NITE - Chemical Management Field

GHS Classification Result

GENERAL INFORMATION

Item	Information
CAS RN	10377-66-9
Chemical Name	Manganese(II) Nitrate
Substance ID	H28-A-054, C-113A
Classification year (FY)	FY2016
Ministry who conducted the classification	Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised	New
Classification result in other fiscal year
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
UN GHS document (External link)	UN GHS document
Definitions/Abbreviations (Excel file)	Definitions/Abbreviations
Model Label by MHLW (External link)	MHLW Website (in Japanese Only)
Model SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	eChemPortal

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Explosives	Not classified	- -	-	-	There is a chemical group associated with explosive properties (nitrates) present in the molecule, but it does not correspond to explosives, which is hazard class with the highest precedence, because it is classified in Division 5.1, PG III (UN2724) in UNRTDG.
2	Flammable gases (including chemically unstable gases)	Not applicable	- -	-	-	Solid (GHS definition).
3	Aerosols	Not applicable	- -	-	-	Not aerosol products.
4	Oxidizing gases	Not applicable	- -	-	-	Solid (GHS definition).
5	Gases under pressure	Not applicable	- -	-	-	Solid (GHS definition).
6	Flammable liquids	Not applicable	- -	-	-	Solid (GHS definition).
7	Flammable solids	Not classified	- -	-	-	It is not combustible (GESTIS (Access on August 2016)).
8	Self-reactive substances and mixtures	Not applicable	- -	-	-	There is a chemical group associated with explosive properties (nitrates) present in the molecule, but it is classified in oxidizing solids.
9	Pyrophoric liquids	Not applicable	- -	-	-	Solid (GHS definition).
10	Pyrophoric solids	Not classified	- -	-	-	It is not combustible (GESTIS (Access on August 2016)).
11	Self-heating substances and mixtures	Not classified	- -	-	-	It is not combustible (GESTIS (Access on August 2016)).
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified	- -	-	-	It contains a metal (Mn), but it is estimated that it does not react vigorously with water due to the water solubility data of 380 g/100 g measured (GESTIS (Access on August 2016)).
13	Oxidizing liquids	Not applicable	- -	-	-	Solid (GHS definition).
14	Oxidizing solids	Category 3	Warning	H272	P370+P378 P210 P220 P221 P280 P501	Because it is classified in Division 5.1, PG III (UN2724) in UN RTDG, it was classified in Category 3. Besides, it is written in GESTIS (Access on August 2016) that "it is oxidizing."
15	Organic peroxides	Not applicable	- -	-	-	It is an inorganic compound.
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to solid substances are not available.

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Acute toxicity (Oral)	Classification not possible	- -	-	-	Classification not possible due to lack of data.
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	Classification not possible due to lack of data.
1	Acute toxicity (Inhalation: Gases)	Not applicable	- -	-	-	Solid (GHS definition)
1	Acute toxicity (Inhalation: Vapours)	Not applicable	- -	-	-	Solid (GHS definition)
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	Classification not possible due to lack of data.
2	Skin corrosion/irritation	Classification not possible	- -	-	-	Classification not possible due to lack of data.
3	Serious eye damage/eye irritation	Classification not possible	- -	-	-	Classification not possible due to lack of data.
4	Respiratory sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.
4	Skin sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.
5	Germ cell mutagenicity	Classification not possible	- -	-	-	Classification not possible due to lack of data.
6	Carcinogenicity	Classification not possible	- -	-	-	There is no data available for this substance itself, but as the data on soluble divalent manganese compound, there is a carcinogenicity test conducted by NTP, in which manganese sulfate monohydrate was administered in the diet to rats or mice for 2 years. As for rats, there was no evidence of carcinogenicity in both males and females, but as for mice, there was a slight increase in thyroid gland follicular cell adenoma in both males and females, and it was concluded by NTP that the evidence of carcinogenicity was equivocal (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008), NTP TR428 (1993), CICAD 12 (1999), ATSDR (2012)). There are no classification results for manganese compounds by other organizations. Therefore, it was classified as "classification not possible" due to lack of data for this hazard class.
7	Reproductive toxicity	Category 1B	Danger	H360	P308+P313 P201 P202 P280 P405 P501	There is no data available for this substance itself, but data for soluble divalent manganese compound may be available for classification. In a test in which manganese chloride tetrahydrate was subcutaneously administered to pregnant mice (Gestation days 6 to 15), at doses in which suppression of maternal weight gain and reduction in feed intake were observed in maternal animals or even at lower doses, increased embryo resorptions, hypoplasia of the kidney, and wavy ribs were observed in fetuses (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008), CICAD 12 (1999)). Also, in a test in which manganese chloride was intravenously administered to pregnant rats during organogenesis (gestation days 6 to 17), fetal death, skeletal anomality, wavy ribs, bending of limbs were observed even at doses lower than that of the maternal toxicity (suppression of body weight gain, implantation number reduction) were observed (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008), CICAD 12 (1999)). In addition, it is also reported that increased exencephaly and embryo resorptions were observed in a single intraperitoneal administration of manganese sulfate to pregnant mice on the 8th day of gestation, and at higher doses, inhibition of implantation was observed (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008)). On the other hand, in a test in which manganese chloride was administered by drinking water to pregnant rats, throughout the pregnant period, even at doses exceeding the expression of maternal toxicity (suppression of body weight gain, decrease in water intake), low body weight of the offspring was the only observation seen (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008)). As described above, although it is limited to some extent, the toxicity information of the divalent soluble manganese compounds including this substance showed skeletal abnormality, external malformation, inhibition of implantation, etc. in the fetuses through injection routes such as subcutaneous, intravenous or intraperitoneal injection. Although weak as epidemiological evidence, on the basis of case reports of impotence or decreased libido observed in manganese addicts, and on the basis of embryotoxicity observed in studies using experimental animals, the Japan Society for Occupational Health classified manganese and its compounds in Group 2 of reproductive toxicity (Recommendation of Occupational Exposure Limits (Japan Society For Occupational Health (JSOH), 2016)). Therefore, from the results of studies on divalent soluble manganese compounds using experimental animals, it was deemed appropriate to classify this substance in Category 1B for this hazard class.
8	Specific target organ toxicity - Single exposure	Classification not possible	- -	-	-	Classification not possible due to lack of data.
9	Specific target organ toxicity - Repeated exposure	Category 1 (nervous system, respiratory organs)	Danger	H372	P260 P264 P270 P314 P501	There is no available information on this substance itself. However, it is reported in CICAD 12 (1999) that, "In chronic inhalation exposure to manganese, the main organ systems affected are the lungs, nervous system, and reproductive system. Effects on the nervous system include neurological and neuropsychiatric symptoms that can culminate in a Parkinsonism-like disease known as manganism. Reproductive effects of chronic inhalation exposure to manganese include decreased libido, impotence, and decreased fertility in men; information is not available on the reproductive effects in women. Long-term exposures to manganese in occupational settings can result in a progressive neurological dysfunction, which can produce a disabling syndrome referred to as manganism. Manganism has been documented in welders and in workers exposed to high levels of manganese dust or fumes in mines or foundries. An outbreak of a disease with manganism-like symptoms was reported in a group of six Japanese families (about 25 people) exposed to high levels of manganese in their drinking-water. Symptoms included a masklike face, muscle rigidity and tremors, and mental disturbance. These effects were postulated to be due to the contamination of their well-water with manganese (14 mg/liter) that leached from batteries buried near the well. As a case report, a man noticed weakness and impaired mental capacity after ingesting potassium permanganate (1.8 mg/kg) for several weeks. Although exposure was stopped, a syndrome similar to Parkinson's disease developed. Neurological effects can occur following chronic inhalation exposures in humans and intermediate and chronic oral exposures in animals to different manganese compounds." Furthermore, many cases revealed that manganese compounds, mainly manganese dioxide, produce respiratory disorders (cough, bronchitis, pneumonia, etc.) (ATSDR (2012)). Of the above, the genital organs were not considered as the target organs because they are regarded as findings related to reproductive ability rather than male reproductive toxicity. Therefore, this substance was classified in Category 1 (nervous system, respiratory organs).
10	Aspiration hazard	Classification not possible	- -	-	-	Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
11	Hazardous to the aquatic environment (Acute)	Classification not possible	- -	-	-	No data available.
11	Hazardous to the aquatic environment (Long-term)	Classification not possible	- -	-	-	No data available.
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	No data available.

NOTE:

* A blank or "-" in a cell of classification denotes that the classification of the hazard class was not conducted.
* Hazard_statement_and/or_Precautionary_statement will show when hovering the mouse over a code of Hazard_statement_and/or_Precautionary_statement.
Hazard_statement_and/or_Precautionary_statement are also provided in the Excel file.
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government,
and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.
* Codes assigned to each of the hazard statements and codes for each of the precautionary statement are
based on the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) in United Nations.

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