Item | Information |
---|---|
CAS RN | 1314-23-4 |
Chemical Name | Zirconium oxide |
Substance ID | H27-A-047/C-121A_P |
Classification year (FY) | FY2015 |
Ministry who conducted the classification | Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE) |
New/Revised | New |
Classification result in other fiscal year | |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
UN GHS document (External link) | UN GHS document |
Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
Model Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | eChemPortal |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Explosives | Not applicable |
- |
- | - | There are no chemical groups present in the molecule associated with explosive properties. |
2 | Flammable gases (including chemically unstable gases) | Not applicable |
- |
- | - | "Solids" according to GHS definition. |
3 | Aerosols | Not applicable |
- |
- | - | Not an aerosol product. |
4 | Oxidizing gases | Not applicable |
- |
- | - | "Solids" according to GHS definition. |
5 | Gases under pressure | Not applicable |
- |
- | - | "Solids" according to GHS definition. |
6 | Flammable liquids | Not applicable |
- |
- | - | "Solids" according to GHS definition. |
7 | Flammable solids | Classification not possible |
- |
- | - | Due to no data, the classification is not possible. |
8 | Self-reactive substances and mixtures | Not applicable |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. |
9 | Pyrophoric liquids | Not applicable |
- |
- | - | "Solids" according to GHS definition. |
10 | Pyrophoric solids | Classification not possible |
- |
- | - | Due to no data, the classification is not possible. |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Due to no data, the classification is not possible. |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified |
- |
- | - | Because there is the observation result of being almost insoluble in water (Merck (15th, 2013)), it is estimated that it does not react vigorously with water. |
13 | Oxidizing liquids | Not applicable |
- |
- | - | "Solids" according to GHS definition. |
14 | Oxidizing solids | Classification not possible |
- |
- | - | It is an inorganic compound that contains oxygen, but the classification is not possible due to no data. |
15 | Organic peroxides | Not applicable |
- |
- | - | It is an inorganic compound. |
16 | Corrosive to metals | Classification not possible |
- |
- | - | No established test method suitable for solid substances. |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Classification not possible |
- |
- | - | Due to lack of data, the classification is not possible. |
1 | Acute toxicity (Dermal) | Classification not possible |
- |
- | - | Due to lack of data, the classification is not possible. |
1 | Acute toxicity (Inhalation: Gases) | Not applicable |
- |
- | - | "Solids" according to GHS definition. |
1 | Acute toxicity (Inhalation: Vapours) | Not applicable |
- |
- | - | "Solids" according to GHS definition. |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | Due to lack of data, the classification is not possible. |
2 | Skin corrosion/irritation | Classification not possible |
- |
- | - | Due to lack of data, the classification is not possible. |
3 | Serious eye damage/eye irritation | Classification not possible |
- |
- | - | Due to lack of data, the classification is not possible. |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | The classification is not possible due to lack of data. Besides, in DFGOT vol. 12 (1999), zirconium and its compounds are classified as a respiratory sensitizer from the information on zirconium and other zirconium compounds, but this substance was classified as "Classification not possible" due to no information on the substance. |
4 | Skin sensitization | Category 1 |
Warning |
H317 | P302+P352 P333+P313 P362+P364 P261 P272 P280 P321 P501 |
It is reported that this substance causes Granulomatous skin reactions in humans (DFGOT vol. 12 (1999)). In DFGOT vol. 12 (1999), zirconium and its compounds are classified as a sensitizer (Sah). From the above, this substance was classified in Category 1. |
5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | Due to lack of data, the classification is not possible. |
6 | Carcinogenicity | Classification not possible |
- |
- | - | As described in this hazard class for zirconium (CAS number: 7440-67-7), ACGIH classified zirconium and its compounds in A4 in carcinogenicity (ACGIH (7th, 2001)). Therefore, this substance was classified as "Classification not possible" for this hazard class. |
7 | Reproductive toxicity | Classification not possible |
- |
- | - | Due to lack of data, the classification is not possible. |
8 | Specific target organ toxicity - Single exposure | Classification not possible |
- |
- | - | Due to lack of data, the classification is not possible. |
9 | Specific target organ toxicity - Repeated exposure | Classification not possible |
- |
- | - | As for humans, it is reported that effects on lungs were not observed in workers exposed to this substance (DFGOT vol. 12 (1999)). On the other hand, changes in the lung (asthma, bronchitis, pneumoconiosis, sarcoid granulomatosis, granulomatous interstitial pneumonia) were reported, but it is reported that association with this substance is not clear because they were also exposed to other substances that could cause lung damage (DFGOT vol. 12 (1999)). However, there are cases where zirconium was confirmed in granulomatous lesions in the lungs of three, and extrinsic allergic alveolitis was observed just in one. It is reported that histological examination of the lungs revealed "various stages of epithelioid cell granuloma induced by foreign matter" with foreign matter inclusions in giant cells and fibrosis, and the principal component of foreign matter is zirconium, and similar changes were also found in skin, and granulomatous lesions were observed in mammary and axillary lymph nodes (DFGOT vol. 12 (1999)). As for experimental animals, it is reported that toxic effects were not found in an inhalation toxicity test using rats, rabbits, dogs, guinea pigs, and cats (DFGOT vol. 12 (1999), ACGIH (7th, 2001)). It is also reported that in a diet administration test using rats, toxic effects were not observed (DFGOT vol. 12 (1999)). As above, because effects of this substance cannot be denied completely in humans, the substance was classified as "Classification not possible." |
10 | Aspiration hazard | Classification not possible |
- |
- | - | Due to lack of data, the classification is not possible. |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment (Acute) | Classification not possible |
- |
- | - | No data. |
11 | Hazardous to the aquatic environment (Long-term) | Classification not possible |
- |
- | - | No data. |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | No data. |
* A blank or "-" in a cell of classification denotes that the classification of the hazard class was not conducted. * Hazard_statement_and/or_Precautionary_statement will show when hovering the mouse over a code of Hazard_statement_and/or_Precautionary_statement. Hazard_statement_and/or_Precautionary_statement are also provided in the Excel file. * Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. * Codes assigned to each of the hazard statements and codes for each of the precautionary statement are based on the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) in United Nations. |