GHS Classification Result

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GENERAL INFORMATION
Item Information
CAS RN 629-14-1
Chemical Name 1,2-Diethoxyethane [Ethylene glycol diethyl ether]
Substance ID H29-A-018
Classification year (FY) FY2017
Ministry who conducted the classification Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised New
Classification result in other fiscal year  
Download of Excel format Excel file

REFERENCE INFORMATION
Item Information
Guidance used for the classification (External link) GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
UN GHS document (External link) UN GHS document
Definitions/Abbreviations (Excel file) Definitions/Abbreviations
Model Label by MHLW (External link)  
Model SDS by MHLW (External link)  
OECD/eChemPortal (External link) eChemPortal

PHYSICAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Explosives Not applicable
-
-
- - There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases (including chemically unstable gases) Not applicable
-
-
- - Liquid (GHS definition)
3 Aerosols Not applicable
-
-
- - Not aerosol products.
4 Oxidizing gases Not applicable
-
-
- - Liquid (GHS definition)
5 Gases under pressure Not applicable
-
-
- - Liquid (GHS definition)
6 Flammable liquids Category 2


Danger
H225 P303+P361+P353
P370+P378
P403+P235
P210
P233
P240
P241
P242
P243
P280
P501
Based on a flash point of 19 deg C (closed cup), and a boiling point of 122 deg C (GESTIS (Access on August 2017)), it was classified in Category 2. Besides, it is classified in Class 3, PGII, III in UNRTDG (UN1153).
7 Flammable solids Not applicable
-
-
- - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable
-
-
- - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not classified
-
-
- - It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 208 deg C (NFPA (14th, 2010)).
10 Pyrophoric solids Not applicable
-
-
- - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible
-
-
- - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable
-
-
- - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable
-
-
- - The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen.
14 Oxidizing solids Not applicable
-
-
- - Liquid (GHS definition)
15 Organic peroxides Not applicable
-
-
- - Organic compounds containing no bivalent -O-O- structure in the molecule
16 Corrosive to metals Classification not possible
-
-
- - No data available.

HEALTH HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Acute toxicity (Oral) Not classified
-
-
- - Based on a report of an LD50 value of 4,390 mg/kg for rats (PATTY (6th, 2012)), it was classified as "Not classified" (Category 5 in UN GHS classification).
1 Acute toxicity (Dermal) Not classified
-
-
- - Based on a report of an LD50 value of 8.0 mL/kg (6,800 mg/kg) for rabbits (PATTY (6th, 2012)), it was classified as "Not classified."
1 Acute toxicity (Inhalation: Gases) Not applicable
-
-
- - Liquid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible
-
-
- - Classification not possible due to lack of data.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible
-
-
- - Classification not possible due to lack of data.
2 Skin corrosion/irritation Not classified
-
-
- - Based on the descriptions that in a skin irritation test with rabbits (OECD Test Guideline-compliant (no description of test numbers)), it was slightly irritating (ECETOC TR64 (1995)), and that in another test with rabbits, this substance was not irritating to the skin (PATTY (6th, 2012)), it was classified as "Not classified" (Category 3 in UN GHS classification).
3 Serious eye damage/eye irritation Category 2


Warning
H319 P305+P351+P338
P337+P313
P264
P280
There is a report that in an eye irritation test with rabbits (OECD TG 405-compliant), the MMAS (Modified Maximum Average Score), which is an index of eye irritation, was 0 in a 7-day observation, and it was not irritating (ECETOC TR48 (1998)). On the other hand, there is a report that in another test, since severe injury in the application of 0.1 mL of this substance into the eyes of rabbits and minor injury in the application of 0.02 mL were shown, it would cause conjunctival irritation and transitory damage of the cornea (both in PATTY (6th, 2012)). Based on a comprehensive judgement from these, this substance is considered to be irritating to the eyes, and was classified in Category 2. Besides, this substance was classified as "Eye Irrit. 2, H319" in the EU CLP classification (ECHA CL Inventory (Access on August 2017)).
4 Respiratory sensitization Classification not possible
-
-
- - Classification not possible due to lack of data.
4 Skin sensitization Classification not possible
-
-
- - Classification not possible due to lack of data.
5 Germ cell mutagenicity Classification not possible
-
-
- - Classification not possible due to lack of data. There is no in vivo data. As for in vitro, a bacterial reverse mutation test was positive (NTP DB (Access on August 2017)).
6 Carcinogenicity Classification not possible
-
-
- - Classification not possible due to lack of data.
7 Reproductive toxicity Category 1B


Danger
H360 P308+P313
P201
P202
P280
P405
P501
There is no information on the reproductive effects in humans. As for experimental animals, in a development toxicity study with pregnant mice dosed orally at 50-1,000 mg/kg/day during the organogenesis period (gestational day 6-15), decreased weight gain was observed in the maternal animals at 1000 mg/kg/day, and increased incidence of malformations including exencephaly and fused ribs were observed in the fetuses of the groups at or above 150 mg/kg/day (PATTY (6th, 2012), ECETOC TR64 (1995), HSDB (Access on August 2017)). Additionally, in a development toxicity study with pregnant rabbits dosed orally at 25-100 mg/kg/day during the organogenesis period (gestational day 6-19), maternal toxicity was not observed, but increased incidence of malformed fetuses including small spleens, short tails, and fused ribs was observed in the fetuses of the groups at or above 50 mg/kg/day, in addition, an increase in the embryo and fetal absorption was observed at 100 mg/kg/day (PATTY (6th, 2012), ECETOC TR64 (1995), HSDB (Access on August 2017)).
From the above, as for experimental animals, increased incidence of malformations was observed at doses where general toxicity effects were not observed in maternal animals, therefore, it was classified in Category 1B. Besides, this substance is classified as "Repr. 1A" in EU (ECHA CL Inventory (Access on August 2017)).
8 Specific target organ toxicity - Single exposure Classification not possible
-
-
- - Classification not possible due to lack of data. There is no information on single exposure in humans. As for experimental animals, there is a report that in single inhalation exposure studies with guinea pigs, rabbits, dogs and cats by inhalation of 10,000 ppm for 1 hour, findings suggesting mucosal irritation and narcotic effects were observed, but all survived (PATTY (6th, 2012), HSDB (Access on August 2017)). However, these were not adopted as evidence because details were unknown. Therefore, it was classified as "Classification not possible."
9 Specific target organ toxicity - Repeated exposure Classification not possible
-
-
- - Classification not possible due to lack of data.
10 Aspiration hazard Classification not possible
-
-
- - Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Classification not possible
-
-
- - No data available.
11 Hazardous to the aquatic environment (Long-term) Classification not possible
-
-
- - No data available.
12 Hazardous to the ozone layer Classification not possible
-
-
- - No data available.


NOTE:
* A blank or "-" in a cell of classification denotes that the classification of the hazard class was not conducted.
* Hazard_statement_and/or_Precautionary_statement will show when hovering the mouse over a code of Hazard_statement_and/or_Precautionary_statement.
Hazard_statement_and/or_Precautionary_statement are also provided in the Excel file.
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government,
and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.
* Codes assigned to each of the hazard statements and codes for each of the precautionary statement are
based on the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) in United Nations.

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