| Item | Information |
|---|---|
| CAS RN | 7440-74-6 |
| Chemical Name | Indium |
| Substance ID | H28-B-001, C-001B |
| Classification year (FY) | FY2016 |
| Ministry who conducted the classification | Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE) |
| New/Revised | Revised |
| Classification result in other fiscal year | FY2006 |
| Download of Excel format | Excel file |
| Item | Information |
|---|---|
| Guidance used for the classification (External link) | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
| UN GHS document (External link) | UN GHS document |
| Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
| Model Label by MHLW (External link) | MHLW Website (in Japanese Only) |
| Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
| OECD/eChemPortal (External link) | eChemPortal |
| Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. |
| 2 | Flammable gases (including chemically unstable gases) | Not applicable |
- |
- | - | Solid (GHS definition). |
| 3 | Aerosols | Not applicable |
- |
- | - | Not aerosol products. |
| 4 | Oxidizing gases | Not applicable |
- |
- | - | Solid (GHS definition). |
| 5 | Gases under pressure | Not applicable |
- |
- | - | Solid (GHS definition). |
| 6 | Flammable liquids | Not applicable |
- |
- | - | Solid (GHS definition). |
| 7 | Flammable solids | Classification not possible |
- |
- | - | No data available. Besides, it is written that powder indium is combustible (GESTIS (Access on May 2016)). |
| 8 | Self-reactive substances and mixtures | Not applicable |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. |
| 9 | Pyrophoric liquids | Not applicable |
- |
- | - | Solid (GHS definition). |
| 10 | Pyrophoric solids | Classification not possible |
- |
- | - | No data available. |
| 11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | No data available. |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified |
- |
- | - | It is estimated that it does not react vigorously with water due to the observation result of being insoluble in water (ICSC (2001)). |
| 13 | Oxidizing liquids | Not applicable |
- |
- | - | Solid (GHS definition). |
| 14 | Oxidizing solids | Not applicable |
- |
- | - | Indium is an element and an inorganic substance not containing oxygen or halogen. |
| 15 | Organic peroxides | Not applicable |
- |
- | - | It is an inorganic element. |
| 16 | Corrosive to metals | Classification not possible |
- |
- | - | Test methods applicable to solid substances are not available. |
| Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Acute toxicity (Oral) | Not classified |
- |
- | - | Based on the LD50 values of >2,000 mg/kg, 4,200 mg/kg for rats (PATTY (6th, 2012)), the substance was classified as "Not classified" (Category 5 in UN GHS classification). |
| 1 | Acute toxicity (Dermal) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 1 | Acute toxicity (Inhalation: Gases) | Not applicable |
- |
- | - | Solid (GHS definition) |
| 1 | Acute toxicity (Inhalation: Vapours) | Not applicable |
- |
- | - | Solid (GHS definition) |
| 1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 2 | Skin corrosion/irritation | Classification not possible |
- |
- | - |
Classification not possible due to lack of data. Besides, it is described that indium and its compounds are irritating to the skin (HSDB (Access on June 2016)), however, it was not adopted for the evidence of the classification because this information source is equivalent to List 2 and the original source could not be confirmed. |
| 3 | Serious eye damage/eye irritation | Classification not possible |
- |
- | - |
Classification not possible due to lack of data. Although it is described that indium is irritating to the eyes and the respiratory tract and that inhalation causes a cough and shortness of breath (Environmental Risk Assessment for Chemical Substances Vol. 11 (Ministry of the Environment, 2013)), it was not adopted for the evidence of the classification because this is considered to be a description on soluble indium compounds. |
| 4 | Respiratory sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 4 | Skin sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 5 | Germ cell mutagenicity | Classification not possible |
- |
- | - |
Classification not possible due to lack of data. No in vivo data are available. As for in vitro data, it is reported that both a bacterial reverse mutation test and a mammalian cell chromosomal aberration test were negative (Environmental Risk Assessment for Chemical Substances Vol. 11 (Ministry of the Environment, 2013), PATTY (6th, 2012)). |
| 6 | Carcinogenicity | Classification not possible |
- |
- | - |
The substance was classified as "Classification not possible" due to lack of data because no data on carcinogenicity of this substance itself are available. Besides, as described in the same hazard class of the GHS classification of indium oxide (CAS 1312-43-2), carcinogenicity classifications by other organizations of related compounds are Group 2A for indium phosphide by IARC (IARC 86 (2006)) and Group 2A for indium and compounds (inorganic, hardly soluble) by the Japan Society For Occupational Health (JSOH) (Recommendation of Occupational Exposure Limits (2015)). |
| 7 | Reproductive toxicity | Classification not possible |
- |
- | - |
Classification not possible due to lack of data. Besides, it is described that in inhalation developmental toxicity studies using rats or mice exposed by inhalation to indium phosphide during gestation, early deaths and reduced weight gain of maternal animals and no fetal malformation were observed at high concentration (100 mg/m3) in mice, while no severe effects on both maternal animals and the fetuses were observed in rats (NTP TR499 (2001)). In contrast, it is described that in the study using rats with a single intravenous dose of indium trichloride on Day 9 of gestation, malformations of the tail and digits were observed (Environmental Risk Assessment for Chemical Substances Vol. 11 (Ministry of the Environment, 2013)), and that in a study using rats given indium trichloride by gavage administration during the organogenesis period (Day 6 to 15 of gestation), increases in the external, visceral and skeletal malformations were observed (Environmental Risk Assessment for Chemical Substances Vol. 11 (Ministry of the Environment, 2013)). |
| 8 | Specific target organ toxicity - Single exposure | Classification not possible |
- |
- | - |
Classification not possible due to lack of data. Besides, it is described that indium is irritating to the respiratory tract (Environmental Risk Assessment for Chemical Substances Vol. 11 (Ministry of the Environment, 2013)), however, the source of this information is ICSC and the original article cannot be confirmed. Moreover, it is not clear whether this description is about metallic indium or indium compounds . Therefore, it was not adopted as evidence of the classification because it is considered that this information alone is insufficient for the evidence of classification. |
| 9 | Specific target organ toxicity - Repeated exposure | Classification not possible |
- |
- | - |
As for experimental animals, in a 28-day repeated dose toxicity study by oral administration, no adverse effects were observed at 1,000 mg/kg/day (Environmental Risk Assessment for Chemical Substances Vol. 11 (Ministry of the Environment, 2013)). No information on the inhalation route was available. Besides, there are reports of interstitial pneumonia caused by inhalation of indium tin compounds and indium oxide in humans (Environmental Risk Assessment for Chemical Substances vol. 11 (Ministry of the Environment, 2013), OEL Documentations (2007) and Recommendation of Occupational Exposure Limits, Vol. 55, 2013 (Japan Society For Occupational Health (JSOH)). In the previous classification, based on the descriptions in ACGIH (7th, 2001) etc. such as "TLV-TWA for indium and its compounds were set up due to skeletal and gastrointestinal effects, and particularly pulmonary toxicity by inhalation into the lung," skeleton and digestive system as well as respiratory organs were determined as target organs. However, because the information was based on the preliminary investigation on indium compounds exposure by the EPA, it is thought to be not reliable due to being a preliminary survey and no information other than symptom names based on complaints, and the information was not adopted for the evidence of classification. Therefore, the substance was classified as "Classification not possible" due to lack of data. |
| 10 | Aspiration hazard | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment (Acute) | Classification not possible |
- |
- | - | No data available. |
| 11 | Hazardous to the aquatic environment (Long-term) | Classification not possible |
- |
- | - | No data available. |
| 12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | No data available. |
|
* A blank or "-" in a cell of classification denotes that the classification of the hazard class was not conducted. * Hazard_statement_and/or_Precautionary_statement will show when hovering the mouse over a code of Hazard_statement_and/or_Precautionary_statement. Hazard_statement_and/or_Precautionary_statement are also provided in the Excel file. * Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. * Codes assigned to each of the hazard statements and codes for each of the precautionary statement are based on the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) in United Nations. |