GHS Classification Result
GENERAL INFORMATION
REFERENCE INFORMATION
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
GENERAL INFORMATION
| Item | Information |
|---|---|
| CAS RN | 25168-24-5 |
| Chemical Name | Dibutyltin bis(isooctyl thioglycolate) |
| Substance ID | H28-A-027, C-072A |
| Classification year (FY) | FY2016 |
| Ministry who conducted the classification | Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE) |
| New/Revised | New |
| Classification result in other fiscal year | |
| Download of Excel format | Excel file |
REFERENCE INFORMATION
| Item | Information |
|---|---|
| Guidance used for the classification (External link) | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
| UN GHS document (External link) | UN GHS document |
| Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
| Model Label by MHLW (External link) | MHLW Website (in Japanese Only) |
| Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
| OECD/eChemPortal (External link) | eChemPortal |
| Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. |
| 2 | Flammable gases (including chemically unstable gases) | Not applicable |
- |
- | - | Liquid (GHS definition) |
| 3 | Aerosols | Not applicable |
- |
- | - | Not aerosol products. |
| 4 | Oxidizing gases | Not applicable |
- |
- | - | Liquid (GHS definition) |
| 5 | Gases under pressure | Not applicable |
- |
- | - | Liquid (GHS definition) |
| 6 | Flammable liquids | Classification not possible |
- |
- | - | No data available. |
| 7 | Flammable solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
| 8 | Self-reactive substances and mixtures | Not applicable |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. |
| 9 | Pyrophoric liquids | Classification not possible |
- |
- | - | No data available. |
| 10 | Pyrophoric solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
| 11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Test methods applicable to liquid substances are not available. |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified |
- |
- | - | It contains a metalloid (Sn), but it is estimated that it does not react vigorously with water because the observation result of being practically insoluble in water was obtained for an analog substance, Dibutyltin bis(2-ethylhexyl thioglycolate) (GESTIS (Access on June 2016)). |
| 13 | Oxidizing liquids | Not applicable |
- |
- | - | The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen. |
| 14 | Oxidizing solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
| 15 | Organic peroxides | Not applicable |
- |
- | - | Organic compounds containing no bivalent -O-O- structure in the molecule |
| 16 | Corrosive to metals | Classification not possible |
- |
- | - | No data available. |
| Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Acute toxicity (Oral) | Classification not possible |
- |
- | - |
Classification not possible due to lack of data. Besides, in rats, 2 LD50 values (OECD TG 401) for mixtures of this substance and the monobutyl form of this substance (CAS RN 25852-70-4, abbreviation: MBT (IOTG)) are described in SIDS (2009) (mixing ratio of 67:33, 2,086 mg/kg and 3,088 mg/kg). Both data are equivalent to "Not classified" (Category 5 of UN GHS classification). |
| 1 | Acute toxicity (Dermal) | Classification not possible |
- |
- | - |
Classification not possible due to lack of data. Besides, 2 LD50 values were reported in SIDS (2009) for the mixtures of an analogous substance, dibutyltin bis (2-ethylhexyl thioglycolate) (CAS RN 10584-98-2, abbreviation: DBT (EHTG)) and the monobutyl form of DBT (EHTG) (CAS RN 26864-37-9, abbreviation: MBT (EHTG)). It is described that DBT (EHTG) and this substance, DBT (IOTG) are isomers and are considered toxicologically equivalent. Also, in rats, the LD50 values for a mixture of DBT (EHTG) and MBT (EHTG) are > 1,000 mg/kg (OECD TG 402, a mixing rate of 61.8:25.3 with 12.9% of soybean oil as a vehicle) and 777 mg/kg (comparable to OECD TG 402, a mixing ratio of 72:14 with 14% of soybean oil as a vehicle). One is equivalent to Category 4 and "Not classified," and the other is equivalent to Category 3. |
| 1 | Acute toxicity (Inhalation: Gases) | Not applicable |
- |
- | - | Liquid (GHS definition) |
| 1 | Acute toxicity (Inhalation: Vapours) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 1 | Acute toxicity (Inhalation: Dusts and mists) | Not classified |
- |
- | - | This substance was classified as "Not classified," based on the LC50 value of 22 mg/L (1 hour, comparable to OECD TG 403, 4-hour converted value: 5.5 mg/L, males and females) for rats (SIDS (2009)). Since the LC50 value was higher than the saturated vapor concentration (0.00000297 ppm (converted value: 0.078 ng/L)), the reference value in the unit mg/L was applied as mists. |
| 2 | Skin corrosion/irritation | Category 1 |
 Danger |
H314 |
P301+P330+P331
P303+P361+P353 P305+P351+P338 P304+P340 P260 P264 P280 P310 P321 P363 P405 P501 |
In a skin irritation test (4-hour application) (OECD TG 404) using rabbits, a mixture of this substance and the monobutyl form (CAS RN 25852-70-4, abbreviation: MBT (IOTG)) (95:5) was reported to be corrosive (SIDS (2009)). Therefore, this substance was classified in Category 1. |
| 3 | Serious eye damage/eye irritation | Category 1 |
Danger |
H318 |
P305+P351+P338
P280 P310 |
Eye irritation tests using rabbits were reported to be slightly irritating (SIDS (2009)). Moreover, because this substance was classified in Category 1 in skin corrosion/irritation, it was classified in Category 1. |
| 4 | Respiratory sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 4 | Skin sensitization | Category 1 |
 Warning |
H317 |
P302+P352
P333+P313 P362+P364 P261 P272 P280 P321 P501 |
In a skin sensitization study (maximization test, OECD TG 406) using guinea pigs, a mixture of this substance and butyltin tris (isooctylthioglycolate) (67:33) was sensitizing (Sensitization Rate = 40-95%), and SIDS determined this substance as a sensitizer (SIDS (2009)). Therefore, this substance was classified in Category 1. |
| 5 | Germ cell mutagenicity | Classification not possible |
- |
- | - |
Classification not possible due to lack of data. No in vivo data available. As for an in vitro test, the result was negative for the bacterial reverse mutation test (SIDS (2009)). |
| 6 | Carcinogenicity | Classification not possible |
- |
- | - | Since organotin compounds were classified in A4 by ACGIH (ACGIH (7th, 2001)), this substance was classified as "Classification not possible." |
| 7 | Reproductive toxicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 8 | Specific target organ toxicity - Single exposure | Category 2 (respiratory organs) |
 Warning |
H371 |
P308+P311
P260 P264 P270 P405 P501 |
No data available for single exposure to humans. As for experimental animals, it was reported that in a 1-hour single inhalation exposure test, at the concentration of 5mg/L (4 hour converted value of 1.25 mg/L), blood in the lungs, enlarged thymus, adhesions in the chest cavity, and dark spleen were observed (SIDS (2009)). Therefore, this substance was classified in Category 2 (respiratory organs). Besides, it was reported that by single oral administration with a 67:33 mixture of this substance and the monobutyl form, rats exhibited dyspnoea, ruffled fur, ventral body position, exophthalmos, sedation, and salivation at 500 mg/kg (SIDS (2009)). Moreover, dibutyltin bis(2-ethylhexyl thioglycolate) (CAS RN 10584-98-2), which is an isomer of this substance, is converted to dibutyltin dichloride (CAS RN 683-18-1) with a half-life of less than 30 minutes in hydrolysis tests in artificial gastric solution (Environmental Risk Assessment for Chemical Substances Vol. 8 (Ministry of the Environment) (2010), SIDS (2009)). It is described that its conversion rate is 97% and it is estimated that this substance will undergo hydrolysis at the similar rate (SIDS (2009)). Therefore, this substance may also be converted into dibutyltin dichloride in vivo, and in the case of oral intake, it is considered that this substance may also indicate the similar effect to dibutyltin dichloride. |
| 9 | Specific target organ toxicity - Repeated exposure | Category 1 (liver, immune system) |
Danger |
H372 |
P260
P264 P270 P314 P501 |
No data available for humans or experimental animals. However, for dibutyltin compounds which convert to dibutyltin oxide and dibutyltin chloride in the body, it is considered that their toxicity can be adopted in common. It is reported that dibutyltin bis(2-ethylhexyl thioglycolate) (CAS RN 10584-98-2), which is an isomer of this substance, is converted to dibutyltin dichloride (CAS RN 683-18-1) with a half-life of less than 30 minutes in hydrolysis tests in artificial gastric solution (Environmental Risk Assessment for Chemical Substances Vol. 8 (Ministry of the Environment, 2010), SIDS (2009)). It is described that its conversion rate is 97% and this substance will be expected to undergo hydrolysis at a similar rate. Therefore, it is considered that this substance shows effects on the same target organ as dibutyltin dichloride (CAS RN 683-18-1). For dibutyltin dichloride, the effects on the liver were observed at 1.17 mg/kg/day, which is equivalent to Category 1, and the effect on the immune system was observed at 0.39 mg/kg/day, equivalent to Category 1, or above. Since the molecular weight of dibutyltin dichloride is 303.8, and the molecular weight of this substance is 346.98, it is estimated that this substance also shows the effect on the liver and the immune system at doses equivalent to Category 1 (the effect on the liver at 2.5 mg/kg/day, the effect on the immune system at 0.8 mg/kg/day as converted from molecular weight). Thus, this substance was classified in Category 1 (liver, immune system). |
| 10 | Aspiration hazard | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment (Acute) | Classification not possible |
- |
- | - |
The classification is not possible because data are not obtained for Dibutyltin bis(isooctyl thioglycolate) (DBT(IOTG)). Besides, it is written in SIDS (2006) that DBT(IOTG) and Dibutyltin bis(2-ethylhexyl thioglycolate) (DBT(2-EHMA)) are isomers and have similar toxicological properties, and the ecological toxicity of DBT (IOTG) was evaluated using the data on DBT(2-EHMA). However, because a hydrolysis degradation rate varies from one dibutyltin compound to another, and it is estimated that parent substances also exist for a considerable time, the classification was not conducted using the data on DBT(2-EHMA) for this hazard class. |
| 11 | Hazardous to the aquatic environment (Long-term) | Classification not possible |
- |
- | - | The classification is not possible because appropriate data are not obtained. |
| 12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | No data available. |
NOTE:
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* A blank or "-" in a cell of classification denotes that the classification of the hazard class was not conducted. * Hazard_statement_and/or_Precautionary_statement will show when hovering the mouse over a code of Hazard_statement_and/or_Precautionary_statement. Hazard_statement_and/or_Precautionary_statement are also provided in the Excel file. * Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. * Codes assigned to each of the hazard statements and codes for each of the precautionary statement are based on the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) in United Nations. |