GHS Classification Result
GENERAL INFORMATION
REFERENCE INFORMATION
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
GENERAL INFORMATION
| Item | Information |
|---|---|
| CAS RN | 122-34-9 |
| Chemical Name | Simazine |
| Substance ID | H28-B-043, C-060B |
| Classification year (FY) | FY2016 |
| Ministry who conducted the classification | Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE) |
| New/Revised | Revised |
| Classification result in other fiscal year | FY2006 |
| Download of Excel format | Excel file |
REFERENCE INFORMATION
| Item | Information |
|---|---|
| Guidance used for the classification (External link) | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
| UN GHS document (External link) | UN GHS document |
| Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
| Model Label by MHLW (External link) | MHLW Website (in Japanese Only) |
| Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
| OECD/eChemPortal (External link) | eChemPortal |
| Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. |
| 2 | Flammable gases (including chemically unstable gases) | Not applicable |
- |
- | - | Solid (GHS definition). |
| 3 | Aerosols | Not applicable |
- |
- | - | Not aerosol products. |
| 4 | Oxidizing gases | Not applicable |
- |
- | - | Solid (GHS definition). |
| 5 | Gases under pressure | Not applicable |
- |
- | - | Solid (GHS definition). |
| 6 | Flammable liquids | Not applicable |
- |
- | - | Solid (GHS definition). |
| 7 | Flammable solids | Classification not possible |
- |
- | - | It is combustible (ICSC (1999)), but the classification is not possible due to no data. |
| 8 | Self-reactive substances and mixtures | Not applicable |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. |
| 9 | Pyrophoric liquids | Not applicable |
- |
- | - | Solid (GHS definition). |
| 10 | Pyrophoric solids | Classification not possible |
- |
- | - | No data available. |
| 11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | No data available. |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable |
- |
- | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
| 13 | Oxidizing liquids | Not applicable |
- |
- | - | Solid (GHS definition). |
| 14 | Oxidizing solids | Not applicable |
- |
- | - | The substance is an organic compound containing chlorine (but not fluorine or oxygen) which is chemically bonded only to carbon or hydrogen. |
| 15 | Organic peroxides | Not applicable |
- |
- | - | Organic compounds containing no bivalent -O-O- structure in the molecule |
| 16 | Corrosive to metals | Classification not possible |
- |
- | - | Test methods applicable to solid substances are not available. |
| Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Acute toxicity (Oral) | Not classified |
- |
- | - | Based on three reported LD50 values for rats of > 5,000 mg/kg (EPA RED (2006), Japanese Journal of Pesticide Science Vol.15 (Pesticide Science Society of Japan, 1990)), > 7,000 mg/kg and > 10,000 mg/kg (Japanese Journal of Pesticide Science Vol.15 (Pesticide Science Society of Japan, 1990)), this substance was classified as "Not classified." |
| 1 | Acute toxicity (Dermal) | Not classified |
- |
- | - |
There is a report that the LD50 value for rats is > 5,000 mg/kg (Japanese Journal of Pesticide Science Vol.15 (Pesticide Science Society of Japan, 1990)), which corresponds to "Not classified." There is a report that the LD50 value for rabbits is > 2,000 mg/kg (EPA RED (2006)), which corresponds to "Not classified." Based on these reports, this substance was classified as "Not classified." |
| 1 | Acute toxicity (Inhalation: Gases) | Not applicable |
- |
- | - | Solid (GHS definition) |
| 1 | Acute toxicity (Inhalation: Vapours) | Not applicable |
- |
- | - | Solid (GHS definition) |
| 1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. Besides, there are two reported LC50 values (4 hours) for rats of > 1.71 mg/L (EPA RED (2006)) and > 2,100 mg/m3 (converted value: > 2.1 mg/L) (Japanese Journal of Pesticide Science Vol.15 (Pesticide Science Society of Japan, 1990)), and it is presumed that these correspond to Category 4 or "Not classified." However, it was not possible to specify a category from these values. |
| 2 | Skin corrosion/irritation | Not classified |
- |
- | - | It is reported that this substance is slightly irritating to rabbits (PATTY (6th, 2012)). However, it is also reported that there was no irritation in a rabbit skin irritation test (ACGIH (2016), EPA RED (2006)). This substance was classified as "Not classified" since it is judged that there is no irritation corresponding to Category 2 in the GHS classification. |
| 3 | Serious eye damage/eye irritation | Category 2B |
Warning |
H320 |
P305+P351+P338
P337+P313 P264 |
In an eye irritation test using rabbits, slight irritation (ACGIH (2016), EPA RED (2006)) or moderate irritation (PATTY (6th, 2012)) was observed. However, the US EPA assesses that the substance is not an eye irritant (EPA RED (2006)). Therefore, it is judged that the substance is a slight eye irritant, and it was classified in Category 2B. |
| 4 | Respiratory sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 4 | Skin sensitization | Classification not possible |
- |
- | - |
It is reported that in skin sensitization tests using guinea pigs, all results indicated negative (ACGIH (2016), EPA RED (2006), PATTY (6th, 2012)). It is reported that also in human patch tests, no sensitization was seen (PATTY (6th, 2012)). However, this substance was classified as "Classification not possible" because details could not be confirmed on any of the above. The category was revised with the revision of the GHS classification guidance for the Japanese Government. |
| 5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | This substance was classified as "Classification not possible," because it was not possible to classify a substance as "Not classified" according to the revised GHS classification guidance for the Japanese Government. As for in vivo, a mouse dominant lethal test is negative, micronucleus tests using peripheral blood and bone marrow cells of mice are negative and a DNA damage test using mouse leukocytes is negative (IARC 73 (1999), ACGIH (7th, 2016), PATTY (6th, 2012)). As for in vitro, bacterial reverse mutation tests are negative, a gene mutation test using cultured mammalian cells is positive, chromosomal aberration tests show negative or positive results, and sister chromatid exchange tests are negative (IARC 73 (1999), ACGIH (7th, 2016), PATTY (6th, 2012), Japanese Journal of Pesticide Science Vol.15 (Pesticide Science Society of Japan, 1990)). |
| 6 | Carcinogenicity | Category 2 |
 Warning |
H351 |
P308+P313
P201 P202 P280 P405 P501 |
There is no carcinogenicity information on humans. As for experimental animals, in carcinogenicity studies using rats and mice by the oral route (feeding), an increase in the incidence of mammary gland tumors (fibroadenoma, adenocarcinoma) was observed in female rats, but no increase in tumors was observed in both sexes of mice (IARC 73 (1999)). From the above, IARC classified this substance in Group 3 based on inadequate evidence for carcinogenicity in humans and limited evidence in experimental animals (IARC 73 (1999)). However, ACGIH focused on the mammary gland tumors in female rats and classified the substance in A3 (ACGIH (7th, 2016)). Moreover, the EU classified the substance in Carc. 2 (ECHA C&L Inventory (Access on August 2016)). Although the classification results differed depending on the evaluation organization, it was determined that more recent classification results of carcinogenicity by ACGIH and the EU than that by IARC was adopted in this classification, and this substance was classified in Category 2. |
| 7 | Reproductive toxicity | Category 2 |
Warning |
H361 |
P308+P313
P201 P202 P280 P405 P501 |
In a reproductive toxicity study in which rats were orally given (feeding) this substance at up to 100 ppm for three generations or up to 500 ppm for two generations, no reproductive effects were observed in any of the generations (ACGIH (7th, 2016), PATTY (6th, 2012), HSDB (Access on June 2016)). On the other hand, in developmental toxicity studies using pregnant rats administered by oral or inhalation exposure, no effects or only slight effects were observed in the fetuses (ACGIH (7th, 2016), IARC 73 (1999)). However, in a gavage study using pregnant rabbits (Days 7-19 of gestation), at doses at which maternal toxicity (suppression of body weight gain, tremor, lowered locomotor activity) was seen, delayed ossification, skeletal variations, reduced fetal weight, and also an increase in embryo/fetus resorptions were observed (ACGIH (7th, 2016), PATTY (6th, 2012), HSDB (Access in June 2016)). Moreover, there is a report that as the result of oral administration to female rats from postnatal days 22 to 42, delayed vaginal opening, an increase in abnormal estrous cycles, and a delay in the day of first estrus were observed (HSDB (Access on June 2016), PATTY (6th, 2012)). Also there is a report that in postnatal administration to male rats, sexual maturity (puberty) was altered in conjunction with an increase in serum testosterone level (ACGIH (7th, 2016)). From the above, this substance was classified in Category 2 for this hazard class because of a concern of developmental effects and effects on the sexual maturation of pups. |
| 8 | Specific target organ toxicity - Single exposure | Category 3 (respiratory tract irritation, narcotic effects) |
 Warning |
H335
H336 |
P304+P340
P403+P233 P261 P271 P312 P405 P501 |
It is described that in humans, by exposure to this substance, respiratory tract irritation effects, and in some cases, effects on the central nervous system including nausea, dizziness, headache, restlessness, etc. were observed (PATTY (6th, 2012), EPA RED (2006), HSDB (Access on June 2016)). Therefore, this substance was classified in Category 3 (respiratory tract irritation, narcotic effects). |
| 9 | Specific target organ toxicity - Repeated exposure | Category 1 (haemal system), Category 2 (nervous system) |
Danger Warning |
H372
H373 |
P260
P264 P270 P314 P501 |
There is no relevant information on humans. As for experimental animals, it is reported that in a 104-week repeated dose toxicity study using rats dosed by feeding, hematologic effects (decreases in red blood cell count, hemoglobin concentration and hematocrit, etc.) were observed at 100 ppm (5.2 mg/kg/day), which is equivalent to Category 1. Also it is reported that in a one-year repeated dose toxicity study using dogs dosed by feeding, hematologic effects (decreases in red blood cell count, hemoglobin concentration and hematocrit, etc.) were observed at 3.6 mg/kg/day, which is equivalent to Category 1 (EPA IRIS Summary (1993), ACGIH (2016), IARC 73 (1999)). Moreover, in a 13-week repeated dose toxicity study using dogs dosed by feeding, tremors are reported at 4,000 ppm (converted guidance value: 100 mg/kg/day), which is equivalent to Category 2 (Japanese Journal of Pesticide Science Vol.15 (Pesticide Science Society of Japan, 1990)). Therefore, this substance was classified in Category 1 (haemal system) and Category 2 (nervous system). |
| 10 | Aspiration hazard | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment (Acute) | Category 1 |
 Warning |
H400 |
P273
P391 P501 |
From 14-day EC50 = 0.14 ppm for an aquatic plant (Lemna gibba) (USDA: IPM Database, 2016), it was classified in Category 1. |
| 11 | Hazardous to the aquatic environment (Long-term) | Category 1 |
Warning |
H410 |
P273
P391 P501 |
Due to being not rapidly degradable (Non-biodegradable, a degradation rate by BOD: 0.7% (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 1978)), and 14-day NOEL = 0.05 ppm for an aquatic plant (Lemna gibba) (USDA: IPM Database, 2016), it was classified in Category 1. |
| 12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | No data available. |
NOTE:
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* A blank or "-" in a cell of classification denotes that the classification of the hazard class was not conducted. * Hazard_statement_and/or_Precautionary_statement will show when hovering the mouse over a code of Hazard_statement_and/or_Precautionary_statement. Hazard_statement_and/or_Precautionary_statement are also provided in the Excel file. * Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. * Codes assigned to each of the hazard statements and codes for each of the precautionary statement are based on the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) in United Nations. |