Item | Information |
---|---|
CAS RN | 78-94-4 |
Chemical Name | Methyl vinyl ketone |
Substance ID | H27-B-065/C-101B_P |
Classification year (FY) | FY2015 |
Ministry who conducted the classification | Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE) |
New/Revised | Revised |
Classification result in other fiscal year | FY2006 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
UN GHS document (External link) | UN GHS document |
Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
Model Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | eChemPortal |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Explosives | Not applicable |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. |
2 | Flammable gases (including chemically unstable gases) | Not applicable |
- |
- | - | Liquid (GHS definition) |
3 | Aerosols | Not applicable |
- |
- | - | Not aerosol products. |
4 | Oxidizing gases | Not applicable |
- |
- | - | Liquid (GHS definition) |
5 | Gases under pressure | Not applicable |
- |
- | - | Liquid (GHS definition) |
6 | Flammable liquids | Category 2 |
Danger |
H225 | P303+P361+P353 P370+P378 P403+P235 P210 P233 P240 P241 P242 P243 P280 P501 |
Based on a flash point of -7 deg C (closed cup), and a boiling point of 81 deg C (ICSC (2003)), it was classified in Category 2. Besides, stabilized one is classified in Division 6.1, Subsidiary Risk 3, 8, PG I (UN1251) in UNRTDG. |
7 | Flammable solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
8 | Self-reactive substances and mixtures | Type G |
- |
- | - | There is an unsaturated bond (olefins) in the chemical structure, but the one containing stabilizer is classified in Division in 6.1 (3, 8), PG I in UNRTDG and does not correspond to the hazard class of the highest precedence, self-reactive substances and mixtures. Besides, the transport of the one with insufficient stabilizer is prohibited, and a pure substance corresponds to Type A. |
9 | Pyrophoric liquids | Not classified |
- |
- | - | It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 491 deg C (ICSC (2003)). |
10 | Pyrophoric solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Test methods applicable to liquid substances are not available. |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable |
- |
- | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
13 | Oxidizing liquids | Not applicable |
- |
- | - | The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen. |
14 | Oxidizing solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
15 | Organic peroxides | Not applicable |
- |
- | - | Organic compounds containing no bivalent -O-O- structure in the molecule |
16 | Corrosive to metals | Classification not possible |
- |
- | - | No data available. |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Category 2 |
Danger |
H300 | P301+P310 P264 P270 P321 P330 P405 P501 |
Based on reports of LD50 values of about 22 mg/kg (DFGOT Vol. 9 (1998)), 23.1 mg/kg (ACGIH (7th, 2001)), about 30 mg/kg, and 31 mg/kg (DFGOT Vol. 9 (1998)) for rats, this substance was classified in Category 2. |
1 | Acute toxicity (Dermal) | Category 1 |
Danger |
H310 | P302+P352 P361+P364 P262 P264 P270 P280 P310 P321 P405 P501 |
Based on reports that in dermal application to rabbits at 0.05 mg/kg and 0.2 mg/kg, 3/3 died in both cases (DFGOT vol. 9 (1998)), this substance was classified in Category 1. |
1 | Acute toxicity (Inhalation: Gases) | Not applicable |
- |
- | - | Liquid (GHS definition) |
1 | Acute toxicity (Inhalation: Vapours) | Category 1 |
Danger |
H330 | P304+P340 P403+P233 P260 P271 P284 P310 P320 P405 P501 |
Based on reports of LC50 values of 2.4 ppm (ACGIH (7th, 2001)), 22.4 ppm (DFGOT vol. 9 (1998)) for rats, this substance was classified in Category 1. Besides, since the LC50 values were lower than 90% of the saturated vapor pressure concentration (123,552 ppm), a reference value in the unit of ppm was applied as vapor without mist. |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
2 | Skin corrosion/irritation | Category 1 |
Danger |
H314 | P301+P330+P331 P303+P361+P353 P305+P351+P338 P304+P340 P260 P264 P280 P310 P321 P363 P405 P501 |
There is a report that in a skin irritation test with rabbits, as the result of application of undiluted 0.2 mL solution of this substance, hyperemia, oedema, ulcers, and scar formation were observed, and resolving of symptoms required 28 to 30 days (DFGOT Vol. 9 (1998)). In addition, there is a report that in another test with rabbits, at 1.5 and 15 minutes after application of this substance, severe inflammation was observed, severe necrosis leading to the skin tissue and muscle tissue was observed, and recovery property was not observed (DFGOT Vol. 9 (1998)). Moreover, there are descriptions that this substance shows severe irritation to human skin (ACGIH (7th, 2001)), and it shows corrosivity (DFGOT Vol.9 (1998)). From the above, this substance was classified in Category 1. |
3 | Serious eye damage/eye irritation | Category 1 |
Danger |
H318 | P305+P351+P338 P280 P310 |
There is a report that in an eye irritation test with rabbits, as the result of application of one drop of this substance, severe damage was observed, and loss of vision occurred (DFGOT Vol. 9 (1998)). In addition, there are descriptions that this substance shows severe irritation to human eyes (ACGIH (7th, 2001)), and it shows corrosivity (DFGOT Vol.9 (1998)). This substance was classified in Category 1 for skin corrosion/irritation. From the above, this substance was classified in Category 1. |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
4 | Skin sensitization | Category 1 |
Warning |
H317 | P302+P352 P333+P313 P362+P364 P261 P272 P280 P321 P501 |
There is a report that sensitization was observed in a skin sensitization test with guinea pigs (DFGOT Vol. 9 (1998)), and it is described that severe contact dermatitis or slight sensitization was observed in two open epicutaneous tests with guinea pigs (DFGOT Vol. 9 (1998)). In addition, this substance was classified as Sh in DFG (MAK/BAT, 2004). From the above, this substance was classified in Category 1. |
5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | As for in vivo, a micronucleus test with the bone marrow cells of male rats gave an equivocal result, and the results of micronucleus test with mouse peripheral blood were negative in females and equivocal in males (NTP DB (Access on October 2015)). As for in vitro, there are positive and negative results in bacterial reverse mutation tests (DFGOT Vol. 9 (1998), ACGIH (7th, 2001), NTP DB (Access on October 2015)). Because there were no clear positive findings in in-vivo tests, it was classified as "Classification not possible" according to the GHS Classification Guidance for the Japanese Government. |
6 | Carcinogenicity | Classification not possible |
- |
- | - | There was no classification result by other organizations. Therefore, classification was not possible to due to lack of data. |
7 | Reproductive toxicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
8 | Specific target organ toxicity - Single exposure | Category 1 (respiratory organs, kidney), Category 3 (narcotic effects) |
Danger Warning |
H370 H336 |
P308+P311 P260 P264 P270 P321 P405 P501 P304+P340 P403+P233 P261 P271 P312 |
This substance has respiratory tract irritating potential and narcotic effects in humans (ACGIH (7th, 2001), DFGOT Vol. 9 (1998)). As for experimental animals, there are reports of effects on the respiratory organs (severe damage in the respiratory tract mucosa, and pulmonary oedema) by inhalation exposure (corresponding to Category 1) of rats, mice, and guinea pigs, and severe kidney damage (details were unknown) by oral administration (corresponding to Category 1) to rabbits and cats (DFGOT Vol. 9 (1998), BUA 233 (2003)). From the above, this substance has effects on the respiratory organs and kidney in addition to narcotic effects, and it was classified in Category 1 (respiratory organs, kidney), Category 3 (narcotic effects). |
9 | Specific target organ toxicity - Repeated exposure | Category 1 (respiratory organs) |
Danger |
H372 | P260 P264 P270 P314 P501 |
There is no adverse information on repeated exposure in humans. As for experimental animals, there is a report that in the tests in which rats and mice were exposed 12 times by inhalation to 1 ppm of this substance, damage in the upper respiratory tract was observed in both species, and no effects was observed at 0.5 ppm (BUA 233 (2003)). Also, there is a description that in a test where rats were exposed by inhalation to 6.9 ppm of this substance for 2.5 months, dyspnea was observed (DFGOT Vol. 9 (1998)). Therefore, the respiratory organs were considered as the target organ in the inhalation route. The converted guidance concentration as exposure by vapor was calculated to be 0.00038, 0.0011 mg/L/6 hr, respectively, and they correspond to Category 1. Therefore, it was classified in Category 1 (respiratory organs) for this hazard class. |
10 | Aspiration hazard | Classification not possible |
- |
- | - | There is no case of aspiration hazard in humans. However, this substance belongs to ketones composed of carbon atoms of 3 or more and not more than 13, and the calculated kinematic viscosity value is 0.934 mm2/sec (21/20 deg C) based on the numerical data listed in HSDB (Access on August 2015) (viscosity: 0.807 mPa*s (21 deg C), density (specific gravity): 0.8636 (20 deg C)). From the above, it corresponds to Category 2 in the UN GHS classification, but it was classified as "Classification not possible" according to the current GHS classification guidance for the Japanese Government revised after the previous classification. |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment (Acute) | Category 1 |
Warning |
H400 | P273 P391 P501 |
From 96-hour EC50 (biomass) = 0.12 mg/L for algae (Pseudokirchneriella subcapitata) (HSDB, 2007, AQUIRE, 2016), it was classified in Category 1. |
11 | Hazardous to the aquatic environment (Long-term) | Category 1 |
Warning |
H410 | P273 P391 P501 |
Reliable chronic toxicity data were not obtained. Because appropriate data on rapid degradability are not obtained, and due to acute toxicity Category 1, it was classified in Category 1. |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | No data available. |
* A blank or "-" in a cell of classification denotes that the classification of the hazard class was not conducted. * Hazard_statement_and/or_Precautionary_statement will show when hovering the mouse over a code of Hazard_statement_and/or_Precautionary_statement. Hazard_statement_and/or_Precautionary_statement are also provided in the Excel file. * Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. * Codes assigned to each of the hazard statements and codes for each of the precautionary statement are based on the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) in United Nations. |