GHS Classification Result
GENERAL INFORMATION
REFERENCE INFORMATION
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
GENERAL INFORMATION
| Item | Information |
|---|---|
| CAS RN | 72-54-8 |
| Chemical Name | 1,1-Dichloro-2,2-bis(4-chlorophenyl)ethane [p,p'-DDD] |
| Substance ID | H29-A-011 |
| Classification year (FY) | FY2017 |
| Ministry who conducted the classification | Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE) |
| New/Revised | New |
| Classification result in other fiscal year | |
| Download of Excel format | Excel file |
REFERENCE INFORMATION
| Item | Information |
|---|---|
| Guidance used for the classification (External link) | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
| UN GHS document (External link) | UN GHS document |
| Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
| Model Label by MHLW (External link) | |
| Model SDS by MHLW (External link) | |
| OECD/eChemPortal (External link) | eChemPortal |
| Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. |
| 2 | Flammable gases (including chemically unstable gases) | Not applicable |
- |
- | - | Solid (GHS definition). |
| 3 | Aerosols | Not applicable |
- |
- | - | Not aerosol products. |
| 4 | Oxidizing gases | Not applicable |
- |
- | - | Solid (GHS definition). |
| 5 | Gases under pressure | Not applicable |
- |
- | - | Solid (GHS definition). |
| 6 | Flammable liquids | Not applicable |
- |
- | - | Solid (GHS definition). |
| 7 | Flammable solids | Classification not possible |
- |
- | - | No data available. |
| 8 | Self-reactive substances and mixtures | Not applicable |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. |
| 9 | Pyrophoric liquids | Not applicable |
- |
- | - | Solid (GHS definition). |
| 10 | Pyrophoric solids | Classification not possible |
- |
- | - | No data available. |
| 11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Test methods applicable to solid (melting point <= 140 deg C) substances are not available. |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable |
- |
- | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
| 13 | Oxidizing liquids | Not applicable |
- |
- | - | Solid (GHS definition). |
| 14 | Oxidizing solids | Not applicable |
- |
- | - | The substance is an organic compound containing chlorine (but not fluorine or oxygen) which is chemically bonded only to carbon or hydrogen. |
| 15 | Organic peroxides | Not applicable |
- |
- | - | Organic compounds containing no bivalent -O-O- structure in the molecule |
| 16 | Corrosive to metals | Classification not possible |
- |
- | - | Test methods applicable to solid substances are not available. |
| Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Acute toxicity (Oral) | Category 3 |
 Danger |
H301 |
P301+P310
P264 P270 P321 P330 P405 P501 |
There are four reports of LD50 values for rats of 113 mg/kg (HSDB (Access on August 2017), original source: Montgomery, J.H.; Agrochemical's Desk Reference 2nd ed. Lewis Publishers, Boca Raton, FL (1997), p. 131, the original source of the LD 50 value was Guide to the Chemicals Used in Crop Protection (Information Canada, 171 Slater St., Ottawa, Ont., Canada), Vol. 6, p. 154 (1973)), 400 mg/kg (ATSDR (2002), original source: Ben-Dyke R.; Sanderson D, Noakes D. 1970. Acute toxicity data for pesticides (1970). World Rev Pestic Cont 9:119-127, it was described in the original source that LD 50 values were 400-4,000 mg/kg), 3,400 mg/kg (HSDB (Access on August 2017), original source: Montgomery, J.H.; Agrochemical's Desk Reference 2nd ed. Lewis Publishers, Boca Raton, FL (1997), p. 131), and 4,000 mg/kg (ATSDR (2002), original source: Gaines T.; Acute toxicity of pesticides. Toxicol Appl Pharmacol 14:515-534 (1969), it was described in the original source that the LD 50 value was > 4,000 mg/kg). The LD 50 values described in original sources were 113 mg/kg, 400-4,000 mg/kg, 3,400 mg/kg, and > 4,000 mg/kg, and LD50 values varied in wide range. Therefore, this substance was classified in Category 3 by adopting the category with higher hazard. |
| 1 | Acute toxicity (Dermal) | Category 4 |
 Warning |
H312 |
P302+P352
P362+P364 P280 P312 P321 P501 |
Based on a report of an LD50 value of 1,200 mg/kg (HSDB (Access on August 2017)) for rabbits, this substance was classified in Category 4. |
| 1 | Acute toxicity (Inhalation: Gases) | Not applicable |
- |
- | - | Solid (GHS definition) |
| 1 | Acute toxicity (Inhalation: Vapours) | Not applicable |
- |
- | - | Solid (GHS definition) |
| 1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 2 | Skin corrosion/irritation | Not classified |
- |
- | - | Since there is a description that it is slightly irritating to the skin of humans and animals (HSDB (Access on August 2017)), it was classified as "Not classified" (Category 3 in UN GHS classification). |
| 3 | Serious eye damage/eye irritation | Category 2B |
Warning |
H320 |
P305+P351+P338
P337+P313 P264 |
Based on a description that exposure to this substance may cause irritation of the eyes (HSDB (Access on August 2017)), it was classified in Category 2B. |
| 4 | Respiratory sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 4 | Skin sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. There was no in vivo data. As for in vitro, a bacterial reverse mutation test, a mammalian cell chromosome aberration test, and a mammalian cell sister chromatid exchange test were all negative (NTP DB (Access on August 2017)). |
| 6 | Carcinogenicity | Category 1B |
 Danger |
H350 |
P308+P313
P201 P202 P280 P405 P501 |
In a carcinogenicity test, where this substance for industrial use (p, p'-DDD: containing about 60% of this substance and 19 or more impurities) was administered by feeding for 78 weeks to rats and mice, and planned slaughtering was performed after an untreated period of 35 weeks for rats and 15 weeks for mice, there was no evidence for carcinogenicity in female rats and both sexes of mice. However, a significant increase in the combined incidence of follicular cell adenomas and follicular cell carcinomas of the thyroid was observed in male rats in the low dose (1,648 ppm) group (in the high dose (3,294 ppm) group, it was only an increased trend and was not significant), and a possibility of carcinogenicity was suggested. However, tumors of the thyroid were also observed in control male rats, so NCI concluded that a definitive interpretation of the data was not possible (NTP TR131 (1978), IRIS (1988)). On the other hand, in a 130-week test in which this substance was administered by feeding to mice, lung tumors in both sexes and liver tumors in males were observed at a dose corresponding to 42.6 mg/kg/day (IRIS (1988), ATSDR (2002)). Because there was sufficient evidence of carcinogenicity in experimental animals, and this substance is a known metabolite of DDT (dichlorodiphenyltrichloroethane: CAS RN 50-29-3), this substance was classified in B2 (Probable human carcinogen) by EPA (IRIS (1988)). From the above, the substance was classified in Category 1B based on the animal test results and classification results by other organizations. Besides, as for carcinogenicity of the parent compound DDT, IARC announced that the classification would be changed from the previous Group 2B to Group 2A (IARC Press release No. 236 (2015)). |
| 7 | Reproductive toxicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. Besides, there is a description that by administration of this substance to rats, earlier sexual maturation was indicated and an inverse relationship between doses and the age of vaginal opening was observed (HSDB (Access on August 2017)). |
| 8 | Specific target organ toxicity - Single exposure | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 9 | Specific target organ toxicity - Repeated exposure | Classification not possible |
- |
- | - |
Classification not possible due to lack of data. Besides, as for experimental animals, in 78-week tests with rats and mice dosed by feeding, dose-related body weight gain depression was reported (NTP TR131 (1978)). |
| 10 | Aspiration hazard | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment (Acute) | Category 1 |
 Warning |
H400 |
P273
P391 P501 |
From 96-hour LC50 = 0.0006 mg/L for crustacea (Gammarus fasciatus) (NLM HSDB: 2015, EPA AQUIRE: 2017, Mayer, F. L. et al. (1986)), it was classified in Category 1. |
| 11 | Hazardous to the aquatic environment (Long-term) | Category 1 |
Warning |
H410 |
P273
P391 P501 |
Chronic toxicity data were not obtained. Due to being not rapidly degradable (BioWin), and acute toxicity Category 1, it was classified in Category 1. |
| 12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | No data available. |
NOTE:
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* A blank or "-" in a cell of classification denotes that the classification of the hazard class was not conducted. * Hazard_statement_and/or_Precautionary_statement will show when hovering the mouse over a code of Hazard_statement_and/or_Precautionary_statement. Hazard_statement_and/or_Precautionary_statement are also provided in the Excel file. * Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. * Codes assigned to each of the hazard statements and codes for each of the precautionary statement are based on the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) in United Nations. |