GHS Classification Result

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GENERAL INFORMATION
Item Information
CAS RN 7440-67-7
Chemical Name Zirconium
Substance ID H27-B-073/C-118B_P
Classification year (FY) FY2015
Ministry who conducted the classification Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised Revised
Classification result in other fiscal year FY2007  
Download of Excel format Excel file

REFERENCE INFORMATION
Item Information
Guidance used for the classification (External link) GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
UN GHS document (External link) UN GHS document
Definitions/Abbreviations (Excel file) Definitions/Abbreviations
Model Label by MHLW (External link) MHLW Website (in Japanese Only)
Model SDS by MHLW (External link) MHLW Website (in Japanese Only)
OECD/eChemPortal (External link) eChemPortal

PHYSICAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Explosives Not applicable
-
-
- - There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases (including chemically unstable gases) Not applicable
-
-
- - Solid (GHS definition).
3 Aerosols Not applicable
-
-
- - Not aerosol products.
4 Oxidizing gases Not applicable
-
-
- - Solid (GHS definition).
5 Gases under pressure Not applicable
-
-
- - Solid (GHS definition).
6 Flammable liquids Not applicable
-
-
- - Solid (GHS definition).
7 Flammable solids Category 1


Danger
H228 P370+P378
P210
P240
P241
P280
It is described that finely dispersed particles form explosive mixtures in air (ICSC (2004)). For mechanically-produced powders with particle size less than 53 microns or chemically-produced powders with particle size less than 840 microns, if wetted with water, it is classified in Division 4.1, PG II (UN 1358) in UNRTDG, therefore, it is classified in Category 1. On the other hand, dry one is classified in Division 4.2, PG I, II, III (UN 2008) in UNRTDG. Because it is thought that the dry one is more combustible than the wet one, it was classified in Category 1 regardless of whether it is dry or wet.
8 Self-reactive substances and mixtures Not applicable
-
-
- - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not applicable
-
-
- - Solid (GHS definition).
10 Pyrophoric solids Classification not possible
-
-
- - Because it is described that an autoignition temperature is > 200 deg C (HSDB (Access on September 2015)), it is classified as "Not classified." On the other hand, a dry zirconium powder is classified in Division 4.2, PG I, II, III (UN 2008) in UNRTDG, and if PG I is allocated, it is classified in Category 1. From the above, because a tendency to ignite spontaneously is different depending on particle size and so on, the unified classification cannot be given for the substance.
11 Self-heating substances and mixtures Classification not possible
-
-
- - A dry zirconium powder is classified in Division 4.2, PG I, II, III (UN 2008) in UNRTDG. If PG I is allocated, it is classified as "Not applicable" because it is pyrophoric solid, and if PG II is allocated, it is classified in Category 1, and if PG III is allocated, it is classified in Category 2. Because a self-heating property is different depending on particle size and so on, the unified classification cannot be given for the substance.
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified
-
-
- - It is estimated that it does not react vigorously with water from the observation result that it is insoluble in water (ICSC (2004)).
13 Oxidizing liquids Not applicable
-
-
- - Solid (GHS definition).
14 Oxidizing solids Not applicable
-
-
- - It is an inorganic substance not containing oxygen or halogen.
15 Organic peroxides Not applicable
-
-
- - It is an inorganic substance.
16 Corrosive to metals Classification not possible
-
-
- - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Acute toxicity (Oral) Classification not possible
-
-
- - Classification not possible due to lack of data.
1 Acute toxicity (Dermal) Classification not possible
-
-
- - Classification not possible due to lack of data.
1 Acute toxicity (Inhalation: Gases) Not applicable
-
-
- - Solid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Not applicable
-
-
- - Solid (GHS definition)
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible
-
-
- - Classification not possible due to lack of data.
2 Skin corrosion/irritation Classification not possible
-
-
- - Classification not possible due to lack of data.
3 Serious eye damage/eye irritation Classification not possible
-
-
- - Classification not possible due to lack of data.
4 Respiratory sensitization Classification not possible
-
-
- - Classification not possible due to lack of data. Besides, zirconium and zirconium compounds were classified as respiratory sensitizing substance in DFGOT vol. 12 (1999). However, this substance was classified as "Classification not possible" since it could not be determined whether it was applicable to this substance or not.
4 Skin sensitization Classification not possible
-
-
- - Classification not possible due to lack of data. Besides, there are epidemiological studies that this substance and zirconium compounds cause epithelioid granuloma skin sensitization to humans, and a report that zirconium compounds cause delayed hypersensitivity to experimental animals (DFGOT vol. 12 (1999)). Also, this substance and zirconium compounds were classified as a skin sensitizer in DFGOT vol. 12 (1999). But, it was not judged as sensitizer by ACGIH because sufficient data were not available (ACGIH (7th, 2001)). From the above, this substance was classified as "Classification not possible."
5 Germ cell mutagenicity Classification not possible
-
-
- - Classification not possible due to lack of data.
6 Carcinogenicity Classification not possible
-
-
- - There is no information on carcinogenicity in humans. As for experimental animals, in a study in which rats were orally given 5 ppm of zirconium sulfate for their lifetime, no difference in survival time and tumor incidence between the zirconium administered group and the control group was observed (ACGIH (7th, 2001), DFGOT vol. 12 (1999)). Zirconium and zirconium compounds were classified in A4 for carcinogenicity by ACGIH based on the test results of rats (ACGIH (7th, 2001)). Therefore, it was classified as "Classification not possible" for this hazard class.
7 Reproductive toxicity Classification not possible
-
-
- - Classification not possible due to lack of data.
8 Specific target organ toxicity - Single exposure Category 3 (Respiratory tract irritation)


Warning
H335 P304+P340
P403+P233
P261
P271
P312
P405
P501
Based on a description that this substance is irritating to the respiratory tract (ACGIH (7th, 2001)), this substance was classified in Category 3 (respiratory tract irritation).
9 Specific target organ toxicity - Repeated exposure Classification not possible
-
-
- - Classification not possible due to lack of data.
Besides, in 22 workers who were exposed to fumes of zirconium (zirconium chloride, zirconium oxide, metallic zirconium) in a refining and reduction process for 1-5 years (the amount of exposure was not specified), no pulmonary granulomas were observed, but mild bronchial asthma in 2 workers and chronic bronchitis in 5 workers were observed. However, there are reports that some of these people had also been exposed to chlorine (DFGOT Vol.12 (1999), Reed (1956) cited in DFGOT Vol.12 (1999)). Also, based on the same information, it is described in ACGIH (7th, 2001) and PATTY (6th, 2012) that there were no (striking) abnormalities related to zirconium.
10 Aspiration hazard Classification not possible
-
-
- - Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Classification not possible
-
-
- - No data available.
11 Hazardous to the aquatic environment (Long-term) Classification not possible
-
-
- - No data available.
12 Hazardous to the ozone layer Classification not possible
-
-
- - No data available.


NOTE:
* A blank or "-" in a cell of classification denotes that the classification of the hazard class was not conducted.
* Hazard_statement_and/or_Precautionary_statement will show when hovering the mouse over a code of Hazard_statement_and/or_Precautionary_statement.
Hazard_statement_and/or_Precautionary_statement are also provided in the Excel file.
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government,
and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.
* Codes assigned to each of the hazard statements and codes for each of the precautionary statement are
based on the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) in United Nations.

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