| Item | Information |
|---|---|
| CAS RN | 6259-76-3 |
| Chemical Name | Hexyl 2-hydroxybenzoate [Hexyl salicylate] |
| Substance ID | H27-A-061/C-139A_P |
| Classification year (FY) | FY2015 |
| Ministry who conducted the classification | Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE) |
| New/Revised | New |
| Classification result in other fiscal year | |
| Download of Excel format | Excel file |
| Item | Information |
|---|---|
| Guidance used for the classification (External link) | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
| UN GHS document (External link) | UN GHS document |
| Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
| Model Label by MHLW (External link) | MHLW Website (in Japanese Only) |
| Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
| OECD/eChemPortal (External link) | eChemPortal |
| Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable |
- |
- | - | There are no chemical groups present in the molecule associated with explosive properties. |
| 2 | Flammable gases (including chemically unstable gases) | Not applicable |
- |
- | - | "Liquids" according to GHS definition. |
| 3 | Aerosols | Not applicable |
- |
- | - | Not an aerosol product. |
| 4 | Oxidizing gases | Not applicable |
- |
- | - | "Liquids" according to GHS definition. |
| 5 | Gases under pressure | Not applicable |
- |
- | - | "Liquids" according to GHS definition. |
| 6 | Flammable liquids | Not classified |
- |
- | - | Based on a flash point of 151 degrees C (closed cup) (GESTIS (Access on October 2015)), it was classified as "Not classified." |
| 7 | Flammable solids | Not applicable |
- |
- | - | "Liquids" according to GHS definition. |
| 8 | Self-reactive substances and mixtures | Not applicable |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. |
| 9 | Pyrophoric liquids | Not classified |
- |
- | - | It is estimated that it does not ignite at normal temperatures from an ignition point of 251 degrees C (GESTIS (Access on October 2015)). |
| 10 | Pyrophoric solids | Not applicable |
- |
- | - | "Liquids" according to GHS definition. |
| 11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | No established test method suitable for liquid substances. |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable |
- |
- | - | Not containing metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
| 13 | Oxidizing liquids | Not applicable |
- |
- | - | It is an organic compound which does not contain fluorine or chlorine but contains oxygen, and the oxygen is not chemically bonded to the elements other than carbon or hydrogen. |
| 14 | Oxidizing solids | Not applicable |
- |
- | - | "Liquids" according to GHS definition. |
| 15 | Organic peroxides | Not applicable |
- |
- | - | It is an organic compound that does not contain bivalent -O-O- structure in the molecule. |
| 16 | Corrosive to metals | Classification not possible |
- |
- | - | Due to no data, the classification is not possible. |
| Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Acute toxicity (Oral) | Classification not possible |
- |
- | - | Due to no data in information sources listed in the GHS classification guidance for the Japanese Government, ECHA information was described as reference data. The classification is not possible due to lack of data. Besides, an LD50 value of > 5,000 mg/kg for rats is reported (ECHA (Access on January 2016)). |
| 1 | Acute toxicity (Dermal) | Classification not possible |
- |
- | - | The classification is not possible due to lack of data. Besides, an LD50 value of > 5,000 mg/kg for rabbits is reported (ECHA (Access on January 2016)). |
| 1 | Acute toxicity (Inhalation: Gases) | Not applicable |
- |
- | - | "Liquids" according to GHS definition. |
| 1 | Acute toxicity (Inhalation: Vapours) | Classification not possible |
- |
- | - | Due to lack of data, the classification is not possible. |
| 1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | Due to lack of data, the classification is not possible. |
| 2 | Skin corrosion/irritation | Classification not possible |
- |
- | - | The classification is not possible due to lack of data. Besides, as ECHA information, it is reported that in a skin irritation test using rabbits (EEC Directive 79/832), this substance is irritating because edema and erythema were observed after 4-hour semi-occlusive application of the substance (undiluted liquid) (ECHA (Access on January 2016)). |
| 3 | Serious eye damage/eye irritation | Classification not possible |
- |
- | - | The classification is not possible due to lack of data. Besides, as ECHA information, it is reported that in an eye irritation test using rabbits (OECD TG405), this substance is not irritating because slight irritation signs were observed after application of the substance (undiluted liquid) but were reversible (ECHA (Access on January 2016)). |
| 4 | Respiratory sensitization | Classification not possible |
- |
- | - | Due to lack of data, the classification is not possible. |
| 4 | Skin sensitization | Classification not possible |
- |
- | - | The classification is not possible due to lack of data. Besides, it is reported that sensitization was observed after application of this substance (10% and 25%) in a LLNA test using mice (OECD TG429), and that sensitization was not observed in a patch test with this substance (30%) in 104 volunteers (ECHA (Access on January 2016)). |
| 5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | The classification is not possible due to lack of data. Besides, as ECHA information, as for in vitro, there are the data of a negative bacterial reverse mutation test (ECHA (Access on January 2016)). |
| 6 | Carcinogenicity | Classification not possible |
- |
- | - | Due to lack of data, the classification is not possible. |
| 7 | Reproductive toxicity | Classification not possible |
- |
- | - | The classification is not possible due to lack of data. Besides, as information registered in ECHA, there are developmental toxicity data for cyclohexyl salicylate (CAS number: 25485-88-5) as an analog compound of this substance. It is written that after gavage administration to pregnant rats during an organogenetic period (day 6 to 15 of gestation) at maximum 360 mg/kg/day, toxic effects on maternal animals and fetuses were not observed (ECHA (Access on January 2016)). |
| 8 | Specific target organ toxicity - Single exposure | Classification not possible |
- |
- | - | The classification is not possible due to lack of data. Besides, as ECHA information, there are data in an oral and a dermal route, but there is information of result only, and no toxic effects usable for the classification were observed (ECHA (Access on January 2016)). |
| 9 | Specific target organ toxicity - Repeated exposure | Classification not possible |
- |
- | - | Due to lack of data, the classification is not possible. |
| 10 | Aspiration hazard | Classification not possible |
- |
- | - | The classification is not possible due to lack of data. Besides, kinematic viscosity is calculated to be 9.62 mm2/sec (25 degrees C) from numerical data (viscosity: 10 mPas (25 degrees C), density: 1.04 g/cm3 (25 degrees C)) listed in GESTIS (Access on October 2015). |
| Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment (Acute) | Classification not possible |
- |
- | - | No data. |
| 11 | Hazardous to the aquatic environment (Long-term) | Classification not possible |
- |
- | - | No data. |
| 12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | No data. |
| * A blank or "-" in a cell of classification denotes that the classification of the hazard class was not conducted. * Hazard_statement_and/or_Precautionary_statement will show when hovering the mouse over a code of Hazard_statement_and/or_Precautionary_statement. Hazard_statement_and/or_Precautionary_statement are also provided in the Excel file. * Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. * Codes assigned to each of the hazard statements and codes for each of the precautionary statement are based on the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) in United Nations. |