GHS Classification Result

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GENERAL INFORMATION
Item Information
CAS RN 95-73-8
Chemical Name 2,4-Dichlorotoluene
Substance ID H28-B-058, C-105B
Classification year (FY) FY2016
Ministry who conducted the classification Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised Revised
Classification result in other fiscal year FY2008  
Download of Excel format Excel file

REFERENCE INFORMATION
Item Information
Guidance used for the classification (External link) GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
UN GHS document (External link) UN GHS document
Definitions/Abbreviations (Excel file) Definitions/Abbreviations
Model Label by MHLW (External link) MHLW Website (in Japanese Only)
Model SDS by MHLW (External link) MHLW Website (in Japanese Only)
OECD/eChemPortal (External link) eChemPortal

PHYSICAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Explosives Not applicable
-
-
- -  There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases (including chemically unstable gases) Not applicable
-
-
- -  Liquid (GHS definition)
3 Aerosols Not applicable
-
-
- -  Not aerosol products.
4 Oxidizing gases Not applicable
-
-
- -  Liquid (GHS definition)
5 Gases under pressure Not applicable
-
-
- -  Liquid (GHS definition)
6 Flammable liquids Category 4
-
Warning
H227 P370+P378
P403+P235
P210
P280
P501
 Based on a flash point of 87 deg C (closed-cup) (ICSC(J) (2009)), it was classified in Category 4.
7 Flammable solids Not applicable
-
-
- -  Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable
-
-
- -  There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not classified
-
-
- -  It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 190 deg C (HSDB (Access on July 2016)).
10 Pyrophoric solids Not applicable
-
-
- -  Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible
-
-
- -  Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable
-
-
- -  The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable
-
-
- -  The substance is an organic compound containing chlorine (but not fluorine or oxygen) which is chemically bonded only to carbon or hydrogen.
14 Oxidizing solids Not applicable
-
-
- -  Liquid (GHS definition)
15 Organic peroxides Not applicable
-
-
- -  Organic compounds containing no bivalent -O-O- structure in the molecule
16 Corrosive to metals Classification not possible
-
-
- -  No data available.

HEALTH HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Acute toxicity (Oral) Not classified
-
-
- -  Based on the LD50 value (OECD TG 401) of > 2,000 mg/kg for rats (JECDB (Access on September 2016), SIDS (2005)), this substance was classified as "Not classified."
1 Acute toxicity (Dermal) Classification not possible
-
-
- -  Classification not possible due to lack of data.
1 Acute toxicity (Inhalation: Gases) Not applicable
-
-
- -  Liquid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible
-
-
- -  Classification not possible due to lack of data.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible
-
-
- -  Classification not possible due to lack of data.
 LC50 value of > 2,669 mg/L (SIDS (1995)) in the previous classification is described as > 2,669 mg/kg in SIDS (2005).
 Since the data is owned by a company and could not be confirmed, it was not adopted as the evidence for classification.
2 Skin corrosion/irritation Category 2


Warning
H315 P302+P352
P332+P313
P362+P364
P264
P280
P321
 In a skin irritation study using rabbits according to the U.S. guidelines (Code of Federal Regulations, Title 16, Section 1500.41), moderate irritation was observed. Therefore, this substance was classified in Category 2.
 Besides, irritation is also observed in humans although no details are available (Environmental Risk Assessment for Chemical Substances vol.8 (Ministry of the Environment, 2010), HSDB (Access on August 2016)).
3 Serious eye damage/eye irritation Classification not possible
-
-
- -  In an eye irritation study using rabbits according to the US guidelines (Code of Federal Regulations, Title 16, Section 1500.41), no irritation was reported. However, it was classified as "classification not possible" because the details are not available.
 Besides, it is reported that there is irritation in humans (Environmental Risk Assessment for Chemical Substances vol.8 (Ministry of the Environment, 2010), HSDB (Access on August 2016)). However, it was not adopted since the details are unknown.
4 Respiratory sensitization Classification not possible
-
-
- -  Classification not possible due to lack of data.
4 Skin sensitization Classification not possible
-
-
- -  Classification not possible due to lack of data.
 Besides, in the maximization test using guinea pigs, no sensitization was reported (GESTIS (Access on July 2016)). However, it was not adopted as the evidence for the classification because the original article could not be confirmed.
5 Germ cell mutagenicity Classification not possible
-
-
- -  Classification not possible due to lack of data. There is no in vivo data. As for in vitro, a bacterial reverse mutation test and a mammalian cell chromosome aberration test were negative (JECDB (Access on September 2016), SIDS (2005)).
6 Carcinogenicity Classification not possible
-
-
- -  Classification not possible due to lack of data.
7 Reproductive toxicity Category 2


Warning
H361 P308+P313
P201
P202
P280
P405
P501
 In a combined repeated dose toxicity study with the reproduction/developmental toxicity screening test (OECD TG 422) using rats administered by the oral route (gavage), a lowered fertility index was observed at 500 mg/kg/day where general toxicity (reduced body weight gain, increases in liver weights, atrophy and regeneration of tubular epithelium) was observed in the parental animals, and in non-pregnant animals, examples in which vaginal plugs were not seen or in which the number of sperm was small in vaginal smears, were observed. Also low body weights were observed in offspring (SIDS (2005), Environmental Risk Assessment for Chemical Substances Vol.8 (Ministry of the Environment, 2010), JECDB (Access, September 2016)).
 Therefore, this substance was classified in Category 2.
8 Specific target organ toxicity - Single exposure Category 3 (Narcotic effects)


Warning
H336 P304+P340
P403+P233
P261
P271
P312
P405
P501
 It is reported that in a single oral dose test of this substance using rats, a decrease in motor activity and staggering gait were observed. (JECDB (Access on September 2016)). Also, it is reported that in a single oral dose of this substance in rats, prostration, tremors, depression, ataxia, labored respiration and blood-like crust around the nostrils were observed after 24 hours (HSDB (Access on September 2016)).
 From the above, this substance was classified in Category 3 (narcotic effects).
9 Specific target organ toxicity - Repeated exposure Category 2 (kidney)


Warning
H373 P260
P314
P501
 There is no information on humans.
 As for experimental animals, it is reported that in a combined repeated dose toxicity study with the reproduction/developmental toxicity screening test (OECD TG 422) using rats administered by gavage, atrophy, regeneration and swelling of renal tubular epithelium, dilatation of renal tubule, and centrilobular swelling of hepatocytes were observed at a dose of 79 mg/kg/day (converted guidance value: 41.3 mg/kg/day) equivalent to Category 2 for 46 days (JECDB (Access on September 2016), Environmental Risk Assessment for Chemical Substances Vol. 8 (Ministry of the Environment, 2010), SIDS (2005)).
 As for the liver, the swelling of hepatocytes was not adopted as the evidence of classification because it was the only thing found.
 Therefore, this substance was classified in Category 2 (kidney).
10 Aspiration hazard Classification not possible
-
-
- -  Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 2
-
-
H401 P273
P501
 From 96-hour LC50 = 2.7 mg/L for fish (Oryzias latipes) (SIDS, 2005), it was classified in Category 2.
11 Hazardous to the aquatic environment (Long-term) Category 2


-
H411 P273
P391
P501
 If chronic toxicity data are used, then it is classified as "Not classified" because it is not rapidly degradable (Non-biodegradable, a degradation rate by BOD: 0% (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 1995)), but 21-day NOEC = 2 mg/L for crustacea (Daphnia magna) (SIDS, 2005).
 If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified in Category 2 due to being not rapidly degradable (Non-biodegradable, a degradation rate by BOD: 0% (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 1995)), and 96-hour LC50 = 2.7 mg/L for fish (Oryzias latipes) (SIDS, 2005).
 It was classified in Category 2 by drawing a comparison between the above results.
12 Hazardous to the ozone layer Classification not possible
-
-
- -  No data available.


NOTE:
* A blank or "-" in a cell of classification denotes that the classification of the hazard class was not conducted.
* Hazard_statement_and/or_Precautionary_statement will show when hovering the mouse over a code of Hazard_statement_and/or_Precautionary_statement.
Hazard_statement_and/or_Precautionary_statement are also provided in the Excel file.
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government,
and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.
* Codes assigned to each of the hazard statements and codes for each of the precautionary statement are
based on the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) in United Nations.

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