GHS Classification Result
GENERAL INFORMATION
REFERENCE INFORMATION
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
GENERAL INFORMATION
| Item | Information |
|---|---|
| CAS RN | 123-51-3 |
| Chemical Name | Isopentyl alcohol |
| Substance ID | H28-B-047, C-076B |
| Classification year (FY) | FY2016 |
| Ministry who conducted the classification | Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE) |
| New/Revised | Revised |
| Classification result in other fiscal year | FY2006 |
| Download of Excel format | Excel file |
REFERENCE INFORMATION
| Item | Information |
|---|---|
| Guidance used for the classification (External link) | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
| UN GHS document (External link) | UN GHS document |
| Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
| Model Label by MHLW (External link) | MHLW Website (in Japanese Only) |
| Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
| OECD/eChemPortal (External link) | eChemPortal |
| Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. |
| 2 | Flammable gases (including chemically unstable gases) | Not applicable |
- |
- | - | Liquid (GHS definition) |
| 3 | Aerosols | Not applicable |
- |
- | - | Not aerosol products. |
| 4 | Oxidizing gases | Not applicable |
- |
- | - | Liquid (GHS definition) |
| 5 | Gases under pressure | Not applicable |
- |
- | - | Liquid (GHS definition) |
| 6 | Flammable liquids | Category 3 |
 Warning |
H226 |
P303+P361+P353
P370+P378 P403+P235 P210 P233 P240 P241 P242 P243 P280 P501 |
Based on a flash point of 42 deg C (closed cup) (ICSC (2015)), it was classified in Category 3. |
| 7 | Flammable solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
| 8 | Self-reactive substances and mixtures | Not applicable |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. |
| 9 | Pyrophoric liquids | Not classified |
- |
- | - | It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 340 deg C (ICSC (2015)). |
| 10 | Pyrophoric solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
| 11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Test methods applicable to liquid substances are not available. |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable |
- |
- | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
| 13 | Oxidizing liquids | Not applicable |
- |
- | - | The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen. |
| 14 | Oxidizing solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
| 15 | Organic peroxides | Not applicable |
- |
- | - | Organic compounds containing no bivalent -O-O- structure in the molecule |
| 16 | Corrosive to metals | Classification not possible |
- |
- | - | No data available. |
| Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Acute toxicity (Oral) | Category 4 |
 Warning |
H302 |
P301+P312
P264 P270 P330 P501 |
Three LD50 values are reported for rats (1,300 mg/kg (HSDB (Access on June 2016)), 1,300?4,000 mg/kg (PATTY (6th, 2012)), and 5,770 mg/kg (ACGIH (7th, 2001), PATTY (6th, 2012))). These correspond to Category 4, Category 4?"Not classified" (Category 5 in UN-GHS classification), and "Not classified," respectively. By adopting the category with higher hazard, this substance was classified in Category 4. On the basis of the newly obtained information, the classification was revised. As for the data on IUCLID (2000) and RTECS (2000) which were used for the former classification, these were not adopted because their details are unknown. |
| 1 | Acute toxicity (Dermal) | Not classified |
- |
- | - | On the basis of two reported LD50 values for rabbits of 3,240 mg/kg (ACGIH (7th, 2001), PATTY (6th, 2012)) and 3,970 mg/kg (HSDB (Access on June 2016), this substance was classified as "Not classified" (Category 5 in UN-GHS classification). The classification was revised on the basis of the newly obtained information. |
| 1 | Acute toxicity (Inhalation: Gases) | Not applicable |
- |
- | - | Liquid (GHS definition) |
| 1 | Acute toxicity (Inhalation: Vapours) | Classification not possible |
- |
- | - | As an LC50 value (8 hours) for rats, >2,000 ppm (converted to a 4-hour equivalent value: >2,828 ppm) (ACGIH (7th, 2001)) is reported. However, classification was not possible because a category could not be determined based on this value alone. Besides, a reference value in the unit of ppm was applied as vapor without mist because the LC50 value is lower than 90% of the saturated vapor pressure concentration (3,128 ppm). |
| 1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 2 | Skin corrosion/irritation | Not classified |
- |
- | - | As topical application of this substance to rabbit skin was associated with only minimal skin irritation (ACGIH (7th, 2001), PATTY (6th, 2012)), it was classified as "Not classified" (Category 3 in UN-GHS classification). |
| 3 | Serious eye damage/eye irritation | Category 1 |
 Danger |
H318 |
P305+P351+P338
P280 P310 |
Following instillation into the eye of rabbits, this substance caused corneal necrosis (ACGIH (7th, 2001)). Therefore, this substance was classified in Category 1. Although the previous classification was Category 2A on the basis of the same information, the classification was changed to Category 1 based on the description that the substance caused "severe burns with moderately severe corneal necrosis." |
| 4 | Respiratory sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 4 | Skin sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. Besides, although it is reported that skin sensitization could not be demonstrated in a maximization test on 25 volunteers, the results of this test was not adopted because the details were unknown (GESTIS (Access on June 2016)). |
| 5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. Besides, the information in IUCLID which was adopted for the former classification could not be verified because it is no longer publicly available. |
| 6 | Carcinogenicity | Classification not possible |
- |
- | - |
Classification not possible due to lack of data. Besides, there is a description of a lifetime test in rats which were dosed orally or subcutaneously. The study was inadequate for carcinogenicity assessment (PATTY (6th, 2012)), however. |
| 7 | Reproductive toxicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. Besides, there is a description that in a test using pregnant rabbits exposed by inhalation during organogenetic period, no adverse developmental effects were found, even at a high dose level in which maternal toxicity (reduced body weight gain) was observed (PATTY (6th, 2012)). There is nonetheless no information on the effects of this substance on fertility and sexual function. |
| 8 | Specific target organ toxicity - Single exposure | Category 3 (respiratory tract irritation, narcotic effects) |
Warning |
H335
H336 |
P304+P340
P403+P233 P261 P271 P312 P405 P501 |
As for humans, upper respiratory tract irritation is reported in a single inhalation exposure test of this substance on human volunteers (ACGIH (7th, 2001), PATTY (6th, 2012)). In addition, central nervous system depression, weakness, pain, a burning sensation in the chest and stomach, nausea, headache, sleep within 10?15 min, and terminal coma and death within 1h to 6 days are reported in humans who ingested 50?100 mL of this substance (PATTY (6th, 2012)). As for animal experiments, in a single oral exposure study using rabbits, stupor and loss of voluntary movement occurred in one-half of the test animals (ACGIH (7th, 2001)). From the above, this substance was classified in Category 3 (respiratory tract irritation, narcotic effects). |
| 9 | Specific target organ toxicity - Repeated exposure | Classification not possible |
- |
- | - |
There is no information on humans. As for experimental animals, in a 3 to 17-week repeated dose toxicity test using rats (the administration route is unknown but is presumably oral administration), in a 1,000 mg/kg/day dose group, there were reported decreases in body weight gain due to reduced food intake and in testes relative weight after 3 weeks, but not after 6 or 17 weeks. The NOAEL is reported as 1,000 mg/kg in this study (HSDB (Access on June 2016)). From the above, the effects that provide the rationale for GHS classification was not seen, even at doses above Category 2 levels. Nonetheless, this substance was classified as "Classification not possible" because hazard-related information was not obtained on other administration routes. |
| 10 | Aspiration hazard | Classification not possible |
- |
- | - | Classification not possible due to lack of data. Note that the kinematic viscosity of this substance is calculated to be 4.60 mm2/sec (25/15degC) from numerical data (viscosity: 3.74 mPa*s (25degC), density (specific gravity): 0.813 (15/4degC)) listed on HSDB (Access on June 2015). |
| Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment (Acute) | Classification not possible |
- |
- | - | No data available. |
| 11 | Hazardous to the aquatic environment (Long-term) | Classification not possible |
- |
- | - | No data available. |
| 12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | No data available. |
NOTE:
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* A blank or "-" in a cell of classification denotes that the classification of the hazard class was not conducted. * Hazard_statement_and/or_Precautionary_statement will show when hovering the mouse over a code of Hazard_statement_and/or_Precautionary_statement. Hazard_statement_and/or_Precautionary_statement are also provided in the Excel file. * Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. * Codes assigned to each of the hazard statements and codes for each of the precautionary statement are based on the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) in United Nations. |