GHS Classification Result

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GENERAL INFORMATION
Item Information
CAS RN 112-55-0
Chemical Name n-Dodecyl mercaptan
Substance ID H29-A-020
Classification year (FY) FY2017
Ministry who conducted the classification Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised New
Classification result in other fiscal year  
Download of Excel format Excel file

REFERENCE INFORMATION
Item Information
Guidance used for the classification (External link) GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
UN GHS document (External link) UN GHS document
Definitions/Abbreviations (Excel file) Definitions/Abbreviations
Model Label by MHLW (External link)  
Model SDS by MHLW (External link)  
OECD/eChemPortal (External link) eChemPortal

PHYSICAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Explosives Not applicable
-
-
- - There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases (including chemically unstable gases) Not applicable
-
-
- - Liquid (GHS definition)
3 Aerosols Not applicable
-
-
- - Not aerosol products.
4 Oxidizing gases Not applicable
-
-
- - Liquid (GHS definition)
5 Gases under pressure Not applicable
-
-
- - Liquid (GHS definition)
6 Flammable liquids Not classified
-
-
- - From a flash point of 128 deg C (open cup) (NFPA (14th, 2010)), it is judged that it will be above 93 deg C also in the prescribed closed-cup method. Therefore, it was classified as "Not classified."
7 Flammable solids Not applicable
-
-
- - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable
-
-
- - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Classification not possible
-
-
- - No data available.
10 Pyrophoric solids Not applicable
-
-
- - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible
-
-
- - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable
-
-
- - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable
-
-
- - Organic compounds containing no oxygen, fluorine or chlorine.
14 Oxidizing solids Not applicable
-
-
- - Liquid (GHS definition)
15 Organic peroxides Not applicable
-
-
- - Organic compounds containing no bivalent -O-O- structure in the molecule
16 Corrosive to metals Classification not possible
-
-
- - No data available.

HEALTH HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Acute toxicity (Oral) Not classified
-
-
- - There is a report of an LD50 value of > 5,000 mg/kg (SIDS (2014)) for rats, and it corresponds to "Not classified." There is a report of an LD50 value of 4,225 mg/kg (PATTY (6th, 2012), ACGIH (7th, 2014)) for mice, and it corresponds to "Not classified" (Category 5 in UN GHS classification). The category with higher hazard was adopted, and it was classified as "Not classified" (Category 5 in UN GHS classification).
1 Acute toxicity (Dermal) Not classified
-
-
- - Based on a report of an LD50 value of > 2,000 mg/kg (SIDS (2014)) for rats, it was classified as "Not classified."
1 Acute toxicity (Inhalation: Gases) Not applicable
-
-
- - Liquid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible
-
-
- - Classification not possible due to lack of data. Besides, there are reports that in single inhalation exposure to the saturated vapor (about 8-9 ppm) for 1-6 hours in rats and mice, there were no deaths, and no toxic symptoms were observed (ACGIH (7th, 2014)).
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible
-
-
- - Classification not possible due to lack of data.
2 Skin corrosion/irritation Category 1


Danger
H314 P301+P330+P331
P303+P361+P353
P305+P351+P338
P304+P340
P260
P264
P280
P310
P321
P363
P405
P501
There is the following report on a skin irritation test (OECD TG 404 and EEC Method B4 compliant) with rabbits: when this substance was applied for 3 minutes, a slight to severe erythema and a slight or moderate edema occurred, the symptoms continued during an observation period; when applied for 1 hour, a well-defined to severe erythema and a slight or moderate edema occurred and this continued during the observation period, and a crust continued until day 13; when applied for 4 hours, a well-defined and moderate to severe erythema in both of 2 animals and a slight to severe edema in the second animal occurred; and in a 4-hour application, the mean scores for 2 animals after 24, 48 and 72 hours were 2.3, 3.0 for erythema, and 0.0, 1.0 for edema, respectively, they did not resolve within 14 days, and corrosivity was shown (SIDS (2014)). From the above report, it was classified in Category 1. Besides, there is a report that this substance is not irritating to the skin (SIDS (2014), ACGIH (7th, 2014)), however, it was not adopted since it was not the test results according to guideline tests.
3 Serious eye damage/eye irritation Category 1


Danger
H318 P305+P351+P338
P280
P310
Since this substance is classified in Category 1 for skin corrosion/irritation, it was classified in Category 1. Besides, there are descriptions that in an eye irritation test with rabbits, it showed irreversible strong eye irritation (ACGIH (7th, 2014)), that in another eye irritation test with rabbits, it showed eye irritation which took more than seven days to resolve (SIDS (2014)), and that in another test with rabbits, it was slightly irritating (SIDS (2014)).
4 Respiratory sensitization Classification not possible
-
-
- - Classification not possible due to lack of data.
4 Skin sensitization Category 1


Warning
H317 P302+P352
P333+P313
P362+P364
P261
P272
P280
P321
P501
In a skin sensitization test (similar to OECD TG 406 and EPA OPPTS 870.2600) with guinea pigs, a very slight to well-defined erythema occurred 24 and 48 hours after the challenge in 5 out of 10 animals, and in one of them, very mild erythema persisted until after 72 hours. Very slight edema in one animal after 24 hours and blanching in 2 animals were observed. Based on a report that this substance is thought to be sensitizing from these results (SIDS (2014)), it was classified in Category 1.
5 Germ cell mutagenicity Classification not possible
-
-
- - As for in vivo, a chromosomal aberration test with rats and a mouse bone marrow micronucleus test were both negative (SIDS (2014), ACGIH (7th, 2014)). As for in vitro, bacterial reverse mutation tests, and a mouse lymphoma test and a sister chromatid exchange test with mammalian cultured cells were all negative (SIDS (2014), ACGIH (7th, 2014), PATTY (6th, 2012), NTP DB (Access on August 2017)). From the above, it was classified as "Classification not possible" according to the GHS Classification Guidance for the Japanese Government.
6 Carcinogenicity Classification not possible
-
-
- - Classification not possible due to lack of data.
7 Reproductive toxicity Classification not possible
-
-
- - There is no information on reproductive effects in humans. As for experimental animals, there is a description that in a 3-generation study with rats dosed by feeding, no adverse effects on reproduction and lactation were observed at doses of up to 2,500 ppm (about 170 mg/kg/day) (ACGIH (7th, 2014)). However, in addition to the lack of description, there is a possibility that it was not administered at up to doses where general toxic effects were observed in parental animals, therefore, it is thought that it is not a sufficient study result to evaluate reproductive toxicity effects, and it was judged to be not available for classification (the original literature is not available because it is a study report). Besides, there is a report that in a developmental toxicity study in which pregnant rats were exposed by inhalation at 10 ppm (measured value: 7.4 ppm) on gestational day 6-19, maternal toxicity such as the following was observed in maternal animals of the dosed group: unkempt fur, irritation-like symptoms of the eyes and nose, and attachment of wet red or black matter in the vagina were observed; and in addition, significantly decreased body weight gain was observed, and 1/25 animals was sacrificed in extremis on the 15th day of gestation, but the fetuses were not affected, and no developmental effects were shown (SIDS (2014), PATTY (6th, 2012), ACGIH (7th, 2014)). However, there is no data of developmental toxicity tests in the oral route.
From the above, due to a lack of information to evaluate reproductive and developmental effects in the oral and inhalation routes of this substance, it was classified as "Classification not possible" due to lack of data.
8 Specific target organ toxicity - Single exposure Classification not possible
-
-
- - Classification not possible due to lack of data.
9 Specific target organ toxicity - Repeated exposure Category 1 (respiratory organs)


Danger
H372 P260
P264
P270
P314
P501
No information on humans is available.
As for experimental animals, in 4-week inhalation toxicity tests (6 hours/day, 5 days/week) with rats, mice and dogs, in rats, at 7.0 ppm (converted guidance value: 0.0129 mg/L) within the guidance value range for Category 1 (vapour), dryness, cracking, and peeling of the skin, swelling and flushing of the auricle, discharge from the nose and mouth, gasping respirations, dyspnea, reduced body weight gain, increased leukocyte count, decreased hematocrit level, increases in AST and ALT, increased BUN, acanthosis, hyperkeratosis, chronic active inflammation of the skin, secondary changes in the regional lymph nodes, etc. were observed. In mice, a low incidence of centrilobular hepatocellular hypertrophy at or above 2.0 ppm (converted guidance value: 0.004 mg/L) within the guidance value range for Category 1 (vapour), death or emergency slaughter, hypoactivity, tremors, ptosis, and wet yellow stains of the genetic organ or abdominal area at 7.0 ppm (converted guidance value: 0.0129 mg/L) were observed. In dogs, thickening or crust formation of the skin, acanthosis and hyperkeratosis in the skin, and dermatitis at or above 2.0 ppm (converted guidance value: 0.004 mg/L) within the guidance value range for Category 1 (vapour), and inanimation, ptosis, dryness, cracking, and peeling of the skin, secondary changes in the regional lymph nodes, etc. at 7.0 ppm (converted guidance value: 0.0129 mg/L) were observed (SIDS (2014)). Besides, it is described in SIDS (2014) that death was observed in mice, but there were no morphological changes associated with death, and the cause of death was unknown, however, because all the animals died, it is considered to be associated with the administration of the test substance.
From the above, effects on skin irritation were mainly observed. Since skin lesions are due to irritation, it was not adopted as evidence of the classification. There are no pathological findings in the respiratory organs, but this substance is irritating, and secretions from the nose and mouth, gasping and dyspnea were observed, thus, it was judged as effects on the respiratory organs. Since it is described in SIDS (2014) that no relevant pathological changes were observed for increased AST and ALT in rats, it was not adopted as evidence of the classification.
Therefore, it was classified in Category 1 (respiratory organs).
10 Aspiration hazard Classification not possible
-
-
- - Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Classification not possible
-
-
- - No data available.
11 Hazardous to the aquatic environment (Long-term) Classification not possible
-
-
- - No data available.
12 Hazardous to the ozone layer Classification not possible
-
-
- - No data available.


NOTE:
* A blank or "-" in a cell of classification denotes that the classification of the hazard class was not conducted.
* Hazard_statement_and/or_Precautionary_statement will show when hovering the mouse over a code of Hazard_statement_and/or_Precautionary_statement.
Hazard_statement_and/or_Precautionary_statement are also provided in the Excel file.
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government,
and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.
* Codes assigned to each of the hazard statements and codes for each of the precautionary statement are
based on the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) in United Nations.

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