acute toxicity (Oral) | Not classified |
- |
- | - | There are reports that LD50 values for rats were 1,600-3,200 mg/kg (ACGIH (7th, 2001)), and that there was no death from 5,000 mg/kg administration to rats (CICAD 36 (2001)). The category cannot be identified in one case, but another case corresponds to "Not classified." Therefore, it was classified as "Not classified." The LD50 value of the evidence for the previous classification was corrected to 1,600-3,200 mg/kg, and the category was revised. |
| 1 | Acute toxicity (Dermal) | Not classified |
- |
- | - | Based on a report of an LD50 value of > 11,000 mg/kg for guinea pigs (ACGIH (7th, 2001)), this substance was classified as "Not classified." |
| 1 | Acute toxicity (Inhalation: Gases) | Not applicable |
- |
- | - | Liquid (GHS definition) |
| 1 | Acute toxicity (Inhalation: Vapours) | Category 2 |
 Danger |
H330 | P304+P340 P403+P233 P260 P271 P284 P310 P320 P405 P501 |
Based on a report of an LC50 value (6 hours) of 101 ppm (converted 4-hour equivalent value: 123 ppm) for rats (ACGIH (7th, 2001)), this substance was classified in Category 2. Besides, since the LC50 value was lower than the saturated vapor pressure concentration (< 2,700 ppm), a reference value in ppm units was applied as vapor without mist. |
| 1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 2 | Skin corrosion/irritation | Not classified |
- |
- | - | There is a report that in a skin irritation test with rabbits, as the result of 24-hour semi-occlusive application of 0.5 mL of this substance, slight erythema (score 0.75) was observed (CICAD 36 (2001)). In addition, there is a description that no irritation was seen in a single exposure in humans (CICAD 36 (2001)). From the above, this substance was classified as "Not classified." |
| 3 | Serious eye damage/eye irritation | Category 2B |
Warning |
H320 | P305+P351+P338 P337+P313 P264 |
There is a report that in an eye irritation test with rabbits, as the result of application of this substance, mean scores for irritation were conjunctival redness, 1.37; conjunctival edema, 0.96; corneal opacity, 1.00; and iritis, 0.48, and a recovery tendency was shown in the symptoms in the 72-hour observation period (CICAD 36 (2001)). In addition, there is a report that also in humans, reversible eye irritation was seen (ACGIH (7th, 2001)). From the above results, this substance was classified in Category 2B. Besides, this substance was classified as "Eye. Irrit. 2 H319" in the EU CLP classification (ECHA CL Inventory (Access on September 2015)). |
| 4 | Respiratory sensitization | Classification not possible |
- |
- | - | Asthma symptoms are reported in occupational exposure in which this substance was handled (ACGIH (7th, 2001), CICAD 36 (2001), DFGOT Vol. 13 (1999)), but none of the assessment reports conclude that they are due to this substance because there is a possibility of combined exposures. In addition, it was described in CICAD 36 (2001) that it was not possible to make conclusions regarding as to which mechanism, allergenic or an irritation, induced the asthma (CICAD 36 (2001)). From the above, it was classified as "Classification not possible." |
| 4 | Skin sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. Besides, there is a report that in a skin sensitization test with guinea pigs, no sensitization was observed (CICAD 36 (2001)). However, this was judged to be insufficient data for use in classification because details such as presence or absence of the control group were unknown. |
| 5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | The substance was classified as "Classification not possible" because it was not possible to classify a substance as "Not classified" according to the revised GHS classification guidance for the Japanese government. As for in vivo, a micronucleus test with bone marrow cells of mice was negative (CICAD 36 (2001)). As for in vitro, bacterial reverse mutation tests were positive, and mammalian cell gene mutation tests were negative (DFGOT Vol. 1 (1990), CICAD 36 (2001), ACGIH (7th, 2001), NTP DB (Access on October 2015)). |
| 6 | Carcinogenicity | Classification not possible |
- |
- | - | There are no classification results by other organizations, therefore, it was not possible to classify due to lack of data. |
| 7 | Reproductive toxicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 8 | Specific target organ toxicity - Single exposure | Category 3 (Respiratory tract irritation) |
 Warning |
H335 | P304+P340 P403+P233 P261 P271 P312 P405 P501 |
This substance is an irritant to the respiratory tract (ACGIH (7th, 2001), CICAD 36 (2001), DFGOT Vol. 1 (1990)). There was no other data in humans and experimental animals. From the above, this substance was classified in Category 3 (respiratory tract irritation). |
| 9 | Specific target organ toxicity - Repeated exposure | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 10 | Aspiration hazard | Classification not possible |
- |
- | - | Classification not possible due to lack of data. Besides, the kinematic viscosity is calculated to be 2.0 mm2/sec (25/20 deg C) from the numerical data (viscosity: 2.2 mPa*s (25 deg C), density (specific gravity): 1.1012 g/cm3 (20 deg C)) listed on HSDB (Access, August 2015). |
| Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment (Acute) | Classification not possible |
- |
- | - | No data available. |
| 11 | Hazardous to the aquatic environment (Long-term) | Classification not possible |
- |
- | - | No data available. |
| 12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | No data available. |
NOTE:
| * A blank or "-" in a cell of classification denotes that the classification of the hazard class was not conducted. * Hazard_statement_and/or_Precautionary_statement will show when hovering the mouse over a code of Hazard_statement_and/or_Precautionary_statement. Hazard_statement_and/or_Precautionary_statement are also provided in the Excel file. * Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. * Codes assigned to each of the hazard statements and codes for each of the precautionary statement are based on the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) in United Nations. |