GHS Classification Result

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GENERAL INFORMATION
Item Information
CAS RN 1321-64-8
Chemical Name Pentachloronaphthalene
Substance ID H28-B-055, C-100B
Classification year (FY) FY2016
Ministry who conducted the classification Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised Revised
Classification result in other fiscal year FY2006  
Download of Excel format Excel file

REFERENCE INFORMATION
Item Information
Guidance used for the classification (External link) GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
UN GHS document (External link) UN GHS document
Definitions/Abbreviations (Excel file) Definitions/Abbreviations
Model Label by MHLW (External link) MHLW Website (in Japanese Only)
Model SDS by MHLW (External link) MHLW Website (in Japanese Only)
OECD/eChemPortal (External link) eChemPortal

PHYSICAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Explosives Not applicable
-
-
- -  There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases (including chemically unstable gases) Not applicable
-
-
- -  Solid (GHS definition).
3 Aerosols Not applicable
-
-
- -  Not aerosol products.
4 Oxidizing gases Not applicable
-
-
- -  Solid (GHS definition).
5 Gases under pressure Not applicable
-
-
- -  Solid (GHS definition).
6 Flammable liquids Not applicable
-
-
- -  Solid (GHS definition).
7 Flammable solids Not classified
-
-
- -  It is not combustible (ICSC(J) (2001)).
8 Self-reactive substances and mixtures Not applicable
-
-
- -  There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not applicable
-
-
- -  Solid (GHS definition).
10 Pyrophoric solids Not classified
-
-
- -  It is not combustible (ICSC(J) (2001)).
11 Self-heating substances and mixtures Not classified
-
-
- -  It is not combustible (ICSC(J) (2001)).
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable
-
-
- -  The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable
-
-
- -  Solid (GHS definition).
14 Oxidizing solids Not applicable
-
-
- -  The substance is an organic compound containing chlorine (but not fluorine or oxygen) which is chemically bonded only to carbon or hydrogen.
15 Organic peroxides Not applicable
-
-
- -  Organic compounds containing no bivalent -O-O- structure in the molecule
16 Corrosive to metals Classification not possible
-
-
- -  Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Acute toxicity (Oral) Category 4


Warning
H302 P301+P312
P264
P270
P330
P501
 Based on a 100% lethal dose of 1,800 mg/kg and a 100% survival dose of 600 mg/kg for rats (HSDB (Access October 2016)), this substance was classified in Category 4.
 Besides, from a report on a 100% lethal dose of 30 mg/kg and a 100% survival dose of 5 mg/kg in guinea pigs (HSDB (Access October 2016)), and a description that the mortality observed for 7 days after administration to rabbits at 500 mg/kg was 60% (CICAD 34 (2001)), this substance and chlorinated naphthalenes have possibility of large interspecies differences.
1 Acute toxicity (Dermal) Classification not possible
-
-
- -  Classification not possible due to lack of data.
1 Acute toxicity (Inhalation: Gases) Not applicable
-
-
- -  Solid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Not applicable
-
-
- -  Solid (GHS definition)
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible
-
-
- -  Classification not possible due to lack of data.
2 Skin corrosion/irritation Classification not possible
-
-
- -  Classification not possible due to lack of data. Besides, strong dermal irritations were reported in guinea pigs dermally exposed to polychloronaphthalenes (CICAD 34 (2001)), however, this was not adopted as the evidence for classification because the cause of the irritation was not specified to be this substance. Moreover, because the information adopted in the previous classification was from List 3 information sources and the original source could not be confirmed, it was not adopted.
3 Serious eye damage/eye irritation Classification not possible
-
-
- -  Classification not possible due to lack of data. Besides, irritation of the eyes was reported in workers exposed to polychloronaphthalenes, however, because it was also pointed out that there had been a possible exposure to other chemicals (CICAD 34 (2001)), it was not adopted as the evidence for classification. Moreover, because the information adopted in the previous classification was from List 3 information sources and the original source could not be confirmed, it was not adopted.
4 Respiratory sensitization Classification not possible
-
-
- -  Classification not possible due to lack of data.
4 Skin sensitization Classification not possible
-
-
- -  Classification not possible due to lack of data.
5 Germ cell mutagenicity Classification not possible
-
-
- -  Classification not possible due to lack of data.
6 Carcinogenicity Classification not possible
-
-
- -  Classification not possible due to lack of data.
7 Reproductive toxicity Classification not possible
-
-
- -  Classification not possible due to lack of data.
8 Specific target organ toxicity - Single exposure Classification not possible
-
-
- -  Classification not possible due to lack of data. There is no data on single exposure of this substance in humans and experimental animals. Besides, there are descriptions that chlorinated naphthalenes exhibited hepatotoxicity (CICAD 34 (2001), DFGOT vol. 13 (1997)) and description that symptoms in workers exposed to chlorinated naphthalenes included irritation of the eyes, fatigue, headache, anaemia, haematuria, anorexia, vomiting, and severe abdominal pain etc. (CICAD 34 (2001)). None of these had information on exposure times.
9 Specific target organ toxicity - Repeated exposure Category 1 (liver, skin)


Danger
H372 P260
P264
P270
P314
P501
 As for humans, it is reported that chloracne was observed from trichloronaphthalenes or higher chlorinated naphthalenes (DFGOT vol. 13 (1997)), and that in dermal application to volunteers, only Halowax 1014, containing penta- and hexachloronaphthalenes, produced chloracne, and Halowaxes containing mono-, di-, tri-, tetra-, hepta-, and octachloronaphthalene did not (CICAD 34 (2001)).
 Although it is not this substance alone, in the workplace environments with mixtures of this substance and hexachloronaphthalene between 1 and 2 mg/m3, fatalities due to yellow atrophy of the liver were reported (ACGIH (7th, 2001)). It is reported that in wire manufacturing plants, contact with fabric impregnated with this substance and hexachloronaphthalenes caused chloracne (ACGIH (7th, 2001)).
 Chlorinated naphthalenes containing this substance as a major component caused numerous dermatitis cases (chloracne), a number of cases of liver damage and several deaths, and Cotter (1944) stated this substance was responsible for seven cases of toxic hepatitis, two of them fatal. Kleinfeld et al. (1972) reported on clinical findings from an examination of 59 workers exposed to tetrachloronaphthalene and this substance; 56 workers showed dermatoses consistent with chloracne resulting from skin contact, and systemic signs and symptoms including headache, fatigue, vertigo, and anorexia through inhalation of vapors (ACGIH (7th, 2001)).
 As for experimental animals, there is no report on this substance alone.
 However, in studies using rats administered by inhalation with mixtures of this substance and hexachloronaphthalene at 0.00116 mg/L for 134 days (16 hours/day) or at 0.00144 mg/L (8 hours/day) for 143 days, liver damage (enlargement of liver cells, fatty vacuolization, granulation, mitotic figures) were reported. In a study using rats administered by inhalation at 0.00088 mg/L for 134 days (16 hours/day), death, jaundice, fatty degeneration of hepatocytes, and centrilobular necrosis were reported (CICAD 34 (2001), ACGIH (7th, 2001)).
 Those were all seen at the doses within the range of Category 1.
 Besides, it is reported that in medium-term experiments, performed with technical mixtures of poly chlorinated naphthalenes in rats and guinea pigs, liver damage (mainly enlarged liver cells with increased granularity and vacuolization) etc. were found, but the higher chlorinated mixtures seemed to be more toxic (CICAD 34 (2001)).
 In addition, it is reported that studies in humans and animals demonstrated that toxicity was dependent on the congener/isomer and that it is in agreement in all the studies that the toxicity of penta- and hexa- chloronaphthalene are the strongest (CICAD 34 (2001)).
 As described above, there are few reports on this substance alone. However, chlorinated naphthalenes affected the liver and skin, and this substance and hexachloronaphthalenes are thought to be the major causal substances for toxicity of chlorinated naphthalenes. Therefore, this substance was classified in Category 1 (liver, skin).
10 Aspiration hazard Classification not possible
-
-
- -  Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Classification not possible
-
-
- -  No data available.
11 Hazardous to the aquatic environment (Long-term) Classification not possible
-
-
- -  No data available.
12 Hazardous to the ozone layer Classification not possible
-
-
- -  No data available.


NOTE:
* A blank or "-" in a cell of classification denotes that the classification of the hazard class was not conducted.
* Hazard_statement_and/or_Precautionary_statement will show when hovering the mouse over a code of Hazard_statement_and/or_Precautionary_statement.
Hazard_statement_and/or_Precautionary_statement are also provided in the Excel file.
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government,
and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.
* Codes assigned to each of the hazard statements and codes for each of the precautionary statement are
based on the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) in United Nations.

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