GHS Classification Result

日本語で表示



GENERAL INFORMATION
Item Information
CAS RN 121-44-8
Chemical Name Triethylamine
Substance ID H28-B-039, C-051B
Classification year (FY) FY2016
Ministry who conducted the classification Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised Revised
Classification result in other fiscal year FY2006  
Download of Excel format Excel file

REFERENCE INFORMATION
Item Information
Guidance used for the classification (External link) GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
UN GHS document (External link) UN GHS document
Definitions/Abbreviations (Excel file) Definitions/Abbreviations
Model Label by MHLW (External link) MHLW Website (in Japanese Only)
Model SDS by MHLW (External link) MHLW Website (in Japanese Only)
OECD/eChemPortal (External link) eChemPortal

PHYSICAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Explosives Not applicable
-
-
- -  There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases (including chemically unstable gases) Not applicable
-
-
- -  Liquid (GHS definition)
3 Aerosols Not applicable
-
-
- -  Not aerosol products.
4 Oxidizing gases Not applicable
-
-
- -  Liquid (GHS definition)
5 Gases under pressure Not applicable
-
-
- -  Liquid (GHS definition)
6 Flammable liquids Category 2


Danger
H225 P303+P361+P353
P370+P378
P403+P235
P210
P233
P240
P241
P242
P243
P280
P501
 From a flash point of -6 deg C (closed cup) and a boiling point of 89.9 deg C (Merck (15th, 2013)), it was classified in Category 2. It is classified in Class 3, Subsidiary Risk 8, PG II (UN1296) in UNRTDG.
7 Flammable solids Not applicable
-
-
- -  Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable
-
-
- -  There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not classified
-
-
- -  It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 230 deg C (ICSC(J) (2002)).
10 Pyrophoric solids Not applicable
-
-
- -  Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible
-
-
- -  Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable
-
-
- -  The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable
-
-
- -  Organic compounds containing no oxygen, fluorine or chlorine
14 Oxidizing solids Not applicable
-
-
- -  Liquid (GHS definition)
15 Organic peroxides Not applicable
-
-
- -  Organic compounds containing no bivalent -O-O- structure in the molecule
16 Corrosive to metals Classification not possible
-
-
- -  No data available.

HEALTH HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Acute toxicity (Oral) Category 4


Warning
H302 P301+P312
P264
P270
P330
P501
 Six LD50 values are reported: 182 mg/kg (DFGOT Vol.13 (1999)), 460 mg/kg (ACGIH (7th, 2015), DFGOT Vol.13 (1999), PATTY (6th, 2012)), 590 mg/kg, 560 mg/kg, 730 mg/kg (DFGOT Vol.13 (1999)) and 1,029 mg/kg (DFGOT Vol.13 (1999)).
 This substance was classified in Category 4, which has the largest number of cases, since one case corresponds to Category 3 and 5 cases correspond to Category 4.
1 Acute toxicity (Dermal) Category 3


Danger
H311 P302+P352
P361+P364
P280
P312
P321
P405
P501
 There are five reports of LD50 values of 415 mg/kg (DFGOT Vol.13 (1999)), 416 mg/kg (PATTY (6th, 2012)), 420 mg/kg (ACGIH (7th, 2015)), 578 mg/kg (DFGOT Vol.13 (1999)) and 580 mg/kg (SIAP (2012)) for rabbits. Based on these, this substance was classified in Category 3.
1 Acute toxicity (Inhalation: Gases) Not applicable
-
-
- -  Liquid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Category 4


Warning
H332 P304+P340
P261
P271
P312
 There are three reports of LC50 (4hours) values for rats of 1,250 ppm, 2,600 ppm (DFGOT Vol.13 (1999)) and 2,633 ppm (SIDS (2012)). One corresponds to Category 3 and two correspond to Category 4. Therefore it was classified in Category 4 which has the largest number of cases.
 Besides, since the LC50 value is lower than 90% of the saturated vapor pressure concentration (75,360 ppm), a reference value in the unit of ppm was applied as vapour without mist. The classification was revised based on the newly obtained information.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible
-
-
- -  Classification not possible due to lack of data.
2 Skin corrosion/irritation Category 1


Danger
H314 P301+P330+P331
P303+P361+P353
P305+P351+P338
P304+P340
P260
P264
P280
P310
P321
P363
P405
P501
 In a skin irritation test using rabbits under occlusive application for 3 minutes, 1 hour or 4 hours, it was found to be corrosive (DFGOT Vol.13 (1999)). Therefore, this substance was classified in Category 1.
3 Serious eye damage/eye irritation Category 1


Danger
H318 P305+P351+P338
P280
P310
 In an eye irritation test using rabbits with application of 0.1 mL of this substance, it was found to be corrosive (DFGOT Vol.13 (1999)).
 Therefore, this substance was classified in Category 1.
4 Respiratory sensitization Classification not possible
-
-
- -  Classification not possible due to lack of data.
4 Skin sensitization Not classified
-
-
- -  A skin sensitization test using guinea pigs was negative, and in a human patch test, no skin sensitization was observed (DFGOT Vol.13 (1999)). Therefore, this substance was classified as "Not classified."
5 Germ cell mutagenicity Classification not possible
-
-
- -  As for in vivo, a micronucleus test using mouse peripheral blood was equivocal in males and negative in females (NTP DB (Access on June 2016)). However, this substance was not judged as positive because reproducibility of this equivocal result was not confirmed.
 As for in vitro, a bacterial reverse mutation test and a mammalian cell sister chromatid exchange assay were negative (DFGOT Vol.13 (1999), ACGIH (7th, 2015), Environmental Risk Assessment for Chemical Substances Vol.6 (Ministry of the Environment, 2008), NTP DB (Access on June 2016)).
 From the above, this substance was classified as "Classification not possible" according to the GHS classification guidance for the Japanese Government.
6 Carcinogenicity Classification not possible
-
-
- -  As for classifications by other organizations, ACGIH classified in A4. Therefore, this substance was classified as "Classification not possible."
 Besides, in workers exposed to numerous chemicals including this substance, increased incidence of several tumors, especially bladder tumors, were observed, but it is thought that the causative substance was not this substance but aromatic amines such as 1-naphthylamine etc. and benzidine (DFGOT Vol. 13 (1999)).
7 Reproductive toxicity Classification not possible
-
-
- -  Classification not possible due to lack of data.
 Besides, it is reported that in a three-generation study using rats administered by drinking water, no effects on reproduction and development were observed in any generation (Environmental Risk Assessment for Chemical Substances Vol. 6 (Ministry of the Environment, 2008), ACGIH (7th, 2015)). In addition, it is reported that in a test using pregnant rabbits intravenously injected, fetotoxicity occurred at doses less than those where maternal toxicity was observed (Environmental Risk Assessment for Chemical Substances Vol. 6 (Ministry of the Environment, 2008), ACGIH (7th, 2015)).
8 Specific target organ toxicity - Single exposure Category 1 (central nervous system), Category 3 (respiratory tract irritation)



Danger
Warning
H370
H335
P308+P311
P260
P264
P270
P321
P405
P501
P304+P340
P403+P233
P261
P271
P312
 It is reported that in humans inhalation of this substance resulted in electroencephalogram changes (PATTY (6th, 2012)).
 As for experimental animals, it is reported that in a 4-hour single inhalation exposure study using rats or mice, irritation of the respiratory tract, breathing difficulties, excitation, tremors, convulsions and coordination disturbances were observed at doses within a guidance value range for Category 2 (ACGIH (7th, 2015), DFGOT Vol. 13 (1999)). Therefore, this substance was classified in Category 1 (central nervous system) and Category 3 (respiratory tract irritation).
 Besides, it is reported that in a single inhalation exposure study of this substance in human volunteers, visual disturbances (blurring of vision, decrease in visual acuity, decrease in contrast sensitivity) and associated oedema of the cornea were observed (ACGIH (7th, 2015), DFGOT Vol.13 (1999), IRIS (1991)), but it is considered that these effects were caused by corrosive nature of this substance. And also, in the previous classification it was classified in Category 1 (respiratory organs) based on the description that a decrease in breathing rate was observed at the low concentrations of 156 - 180 ppm in the inhalation exposure test using mice (ACGIH (7th, 2001)), and the description that it is corrosive. However, because no information was provided for details of exposure time, the information was not adopted for the evidence of classification.
9 Specific target organ toxicity - Repeated exposure Category 2 (respiratory organs)


Warning
H373 P260
P314
P501
 There is no relevant information about humans.
 As for experimental animals, as an example of a short term exposure at high concentrations using rats, it is reported that in an inhalation exposure study for 10 days, effects on respiratory organs (necrotic inflammation in the nasal cavity, squamous metaplasia in the trachea, perivascular edema of the lungs in death) were observed at 4,140 mg/m3 (converted guidance value: 0.46 mg/L), which is equivalent to Category 2 (Environmental Risk Assessment for Chemical Substances Vol.6 (Ministry of the Environment, 2008)). Therefore, this substance was classified in Category 2 (respiratory organs).
 Besides, in the previous classification, the central nervous system was adopted as the target organ because effects on the central nervous system were observed in a test using rats, and visual impairment was also seen in humans.
 However, no information was provided for details of this study using rats (Environmental Risk Assessment for Chemical Substances Vol.6 (Ministry of the Environment, 2008)) and human visual impairment is thought to be due to irritancy. The central nervous system was not adopted as the target organ this time.
10 Aspiration hazard Classification not possible
-
-
- -  Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 2
-
-
H401 P273
P501
 From 72-hour ErC50 = 7.97 mg/L for algae (Pseudokirchneriella subcapitata) (Results of Aquatic Toxicity Tests of Chemicals conducted by Environment Agency in Japan (Environment Agency, 1999), Environmental Risk Assessment for Chemical Substances vol. 6 (Ministry of the Environment, 2008)), it was classified in Category 2.
11 Hazardous to the aquatic environment (Long-term) Category 3
-
-
H412 P273
P501
 If chronic toxicity data are used, then it is classified as "Not classified" because it is not rapidly degradable (Non-biodegradable, a degradation rate by BOD: 34%, 25%, 26% (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 1990)), but its 72-hour NOEC (r) = 1.1 mg/L for algae (Pseudokirchneriella subcapitata) (Results of Aquatic Toxicity Tests of Chemicals conducted by Environment Agency in Japan (Environment Agency, 1999), Environmental Risk Assessment for Chemical Substances vol. 6 (Ministry of the Environment, 2008)), and its 7-day NOEC = 7.1 mg/L for crustacea (Ceriodaphnia dubia) (SIAP, Conclusions Agreed in CoCAM 2, 2012).
 If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified in Category 3 due to being not rapidly degradable (Non-biodegradable, a degradation rate by BOD: 34%, 25%, 26% (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 1990)), and 96-hour LC50 = 24 mg/L for fish (Oryzias latipes) (Results of Aquatic Toxicity Tests of Chemicals conducted by Environment Agency in Japan (Environment Agency, 1999), Environmental Risk Assessment for Chemical Substances vol. 6 (Ministry of the Environment, 2008)).
 It was classified in Category 3 by drawing a comparison between the above results.
12 Hazardous to the ozone layer Classification not possible
-
-
- -  No data available.


NOTE:
* A blank or "-" in a cell of classification denotes that the classification of the hazard class was not conducted.
* Hazard_statement_and/or_Precautionary_statement will show when hovering the mouse over a code of Hazard_statement_and/or_Precautionary_statement.
Hazard_statement_and/or_Precautionary_statement are also provided in the Excel file.
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government,
and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.
* Codes assigned to each of the hazard statements and codes for each of the precautionary statement are
based on the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) in United Nations.

To GHS Information