GHS Classification Result

日本語で表示



GENERAL INFORMATION
Item Information
CAS RN 106-37-6
Chemical Name p-Dibromobenzene
Substance ID H28-A-050, C-109A
Classification year (FY) FY2016
Ministry who conducted the classification Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised New
Classification result in other fiscal year  
Download of Excel format Excel file

REFERENCE INFORMATION
Item Information
Guidance used for the classification (External link) GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
UN GHS document (External link) UN GHS document
Definitions/Abbreviations (Excel file) Definitions/Abbreviations
Model Label by MHLW (External link) MHLW Website (in Japanese Only)
Model SDS by MHLW (External link) MHLW Website (in Japanese Only)
OECD/eChemPortal (External link) eChemPortal

PHYSICAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Explosives Not applicable
-
-
- -  There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases (including chemically unstable gases) Not applicable
-
-
- -  Solid (GHS definition).
3 Aerosols Not applicable
-
-
- -  Not aerosol products.
4 Oxidizing gases Not applicable
-
-
- -  Solid (GHS definition).
5 Gases under pressure Not applicable
-
-
- -  Solid (GHS definition).
6 Flammable liquids Not applicable
-
-
- -  Solid (GHS definition).
7 Flammable solids Classification not possible
-
-
- -  It is a poorly flammable substance (GESTIS (Access on August 2016)), but the classification is not possible due to no data.
8 Self-reactive substances and mixtures Not applicable
-
-
- -  There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not applicable
-
-
- -  Solid (GHS definition).
10 Pyrophoric solids Classification not possible
-
-
- -  No data available.
11 Self-heating substances and mixtures Classification not possible
-
-
- -  Test methods applicable to solid (melting point <= 140 deg C) substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable
-
-
- -  The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable
-
-
- -  Solid (GHS definition).
14 Oxidizing solids Not applicable
-
-
- -  Organic compounds containing no oxygen, fluorine or chlorine
15 Organic peroxides Not applicable
-
-
- -  Organic compounds containing no bivalent -O-O- structure in the molecule
16 Corrosive to metals Classification not possible
-
-
- -  Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Acute toxicity (Oral) Classification not possible
-
-
- -  Classification not possible due to lack of data.
1 Acute toxicity (Dermal) Classification not possible
-
-
- -  Classification not possible due to lack of data.
1 Acute toxicity (Inhalation: Gases) Not applicable
-
-
- -  Solid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Not applicable
-
-
- -  Solid (GHS definition)
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible
-
-
- -  Classification not possible due to lack of data.
2 Skin corrosion/irritation Classification not possible
-
-
- -  Classification not possible due to lack of data.
3 Serious eye damage/eye irritation Classification not possible
-
-
- -  Classification not possible due to lack of data.
4 Respiratory sensitization Classification not possible
-
-
- -  Classification not possible due to lack of data.
4 Skin sensitization Classification not possible
-
-
- -  Classification not possible due to lack of data.
5 Germ cell mutagenicity Classification not possible
-
-
- -  As for in vivo data, micronucleus test using mouse bone marrow was negative (JECDB (Access on August 2016)). As for in vitro data, bacterial reverse mutation test was negative, and a mammalian cell chromosomal aberration test was positive (JECDB (Access on August 2016)). Therefore, the substance was classified as "Classification not possible" according to the GHS classification guidance for the Japanese Government.
6 Carcinogenicity Classification not possible
-
-
- -  Classification not possible due to lack of data.
7 Reproductive toxicity Classification not possible
-
-
- -  In a reproduction/developmental toxicity screening test (OECD TG 421) using rats administered by gavage, no reproductive effects on parental animals and only minor effects on offspring (low or lower tendency of body weights, high tendency of stillbirth index, lower tendency of number of live born and live birth index), which could not be classification basis, were observed up to the high dose (100 mg/kg/day), where enlarged liver and centrilobular hypertrophy of hepatocytes were observed in males (JECDB (Access on September 2016)).
 In this study, reproduction/developmental effects were not observed, however, it is not possible to classify as "Not classified" with this result alone since this study is a screening test. No other data were available for classification. From these reasons, classification is not possible due to lack of data.
8 Specific target organ toxicity - Single exposure Classification not possible
-
-
- -  Classification not possible due to lack of data.
9 Specific target organ toxicity - Repeated exposure Category 1 (kidney), Category 2 (liver)


Danger
Warning
H372
H373
P260
P264
P270
P314
P501
 No data available for humans.
 As for experimental animals, in a 28-day repeated dose toxicity test using rats administered by gavage, PAS-negative eosinophil bodies in the proximal tubules in the kidney (decrease with increasing dose), PAS-positive hyaline droplets and regeneration of the damaged tubules were observed in males at greater than or equal to 20 mg/kg/day (converted guidance value: 6.2 mg/kg/day), which is equivalent to Category 1 (JECDB (Access on August 2016)). An increase in total cholesterol and total bilirubin in males, a decrease in blood glucose in males, an increase in kidney and liver weights in males, hepatocellular swelling and vacuolization of the fasciculated zone cells of the adrenal cortex in both sexes, and dilated glomerular capillaries in females were observed at greater than or equal to 100 mg/kg/day (converted guidance value: 31.1 mg/kg/day), which is equivalent to Category 2 (JECDB (Access on August 2016)). Moreover, an increase in total proteins and triglycerides in both sexes, a decrease in blood glucose in females, prolonged activated partial thromboplastin times in both sexes, an increase in gamma-GT, blood urea nitrogen and inorganic phosphorus in males, an increase in ALT and calcium in females, an increase in kidney and liver weights in females, an increase in adrenal gland weights in males, epithelial vacuolization of the mucosa from lipid accumulation in small intestine and erosion of the glandular stomach mucosa in both sexes were observed at 500 mg/kg/day (converted guidance value: 155.6 mg/kg/day), which is above Category 2 (JECDB (Access on August 2016)). From these findings, it was considered that the target organs were liver, adrenal gland, kidney and gastrointestinal tract. However, it is considered that there are no severe findings in adrenal gland and gastrointestinal tract at up to Category 2. Therefore, the substance was classified in Category 1 (kidney), Category 2 (liver).
10 Aspiration hazard Classification not possible
-
-
- -  Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 1


Warning
H400 P273
P391
P501
 From 96-hour LC50 = 0.68 mg/L for fish (Pimephales promelas) (ECETOC TR91, 2003), it was classified in Category 1.
11 Hazardous to the aquatic environment (Long-term) Category 1


Warning
H410 P273
P391
P501
 Reliable chronic toxicity data were not obtained. Because it is not rapidly degradable (a degradation rate by BOD: 0 % (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 1980)), and classified in Category 1 for acute toxicity, it was classified in Category 1.
12 Hazardous to the ozone layer Classification not possible
-
-
- -  No data available.


NOTE:
* A blank or "-" in a cell of classification denotes that the classification of the hazard class was not conducted.
* Hazard_statement_and/or_Precautionary_statement will show when hovering the mouse over a code of Hazard_statement_and/or_Precautionary_statement.
Hazard_statement_and/or_Precautionary_statement are also provided in the Excel file.
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government,
and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.
* Codes assigned to each of the hazard statements and codes for each of the precautionary statement are
based on the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) in United Nations.

To GHS Information