GHS Classification Result
GENERAL INFORMATION
REFERENCE INFORMATION
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
GENERAL INFORMATION
| Item | Information |
|---|---|
| CAS RN | 13446-18-9 |
| Chemical Name | Magnesium nitrate hexahydrate |
| Substance ID | H28-B-015, C-022B |
| Classification year (FY) | FY2016 |
| Ministry who conducted the classification | Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE) |
| New/Revised | Revised |
| Classification result in other fiscal year | FY2010 |
| Download of Excel format | Excel file |
REFERENCE INFORMATION
| Item | Information |
|---|---|
| Guidance used for the classification (External link) | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
| UN GHS document (External link) | UN GHS document |
| Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
| Model Label by MHLW (External link) | MHLW Website (in Japanese Only) |
| Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
| OECD/eChemPortal (External link) | eChemPortal |
| Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Explosives | Not classified |
- |
- | - | It is a nitrate, which contains a chemical group associated with explosive properties. Dihydrate is classified in Division 5.1, PG III (UN1474) in UNRTDG, and Division 5.1 is not applied to this substance, hexahydrate under Special Provisions. It is estimated that this substance, which is hexahydrate, does not correspond to explosives which is hazard class with the highest precedence. |
| 2 | Flammable gases (including chemically unstable gases) | Not applicable |
- |
- | - | Solid (GHS definition). |
| 3 | Aerosols | Not applicable |
- |
- | - | Not aerosol products. |
| 4 | Oxidizing gases | Not applicable |
- |
- | - | Solid (GHS definition). |
| 5 | Gases under pressure | Not applicable |
- |
- | - | Solid (GHS definition). |
| 6 | Flammable liquids | Not applicable |
- |
- | - | Solid (GHS definition). |
| 7 | Flammable solids | Not classified |
- |
- | - | It is not combustible (Hommel (1991)). |
| 8 | Self-reactive substances and mixtures | Not applicable |
- |
- | - | Because dihydrate is classified in Division 5.1, PG III (UN1474) in UNRTDG and is an oxidizing solid, this substance, which is hexahydrate, corresponds to "Not applicable." |
| 9 | Pyrophoric liquids | Not applicable |
- |
- | - | Solid (GHS definition). |
| 10 | Pyrophoric solids | Not classified |
- |
- | - | It is not combustible (Hommel (1991)). |
| 11 | Self-heating substances and mixtures | Not classified |
- |
- | - | It is not combustible (Hommel (1991)). |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified |
- |
- | - | It contains a metal (Mg), but it is estimated that it does not react vigorously with water due to water solubility measured (soluble in water (0.8%)) (Merck (15th, 2013)). |
| 13 | Oxidizing liquids | Not applicable |
- |
- | - | Solid (GHS definition). |
| 14 | Oxidizing solids | Not classified |
- |
- | - | Because dihydrate is classified in Division 5.1, PG III (UN1474) in UNRTDG, and Division 5.1 is not applied to this substance, hexahydrate under Special Provisions, it is estimated to be "Not classified." |
| 15 | Organic peroxides | Not applicable |
- |
- | - | It is an inorganic compound. |
| 16 | Corrosive to metals | Classification not possible |
- |
- | - | Test methods applicable to solid substances are not available. |
| Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Acute toxicity (Oral) | Not classified |
- |
- | - | Based on the LD50 value of 5,440 mg/kg (ChemID (Access on July 2016)) for rats, this substance was classified as "Not classified." |
| 1 | Acute toxicity (Dermal) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 1 | Acute toxicity (Inhalation: Gases) | Not applicable |
- |
- | - | Solid (GHS definition) |
| 1 | Acute toxicity (Inhalation: Vapours) | Not applicable |
- |
- | - | Solid (GHS definition) |
| 1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 2 | Skin corrosion/irritation | Classification not possible |
- |
- | - |
Classification not possible due to lack of data. Besides, there is a description that severe irritation of the skins is observed for anhydrous magnesium nitrate (CAS RN 10377-60-3) (HSDB (Access on May 2016)), but it was not adopted as the evidence of the classification because the reference could not be confirmed. |
| 3 | Serious eye damage/eye irritation | Classification not possible |
- |
- | - |
Classification not possible due to lack of data. The classification was changed because the information used for the previous classification could not be obtained. Besides, there is a description that severe irritation of the eyes is observed for anhydrous magnesium nitrate (CAS RN 10377-60-3) (HSDB (Access on May 2016)), but it was not adopted as the evidence of the classification because the reference could not be confirmed. |
| 4 | Respiratory sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 4 | Skin sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 6 | Carcinogenicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. Besides, when nitrates and nitrites are administered in combination with a compound having an amine or amide group, nitrosamination occurs in the stomach to form nitrosamines or nitrosamides, and there is sufficient evidence for their carcinogenicity in experimental animals, but IARC has concluded that evidence for the carcinogenicity of nitrates or nitrites administered alone in experimental animals is inadequate or limited (IARC 94 (2010)). |
| 7 | Reproductive toxicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 8 | Specific target organ toxicity - Single exposure | Category 1 (haemal system) |
 Danger |
H370 |
P308+P311
P260 P264 P270 P321 P405 P501 |
There are no reports on this substance itself in humans, but there is a report as general water-soluble nitrates that 15 soldiers who consumed sodium nitrate mistakenly for table salt, showed methemoglobinemia, 13 who consumed about 15 g died and 2 who consumed 5 g survived (ECETOC TR27 (1988)). Therefore, this substance was classified in Category 1 (haemal system) because a single oral exposure to this substance poses the risk of methemoglobinemia in humans. |
| 9 | Specific target organ toxicity - Repeated exposure | Category 1 (haemal system) |
Danger |
H372 |
P260
P264 P270 P314 P501 |
There is no information about this substance. However, it is described that as the human health concern for water-soluble nitrate intake, there is infantile methaemoglobinaemia attributed to nitrites formed by enteric microbial reduction of nitrates contained in food and water, and that neonates have an incompletely developed system for methaemoglobin reduction and their risk are thus high (ECETOC TR27 (1988)). In addition, there are the following descriptions: Three patients developed cyanosis due to methaemoglobinaemia after administration of ammonium nitrate at 10 g/day for 4-5 days as a diuretic. Of 268 patients who were given ammonium nitrate of 2-9 g/day to prevent renal calculi, methaemoglobinaemia was reported in only two cases, one of which was the case of genetic defects of methaemoglobin reductase (ECETOC TR27 (1988)). Therefore, this substance was classified in Category 1 (haemal system) because oral exposure to this substance has the risk of causing methaemoglobinaemia in humans, especially in neonates. |
| 10 | Aspiration hazard | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment (Acute) | Classification not possible |
- |
- | - | No data available. |
| 11 | Hazardous to the aquatic environment (Long-term) | Classification not possible |
- |
- | - | No data available. |
| 12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | No data available. |
NOTE:
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* A blank or "-" in a cell of classification denotes that the classification of the hazard class was not conducted. * Hazard_statement_and/or_Precautionary_statement will show when hovering the mouse over a code of Hazard_statement_and/or_Precautionary_statement. Hazard_statement_and/or_Precautionary_statement are also provided in the Excel file. * Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. * Codes assigned to each of the hazard statements and codes for each of the precautionary statement are based on the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) in United Nations. |