GHS Classification Result

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GENERAL INFORMATION
Item Information
CAS RN 65996-93-2
Chemical Name Coal tar pitch (high-temp.)/coal tar pitch
Substance ID H27-A-057/C-135A_P
Classification year (FY) FY2015
Ministry who conducted the classification Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised New
Classification result in other fiscal year  
Download of Excel format Excel file

REFERENCE INFORMATION
Item Information
Guidance used for the classification (External link) GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
UN GHS document (External link) UN GHS document
Definitions/Abbreviations (Excel file) Definitions/Abbreviations
Model Label by MHLW (External link) MHLW Website (in Japanese Only)
Model SDS by MHLW (External link) MHLW Website (in Japanese Only)
OECD/eChemPortal (External link) eChemPortal

PHYSICAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Explosives Not applicable
-
-
- - It is estimated that there are no chemical groups present in the molecule associated with explosive properties.
2 Flammable gases (including chemically unstable gases) Not applicable
-
-
- - "Solids" according to GHS definition.
3 Aerosols Not applicable
-
-
- - Not an aerosol product.
4 Oxidizing gases Not applicable
-
-
- - "Solids" according to GHS definition.
5 Gases under pressure Not applicable
-
-
- - "Solids" according to GHS definition.
6 Flammable liquids Not applicable
-
-
- - "Solids" according to GHS definition.
7 Flammable solids Classification not possible
-
-
- - The classification is not possible due to no data. Besides, there is information that it is combustible (ICSC (2002)).
8 Self-reactive substances and mixtures Not applicable
-
-
- - It is estimated that there are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not applicable
-
-
- - "Solids" according to GHS definition.
10 Pyrophoric solids Not classified
-
-
- - It is estimated that it does not ignite at normal temperatures from an ignition point of > 500 degrees C (HSFS (2009)).
11 Self-heating substances and mixtures Classification not possible
-
-
- - The classification is not possible due to no data (melting point 30 to 180 degrees C (ICSC (2002))).
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified
-
-
- - It is estimated that it does not react vigorously with water from water solubility data measured.
water solubility: 0.0035 to 0.0041 mg/L (25 degrees C) (NITE Chemical Risk Information Platform (Access on October 2015))
13 Oxidizing liquids Not applicable
-
-
- - "Solids" according to GHS definition.
14 Oxidizing solids Not applicable
-
-
- - It is estimated that it is an organic compound which contains oxygen, and the oxygen is not chemically bonded to the elements other than carbon or hydrogen.
15 Organic peroxides Not applicable
-
-
- - It is estimated that it is It is an organic compound that does not contain bivalent -O-O- structure in the molecule.
16 Corrosive to metals Classification not possible
-
-
- - The classification is not possible due to no data (melting point 30 to 180 degrees C (ICSC (2002))).

HEALTH HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Acute toxicity (Oral) Not classified
-
-
- - From reported LD50 values of 3,300 mg/kg, > 5,000 mg/kg, 6,200 mg/kg, and > 15,000 mg/kg for rats (EU-RAR (2008)), it was classified as "Not classified."
1 Acute toxicity (Dermal) Not classified
-
-
- - There are two reported LD50 values of > 400 mg/kg and > 5,000 mg/kg for rats (EU-RAR (2008)). Because one corresponds to "Classification not possible," and the other corresponds to "Not classified," it was classified as "Not classified."
1 Acute toxicity (Inhalation: Gases) Not applicable
-
-
- - "Solids" according to GHS definition.
1 Acute toxicity (Inhalation: Vapours) Not applicable
-
-
- - "Solids" according to GHS definition.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible
-
-
- - Due to lack of data, the classification is not possible.
2 Skin corrosion/irritation Classification not possible
-
-
- - The classification is not possible due to lack of data. Besides, it is written in EU-RAR (2008) that skin signs occurred in exposure to volatile coal tar pitch (including combined exposure to light) in animals and humans, but it is not possible to judge whether they were caused by skin irritation (EU-RAR (2008)).
3 Serious eye damage/eye irritation Classification not possible
-
-
- - The classification is not possible due to lack of data. Besides, it was concluded that there is a risk of serious damage to eyes (Xi, R41) as eye irritant in occupational exposure to coal tar pitch (fumes, volatiles) (EU-RAR (2008)). Moreover, it is reported that in a test in the application of 10 micro L coal tar pitch distillate into rabbit eyes, congestion of lids (vasodilatation), lacrimation, and slight mucosal discharge were observed after 24 hours but resolved (EU-RAR (2008), IARC 35 (1985)), but the details are unknown.
4 Respiratory sensitization Classification not possible
-
-
- - Due to lack of data, the classification is not possible.
4 Skin sensitization Classification not possible
-
-
- - The classification is not possible due to lack of data. Besides, it is written in EU-RAR (2008) that skin signs occurred in humans and animals after exposure to coal tar pitch (volatiles) alone or combined exposure to light, but it is not possible to judge whether they were caused by skin irritation, skin sensitization, or photosensitization. However, it is proposed that this substance is regarded as a skin sensitizer in accordance with the EU-CLP regulation because it contains 1.5% benzo(a)pyrene (a skin sensitizer) (EU-RAR (2008)).
5 Germ cell mutagenicity Category 1B


Danger
H340 P308+P313
P201
P202
P280
P405
P501
There are no in vivo data on this substance, and as for in vitro, a bacterial reverse mutation test, a mouse lymphoma test and a sister chromatid exchange test in cultured mammalian cells were positive, and a gene mutation test in cultured mammalian cells was negative (ECHA RAC (2011), EU-RAR (2008), IARC 35 (1985), IARC 100F (2012)). Because this substance contains 1.5% benzo(a)pyrene (Muta Cat. 1B), it was classified in "Category 1B" as a mixture (containing 0.1% benzo(a)pyrene or more).
6 Carcinogenicity Category 1A


Danger
H350 P308+P313
P201
P202
P280
P405
P501
IARC concluded in 2010 that there is sufficient evidence of human carcinogenicity in occupational exposure to this substance during road paving and roofing from the epidemiological study result suggesting that there is an increased cancer risk in pavers and roofers who are possibly exposed to coal tar pitch (partly including combined exposure to bitumen (asphalt)) (IARC 100F (2012)). Especially, an epidemiological study in roofers or pavers in USA and UK revealed an excess risk of lung cancer, which was also confirmed in a follow-up study on cancer incidence in pavers in Finland and Netherlands (IARC 100F (2012)). Moreover, high lung cancer mortality and incidence were reported among workers who were exposed to an asphalt mixture containing coal tar in early times before 1970 in France and before 1965 in Norway and Sweden. However, by quality improvement of asphalt, the 2003 report did not show a significant increase in either mortality or an incidence (IARC 100F (2012)). Furthermore, it is also written that a relative risk of lung cancer was elevated to 1.49 for a low exposure group and 10.7 for an intermediate exposure group compared to 1 for an unexposed group as a result of analysis by semi-quantitative ranking of coal tar exposure levels (the product of score and years) in a study in road paving workers in Finland (IARC 100F (2012)).
As for experimental animals, incidences of skin tumors including skin cancers were observed in all of 6 tests in a dermal application of coal tar pitch to mice, and three tests in a dermal application of coal tar pitch extract to mice (IARC 35 (1985), IARC 100F (2012)). As above, IARC classified this substance in Group 1 by claiming that there is sufficient evidence in humans for carcinogenicity of coal tar pitch exposure involved in paving and roofing, and this substance during work can be a causal substance of lung cancer, and there is also sufficient evidence of carcinogenicity in experimental animals for this substance (IARC 100F (2012)). Besides this, as for this substance (including volatiles), EU classified "Pitch, coal tar, high-temp" in "Carc. 1A" (ECHA Termination of Evaluation (2014)), and Japan Society for Occupational Health classified coal tar and coal tar pitch volatiles in "Group 1" (The Recommendation of Acceptable Concentration (2015)). From the above, this substance was classified in Category 1A for this hazard class.
7 Reproductive toxicity Category 1B


Danger
H360 P308+P313
P201
P202
P280
P405
P501
There are no data on this substance itself (Coal-tar, Pitch, High Temperature (CTPHT)). There are test data on "high-boiling coal liquid," coal tar derived products, and creosote as data not usable for evaluating reproductive effects of CTPHT, and fetal toxicity was observed at a dose where maternal toxicity occurred in a developmental toxicity test using pregnant rats. EU regarded this as not usable for classification. However, because this substance contains 1.5% benzo(a)pyrene (Repr. 1B) or lower, and as a mixture containing it 0.5% or more, Repr. 1B classification in reproductive toxicity was proposed for this substance. The EU Committee for Risk Assessment agreed to this (ECHA RAC Opinion (2011)). Therefore, by following EU, also in this hazard classification, the substance was classified in "Category 1B" as a mixture (containing 0.3% benzo(a)pyrene or more) from the classification result of benzo(a)pyrene (CAS number: 50-32-8) in this hazard class (Category 1B (2011)).
8 Specific target organ toxicity - Single exposure Category 3 (Respiratory tract irritation)


Warning
H335 P304+P340
P403+P233
P261
P271
P312
P405
P501
It is reported that this substance is irritating to the respiratory tract, and causes a cough, sneezing, swelling of nasal cavity mucous membrane (PATTY (6th, 2012)). Besides, it is written that the substance has neurotoxicity and causes numbness and tingling in the hands and feet (PATTY (6th, 2012)). It was judged that these symptoms would be caused by repeated exposure although it is unclear.
From the above, because this substance is irritating to the respiratory tract, it was classified in Category 3 (respiratory tract irritation).
9 Specific target organ toxicity - Repeated exposure Category 1 (nervous system)


Danger
H372 P260
P264
P270
P314
P501
It is reported that this substance has neurotoxicity and causes numbness and tingling in hands and feet (PATTY (6th, 2012)).
From the above, because this substance has neurotoxicity, it was classified in Category 1 (nervous system).
10 Aspiration hazard Classification not possible
-
-
- - Due to lack of data, the classification is not possible.

ENVIRONMENTAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 1


Warning
H400 P273
P391
P501
The classification is not possible from acute toxicity test data in Oryzias latipes using WAF written in EU Risk Assessment Report (EU-RAR, 2008). In EU Risk Assessment Report, the substance was classified by using the summation method from the classification of ingredients such as benzo(a)pyrene and a typical composition of coal tar pitch (high temperature).
Because coal tar pitch contains significant concentrations of PAHs (acenaphthylene, fluorene, phenanthrene, anthracene, benzo(a)pyrene and so on), this classification by the Japanese Government was conducted by using the summation method of a mixture in GHS, similarly to EU Risk Assessment Report. Because all of these PAHs are classified in acute Category 1 in hazardous to the aquatic environment in accordance with Classification Guidance for the Japanese Government, coal tar pitch was also classified in Category 1.
11 Hazardous to the aquatic environment (Long-term) Category 1


Warning
H410 P273
P391
P501
Similarly to the classification in acute toxicity, because PAHs are classified in Category 1 for hazardous to the aquatic environment (Long-term) in accordance with the GHS classification guidance for the Japanese Government, coal tar pitch was also classified in Category 1.
12 Hazardous to the ozone layer Classification not possible
-
-
- - No data.


NOTE:
* A blank or "-" in a cell of classification denotes that the classification of the hazard class was not conducted.
* Hazard_statement_and/or_Precautionary_statement will show when hovering the mouse over a code of Hazard_statement_and/or_Precautionary_statement.
Hazard_statement_and/or_Precautionary_statement are also provided in the Excel file.
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government,
and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.
* Codes assigned to each of the hazard statements and codes for each of the precautionary statement are
based on the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) in United Nations.

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