GHS Classification Result

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GENERAL INFORMATION
Item Information
CAS RN 95-75-0
Chemical Name 3,4-Dichlorotoluene
Substance ID H28-A-049, C-108A
Classification year (FY) FY2016
Ministry who conducted the classification Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised New
Classification result in other fiscal year  
Download of Excel format Excel file

REFERENCE INFORMATION
Item Information
Guidance used for the classification (External link) GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
UN GHS document (External link) UN GHS document
Definitions/Abbreviations (Excel file) Definitions/Abbreviations
Model Label by MHLW (External link) MHLW Website (in Japanese Only)
Model SDS by MHLW (External link) MHLW Website (in Japanese Only)
OECD/eChemPortal (External link) eChemPortal

PHYSICAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Explosives Not applicable
-
-
- -  There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases (including chemically unstable gases) Not applicable
-
-
- -  Liquid (GHS definition)
3 Aerosols Not applicable
-
-
- -  Not aerosol products.
4 Oxidizing gases Not applicable
-
-
- -  Liquid (GHS definition)
5 Gases under pressure Not applicable
-
-
- -  Liquid (GHS definition)
6 Flammable liquids Category 4
-
Warning
H227 P370+P378
P403+P235
P210
P280
P501
 Due to the flash point data of 85 deg C (unknown test method) (GESTIS (Access on August 2016)), it is estimated that the data corresponding to Category 4 will be obtained in a prescribed closed-cup test method.
7 Flammable solids Not applicable
-
-
- -  Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable
-
-
- -  There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Classification not possible
-
-
- -  No data available.
10 Pyrophoric solids Not applicable
-
-
- -  Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible
-
-
- -  Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable
-
-
- -  The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable
-
-
- -  The substance is an organic compound containing chlorine (but not fluorine or oxygen) which is chemically bonded only to carbon or hydrogen.
14 Oxidizing solids Not applicable
-
-
- -  Liquid (GHS definition)
15 Organic peroxides Not applicable
-
-
- -  Organic compounds containing no bivalent -O-O- structure in the molecule
16 Corrosive to metals Classification not possible
-
-
- -  No data available.

HEALTH HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Acute toxicity (Oral) Classification not possible
-
-
- -  Classification not possible due to lack of data.
 An LD50 value of 1050 mg/kg for rats is reported (GESTIS (Access on August 2016)), however, the data is from a List 3 information source, and details of the data are not available because the original report was company-owned data. Therefore, the information was not adopted for evidence of classification.
 Besides, for the following health hazards, please also see the structural isomers (2,3-dichlorotoluene (CAS RN 32768-54-0) and 2,4-dichlorotoluene (CAS RN 95-73-8)).
1 Acute toxicity (Dermal) Classification not possible
-
-
- -  Classification not possible due to lack of data.
1 Acute toxicity (Inhalation: Gases) Not applicable
-
-
- -  Liquid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible
-
-
- -  Classification not possible due to lack of data.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible
-
-
- -  Classification not possible due to lack of data.
2 Skin corrosion/irritation Not classified
-
-
- -  Based on the test results as non-irritant after applying 0.5 mL of the test substance for 4 hours on rabbit skin (OECD TG 404) (ECHA (Access on December 2016)), it is classified as "Not classified."
3 Serious eye damage/eye irritation Classification not possible
-
-
- -  Classification not possible due to lack of data.
 Besides, it is described that in a standardized eye irritation test using rabbits, the mean irritating value was 4.4 for the conjunctiva, cornea and iris 24 hours to 8 days after application, and this substance was assessed to be non-irritating (GESTIS (Access on August 2016)). However, it was classified as "Classification not possible" because there is no other information.
4 Respiratory sensitization Classification not possible
-
-
- -  Classification not possible due to lack of data.
4 Skin sensitization Classification not possible
-
-
- -  Classification not possible due to lack of data.
5 Germ cell mutagenicity Classification not possible
-
-
- -  Classification not possible due to lack of data.
6 Carcinogenicity Classification not possible
-
-
- -  Classification not possible due to lack of data.
7 Reproductive toxicity Category 2


Warning
H361 P308+P313
P201
P202
P280
P405
P501
 In a combined repeated dose toxicity study with reproduction/developmental toxicity screening test using rats orally administered, general toxicological findings, such as tubule vacuolation at 100 mg/kg or more in females, found dead, suppressed body weight gain, decreased food consumption, and histopathological changes in the kidneys (tubule vacuolation and regeneration) at 300 mg/kg in males were observed. However, fertility of parent animals was not affected at up to the highest dose (300 mg/kg). Meanwhile, lowered values for the number of live births, tendencies for a decreased birth index, tendencies for a decreased number of live pups on day 4 at 100mg/kg or more, and lowered body weights (only at 300 mg/kg) in pups were observed (Safety Test (Ministry of Economy, Trade and Industry (METI)) (Access on July 2016)). Since adverse effects in the live pups were observed at the dose level which showed maternal toxicity (renal toxicity at 100 mg/kg/day), the substance was classified in Category 2.
8 Specific target organ toxicity - Single exposure Classification not possible
-
-
- -  Classification not possible due to lack of data.
 There is no available data on single dose exposure study of this substance in humans. In experimental animals, sedation, narcosis, reduced general health and loss of body weight were reported after single oral administration to rats (GESTIS (Access on August 2016)). However, the substance was classified as "Classification not possible" because the data is from a List 3 information source, and the original report was not available so that the details of the data are not available.
9 Specific target organ toxicity - Repeated exposure Category 2 (kidney)


Warning
H373 P260
P314
P501
 There were no available data for humans.
 As for experimental animals, in a combined repeated dose toxicity test with reproductive/developmental toxicity screening test using rats administered by gavage (OECD TG 422), renal tubule vacuolation at 100 mg/kg/day equivalent to Category 2 (converted guidance value: 46.7 mg/kg/day) and regenerative renal tubules and renal tubular dilatation at 300 mg/kg/day equivalent to more than Category 2 (converted guidance value: 140 mg/kg/day) were observed. In the recovery group, lymphocytic infiltration and necrosis were found (Safety Test (Ministry of Economy, Trade and Industry (METI)) (Access on July 2016)). Therefore, the substance was classified in Category 2 (kidney).
10 Aspiration hazard Classification not possible
-
-
- -  Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 2
-
-
H401 P273
P501
 From 48-hour ErC50 = 1.4 mg/L for algae (Pseudokirchneriella subcapitata) and 48-hour EC50 = 1.4 mg/L for crustacea (Daphnia magna) (both Results of Aquatic Toxicity Tests of Chemicals conducted by Ministry of the Environment in Japan (Ministry of the Environment, 2009)), it was classified in Category 2. Besides, as for the test on algae, the 48-hour toxicity value conducted taking account of closed system test was used.
11 Hazardous to the aquatic environment (Long-term) Category 2


-
H411 P273
P391
P501
 If chronic toxicity data are used, then it is classified in Category 2 due to not rapidly degradable (Non-biodegradable, a degradation rate by BOD: 0 % (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 2008)), and 48-hour NOEC = 0.23 mg/L for algae (Pseudokirchneriella subcapitata) (Results of Aquatic Toxicity Tests of Chemicals conducted by Ministry of the Environment in Japan (Ministry of the Environment, 2009)). Besides, as for the test on algae, the 48-hour toxicity value conducted taking account of closed system test was used.
 If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified in Category 2 due to being not rapidly degradable (Non-biodegradable,a degradation rate by BOD: 0 % (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 2008)), and 48-hour EC50 = 1.4 mg/L for crustacea (Daphnia magna) (Results of Aquatic Toxicity Tests of Chemicals conducted by Ministry of the Environment in Japan (Ministry of the Environment, 2009)).
 It was classified in Category 2 from the above results.
12 Hazardous to the ozone layer Classification not possible
-
-
- -  No data available.


NOTE:
* A blank or "-" in a cell of classification denotes that the classification of the hazard class was not conducted.
* Hazard_statement_and/or_Precautionary_statement will show when hovering the mouse over a code of Hazard_statement_and/or_Precautionary_statement.
Hazard_statement_and/or_Precautionary_statement are also provided in the Excel file.
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government,
and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.
* Codes assigned to each of the hazard statements and codes for each of the precautionary statement are
based on the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) in United Nations.

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