GHS Classification Result

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GENERAL INFORMATION
Item Information
CAS RN 149-30-4
Chemical Name 2-Mercaptobenzothiazole
Substance ID H28-B-033, C-044B
Classification year (FY) FY2016
Ministry who conducted the classification Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised Revised
Classification result in other fiscal year FY2008  
Download of Excel format Excel file

REFERENCE INFORMATION
Item Information
Guidance used for the classification (External link) GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
UN GHS document (External link) UN GHS document
Definitions/Abbreviations (Excel file) Definitions/Abbreviations
Model Label by MHLW (External link) MHLW Website (in Japanese Only)
Model SDS by MHLW (External link) MHLW Website (in Japanese Only)
OECD/eChemPortal (External link) eChemPortal

PHYSICAL HAZARDS
Hazard class Classification Pictogram
Signal word 		Hazard statement
(code) 		Precautionary statement
(code) 		Rationale for the classification
1 Explosives Not applicable
-
-
- -  There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases (including chemically unstable gases) Not applicable
-
-
- -  Solid (GHS definition)
3 Aerosols Not applicable
-
-
- -  Not aerosol products.
4 Oxidizing gases Not applicable
-
-
- -  Solid (GHS definition)
5 Gases under pressure Not applicable
-
-
- -  Solid (GHS definition)
6 Flammable liquids Not applicable
-
-
- -  Solid (GHS definition)
7 Flammable solids Classification not possible
-
-
- -  It is combustible, but the classification is not possible due to no data.
8 Self-reactive substances and mixtures Not applicable
-
-
- -  There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not applicable
-
-
- -  Solid (GHS definition)
10 Pyrophoric solids Not classified
-
-
- -  It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 628 deg C (ICSC(J) (2004)).
11 Self-heating substances and mixtures Classification not possible
-
-
- -  No data available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable
-
-
- -  The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable
-
-
- -  Solid (GHS definition)
14 Oxidizing solids Not applicable
-
-
- -  Organic compounds containing no oxygen, fluorine or chlorine
15 Organic peroxides Not applicable
-
-
- -  Organic compounds containing no bivalent -O-O- structure in the molecule
16 Corrosive to metals Classification not possible
-
-
- -  Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Pictogram
Signal word 		Hazard statement
(code) 		Precautionary statement
(code) 		Rationale for the classification
1 Acute toxicity (Oral) Not classified
-
-
- -  Based on the LD50 value of > 3,800 mg/kg (PATTY (6th, 2012)) for rats, this substance was classified as "Not classified" (Category 5 in UN GHS classification).
1 Acute toxicity (Dermal) Not classified
-
-
- -  Based on the LD50 value of 7,940 mg/kg (PATTY (6th, 2012), BUA 237 (2000)) for rabbits, this substance was classified as "Not classified."
1 Acute toxicity (Inhalation: Gases) Not applicable
-
-
- -  Solid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Not applicable
-
-
- -  Solid (GHS definition)
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible
-
-
- -  Classification not possible due to lack of data. Besides, there is a report that the LC50 value (4 hours) for rats is > 1,270 mg/m3 (gender unknown) (BUA 237 (2000)). However, classification is not possible because a category cannot be determined based on this value alone.
2 Skin corrosion/irritation Not classified
-
-
- -  No irritation was observed in a test using rabbits (PATTY (6th, 2012)) and in a human patch test (PATTY (6th, 2012)). Therefore, this substance was classified as "Not classified."
3 Serious eye damage/eye irritation Not classified
-
-
- -  Since no irritation was observed in a study using rabbits (PATTY (6th, 2012)), this substance was classified as "Not classified."
4 Respiratory sensitization Classification not possible
-
-
- -  Classification not possible due to lack of data.
4 Skin sensitization Category 1


Warning
H317 P302+P352
P333+P313
P362+P364
P261
P272
P280
P321
P501 		 A maximization test and Buehler test using the guinea pigs were positive (ECETOC (1999), PATTY (6th, 2012)), and a murine local lymph node assay was positive (ECETOC (1999)). Moreover, the occurrence of contact dermatitis and skin sensitization has also been reported in humans (ECETOC (1999), PATTY (6th, 2012)). From the above, this substance was classified in Category 1.
5 Germ cell mutagenicity Classification not possible
-
-
- -  The substance was classified as "Classification not possible," because it was not possible to classify a substance as "Not classified" according to the revised GHS classification guidance for the Japanese Government. As for in vivo data, a mouse dominant lethal assay, a micronucleus assay and an unscheduled DNA synthesis assay using rat liver are negative (EPA RED (1994), PATTY (6th, 2012)). As for in vitro data, a bacterial reverse mutation test and a gene mutation test using mammalian cultured cells are negative, mouse lymphoma assays show positive and negative results, and a chromosomal aberration test and a sister chromatid exchange test are positive (EPA RED (1994), NTP TR332 (1988), PATTY (6th, 2012)).
6 Carcinogenicity Category 1B


Danger
H350 P308+P313
P201
P202
P280
P405
P501 		 IARC recently pre-announced that this substance has been classified in Group 2A, but details on humans etc. are unknown since the monograph itself is unpublished as of June 2016 (IARC 115 (in prep., Access in June 2016)). However, in experimental animals, in a carcinogenicity study using rats or mice given this substance by gavage administration for 2 years, as neoplastic changes showing dose-response relationships in rats, increases in pituitary gland adenomas (females), in the incidence of preputial gland adenomas or carcinomas (combined) (males), in the incidence of benign or malignant pheochromocytomas in the adrenal gland (combined) (males), etc. were observed; and in mice, an increase in the incidence of hepatocellular adenomas or carcinomas (combined) was observed in the low-dose female mice group (NTP TR332 (1988), EPA RED (1994)). As for classifications by other organizations, the EPA has previously classified this substance in Group C (possible human carcinogen: equivalent to Category 2) (EPA RED (1994)). As described above, in the experimental animals, positive results were obtained with two species. Therefore, this substance was classified in Category 1B for this hazard class, taking into account the IARC's pre-announced listing as well.
7 Reproductive toxicity Not classified
-
-
- -  In a 2-generation reproductive toxicity study using rats by oral administration (feeding), no effects on fertility were observed even at doses (695 to 783 mg/kg/day or above) where the effects of general toxicity (decreased weight gain, increased kidney weights, increased brown pigment in the kidneys, increased incidence of basophilic tubules, etc.) were observed in the parental animals (EPA RED (1994), PATTY (6th, 2012)). Also, in a combined repeated dose toxicity study with a reproduction/developmental toxicity screening test using rats, despite administration by gavage at up to 1,000 mg/kg, no reproductive/developmental effects were observed in either dams or fetuses (Safety Test (Ministry of Economy, Trade and Industry (METI), 2007)). On the other hand, it is described that in developmental toxicity studies using pregnant rats or pregnant rabbits by gavage administration during the organogenesis period (rats: Gestation days 6 to 15, rabbits: Gestation days 6 to 18), in the study using rabbits, no effects of administration were observed at up to 300 mg/kg/day in either dams or fetuses; and in the study using rats, increased post implantation loss was observed at 1,800 mg/kg/day where reduced body weight gain and food consumption were observed in the dams (EPA RED (1994)). However, it is reported that this finding is equivocal and is unlikely to be of toxicological significance (PATTY (6th, 2012)).
 From the above, there were no effects on fertility and pups even when administered at up to the limit dose, and clear developmental toxicity effects have not been reported from exposure to pregnant animals either. Therefore, this substance was classified as "Not classified" for this hazard class.
8 Specific target organ toxicity - Single exposure Classification not possible
-
-
- -  Classification not possible due to lack of data.
9 Specific target organ toxicity - Repeated exposure Classification not possible
-
-
- -  There is no relevant information on humans.
 Besides, as for experimental animals, in a 13-week repeated dose toxicity study using rats by gavage administration, necrosis of the renal distal convoluted tubular epithelium is reported at 3,000 mg/kg/day, which is a dose exceeding Category 2 (PATTY (6th, 2012)). In addition, in a combined repeated dose toxicity study with the reproduction/developmental toxicity screening test using rats by gavage administration, effects on the liver (increased relative weights, centrilobular hepatocellular hypertrophy in the liver, high values in gamma-GTP) are reported at 1,000 mg/kg/day (converted guidance value: 466.7 mg/kg/day), which is a dose exceeding Category 2 (Safety Test (Ministry of Economy, Trade and Industry (METI), 2007)).
 Moreover, in a 2-year repeated dose toxicity study using rats by gavage administration, effects on the kidney (hyperplasia of the epithelium of the renal pelvis, focal hyperplasia of the tubular epithelium) are reported at 375 mg/kg/day or more, which is a dose exceeding Category 2; in a 13-week repeated dose toxicity study using mice by gavage administration, there are reports that lethargy was observed at 375 mg/kg/day (converted guidance value: 271 mg/kg/day), which is a dose above Category 2, and that effects on the nervous system (clonic seizure, lacrimation, salivation) were observed at 750 mg/kg/day (converted guidance value: 542 mg/kg/day) (NTP TR332 (1988)).
 As described above, effects on the liver, kidney, and nervous system were observed. However, they were observed at doses above the guidance value ranges of Category 2, so this substance was classified as "Classification not possible."
10 Aspiration hazard Classification not possible
-
-
- -  Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS
Hazard class Classification Pictogram
Signal word 		Hazard statement
(code) 		Precautionary statement
(code) 		Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 1


Warning
H400 P273
P391
P501 		 From 72-hour ErC50 = 0.5 mg/L for algae (Pseudokirchneriella subcapitata) (Results of Aquatic Toxicity Tests of Chemicals conducted by Environment Agency in Japan (Environment Agency, 1999)), it was classified in Category 1.
11 Hazardous to the aquatic environment (Long-term) Category 1


Warning
H410 P273
P391
P501 		 If chronic toxicity data are used, then it is classified in Category 1 due to being not rapidly degradable (Non-biodegradable, a degradation rate by BOD: 2.5 % (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 1977)), and 72-hour NOEC (r) = 0.066 mg/L for algae (Pseudokirchneriella subcapitata) (Results of Aquatic Toxicity Tests of Chemicals conducted by Environment Agency in Japan (Environment Agency, 1999)).
 If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified in Category 1 due to being not rapidly degradable (Non-biodegradable, a degradation rate by BOD: 2.5 % (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 1977)), and LC50 (unknown time) = 0.73 mg/L for fish (Oncorhynchus mykiss) (U.S.EPA: RED, 1994).
 It was classified in Category 1 from the above results.
12 Hazardous to the ozone layer Classification not possible
-
-
- -  No data available.


NOTE:
* A blank or "-" in a cell of classification denotes that the classification of the hazard class was not conducted.
* Hazard_statement_and/or_Precautionary_statement will show when hovering the mouse over a code of Hazard_statement_and/or_Precautionary_statement.
Hazard_statement_and/or_Precautionary_statement are also provided in the Excel file.
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government,
and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.
* Codes assigned to each of the hazard statements and codes for each of the precautionary statement are
based on the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) in United Nations.

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