GHS Classification Result

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GENERAL INFORMATION
Item Information
CAS RN 7440-25-7
Chemical Name Tantalum
Substance ID H27-B-072/C-117B_P
Classification year (FY) FY2015
Ministry who conducted the classification Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised Revised
Classification result in other fiscal year FY2006  
Download of Excel format Excel file

REFERENCE INFORMATION
Item Information
Guidance used for the classification (External link) GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
UN GHS document (External link) UN GHS document
Definitions/Abbreviations (Excel file) Definitions/Abbreviations
Model Label by MHLW (External link) MHLW Website (in Japanese Only)
Model SDS by MHLW (External link) MHLW Website (in Japanese Only)
OECD/eChemPortal (External link) eChemPortal

PHYSICAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Explosives Not applicable
-
-
- - There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases (including chemically unstable gases) Not applicable
-
-
- - Solid (GHS definition).
3 Aerosols Not applicable
-
-
- - Not aerosol products.
4 Oxidizing gases Not applicable
-
-
- - Solid (GHS definition).
5 Gases under pressure Not applicable
-
-
- - Solid (GHS definition).
6 Flammable liquids Not applicable
-
-
- - Solid (GHS definition).
7 Flammable solids Classification not possible
-
-
- - Because combustibility is different depending on forms and so on, the comprehensive classification is not possible.
8 Self-reactive substances and mixtures Not applicable
-
-
- - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not applicable
-
-
- - Solid (GHS definition).
10 Pyrophoric solids Classification not possible
-
-
- - There is an autoignition temperature data of > 250 deg C (ICSC (2005)), but on the other hand, there is the information that the dry powder ignites spontaneously in air (HSDB (Access on September 2015)). Because a tendency to ignite spontaneously is different depending on forms and so on, the comprehensive classification is not possible.
11 Self-heating substances and mixtures Classification not possible
-
-
- - No data available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified
-
-
- - It is estimated that it does not react vigorously with water because water solubility was measured.
Water solubility: < 0.01 g/L (20 deg C) (GESTIS (Access on September 2015))
13 Oxidizing liquids Not applicable
-
-
- - Solid (GHS definition).
14 Oxidizing solids Not applicable
-
-
- - It is an inorganic substance not containing oxygen or halogen.
15 Organic peroxides Not applicable
-
-
- - It is an inorganic substance.
16 Corrosive to metals Classification not possible
-
-
- - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Acute toxicity (Oral) Classification not possible
-
-
- - Classification not possible due to lack of data. Besides, there is a report of an LD50 value of 595 mg/kg for mice (RTECS (Access on September 2015)), however, the original source could not be confirmed. Therefore, it was classified as "Classification not possible."
1 Acute toxicity (Dermal) Classification not possible
-
-
- - Classification not possible due to lack of data.
1 Acute toxicity (Inhalation: Gases) Not applicable
-
-
- - Solid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Not applicable
-
-
- - Solid (GHS definition)
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible
-
-
- - Classification not possible due to lack of data.
2 Skin corrosion/irritation Classification not possible
-
-
- - Classification not possible due to lack of data.
3 Serious eye damage/eye irritation Classification not possible
-
-
- - Classification not possible due to lack of data. Since the information used in the previous classification is from the information sources listed in List 3 or absent from the Lists in the GHS classification guidance for the Japanese government, these were deleted.
4 Respiratory sensitization Classification not possible
-
-
- - Classification not possible due to lack of data.
4 Skin sensitization Classification not possible
-
-
- - Classification not possible due to lack of data.
5 Germ cell mutagenicity Classification not possible
-
-
- - Classification not possible due to lack of data.
6 Carcinogenicity Classification not possible
-
-
- - There is a description that for local influence, 714 days after implantation of metal tantalum into the rats, there is a report that formation of malignant fibrosarcoma was found in 2 out of 50 sites, but objection and controversy occurred against the report (PATTY (6th, 2012)). In addition, there is also a report that for the evaluation of the safety of a novel medical material for implantation in the body, a group in which pellets of this substance were implanted into the bodies of rats (1 mm x 2 mm, cylindrical) was set as a negative control. Up to 20 pellets were intramuscularly implanted in rats, however, tumor development was not observed (PATTY (6th, 2012)). Regarding carcinogenicity of this substance, there are no classification results by other organizations. From the above, it was classified as "Classification not possible" due to lack of data for this hazard class.
7 Reproductive toxicity Classification not possible
-
-
- - Classification not possible due to lack of data. Besides, there is a report that 20 pellets of this substance, 1-2 mm, were implanted into the bodies of male rats, and they were observed for a period corresponding to about 21% of their lifetime, but no adverse effects on the fertility and the quality of sperm (concentration, motility) in males were seen (PATTY (6th, 2012)).
8 Specific target organ toxicity - Single exposure Category 3 (Respiratory tract irritation)


Warning
H335 P304+P340
P403+P233
P261
P271
P312
P405
P501
Base on the description that this substance may be irritating to the respiratory tract (ACGIH (7th, 2001)), it was classified in Category 3 (respiratory tract irritation).
9 Specific target organ toxicity - Repeated exposure Classification not possible
-
-
- - Classification not possible due to lack of data.
Besides, there is a report that the passivity of tantalum metal to biological tissues was sufficiently demonstrated by long-term use in surgical treatment in animals and humans (ACGIH (7th, 2001), DFGOT Vol.16 (2001), PATTY (6th, 2012)). In animals, it is reported that implantation of tantalum plates or screws did not cause inflammation and edema (ACGIH (7th, 2001), DFGOT Vol.16 (2001), PATTY (6th, 2012)), and there is a report that on the insertion of tantalum plates into the bones of dogs and rabbits for 3 weeks to 3 months, no evidence for irritation of the bone and soft tissue was seen in microscopic and X-ray examinations (ACGIH (7th, 2001), DFGOT Vol.16 (2001), PATTY (6th, 2012)).
On the other hand, as one report showing a few effects, it is reported that in patients who had orbital implants, pain, headache, mucopurulent eye discharge, diffuse conjunctival inflammation, and erosion of tissues surrounding the implants were observed 10-15 years after the implantation (PATTY (6th, 2012)).
10 Aspiration hazard Classification not possible
-
-
- - Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Classification not possible
-
-
- - No data available.
11 Hazardous to the aquatic environment (Long-term) Classification not possible
-
-
- - No data available.
12 Hazardous to the ozone layer Classification not possible
-
-
- - No data available.


NOTE:
* A blank or "-" in a cell of classification denotes that the classification of the hazard class was not conducted.
* Hazard_statement_and/or_Precautionary_statement will show when hovering the mouse over a code of Hazard_statement_and/or_Precautionary_statement.
Hazard_statement_and/or_Precautionary_statement are also provided in the Excel file.
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government,
and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.
* Codes assigned to each of the hazard statements and codes for each of the precautionary statement are
based on the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) in United Nations.

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