GHS Classification Result

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GENERAL INFORMATION
Item Information
CAS RN 110-13-4
Chemical Name Acetonylacetone
Substance ID H28-A-019, C-062A
Classification year (FY) FY2016
Ministry who conducted the classification Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised New
Classification result in other fiscal year  
Download of Excel format Excel file

REFERENCE INFORMATION
Item Information
Guidance used for the classification (External link) GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
UN GHS document (External link) UN GHS document
Definitions/Abbreviations (Excel file) Definitions/Abbreviations
Model Label by MHLW (External link) MHLW Website (in Japanese Only)
Model SDS by MHLW (External link) MHLW Website (in Japanese Only)
OECD/eChemPortal (External link) eChemPortal

PHYSICAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Explosives Not applicable
-
-
- -  There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases (including chemically unstable gases) Not applicable
-
-
- -  Liquid (GHS definition)
3 Aerosols Not applicable
-
-
- -  Not aerosol products.
4 Oxidizing gases Not applicable
-
-
- -  Liquid (GHS definition)
5 Gases under pressure Not applicable
-
-
- -  Liquid (GHS definition)
6 Flammable liquids Category 4
-
Warning
H227 P370+P378
P403+P235
P210
P280
P501
 Based on a flash point of 79 deg C (closed cup) (GESTIS (Access on June 2016)), it was classified in Category 4.
7 Flammable solids Not applicable
-
-
- -  Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable
-
-
- -  There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not classified
-
-
- -  It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 490 deg C (GESTIS (Access on June 2016)).
10 Pyrophoric solids Not applicable
-
-
- -  Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible
-
-
- -  Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable
-
-
- -  The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable
-
-
- -  The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen.
14 Oxidizing solids Not applicable
-
-
- -  Liquid (GHS definition)
15 Organic peroxides Not applicable
-
-
- -  Organic compounds containing no bivalent -O-O- structure in the molecule
16 Corrosive to metals Classification not possible
-
-
- -  No data available.

HEALTH HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Acute toxicity (Oral) Category 4


Warning
H302 P301+P312
P264
P270
P330
P501
 There are 3 reports in which LD50 values for rats are 1,600 mg/kg, 2.14 mL/kg (Converted LD50 value using the specific gravity of 0.9734: 2,083 mg/kg) and 2,700 mg/kg (PATTY (6th, 2012)). By adopting the category with the highest hazard, it was classified in Category 4.
1 Acute toxicity (Dermal) Not classified
-
-
- -  Based on the LD50 value of 6.6 mL/kg for guinea pigs (PATTY (6th, 2012)), the LD50 value of 6,426 mg/kg was calculated by converting using the specific gravity of 0.9734. Therefore, it was classified as "Not classified."
1 Acute toxicity (Inhalation: Gases) Not applicable
-
-
- -  Liquid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible
-
-
- -  Classification not possible due to lack of data.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible
-
-
- -  Classification not possible due to lack of data.
2 Skin corrosion/irritation Classification not possible
-
-
- -  It is reported that repeated application to the uncovered backs of guinea pigs was not irritating (PATTY (6th, 2012)). However, because the test conditions such as dosage and exposure time were unknown, only the result of this study was insufficient to judge as "Not classified." Therefore, it was classified as "Classification not possible."
3 Serious eye damage/eye irritation Category 2A


Warning
H319 P305+P351+P338
P337+P313
P264
P280
 This substance was classified in Category 2A because moderate to severe irritation was observed in rabbit eyes (PATTY (6th, 2012)).
4 Respiratory sensitization Classification not possible
-
-
- -  Classification not possible due to lack of data.
4 Skin sensitization Classification not possible
-
-
- -  Classification not possible due to lack of data.
5 Germ cell mutagenicity Classification not possible
-
-
- -  Classification not possible due to lack of data.
 There are no in vivo data. As for in vitro, a bacterial reverse mutation test was negative (PATTY (6th, 2012)).
6 Carcinogenicity Classification not possible
-
-
- -  Classification not possible due to lack of data.
7 Reproductive toxicity Classification not possible
-
-
- -  Classification not possible due to lack of data.
 Besides, it is reported that treatment in drinking water at 10,000 ppm for 6 weeks produced azoospermic testes in male rats (PATTY (6th, 2012)).
8 Specific target organ toxicity - Single exposure Category 3 (Respiratory tract irritation)


Warning
H335 P304+P340
P403+P233
P261
P271
P312
P405
P501
 There are no single exposure data of this substance in humans.
 As for experimental animals, in a single inhalation exposure study using guinea pigs, it is described that this substance showed slight nasal irritation (PATTY (6th, 2012). Therefore, it was classified in Category 3 (respiratory tract irritation).
 Besides, it is reported that although there is no description of the route of administration, in a single dose of this substance, decreased thymus weight and increased spleen weight in rats, and increased thymus weight and decreased spleen weight in mice were observed. As the above, different results were reported depending on animal species (PATTY (6th, 2012)). In addition, it is reported that in the single dose study in mice, delayed-type hypersensitivity and phagocytic activity were suppressed (PATTY (6th, 2012)).
9 Specific target organ toxicity - Repeated exposure Category 1 (nervous system), Category 2 (visual organs)


Danger
Warning
H372
H373
P260
P264
P270
P314
P501
 There is no information on humans.
 As for experimental animals, there are reports of neurotoxicity characterized by swollen axons or visual organ toxicity in rats, cats, monkeys, dogs, etc. (PATTY (6th, 2012)). Although the effects were observed at the lowest dose or single dose of the study, many of the tests were conducted at doses greater than Category 2 and could not be used as the rationale for the classification.
 As an exceptional case, it is reported that only in a 15-17 week repeated dose toxicity study using monkeys given by oral route at 73 mg/kg/day (single dose) corresponding to Category 2, visual contrast sensitivity disappeared, although visual acuity did not disappear, and that histopathological examination indicated a swollen optic nerve axon typical of this substance, and this condition was reversible and recovered in 5 months (PATTY (6th, 2012)).
 This substance has been extensively studied as a typical neurotoxic substance and it is the most active neurotoxic metabolites of n-hexane (CAS RN 110-54-3) or methyl n-butyl ketone (CAS RN 591-78-6). Furthermore, it is reported that in a comparative study with this compound and other metabolites of n-hexane and methyl n-butyl ketone, this substance had neurotoxicity potential as 38 times of n-hexane and 3.3 times of methyl n-butyl ketone (PATTY (6th, 2012).
 Also, both n-hexane and methyl n-butyl ketone showed neuropathy in humans and they were classified in Category 1 (nervous system) in GHS classification (FY2009, FY2015, respectively).
 Therefore, it is considered reasonable to apply Category 1 (nervous system) as well as n-hexane and methyl n-butyl ketone in addition to Category 2 (visual organs).
 Besides, there is a report that as the result of administration by drinking water to male rats at 10,000 ppm (converted guidance value: 933 mg/kg/day) for 6 weeks, aspermia occurred, but since the doses exceeded Category 2, the testis was not considered to be the target organ.
10 Aspiration hazard Classification not possible
-
-
- -  Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Classification not possible
-
-
- -  No data available.
11 Hazardous to the aquatic environment (Long-term) Classification not possible
-
-
- -  No data available.
12 Hazardous to the ozone layer Classification not possible
-
-
- -  No data available.


NOTE:
* A blank or "-" in a cell of classification denotes that the classification of the hazard class was not conducted.
* Hazard_statement_and/or_Precautionary_statement will show when hovering the mouse over a code of Hazard_statement_and/or_Precautionary_statement.
Hazard_statement_and/or_Precautionary_statement are also provided in the Excel file.
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government,
and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.
* Codes assigned to each of the hazard statements and codes for each of the precautionary statement are
based on the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) in United Nations.

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