GHS Classification Result

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GENERAL INFORMATION
Item Information
CAS RN 54464-57-2
Chemical Name 1-(2,3,8,8-Tetramethyl-1,2,3,4,5,6,7,8-octahydronaphthalen-2-yl)ethan-1-one
Substance ID H28-A-072, C-134A
Classification year (FY) FY2016
Ministry who conducted the classification Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised New
Classification result in other fiscal year  
Download of Excel format Excel file

REFERENCE INFORMATION
Item Information
Guidance used for the classification (External link) GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
UN GHS document (External link) UN GHS document
Definitions/Abbreviations (Excel file) Definitions/Abbreviations
Model Label by MHLW (External link) MHLW Website (in Japanese Only)
Model SDS by MHLW (External link) MHLW Website (in Japanese Only)
OECD/eChemPortal (External link) eChemPortal

PHYSICAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Explosives Not applicable
-
-
- -  There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases (including chemically unstable gases) Not applicable
-
-
- -  Liquid (GHS definition)
3 Aerosols Not applicable
-
-
- -  Not aerosol products.
4 Oxidizing gases Not applicable
-
-
- -  Liquid (GHS definition)
5 Gases under pressure Not applicable
-
-
- -  Liquid (GHS definition)
6 Flammable liquids Classification not possible
-
-
- -  No data available.
7 Flammable solids Not applicable
-
-
- -  Liquid (GHS definition)
8 Self-reactive substances and mixtures Classification not possible
-
-
- -  There is a chemical group associated with self-reactive properties (unsaturated bond) present in the molecule, but the classification is not possible due to no data.
9 Pyrophoric liquids Classification not possible
-
-
- -  No data available.
10 Pyrophoric solids Not applicable
-
-
- -  Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible
-
-
- -  Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable
-
-
- -  The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable
-
-
- -  The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen.
14 Oxidizing solids Not applicable
-
-
- -  Liquid (GHS definition)
15 Organic peroxides Not applicable
-
-
- -  Organic compounds containing no bivalent -O-O- structure in the molecule
16 Corrosive to metals Classification not possible
-
-
- -  No data available.

HEALTH HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Acute toxicity (Oral) Not classified
-
-
- -  Based on the LD50 value of >5,000 mg/kg for rats (NTP TOX92 (2016)), the substance was classified as "Not classified."
1 Acute toxicity (Dermal) Not classified
-
-
- -  Based on the LD50 value of >5,000 mg/kg for rats (NTP TOX92 (2016)), the substance was classified as "Not classified."
1 Acute toxicity (Inhalation: Gases) Not applicable
-
-
- -  Liquid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible
-
-
- -  Classification not possible due to lack of data.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible
-
-
- -  Classification not possible due to lack of data.
2 Skin corrosion/irritation Classification not possible
-
-
- -  Classification not possible due to lack of data. Besides, in a skin irritation test by application of 0.5 to 50% solution of this substance to the ears of mice, skin irritation was observed (NTP TOX 92 (2016)). On the other hand, in humans, in a skin irritation test in which this substance was dissolved at 20 to 75% in 3:1 or 3:1 mixture of ethanol and diethyl phthalate and applied to the dorsal part of volunteers, skin irritation was not observed (RIFM (2004)). Either information was not adopted for the evidence of classification because details of either test were unknown.
3 Serious eye damage/eye irritation Classification not possible
-
-
- -  Classification not possible due to lack of data.
4 Respiratory sensitization Classification not possible
-
-
- -  Classification not possible due to lack of data.
4 Skin sensitization Classification not possible
-
-
- -  In humans, several negative results were reported in patch tests using 2.5 to 4.0% solution of this substance. However, in a patch test for dermatitis patients, a few cases of positive reaction were observed (Scognamiglio et al. (2013)). In addition, skin sensitization tests using mice (local lymph node assay (LLNA), two tests) were positive, but both a mouse ear swelling test (details unknown) and a skin sensitization test (LLNA) using mice were negative (NTP (2010), Scognamiglio et al (2013)). As above, because several conflicting results were reported, this substance was classified as "Classification not possible."
5 Germ cell mutagenicity Classification not possible
-
-
- -  As for in vivo, micronucleus tests using peripheral blood of rats or mice in both sexes were negative in rats, equivocal (unclear result) in male mice, and positive in female mice (NTP DB (Access on October 2016)). As for in vitro, bacterial reverse mutation tests were negative (NTP TOX 92 (2016)). From the above, this substance was classified as "Classification not possible" in accordance with the GHS classification guidance for the Japanese Government.
6 Carcinogenicity Classification not possible
-
-
- -  Classification not possible due to lack of data.
7 Reproductive toxicity Classification not possible
-
-
- -  In a developmental toxicity study using pregnant rats given this substance by gavage from gestation days 7 to 17, effects such as decrease in body weight gain, decrease in food consumption, and salivation were observed from the low dose (96 mg/kg/day) in maternal animals, but no specific developmental effects on the fetuses were observed (NTP TOX 92 (2016)). However, because there is no information on the effects on fertility and sexual functions, the classification was not possible due to lack of data for this hazard class.
8 Specific target organ toxicity - Single exposure Classification not possible
-
-
- -  Classification not possible due to lack of data.
9 Specific target organ toxicity - Repeated exposure Classification not possible
-
-
- -  There is no information on humans.
 As for experimental animals, in 3-month studies using rats or mice dermally administered (5 days /week), other than findins on the skin that was the application site, only the decrease in ALT activities was observed at 6.25 % (31.25 mg/kg/day) (converted guidance value: 22 mg/kg/day), which is equivalent to Category 2, in rats, and decreased body weight gain and increased liver weights were observed at 6.25% (125 mg/kg/day) (converted guidance value: 89 mg/kg/day), which is equivalent to Category 2, in mice (NTP TOX92 (2016)).
 As described above, no findings which is available for the evidence were observed at the dose corresponding to Category 2.
 Therefore, the classification was not possible.
10 Aspiration hazard Classification not possible
-
-
- -  Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Classification not possible
-
-
- -  No data available.
11 Hazardous to the aquatic environment (Long-term) Classification not possible
-
-
- -  No data available.
12 Hazardous to the ozone layer Classification not possible
-
-
- -  No data available.


NOTE:
* A blank or "-" in a cell of classification denotes that the classification of the hazard class was not conducted.
* Hazard_statement_and/or_Precautionary_statement will show when hovering the mouse over a code of Hazard_statement_and/or_Precautionary_statement.
Hazard_statement_and/or_Precautionary_statement are also provided in the Excel file.
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government,
and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.
* Codes assigned to each of the hazard statements and codes for each of the precautionary statement are
based on the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) in United Nations.

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