GHS Classification Result

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GENERAL INFORMATION
Item Information
CAS RN 1317-34-6
Chemical Name Dimanganese trioxide
Substance ID H29-A-021_MHLW
Classification year (FY) FY2017
Ministry who conducted the classification Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised New
Classification result in other fiscal year  
Download of Excel format Excel file

REFERENCE INFORMATION
Item Information
Guidance used for the classification (External link) GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
UN GHS document (External link) UN GHS document
Definitions/Abbreviations (Excel file) Definitions/Abbreviations
Model Label by MHLW (External link)  
Model SDS by MHLW (External link)  
OECD/eChemPortal (External link) eChemPortal

PHYSICAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Explosives Not applicable
-
-
- - There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases (including chemically unstable gases) Not applicable
-
-
- - Solid (GHS definition).
3 Aerosols Not applicable
-
-
- - Not aerosol products.
4 Oxidizing gases Not applicable
-
-
- - Solid (GHS definition).
5 Gases under pressure Not applicable
-
-
- - Solid (GHS definition).
6 Flammable liquids Not applicable
-
-
- - Solid (GHS definition).
7 Flammable solids Classification not possible
-
-
- - No data available.
8 Self-reactive substances and mixtures Not applicable
-
-
- - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not applicable
-
-
- - Solid (GHS definition).
10 Pyrophoric solids Classification not possible
-
-
- - No data available.
11 Self-heating substances and mixtures Classification not possible
-
-
- - No data available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified
-
-
- - It contains metals (Mn), but it is estimated that it does not react vigorously with water from the observation result of being insoluble in water (GESTIS (Access on November 2017)).
13 Oxidizing liquids Not applicable
-
-
- - Solid (GHS definition).
14 Oxidizing solids Classification not possible
-
-
- - It is an inorganic compound containing oxygen, but the classification is not possible due to no data.
15 Organic peroxides Not applicable
-
-
- - It is an inorganic compound.
16 Corrosive to metals Classification not possible
-
-
- - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Acute toxicity (Oral) Classification not possible
-
-
- - Classification not possible due to lack of data.
1 Acute toxicity (Dermal) Classification not possible
-
-
- - Classification not possible due to lack of data.
1 Acute toxicity (Inhalation: Gases) Not applicable
-
-
- - Solid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Not applicable
-
-
- - Solid (GHS definition)
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible
-
-
- - Classification not possible due to lack of data.
2 Skin corrosion/irritation Classification not possible
-
-
- - Classification not possible due to lack of data.
3 Serious eye damage/eye irritation Classification not possible
-
-
- - Classification not possible due to lack of data.
4 Respiratory sensitization Classification not possible
-
-
- - Classification not possible due to lack of data.
4 Skin sensitization Classification not possible
-
-
- - Classification not possible due to lack of data. Although it is not the information on this substance, the manganese salt is reported to be negative in the LLNA test (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008)), but details are unknown.
5 Germ cell mutagenicity Classification not possible
-
-
- - Classification not possible due to lack of data.
6 Carcinogenicity Classification not possible
-
-
- - Although there is no data on this substance itself, EPA classified manganese in Category D (not classifiable as to human carcinogenicity) (IRIS (1995)). Therefore, based on this, this substance was classified as "Classification not possible."
7 Reproductive toxicity Category 1B


Danger
H360 P308+P313
P201
P202
P280
P405
P501
There is no data on this substance itself. However, for the classification of reproductive toxicity of manganese and manganese compounds, Japan Society For Occupational Health (JSOH) judged as follows: in humans, although impotence and decreased libido were often observed in manganese poisoning patients, these findings remain at the level of case reports, and are slightly weak as epidemiological evidence, and in addition, the data on decreased fertility in males was also limited (OEL Documentations (2014)). On the other hand, it is reported that fetal toxicity occurred in experimental animals. From the above findings, manganese and manganese compounds were classified as reproductive toxicants Group 2 by the Japan Society For Occupational Health (JSOH) (OEL Documentations (2014)). Therefore, this substance was classified in Category 1B based on the classification results by the Japan Society For Occupational Health.
8 Specific target organ toxicity - Single exposure Category 1 (respiratory organs)


Danger
H370 P308+P311
P260
P264
P270
P321
P405
P501
There is no information on single exposures of this substance in humans and experimental animals. There is the information that the substance is an inorganic manganese compound and is insoluble in water (GESTIS (Access on November 2017)). In the case of manganese dioxide (CAS RN 1313-13-9), another insoluble manganese compound, it is reported that a pulmonary inflammatory reaction occurs due to a single inhalation exposure of the dust in humans and its symptoms are cough, bronchitis, pneumonia, decreased pulmonary function (CICAD 12 (1999)). Based on this information, manganese dioxide was classified in Category 1 (respiratory) in the GHS classification in FY2014. In addition, manganese carbonate (CAS RN 598-62-9), an insoluble manganese compound, for which there is no information on single exposure, but based on the information on manganese dioxide, it was classified in Category 1 (Respiratory organs) in GHS classification in FY2016. It is considered that in the case of inhalation exposure, this substance may affect the respiratory organs like other insoluble manganese compounds. Therefore, it was classified in Category 1 (respiratory organs).
9 Specific target organ toxicity - Repeated exposure Category 1 (nervous system, respiratory organs)


Danger
H372 P260
P264
P270
P314
P501
Although it is not the information on this substance, when humans are exposed to excess amounts of manganese by the oral or inhalation route, memory disorders, psychiatric symptoms, etc. are observed as acute effects, and as chronic effects, symptoms of manganese addiction similar to those of Parkinson's disease are seen, such as gait disturbance and speech disorders. Serious effects were observed especially in inhalation exposure (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008)). As for the oral route, in cases of drinking well water containing high concentrations of manganese, and in epidemiological studies on residents living in regions with high manganese concentrations, symptoms similar to manganese addiction such as mask-like faces, muscle rigidity, tremors and psychiatric disorders were reported (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008)). The influence on the neurobehavioral function by exposure to the dust of manganese dioxide, trimanganese tetraoxide, and manganese salts (sulfate, carbonate, nitrate) in plants manufacturing manganese oxides and manganese salts was reported (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008)). It is reported that neurotoxicity from manganese addiction occurred by occupational exposure to manganese dioxide, and that in addition to decreases in visual simple reaction time and in eye-hand coordination, rigidity of the hands was observed (SIDS (2012), Initial Risk Assessment Report (NITE, CERI, NEDO, 2008), ATSDR (2012)). Furthermore, many case reports revealed that manganese compounds, mainly manganese dioxide, produce respiratory disorders (cough, bronchitis, pneumonia, etc.) (ATSDR (2012)).
No information is available for experimental animals.
Therefore, this substance was classified in Category 1 (nervous system, respiratory organs).
10 Aspiration hazard Classification not possible
-
-
- - Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
11 Hazardous to the aquatic environment (Acute) -
-
-
- - -
11 Hazardous to the aquatic environment (Long-term) -
-
-
- - -
12 Hazardous to the ozone layer -
-
-
- - -


NOTE:
* A blank or "-" in a cell of classification denotes that the classification of the hazard class was not conducted.
* Hazard_statement_and/or_Precautionary_statement will show when hovering the mouse over a code of Hazard_statement_and/or_Precautionary_statement.
Hazard_statement_and/or_Precautionary_statement are also provided in the Excel file.
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government,
and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.
* Codes assigned to each of the hazard statements and codes for each of the precautionary statement are
based on the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) in United Nations.

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