GHS Classification Result

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GENERAL INFORMATION
Item Information
CAS RN 25103-58-6
Chemical Name tert-Dodecanethiol
Substance ID H28-B-05-METI, M-009B
Classification year (FY) FY2016
Ministry who conducted the classification Ministry of Economy, Trade and Industry (METI)/Ministry of the Environment (MOE)
New/Revised Revised
Classification result in other fiscal year FY2008  
Download of Excel format Excel file

REFERENCE INFORMATION
Item Information
Guidance used for the classification (External link) GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
UN GHS document (External link) UN GHS document
Definitions/Abbreviations (Excel file) Definitions/Abbreviations
Model Label by MHLW (External link) MHLW Website (in Japanese Only)
Model SDS by MHLW (External link) MHLW Website (in Japanese Only)
OECD/eChemPortal (External link) eChemPortal

PHYSICAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Explosives Not applicable
-
-
- -  There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases (including chemically unstable gases) Not applicable
-
-
- -  Liquid (GHS definition)
3 Aerosols Not applicable
-
-
- -  Not aerosol products.
4 Oxidizing gases Not applicable
-
-
- -  Liquid (GHS definition)
5 Gases under pressure Not applicable
-
-
- -  Liquid (GHS definition)
6 Flammable liquids Category 4
-
Warning
H227 P370+P378
P403+P235
P210
P280
P501
 There are flash points of 95 deg C (closed cup) and 82 deg C in SIDS Dossier (2014), and it was classified in Category 4 by adopting 82 deg C. Besides, because it is estimated that some of the isomer mixtures have a flash point above 93 deg C, such products should be classified as "Not classified" by checking each flash points of them.
7 Flammable solids Not applicable
-
-
- -  Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable
-
-
- -  There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not classified
-
-
- -  It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 212 deg C (SIDS Dossier (2014)).
10 Pyrophoric solids Not applicable
-
-
- -  Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible
-
-
- -  Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable
-
-
- -  The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable
-
-
- -  Organic compounds containing no oxygen, fluorine or chlorine
14 Oxidizing solids Not applicable
-
-
- -  Liquid (GHS definition)
15 Organic peroxides Not applicable
-
-
- -  Organic compounds containing no bivalent -O-O- structure in the molecule
16 Corrosive to metals Classification not possible
-
-
- -  No data available.

HEALTH HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Acute toxicity (Oral) Not classified
-
-
- -  Based on 2 reports of LD50 values of 4,380 mg/kg and 6,800 mg/kg for rats (PATTY (6th, 2012)), this substance was classified as "Not classified."
1 Acute toxicity (Dermal) Not classified
-
-
- -  Based on the LD50 value of 12,600 mg/kg (PATTY (6th, 2012)) for rabbits, this substance was classified as "Not classified."
1 Acute toxicity (Inhalation: Gases) Not applicable
-
-
- -  Liquid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible
-
-
- -  Classification not possible due to lack of data.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible
-
-
- -  Classification not possible due to lack of data.
 Although there is a report that as the LC50 value for rats of > 12 mg/L (SIDS Dossier (2014)), it is evaluated as Reliability 4 (not assignable), therefore, the substance was not possible to classify by this value alone.
2 Skin corrosion/irritation Category 2


Warning
H315 P302+P352
P332+P313
P362+P364
P264
P280
P321
 It is reported that in a skin irritation test (OECD TG 404) using rabbits, as a result of a semi-occlusive application with an undiluted solution of this substance for 4 hours, it was irritating since well-defined or moderate erythema and slight to moderate erythema were observed (SIDS (2014)). Moreover, it is reported that in another irritation study using rabbits, irritation was observed after 4-hour application (PATTY (6th, 2012)).
 From the above, this substance was classified in Category 2.
 The information of IUCLID used in the previous classification could not be confirmed because it was not available. The classification was revised because of the updated information.
3 Serious eye damage/eye irritation Classification not possible
-
-
- -  In an opacity and permeability assay (OECD TG 437) using bovine corneas, the irritancy score was -0.5 plus or minus 0.6, and the substance was predicted to be a non-corrosive or non-severe eye irritant (SIDS (2014)). The result of this study was negative, however, considering the report of skin irritation observed in rabbits, this substance is considered as a potential eye irritant (SIDS (2014)).
 From the above, this substance was classified as "Classification not possible" due to insufficient information for judgment of eye irritation.
 The information of IUCLID used in the previous classification could not be confirmed because it is not available. The classification was revised along with updating of the information.
4 Respiratory sensitization Classification not possible
-
-
- -  Classification not possible due to lack of data.
4 Skin sensitization Category 1B


Warning
H317 P302+P352
P333+P313
P362+P364
P261
P272
P280
P321
P501
 It is reported that in Buehler tests (OECD TG 406) using guinea pigs, weak sensitization was observed (SIDS (2014)). Moreover, it is reported that in a Local Lymph Node Assay (OECD TG 429) using mice, from the EC3 of 31%, the substance is weakly sensitizing (SIDS (2014)).
 From the above results, in SIDS (2014), it is concluded that this substance is a weak sensitizer.
 Therefore, this substance was classified in Category 1B.
 Information from IUCLID used in the previous classification could not be confirmed because it was not available.
5 Germ cell mutagenicity Classification not possible
-
-
- -  Classification not possible due to lack of data.
 There is no data on in vivo.
 As for in vitro, bacterial reverse mutation tests, a mouse lymphoma assay and a sister chromatid exchange test using cultured mammalian cells were negative, and a chromosomal aberration test had an equivocal result (SIDS (2014), PATTY (6th, 2012)).
6 Carcinogenicity Classification not possible
-
-
- -  Classification not possible due to lack of data.
7 Reproductive toxicity Classification not possible
-
-
- -  In an inhalation study using pregnant rats and mice during organogenesis (rat: Gestational Day 6-19, mouse: Gestational Day 6-16), no effects were observed by administration of the test substance in both maternal animals or fetuses (SIDS (2014), PATTY (6th, 2012)).
 However, there was no information on effects on fertility and sexual function, therefore, the classification was not possible.
8 Specific target organ toxicity - Single exposure Category 3 (Narcotic effects)


Warning
H336 P304+P340
P403+P233
P261
P271
P312
P405
P501
 There is no single exposure data of this substance in humans.
 As for experimental animals, it is reported that in a single oral administration study using rats, moderate sedation, ataxia, mild tremors, and diuresis were observed at 6,830 mg/kg, which is above Category 2 (PATTY (6th, 2012)). Moreover, it is reported that in a single 4-hour inhalation study using rats, labored breathing, exophthalmos and signs of decreased consciousness were observed but no death cases were found (PATTY (6th, 2012)).
 Therefore, this substance was classified in Category 3 (narcotic effects). Based on the data of the new information source, the classification result was changed from the previous classification.
9 Specific target organ toxicity - Repeated exposure Classification not possible
-
-
- -  There is no information on humans.
 As for experimental animals, 28-day inhalation toxicity tests using rats, mice or dogs were conducted at two concentrations. Since the lower exposure concentration was a vapor and the higher exposure concentration was a saturated vapor, classification was conducted using the guidance value of vapor for the lower concentration and the guidance value of the mist for the higher concentration. In rats, increase in liver weights, mild renal tubular degeneration related to nephropathy inherent in male rats and so on were observed at not less than 26 ppm (0.22 mg/L) (converted guidance value: 0.07 mg/L), which is equivalent to Category 1 based on the guidance value of vapor (Environmental Risk Assessment for Chemical Substances vol.9 (Ministry of the Environment, 2011), SIDS (2014)). In mice, hepatocellular hypertrophy was observed at not less than 25 ppm (0.21 mg/L) (converted guidance value: 0.06 mg/L), which is equivalent to Category 1 based on the guidance value of vapor, and increase in ALT, an absence of, or decrease in, corpora lutea in the ovary and so on were observed at 109 ppm (0.90 mg/L) (converted guidance value: 0.28 mg/L), which is above Category 2 based on the guidance value of mist (Environmental Risk Assessment for Chemical Substances Vol. 9 (Ministry of the Environment, 2011), SIDS (2014)). In dogs, hepatocellular hypertrophy, increase in ALT, increase in alkaline phosphatase and so on were observed at 109 ppm (0.90 mg/L) (converted guidance value: 0.28 mg/L), which is above Category 2 based on the guidance value of mist (Environmental Risk Assessment for Chemical Substances vol.9 (Ministry of the Environment, 2011), SIDS (2014)).
 Of the above, since the nephrosis is inherent in male rats, it was not adopted as evidence for classification.
 In addition, although an effect on the liver was observed, no severe effect was observed at the doses equivalent to up to Category 2. Therefore, this substance was classified as "Classification not possible."
 Besides, in the previous classification, hepatocellular hypertrophy was used as the basis for classification, but it was not determined as a serious effect, therefore, the previous classification result was different from this time.
10 Aspiration hazard Classification not possible
-
-
- -  Classification not possible due to lack of data.
 Besides, from the numerical data (viscosity: 2.84 mPa*s (20 deg C), density: 0.856 g/cm 3 (20 deg C)) listed in GESTIS (Access on October 2016), the kinematic viscosity is calculated as 3.32 mm2/sec (20 deg C).

ENVIRONMENTAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 1


Warning
H400 P273
P391
P501
 From 48-hour EC50 = 0.075 mg/L for crustacea (Daphnia magna) (Results of Aquatic Toxicity Tests of Chemicals conducted by Environment Agency in Japan (Environment Agency, 1999)), it was classified in Category 1.
11 Hazardous to the aquatic environment (Long-term) Category 1


Warning
H410 P273
P391
P501
 If chronic toxicity data are used, it is classified in Category 1 because it is not rapidly degradable (Non-biodegradable, a degradation rate by BOD: average 2 % (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 2012)), and its 21-day NOEC = 0.0108 mg/L for crustacea (Daphnia magna) (Results of Aquatic Toxicity Tests of Chemicals conducted by Environment Agency in Japan (Environment Agency, 1999); SIDS, 2014).
 If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, it is classified in Category 1 because it is not rapidly degradable (Non-biodegradable, a degradation rate by BOD: average 2 % (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 2012)), and its 96-hour LC50 = 0.38 mg/L for fish (Oryzias latipes) (Results of Aquatic Toxicity Tests of Chemicals conducted by Environment Agency in Japan (Environment Agency, 1999)).
 It was classified in Category 1 from the above results.
12 Hazardous to the ozone layer Classification not possible
-
-
- -  No data available.


NOTE:
* A blank or "-" in a cell of classification denotes that the classification of the hazard class was not conducted.
* Hazard_statement_and/or_Precautionary_statement will show when hovering the mouse over a code of Hazard_statement_and/or_Precautionary_statement.
Hazard_statement_and/or_Precautionary_statement are also provided in the Excel file.
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government,
and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.
* Codes assigned to each of the hazard statements and codes for each of the precautionary statement are
based on the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) in United Nations.

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