GHS Classification Result
GENERAL INFORMATION
REFERENCE INFORMATION
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
GENERAL INFORMATION
| Item | Information |
|---|---|
| CAS RN | 2675-77-6 |
| Chemical Name | Chloroneb |
| Substance ID | H29-A-019 |
| Classification year (FY) | FY2017 |
| Ministry who conducted the classification | Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE) |
| New/Revised | New |
| Classification result in other fiscal year | |
| Download of Excel format | Excel file |
REFERENCE INFORMATION
| Item | Information |
|---|---|
| Guidance used for the classification (External link) | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
| UN GHS document (External link) | UN GHS document |
| Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
| Model Label by MHLW (External link) | |
| Model SDS by MHLW (External link) | |
| OECD/eChemPortal (External link) | eChemPortal |
| Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. |
| 2 | Flammable gases (including chemically unstable gases) | Not applicable |
- |
- | - | Solid (GHS definition). |
| 3 | Aerosols | Not applicable |
- |
- | - | Not aerosol products. |
| 4 | Oxidizing gases | Not applicable |
- |
- | - | Solid (GHS definition). |
| 5 | Gases under pressure | Not applicable |
- |
- | - | Solid (GHS definition). |
| 6 | Flammable liquids | Not applicable |
- |
- | - | Solid (GHS definition). |
| 7 | Flammable solids | Classification not possible |
- |
- | - | There is the information that it is combustible (GESTIS (Access on September 2017)), but the classification is not possible due to no data. |
| 8 | Self-reactive substances and mixtures | Not applicable |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. |
| 9 | Pyrophoric liquids | Not applicable |
- |
- | - | Solid (GHS definition). |
| 10 | Pyrophoric solids | Classification not possible |
- |
- | - | No data available. |
| 11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Test methods applicable to solid (melting point <= 140 deg C) substances are not available. |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable |
- |
- | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
| 13 | Oxidizing liquids | Not applicable |
- |
- | - | Solid (GHS definition). |
| 14 | Oxidizing solids | Not applicable |
- |
- | - | The substance is an organic compound containing chlorine and oxygen (but not fluorine) which are chemically bonded only to carbon or hydrogen. |
| 15 | Organic peroxides | Not applicable |
- |
- | - | Organic compounds containing no bivalent -O-O- structure in the molecule |
| 16 | Corrosive to metals | Classification not possible |
- |
- | - | Test methods applicable to solid substances are not available. |
| Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Acute toxicity (Oral) | Not classified |
- |
- | - | Based on reported LD50 values for rats of > 5,000 mg/kg (88% in formulation, converted 100% equivalent value: > 4,400 mg/kg) (EPA Pesticide (2005)), and > 8,000 mg/kg (technical grade of active ingredient) (Agricultural Chemicals Times supplement "Agricultural chemicals technology information" Vol.8 (Japan Crop Protection Association, 1991)), it was classified as "Not classified." |
| 1 | Acute toxicity (Dermal) | Not classified |
- |
- | - | Based on a reported LD50 value of > 5,000 mg/kg (75% in formulation, converted 100% equivalent value: > 3,750 mg/kg) for rabbits (Agricultural Chemicals Times supplement "Agricultural chemicals technology information" Vol.8 (Japan Crop Protection Association, 1991)), it was classified as "Not Classified." |
| 1 | Acute toxicity (Inhalation: Gases) | Not applicable |
- |
- | - | Solid (GHS definition) |
| 1 | Acute toxicity (Inhalation: Vapours) | Not applicable |
- |
- | - | Solid (GHS definition) |
| 1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 2 | Skin corrosion/irritation | Not classified |
- |
- | - | Based on a report that in a skin irritation test with rabbits (according to EPA OPPTS 870.2500), it was slightly irritating (EPA Pesticide (2005)), and a report that in another test with rabbits, mild irritation of the skin was observed (Agricultural Chemicals Times supplement "Agricultural chemicals technology information" Vol.8 (Japan Crop Protection Association, 1991)), it was classified as "Not Classified" (Category 3 in UN GHS classification). |
| 3 | Serious eye damage/eye irritation | Classification not possible |
- |
- | - | There is a report that in an eye irritation test with rabbits (according to EPA OPPTS 870.2400), conjunctivitis was observed due to this substance (EPA Pesticide (2005)). On the other hand, there is a report that in another test with rabbits, no irritation of the cornea, iris, and conjunctiva was observed due to this substance, and it was negative (Agricultural Chemicals Times supplement "Agricultural chemicals technology information" Vol.8 (Japan Crop Protection Association, 1991)). It was classified as "Classification not possible" due to the conflicting results. |
| 4 | Respiratory sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 4 | Skin sensitization | Classification not possible |
- |
- | - | There is a description that in a skin sensitization test with guinea pigs (EPA OPPTS 870.2600 compliant), this substance is a sensitizer (EPA Pesticide (2005)). On the other hand, there are descriptions that in another test with guinea pigs, it was judged to be negative for skin sensitization on observation at 24 and 48 hours after the challenge (Agricultural Chemicals Times supplement "Agricultural chemicals technology information" Vol.8 (Japan Crop Protection Association, 1991)), and that in a repeated exposure test in the skin of guinea pigs, no sensitization was indicated (HSDB (Access on August 2017)). Therefore, it was classified as "Classification not possible" due to these contradicting results. |
| 5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. There are no in vivo data. As for in vitro, positive and negative results were observed both in bacterial reverse mutation tests and in mammalian cell chromosome aberration tests (EPA Pesticide (2005), NTP DB (Access on August 2017), Agricultural Chemicals Times supplement "Agricultural chemicals technology information" Vol.8 (Japan Crop Protection Association, 1991), HSDB (Access on August 2017)). |
| 6 | Carcinogenicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. Besides, EPA judged in 2003 that "Data Are Inadequate for an Assessment of Human Carcinogenic Potential" of this substance (Chemicals Evaluated for Carcinogenic Potential: Annual Cancer Report (2016)). |
| 7 | Reproductive toxicity | Classification not possible |
- |
- | - |
There is no information on reproductive effects in humans. As for experimental animals, it is reported that in a 3-generation study with rats dosed by feeding, next generations were obtained after two-time mating in each generation of F0-F2, but at up to the high dose of 500 ppm, no abnormality was seen in mating performance, reproductive performance, and histopathological examination, and that NOEL was 500 ppm in this study (Agricultural Chemicals Times supplement "Agricultural chemicals technology information" Vol.8 (Japan Crop Protection Association, 1991)). In developmental toxicity tests with pregnant rats or pregnant rabbits dosed by gavage, as for the test with rats, no developmental toxicity effect was observed at up to 1,000 mg/kg/day (HSDB (Access on August 2017), Agricultural Chemicals Times supplement "Agricultural chemicals technology information" Vol.8 (Japan Crop Protection Association, 1991)). On the other hand, in the test with rabbits, at 1,000 mg/kg/day, marginally lower body weight and anorexia in maternal animals, and lower body weight and increases in skeletal and ventral midline anomalies in fetuses were observed (HSDB (Access on August 2017)). Details on the anomalies (severity, frequency of incidence, etc.) are unknown, and it could not be judged whether they could be adequate evidence to support assigning a category. From the above, although no adverse effects on reproduction were observed in the 3-generation study with rats, there is a possibility that the doses were not high enough to cause clear general toxicity effects in maternal animals. In addition, as for developmental toxicity effects, it is not possible to judge the degree of the developmental effects from the available information. Therefore, it was classified as "Classification not possible" due to lack of data. |
| 8 | Specific target organ toxicity - Single exposure | Classification not possible |
- |
- | - | There is no information on single exposure in humans. As for experimental animals, there is a report that in a single oral administration test with mice, at 1,000 mg/kg within the range of Category 2, a significant decrease in body temperature was observed, but this resolved after 3 hours, and at 3,000 mg/kg exceeding the Category 2, a significant decrease in body temperature, hyporeactivity, mild hyperesthesia, tremor, excitement state, spasm, reduced grip strength, and tendency to reduce pupil diameter were observed, however, after 5 hours, most of the symptoms except spasm and tremor resolved (Agricultural Chemicals Times supplement "Agricultural chemicals technology information" Vol.8 (Japan Crop Protection Association, 1991)). Transient effects on the central nervous system were observed, but the doses exceeded the range of Category 2, therefore, it was classified as "Classification not possible." |
| 9 | Specific target organ toxicity - Repeated exposure | Classification not possible |
- |
- | - |
As for experimental animals, there is a report that in a 24-month toxicity study with dogs dosed by feeding, at the highest dose (2,500-10,000 ppm: max. 10,000 ppm, 7,500 ppm after the 75th week) (converted guidance value: 62.5-250 mg/kg/day), a decrease in body weight, increases in GPT (ALT) and alkaline phosphatase activity, increases in absolute and relative weights of the liver, increases in absolute and relative weights of the adrenal glands, hyperactivity of the thyroid, pigmentation of the liver, and catarrhal gastritis were observed (Agricultural Chemicals Times supplement "Agricultural chemicals technology information" Vol.8 (Japan Crop Protection Association, 1991)). It was judged that this dose approximately exceeded the guidance value range for Category 2. In addition, in a 24-month toxicity study with rats dosed by feeding, at the highest dose of 2,500 ppm (converted guidance value: 125 mg/kg/day) exceeding the guidance value range for Category 2, only reduced body weight gain and decreased food consumption were observed (Agricultural Chemicals Times supplement "Agricultural chemicals technology information" Vol.8 (Japan Crop Protection Association, 1991)). From the above, it corresponds to "Not Classified," however, since there are no data by other routes, it was classified as "Classification not possible." |
| 10 | Aspiration hazard | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment (Acute) | Category 2 |
- |
H401 |
P273
P501 |
From 96-hour LC50 = 3.7 mg/L for fish (Oncorhynchus mykiss) (NLM HSDB: 2010, EPA AQUIRE: 2017, EPA Pesticide Ecotoxicity Database), it was classified in Category 2. |
| 11 | Hazardous to the aquatic environment (Long-term) | Category 2 |
 - |
H411 |
P273
P391 P501 |
Chronic toxicity data were not obtained. Due to being not rapidly degradable (BioWin), and acute toxicity Category 2, it was classified in Category 2. |
| 12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | No data available. |
NOTE:
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* A blank or "-" in a cell of classification denotes that the classification of the hazard class was not conducted. * Hazard_statement_and/or_Precautionary_statement will show when hovering the mouse over a code of Hazard_statement_and/or_Precautionary_statement. Hazard_statement_and/or_Precautionary_statement are also provided in the Excel file. * Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. * Codes assigned to each of the hazard statements and codes for each of the precautionary statement are based on the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) in United Nations. |