GHS Classification Result
GENERAL INFORMATION
REFERENCE INFORMATION
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
GENERAL INFORMATION
| Item | Information |
|---|---|
| CAS RN | 1067-33-0 |
| Chemical Name | Dibutyltin di(acetate) |
| Substance ID | H28-A-025, C-070A |
| Classification year (FY) | FY2016 |
| Ministry who conducted the classification | Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE) |
| New/Revised | New |
| Classification result in other fiscal year | |
| Download of Excel format | Excel file |
REFERENCE INFORMATION
| Item | Information |
|---|---|
| Guidance used for the classification (External link) | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
| UN GHS document (External link) | UN GHS document |
| Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
| Model Label by MHLW (External link) | MHLW Website (in Japanese Only) |
| Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
| OECD/eChemPortal (External link) | eChemPortal |
| Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. |
| 2 | Flammable gases (including chemically unstable gases) | Not applicable |
- |
- | - | Liquid (GHS definition) |
| 3 | Aerosols | Not applicable |
- |
- | - | Not aerosol products. |
| 4 | Oxidizing gases | Not applicable |
- |
- | - | Liquid (GHS definition) |
| 5 | Gases under pressure | Not applicable |
- |
- | - | Liquid (GHS definition) |
| 6 | Flammable liquids | Not classified |
- |
- | - | A flash point is 143 deg C (closed cup) (GESTIS (Access on May 2016)). |
| 7 | Flammable solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
| 8 | Self-reactive substances and mixtures | Not applicable |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. |
| 9 | Pyrophoric liquids | Not classified |
- |
- | - | It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 479 deg C (GESTIS (Access on May 2016)). |
| 10 | Pyrophoric solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
| 11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Test methods applicable to liquid substances are not available. |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified |
- |
- | - | It contains a metalloid (Sn), but it is estimated that it does not react vigorously with water because water solubility data of 6 mg/L was obtained (SRC (Access on June 2016)). |
| 13 | Oxidizing liquids | Classification not possible |
- |
- | - | No data available. |
| 14 | Oxidizing solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
| 15 | Organic peroxides | Not applicable |
- |
- | - | Organic compounds containing no bivalent -O-O- structure in the molecule |
| 16 | Corrosive to metals | Classification not possible |
- |
- | - | No data available. |
| Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Acute toxicity (Oral) | Category 2 |
 Danger |
H300 |
P301+P310
P264 P270 P321 P330 P405 P501 |
Based on the report of the LD50 value of 32 mg/kg (HSDB (Access on June 2016)) for rats, this substance was classified in Category 2. Besides, although the LD50 value of 32 mg/kg (Environmental Risk Assessment for Chemical Substances Vol.8 (Ministry of the Environment, 2010)) for rats is reported, this data was not adopted for the classification since it is information based on RTECS in List 3, and the details are unknown. |
| 1 | Acute toxicity (Dermal) | Classification not possible |
- |
- | - |
Classification not possible due to lack of data. Besides, although the LD50 value of 2,318 mg/kg (Environmental Risk Assessment for Chemical Substances Vol.8 (Ministry of the Environment, 2010)) for rabbits is reported, this data was not adopted for the classification since it is information based on RTECS in List 3, and the details are unknown. |
| 1 | Acute toxicity (Inhalation: Gases) | Not applicable |
- |
- | - | Liquid (GHS definition) |
| 1 | Acute toxicity (Inhalation: Vapours) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 2 | Skin corrosion/irritation | Classification not possible |
- |
- | - | It is reported to be non-irritating for humans (Environmental Risk Assessment for Chemical Substances Vol.8 (Ministry of the Environment, 2010)), but the details of the test were unknown. Therefore, this substance was classified as "Classification not possible." |
| 3 | Serious eye damage/eye irritation | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 4 | Respiratory sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 4 | Skin sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 5 | Germ cell mutagenicity | Classification not possible |
- |
- | - |
Classification not possible due to lack of data. No in vivo data are available. As for in vitro, a bacterial reverse mutation test was negative, while a mouse lymphoma assay, a chromosomal aberration test, and a sister chromatid exchange test using cultured mammalian cells were positive (Environmental Risk Assessment for Chemical Substances Vol.8 (Ministry of the Environment, 2010), NTP DB (Access on June 2016), HSDB (Access on June 2016)). |
| 6 | Carcinogenicity | Classification not possible |
- |
- | - |
In a carcinogenicity test, where this compound was administered in the feed for 78 weeks to rats and mice, slaughtering and a necropsy were performed after 26 weeks (rats) or 14 weeks (mice). As for rats, no increase in tumor development was observed in male rats, and in female rats, it was not possible to evaluate because there was an accidental loss of tissues from the high dose group. As for mice, there were significant positive associations between the dose level and hepatocellular adenomas in female mice, and this tendency was also observed in males, with no significant difference. Therefore, it was concluded that there was no conclusive evidence associated with carcinogenicity in male rats and male and female mice (NTP TR 183 (1979)). As for classifications by other organizations, ACGIH classified organotin compounds as Category A4 (ACGIH (7th, 2001)). Therefore, this substance was classified as "Classification not possible." |
| 7 | Reproductive toxicity | Category 1B |
 Danger |
H360 |
P308+P313
P201 P202 P280 P405 P501 |
In multiple developmental toxicity studies using pregnant rats administered by gavage during the organogenesis stage, increased incidences in embryo/fetal death, in external malformations (cleft mandible, cleft lower lip, ankyloglossia, encephalocele etc.) and in skeletal malformations (mandible abnormality, fusion of rib and thoracic vertebral arch) were observed in fetuses at doses or lower, where maternal toxicity (thymus weight loss, suppression of body weight gain) were observed (Environmental Risk Assessment for Chemical Substances Vol. 8 (Ministry of the Environment, 2010)). Therefore, this substance was classified in Category 1B. |
| 8 | Specific target organ toxicity - Single exposure | Classification not possible |
- |
- | - |
Classification not possible due to lack of data. Besides, as for dibutyltin compounds which convert into dibutyltin oxide and dibutyltin dichloride in the body, it is considered that their toxicity could be adopted in common, but there was no information which suggests its conversion to dibutyltin oxide or dibutyltin chloride in the body. |
| 9 | Specific target organ toxicity - Repeated exposure | Category 2 (liver) |
Warning |
H373 |
P260
P314 P501 |
No information is available for humans. As for experimental animals, in a 78-week repeated dose toxicity test using mice administered by feeding, effects in the liver (degenerative and necrotizing changes) were reported at 150 ppm (converted guidance value: 22.5 mg/kg/day), which is equivalent to Category 2 (NTP TR183 (1979)). Besides, in a 78-week repeated dose toxicity test using rats administered by feeding, effects in the uterus (suppurative inflammation, cystic or polypoid hyperplasia) were observed at 62.5 ppm (converted guidance value: 3.125 mg/kg/day), which is equivalent to Category 1 (NTP TR183 (1979)). However, in NTP TR183 (1979), it is not clearly described as effects and the dose relationship cannot be confirmed, so these effects were decided to be insufficient. Also, as for dibutyltin compounds which convert into dibutyltin oxide and dibutyltin dichloride in the body, it is considered that their toxicity could be adopted in common, but there was no information which suggests its conversion to dibutyltin oxide or dibutyltin chloride in the body. Therefore, this substance was classified in Category 2 (liver). |
| 10 | Aspiration hazard | Classification not possible |
- |
- | - |
Classification not possible due to lack of data. Besides, from the numerical data reported in HSDB (Access on June 2016) (viscosity: 18 mPa*s (25 degC), density (specific gravity): 1.31 (25 degC)), kinetic viscosity is calculated to be 13.74 mm2/sec (25/25 degC). |
| Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment (Acute) | Category 1 |
 Warning |
H400 |
P273
P391 P501 |
From 72-hour EC50 = 0.1 mg/L for algae (Skeletonema costatum) (CICADs 73, 2006), it was classified in Category 1. |
| 11 | Hazardous to the aquatic environment (Long-term) | Category 1 |
Warning |
H410 |
P273
P391 P501 |
Reliable chronic toxicity data were not obtained. Since it is not rapidly degradable (BIOWIN), and it is classified in Category 1 for acute toxicity, it was classified in Category 1. |
| 12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | No data available. |
NOTE:
|
* A blank or "-" in a cell of classification denotes that the classification of the hazard class was not conducted. * Hazard_statement_and/or_Precautionary_statement will show when hovering the mouse over a code of Hazard_statement_and/or_Precautionary_statement. Hazard_statement_and/or_Precautionary_statement are also provided in the Excel file. * Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. * Codes assigned to each of the hazard statements and codes for each of the precautionary statement are based on the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) in United Nations. |