GHS Classification Result
GENERAL INFORMATION
REFERENCE INFORMATION
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
GENERAL INFORMATION
| Item | Information |
|---|---|
| CAS RN | 1335-88-2 |
| Chemical Name | Tetrachloronaphthalene |
| Substance ID | H28-B-054, C-099B |
| Classification year (FY) | FY2016 |
| Ministry who conducted the classification | Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE) |
| New/Revised | Revised |
| Classification result in other fiscal year | FY2010 FY2006 |
| Download of Excel format | Excel file |
REFERENCE INFORMATION
| Item | Information |
|---|---|
| Guidance used for the classification (External link) | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
| UN GHS document (External link) | UN GHS document |
| Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
| Model Label by MHLW (External link) | MHLW Website (in Japanese Only) |
| Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
| OECD/eChemPortal (External link) | eChemPortal |
| Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. |
| 2 | Flammable gases (including chemically unstable gases) | Not applicable |
- |
- | - | Solid (GHS definition). |
| 3 | Aerosols | Not applicable |
- |
- | - | Not aerosol products. |
| 4 | Oxidizing gases | Not applicable |
- |
- | - | Solid (GHS definition). |
| 5 | Gases under pressure | Not applicable |
- |
- | - | Solid (GHS definition). |
| 6 | Flammable liquids | Not applicable |
- |
- | - | Solid (GHS definition). |
| 7 | Flammable solids | Classification not possible |
- |
- | - | It is combustible (ICSC(J) (2001)), but the classification is not possible due to no data. |
| 8 | Self-reactive substances and mixtures | Not applicable |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. |
| 9 | Pyrophoric liquids | Not applicable |
- |
- | - | Solid (GHS definition). |
| 10 | Pyrophoric solids | Not classified |
- |
- | - | Because it is reported that there is no autoignition temperature to a boiling point (311.5-360 deg C) (HSDB (Access on October 2016)), it is estimated that it does not ignite at normal temperatures. |
| 11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | No data available. |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable |
- |
- | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
| 13 | Oxidizing liquids | Not applicable |
- |
- | - | Solid (GHS definition). |
| 14 | Oxidizing solids | Not applicable |
- |
- | - | The substance is an organic compound containing chlorine (but not fluorine or oxygen) which is chemically bonded only to carbon or hydrogen. |
| 15 | Organic peroxides | Not applicable |
- |
- | - | Organic compounds containing no bivalent -O-O- structure in the molecule |
| 16 | Corrosive to metals | Classification not possible |
- |
- | - | Test methods applicable to solid substances are not available. |
| Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Acute toxicity (Oral) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. It was described in CICAD 34 (2001) that the LD50 of 2,3,6,7-tetrachloronaphthalene (CAS RN 34588-40-4) for guinea pigs was >3 mg/kg. It corresponded to Category 1 - "Not Classified," however, only from this value, the category cannot be determined. |
| 1 | Acute toxicity (Dermal) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 1 | Acute toxicity (Inhalation: Gases) | Not applicable |
- |
- | - | Solid (GHS definition) |
| 1 | Acute toxicity (Inhalation: Vapours) | Not applicable |
- |
- | - | Solid (GHS definition) |
| 1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 2 | Skin corrosion/irritation | Classification not possible |
- |
- | - | Classification not possible due to lack of data. Strong dermal irritations were reported in guinea pigs dermally exposed to polychloronaphthalenes (CICAD 34 (2001)), however, it was not adopted as the evidence for classification because the cause of the irritation was not specified to be this substance. |
| 3 | Serious eye damage/eye irritation | Classification not possible |
- |
- | - | Classification not possible due to lack of data. Irritation of the eyes was reported in workers exposed to polychloronaphthalenes, however, because it was pointed out that there had been possible exposure to other chemicals (CICAD 34 (2001)), it was not adopted as the evidence for classification. |
| 4 | Respiratory sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 4 | Skin sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | There was no in vivo data. As for in vitro data, a bacterial reverse mutation test was negative (CICAD 34 (2001), DFGOT vol. 13 (1997), HSDB (Access on August 2016), NTP DB (Access on August 2016)). From the above, according to the GHS classification guidance for the Japanese government, the substance was classified as "Classification not possible." |
| 6 | Carcinogenicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 7 | Reproductive toxicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 8 | Specific target organ toxicity - Single exposure | Classification not possible |
- |
- | - | Classification not possible due to lack of data. There was no data with regard to single exposure of this substance in humans and experimental animals. There were descriptions that chlorinated naphthalenes exhibited liver toxicity (CICAD 34 (2001), DFGOT Vol. 13 (1997)) and, description that symptoms in workers exposed to chlorinated naphthalenes included irritation of the eyes, fatigue, headaches, anaemia, haematuria, anorexia, vomiting, and severe abdominal pain etc. (CICAD 34 (2001)). None of these had information on the number of exposure times. |
| 9 | Specific target organ toxicity - Repeated exposure | Category 1 (liver, skin) |
 Danger |
H372 |
P260
P264 P270 P314 P501 |
There was no information with regard to this substance as a single substance. Besides, for humans, severe skin reactions (chloracne) and liver disease both were reported after occupational exposure to chlorinated naphthalenes (CICAD 34 (2001), DFGOT vol. 13 (1997), ACGIH (7th, 2001)). The toxicity varies depending on the number of chlorine atoms, it was reported that studies in humans and animals showed that toxicity was dependent on the congener/isomer and that there was agreement in all the studies that the penta- and hexa- naphthalenes were the most toxic (CICAD 34 (2001)). Among these, with regard to the effects on the skin, it was reported that chloracne was observed with trichloronaphthalenes and higher chlorinated naphthalenes (DFGOT vol. 13 (1997)). It was reported that the incidence and severity of chloracne were less when trichloronaphthalene (usually mixed with some of this substance) was used rather than when penta- and hexachloronaphthalene were present (ACGIH (7th, 2001)). It was also reported that dermal application to volunteers caused chloracne only in Halowax 1014, containing penta- and hexachloronaphthalenes and that Halowaxes containing mono-, di-, tri-, tetra-, hepta-, and octachloronaphthalenes did not (CICAD 34 (2001)). With regard to the effects on the liver, as information in which the substance is identified to some extent, a non-fatal case of hepatitis induced by occupational exposure to trichloronaphthalene (this substance was probably also present (CICAD 34 (2001)) at 3mg/m3 was reported (ACGIH (7th, 2001)). On the other hand, as for higher chlorinated congeners, it was reported that mixtures of pentachloronaphthalene and hexachloronaphthalene at the concentration of 1 to 2 mg/m3 in workplace environments, caused fatal cases of yellow atrophy of the liver to occur (ACGIH (7th, 2001)). As for experimental animals, in toxicity tests using rats in inhalation of trichloronaphthalene and small amounts of this substance for 2.5 months (1,232 hours) or 4 months (1,896 hours), very slight swelling of the liver at 0.0013 mg/L and hepatic hypertrophy with granulocytosis and mitotic figures at 0.011 mg/L were observed within the range of Category 1 (ACGIH (7th, 2001)). Besides, it was reported that in medium-term experiments performed with technical mixtures of polychloronaphthalenes in rats and guinea pigs, liver damage (mainly enlarged liver cells with increased granularity and vacuolization) etc. were found and the higher chlorinated mixtures appeared to be more toxic (CICAD 34 (2001)). As described above, chlorinated naphthalenes affected the liver and skin, and pentachloronaphthalene which has five chlorine atoms and hexachloronaphthalenes which has six chlorine atoms were thought to be the major causal substances for toxicity from chlorinated naphthalenes. There was no information on this substance as of single substance, however, because chloracne was reported in humans from mixtures of this compound containing lower chlorinated congeners, and as the effects on the liver were observed at doses corresponding to Category 1 in experimental animals, the substance was classified in Category 1(liver, skin). |
| 10 | Aspiration hazard | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment (Acute) | Classification not possible |
- |
- | - | No data available. |
| 11 | Hazardous to the aquatic environment (Long-term) | Classification not possible |
- |
- | - | No data available. |
| 12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | No data available. |
NOTE:
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* A blank or "-" in a cell of classification denotes that the classification of the hazard class was not conducted. * Hazard_statement_and/or_Precautionary_statement will show when hovering the mouse over a code of Hazard_statement_and/or_Precautionary_statement. Hazard_statement_and/or_Precautionary_statement are also provided in the Excel file. * Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. * Codes assigned to each of the hazard statements and codes for each of the precautionary statement are based on the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) in United Nations. |