GHS Classification Result

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GENERAL INFORMATION
Item Information
CAS RN 13410-01-0
Chemical Name Sodium selenate
Substance ID H28-A-063, C-122A
Classification year (FY) FY2016
Ministry who conducted the classification Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised New
Classification result in other fiscal year  
Download of Excel format Excel file

REFERENCE INFORMATION
Item Information
Guidance used for the classification (External link) GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
UN GHS document (External link) UN GHS document
Definitions/Abbreviations (Excel file) Definitions/Abbreviations
Model Label by MHLW (External link) MHLW Website (in Japanese Only)
Model SDS by MHLW (External link) MHLW Website (in Japanese Only)
OECD/eChemPortal (External link) eChemPortal

PHYSICAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Explosives Not applicable
-
-
- -  There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases (including chemically unstable gases) Not applicable
-
-
- -  Solid (GHS definition).
3 Aerosols Not applicable
-
-
- -  Not aerosol products.
4 Oxidizing gases Not applicable
-
-
- -  Solid (GHS definition).
5 Gases under pressure Not applicable
-
-
- -  Solid (GHS definition).
6 Flammable liquids Not applicable
-
-
- -  Solid (GHS definition).
7 Flammable solids Not classified
-
-
- -  It is not combustible (GESTIS (Access on September 2016)).
8 Self-reactive substances and mixtures Not applicable
-
-
- -  There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not applicable
-
-
- -  Solid (GHS definition).
10 Pyrophoric solids Not classified
-
-
- -  It is not combustible (GESTIS (Access on September 2016)).
11 Self-heating substances and mixtures Not classified
-
-
- -  It is not combustible (GESTIS (Access on September 2016)).
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified
-
-
- -  It is estimated that it does not react vigorously with water due to the water solubility result of 58.5 g/100 g measured (R.Lide (2010)).
13 Oxidizing liquids Not applicable
-
-
- -  Solid (GHS definition).
14 Oxidizing solids Classification not possible
-
-
- -  The substance is an inorganic compound containing oxygen, but the classification is not possible due to no data.
15 Organic peroxides Not applicable
-
-
- -  It is an inorganic compound.
16 Corrosive to metals Classification not possible
-
-
- -  Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Acute toxicity (Oral) Classification not possible
-
-
- -  Classification not possible due to lack of data.
 Besides, although an LD50 value for rats of 1.6 mg/kg was reported (Environmental Risk Assessment for Chemical Substances Vol.14 (Ministry of the Environment, 2016)), the data is from RTECS listed in List 3, and details are unknown. Therefore, it was not adopted as the evidence of the classification.
1 Acute toxicity (Dermal) Classification not possible
-
-
- -  Classification not possible due to lack of data.
1 Acute toxicity (Inhalation: Gases) Not applicable
-
-
- -  Solid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Not applicable
-
-
- -  Solid (GHS definition)
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible
-
-
- -  Classification not possible due to lack of data.
2 Skin corrosion/irritation Classification not possible
-
-
- -  Classification not possible due to lack of data.
3 Serious eye damage/eye irritation Classification not possible
-
-
- -  Classification not possible due to lack of data.
4 Respiratory sensitization Classification not possible
-
-
- -  Classification not possible due to lack of data.
4 Skin sensitization Classification not possible
-
-
- -  Classification not possible due to lack of data.
5 Germ cell mutagenicity Category 2


Warning
H341 P308+P313
P201
P202
P280
P405
P501
 As for in vivo, a micronucleus test and chromosomal aberration tests using mouse bone marrow cells were positive.
 As for in vitro, bacterial reverse mutation tests, chromosomal aberration tests and a sister chromatid exchange test using cultured mammalian cells were positive (ATSDR (2003), Environmental Risk Assessment for Chemical Substances Vol.14 (Ministry of the Environment, 2016)).
 From the above, this substance was classified in Category 2 in accordance with the GHS classification guidance for the Japanese Government.
6 Carcinogenicity Classification not possible
-
-
- -  IARC classified selenium and selenium compounds in Group 3 (IARC Suppl. 7 (1984)). In addition, EPA classified selenium and selenium compounds excluding selenium sulfide (B2 (probable human carcinogen)) in Group D (IRIS Summary (1991)) since evidence of carcinogenicity in humans and experimental animals is insufficient. From the above, this substance was classified as "Classification not possible" for this hazard class.
7 Reproductive toxicity Category 2


Warning
H361 P308+P313
P201
P202
P280
P405
P501
 In humans, it is reported that while ingestion of diet containing high level of selenium affects the sperm quality such as decreased sperm motility, there are reports that there are no effects (ATSDR (2003)). An increasing trend of spontaneous abortions (relative risk [RR] = 1.73; 95% CI = 0.62 - 4.80) was suggested for women in Italy who had ingested drinking water containing selenate, but it was not a statistically significant increase. In addition, body weight and length of live born of the selenium-exposed group were not different from those of live born of the unexposed group, and there was no increase in the incidence of congenital abnormalities (ATSDR (2003)).
 As for experimental animals, it is described that in a three-generation study using mice dosed by oral route (drinking water), about half of the F3 generation failed to breed at 0.57 mg Se/kg/day (ATSDR (2003)), and that in a short-term reproductive toxicity study using rats dosed by oral route (drinking water), adverse effects on sexual function/fertility in females (a decrease in the number of corpora lutea, a decrease in the number of implantations per litter, shorter estrous cycle) were observed at the dose (0.418 mg Se/kg/day) where maternal toxicity (significant reduction in water consumption, etc.) was manifested (ATSDR (2003)). In addition, it is described that in a two-generation study in which potassium selenate was orally administered to rats, at 0.35 mg Se/kg/day where suppression of the body weight gain was observed in maternal animals, about half of F2 pups died, and at 1.05 mg Se/kg/day, decreased fertility index and decreased survival rate of pups were observed (ATSDR (2003)).
 From the above, by oral administration of this substance or potassium selenate to experimental animals, effects on sexual function and fertility were observed in general at the general toxic doses of parent animals, and it was judged as appropriate that this substance was classified in Category 2 for this hazard class.

8 Specific target organ toxicity - Single exposure Classification not possible
-
-
- -  Classification not possible due to lack of data. Besides, one case is reported in which after ingesting approximately 22 mg/kg of this substance by suicidal attempt, a 15-year-old girl showed diarrhea and abnormality in electroencephalogram and that an increase in blood bilirubin concentration and alkaline phosphatase activity was observed (ATSDR (2003), HSDB (Access on September 2016)). Since it was the only case, it was not adopted as the evidence of the classification.
9 Specific target organ toxicity - Repeated exposure Category 1 (skin, hair, nail, teeth, central nervous system, liver, kidney, bone)


Danger
H372 P260
P264
P270
P314
P501
 As for experimental animals, in a 2-year carcinogenicity study using rats dosed by feeding, softening of the bones was observed at 0.2 mg/Se/kg/day, which is equivalent to Category 1, and mottled surface of the liver and nephritis in the kidney were observed at 0.1 mg Se/kg/day. In a lifetime test using mice dosed by drinking water, amyloidosis of the major organs was observed (ATSDR (2003)).
 As for humans, although not this substance, there is a report of selenosis with hair loss or morohological changes of the nails in Enshi County, Hubei Province, China where selenium content in foods is high (Environmental Risk Assessment for Chemical Substances Vol. 14 (Ministry of the Environment, 2016), IRIS Summary (1991), ATSDR (2003)), furthermore, lowered hemoglobin, mottled teeth, skin lesions and effects on the central nervous system (peripheral anesthesia, acroparesthesia, and pain in the extremities) were reported (IRIS Summary (1991)).
 This substance is soluble in water, and it is thought that this substance would cause similar selenosis when orally ingested.
 Of the described above, amyloidosis observed in mice was a spontaneous lesion that is common in the mouse strain (Swiss) used in the experiment, and it was considered that the possibility of extrapolation to humans was small, therefore, it was not adopted as the evidence of the classification.
 Therefore, this substance was classified in Category 1 (skin, hair, nail, teeth, central nervous system, liver, kidney, bone).
10 Aspiration hazard Classification not possible
-
-
- -  Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 1


Warning
H400 P273
P391
P501
 From 96-hour LC50 = 0.057 mg/L for crustacea (Gammarus pseudolimnaeus) (Environmental Risk Assessment for Chemical Substances vol. 14 (Ministry of the Environment, 2016)), it was classified in Category 1.
11 Hazardous to the aquatic environment (Long-term) Category 1


Warning
H410 P273
P391
P501
 Due to unknown environmental dynamics of the inorganic compound, and 28-day NOEC (reproduction) = 0.05 mg/L for crustacea (Daphnia pulicaria) (Environmental Risk Assessment for Chemical Substances vol. 14 (Ministry of the Environment, 2016)), it was classified in Category 1.
12 Hazardous to the ozone layer Classification not possible
-
-
- -  No data available.


NOTE:
* A blank or "-" in a cell of classification denotes that the classification of the hazard class was not conducted.
* Hazard_statement_and/or_Precautionary_statement will show when hovering the mouse over a code of Hazard_statement_and/or_Precautionary_statement.
Hazard_statement_and/or_Precautionary_statement are also provided in the Excel file.
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government,
and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.
* Codes assigned to each of the hazard statements and codes for each of the precautionary statement are
based on the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) in United Nations.

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