| Item | Information |
|---|---|
| CAS RN | 675106-31-7 |
| Chemical Name | Alumina fiber |
| Substance ID | H28-A-004, C-015A |
| Classification year (FY) | FY2016 |
| Ministry who conducted the classification | Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE) |
| New/Revised | New |
| Classification result in other fiscal year | |
| Download of Excel format | Excel file |
| Item | Information |
|---|---|
| Guidance used for the classification (External link) | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
| UN GHS document (External link) | UN GHS document |
| Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
| Model Label by MHLW (External link) | MHLW Website (in Japanese Only) |
| Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
| OECD/eChemPortal (External link) | eChemPortal |
| Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. |
| 2 | Flammable gases (including chemically unstable gases) | Not applicable |
- |
- | - | Solid (GHS definition). |
| 3 | Aerosols | Not applicable |
- |
- | - | Not aerosol products. |
| 4 | Oxidizing gases | Not applicable |
- |
- | - | Solid (GHS definition). |
| 5 | Gases under pressure | Not applicable |
- |
- | - | Solid (GHS definition). |
| 6 | Flammable liquids | Not applicable |
- |
- | - | Solid (GHS definition). |
| 7 | Flammable solids | Not classified |
- |
- | - | It is not combustible (ICSC (2000)). |
| 8 | Self-reactive substances and mixtures | Not applicable |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. |
| 9 | Pyrophoric liquids | Not applicable |
- |
- | - | Solid (GHS definition). |
| 10 | Pyrophoric solids | Not classified |
- |
- | - | It is not combustible (ICSC (2000)). |
| 11 | Self-heating substances and mixtures | Not classified |
- |
- | - | It is not combustible (ICSC (2000)). |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified |
- |
- | - | it is estimated that it does not react vigorously with water because the observation result of being insoluble in water was obtained (ICSC (2000)). |
| 13 | Oxidizing liquids | Not applicable |
- |
- | - | Solid (GHS definition). |
| 14 | Oxidizing solids | Classification not possible |
- |
- | - | It is an inorganic compound containing oxygen, but the classification is not possible due to no data. |
| 15 | Organic peroxides | Not applicable |
- |
- | - | It is an inorganic compound. |
| 16 | Corrosive to metals | Classification not possible |
- |
- | - | Test methods applicable to solid substances are not available. |
| Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Acute toxicity (Oral) | Classification not possible |
- |
- | - |
This substance is a fibrous substance containing aluminum oxide (72 to 97%) and silicon dioxide (3 to 28%). In addition, refractory ceramic fiber (CAS RN 142844-00-6) (amorphous artificial mineral fibers containing aluminum oxide (30 to 60%), silicon dioxide (40 to 60%) and RnOm (0 to 20%) (R is Zr or Cr)) has a similar composition to this substance, thus its information was listed as reference. Classification not possible due to lack of data. Besides, the LD50 value for rats of aluminum oxide (CAS RN 1344-28-1), which is a component of this substance, is reported as > 5,000 mg/kg (HSDB (Access on May 2016)). |
| 1 | Acute toxicity (Dermal) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 1 | Acute toxicity (Inhalation: Gases) | Not applicable |
- |
- | - | Solid (GHS definition) |
| 1 | Acute toxicity (Inhalation: Vapours) | Not applicable |
- |
- | - | Solid (GHS definition) |
| 1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 2 | Skin corrosion/irritation | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 3 | Serious eye damage/eye irritation | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 4 | Respiratory sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 4 | Skin sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 5 | Germ cell mutagenicity | Classification not possible |
- |
- | - |
Classification not possible due to lack of data. Besides, refractory ceramic fiber (CAS RN 142844-00-6) is regarded as genotoxic because it was positive in several reports in both in vitro chromosomal aberration tests, micronucleus tests and there are many reports that it is positive in other genotoxicity tests as well. However, it is also reported that the genotoxicity of refractory ceramic fiber is weak (Risk Assessment Report (Ministry of Health, Labor and Welfare, 2014)). As a mechanism of expression of genotoxicity by fibrous substances, it is described that active oxygen species (ROS) that occur persistently and over a prolonged period from inflammatory cells are thought to play an important role in DNA damage, and that the genotoxicity is not primary but secondary (Risk Assessment Report (Ministry of Health, Labor and Welfare, 2014)). |
| 6 | Carcinogenicity | Classification not possible |
- |
- | - |
It is described that in a study using rats intrapleurally given aluminum oxide fibers, an increase in pleural sarcomas was observed in four of six samples, and carcinogenic potential was indicated in animal experiments (DFGOT Vol. 8 (1997)). On the other hand, in a 2-year study using rats exposed by inhalation to high-alumina, low-silica wool fiber (HT fiber), no increase in tumor was observed, and induction of mesothelioma was not observed in a study of intraperitoneal administration (IARC 81 (2001)). IARC did not evaluate the carcinogenicity of HT fibers since no human data were available, and concluded that there is inadequate evidence in experimental animals for the carcinogenicity (IARC 81 (2001)). Based on the opinion of IARC, this substance was classified as "Classification not possible" for the carcinogenicity. In addition, regarding refractory ceramic fiber (CAS RN 142844-00-6), with sufficient evidence for carcinogenicity in experimental animals, IARC has classified the substance in Group 2B, ACGIH classified it in A2, and the Japan Society For Occupational Health classified it in Group 2B (artificial mineral fiber, ceramic fiber, micro glass fiber) (Risk Assessment Report (Ministry of Health, Labor and Welfare, 2014)). Therefore, these classifications are equivalent to Category 2 or 1B. |
| 7 | Reproductive toxicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 8 | Specific target organ toxicity - Single exposure | Classification not possible |
- |
- | - |
Classification not possible due to lack of data. As for alumina fiber (CAS RN 675106-31-7), there is no single exposure data in either humans or experimental animals. Besides, as for refractory ceramic fiber (CAS RN 142844-00-6), although the information source is listed in List 3, it is described that it may cause mechanical irritation to the respiratory tract, eyes and skin as effects of short-term exposure (ICSC (2012)). |
| 9 | Specific target organ toxicity - Repeated exposure | Classification not possible |
- |
- | - |
Classification not possible due to lack of data. There is no information on this substance (crystalline artificial mineral fiber containing aluminum oxide (72 to 97%) and silicon dioxide (3 to 28%)). Besides, it is reported that in a 104-week inhalation toxicity study using rats at the concentration of 30 mg/m3 of high-alumina, low-silica wool fiber (MMVF 34) containing magnesium oxide, calcium oxide, etc. in addition to aluminum oxide and silicon dioxide (aluminum oxide: 23.2%, silicon dioxide: 38.9%, calcium oxide: 15.0%, magnesium oxide: 9.6%, etc.) or rock wool (MMVF 21) (aluminum oxide: 13.8%, silicon dioxide: 45.9%, calcium oxide: 17.0%, magnesium oxide: 9.5%, etc.), the mortality rate for MMVF 34 did not differ from that for the control group, and that lung fibrosis was observed for rock wool, but not for MMVF 34 (IARC 81 (2002), Kamstrup et al., (1998)). In addition, as for refractory ceramic fiber (CAS RN 142844-00-6) (amorphous artificial mineral fibers containing aluminum oxide (30 to 60%), silicon dioxide (40 to 60%) and RnOm (0 to 20%) (R is Zr or Cr)), it is reported that in a 12-month inhalation toxicity study using rats, macrophage infiltration and microgranuloma formation were observed in the lung at 0.003 mg/L, which is equivalent to Category 1 (IARC 81 (2002)). |
| 10 | Aspiration hazard | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment (Acute) | Classification not possible |
- |
- | - | No data available. |
| 11 | Hazardous to the aquatic environment (Long-term) | Classification not possible |
- |
- | - | No data available. |
| 12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | No data available. |
|
* A blank or "-" in a cell of classification denotes that the classification of the hazard class was not conducted. * Hazard_statement_and/or_Precautionary_statement will show when hovering the mouse over a code of Hazard_statement_and/or_Precautionary_statement. Hazard_statement_and/or_Precautionary_statement are also provided in the Excel file. * Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. * Codes assigned to each of the hazard statements and codes for each of the precautionary statement are based on the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) in United Nations. |