GHS Classification Result
GENERAL INFORMATION
REFERENCE INFORMATION
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
GENERAL INFORMATION
| Item | Information |
|---|---|
| CAS RN | 75-66-1 |
| Chemical Name | tert-Butyl mercaptan |
| Substance ID | H29-A-024 |
| Classification year (FY) | FY2017 |
| Ministry who conducted the classification | Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE) |
| New/Revised | New |
| Classification result in other fiscal year | |
| Download of Excel format | Excel file |
REFERENCE INFORMATION
| Item | Information |
|---|---|
| Guidance used for the classification (External link) | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
| UN GHS document (External link) | UN GHS document |
| Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
| Model Label by MHLW (External link) | |
| Model SDS by MHLW (External link) | |
| OECD/eChemPortal (External link) | eChemPortal |
| Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. |
| 2 | Flammable gases (including chemically unstable gases) | Not applicable |
- |
- | - | Liquid (GHS definition) |
| 3 | Aerosols | Not applicable |
- |
- | - | Not aerosol products. |
| 4 | Oxidizing gases | Not applicable |
- |
- | - | Liquid (GHS definition) |
| 5 | Gases under pressure | Not applicable |
- |
- | - | Liquid (GHS definition) |
| 6 | Flammable liquids | Category 2 |
 Danger |
H225 |
P303+P361+P353
P370+P378 P403+P235 P210 P233 P240 P241 P242 P243 P280 P501 |
Based on a flash point of -26 deg C (closed cup), and a boiling point of 64 deg C (ICSC (J) (2004)), it was classified in Category 2. Besides, it is classified in Class 3, PGII in UNRTDG (UN 2347). |
| 7 | Flammable solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
| 8 | Self-reactive substances and mixtures | Not applicable |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. |
| 9 | Pyrophoric liquids | Not classified |
- |
- | - | It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 253 deg C (GESTIS (Access on September 2017)). |
| 10 | Pyrophoric solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
| 11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Test methods applicable to liquid substances are not available. |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable |
- |
- | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
| 13 | Oxidizing liquids | Not applicable |
- |
- | - | Organic compounds containing no oxygen, fluorine or chlorine |
| 14 | Oxidizing solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
| 15 | Organic peroxides | Not applicable |
- |
- | - | Organic compounds containing no bivalent -O-O- structure in the molecule |
| 16 | Corrosive to metals | Classification not possible |
- |
- | - | No data available. |
| Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Acute toxicity (Oral) | Not classified |
- |
- | - | Based on a report of an LD50 value for rats of 4,729 mg/kg (SIDS (2012), PATTY (6th, 2012)), it was classified as "Not classified" (Category 5 in UN GHS classification). |
| 1 | Acute toxicity (Dermal) | Not classified |
- |
- | - | Based on the report of an LD50 value of > 2,000 mg/kg for rabbits (SIDS (2012)), it was classified as "Not classified." |
| 1 | Acute toxicity (Inhalation: Gases) | Not applicable |
- |
- | - | Liquid (GHS definition) |
| 1 | Acute toxicity (Inhalation: Vapours) | Not classified |
- |
- | - | Based on reports of LC50 values of 22,000 ppm and 26,643 ppm in 4-hour inhalation exposure tests with rats (SIDS (2012), PATTY (6th, 2012)), it was classified as "Not classified." Besides, since the LC50 values were lower than the 90% of saturated vapour concentration (238,884 ppm), a reference value in the unit of ppm was applied as vapour with little mist. |
| 1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 2 | Skin corrosion/irritation | Not classified |
- |
- | - | As for a 4-hour application in skin irritation tests (corresponding to OECD TG 404 and OPPTS 870.2500), it is reported that it was mildly irritating (SIDS (2012)) and that it was not irritating (ECHA registration dossier (Access on December 2017)). Also, there are descriptions that mild irritation was observed in the 24-hour application test (SIDS (2012)), and that mild irritation or mild erythema and discoloration at the application site were observed although the application time was unknown (PATTY (6th, 2012)). Therefore, this substance was considered to have mild irritancy and it was classified as "Not Classified" (Category 3 in UN GHS classification), to which "mild irritation" is considered to correspond in the GHS classification guidance for Japanese government. |
| 3 | Serious eye damage/eye irritation | Category 2B |
Warning |
H320 |
P305+P351+P338
P337+P313 P264 |
It is described that in an eye irritation test using rabbits (compliant with OECD TG 405), eye irritation was observed in all the animals after an application but resolved within 7 days, and it was considered to be mildly irritating to the eyes (ECHA registration dossier (Access on December 2017)), and that mild eye irritation was shown in the other multiple tests with rabbits (SIDS (2012), HSDB (Access on August 2017)), therefore, it was classified in Category 2B. |
| 4 | Respiratory sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 4 | Skin sensitization | Category 1 |
 Warning |
H317 |
P302+P352
P333+P313 P362+P364 P261 P272 P280 P321 P501 |
It is described that in a skin sensitization test with guinea pigs, all of the test animals showed a score of 1-3 on skin findings (redness, edema) after 24 or 48 hours, and it is a sensitizing substance (SIDS (2012)), and that in a skin sensitization test by the LLNA method with mice (according to OECD TG 429), the SI values were greater than 3 at concentrations of 25%, 50% and 100%, and this substance was found to be sensitizing (ECHA registration dossier (Access on December 2017)). Therefore, it was classified in Category 1. |
| 5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | As for in vivo, it was negative in a mouse bone marrow micronucleus test (SIDS (2012)), and as for in vitro, it was negative in a bacterial reverse mutation test, positive and negative results in a mouse lymphoma test with mammalian cultured cells, negative in a sister chromatid exchange test (SIDS (2012), HSDB (Access on August 2017)). From the above, it was classified as "Classification not possible" according to the GHS classification guidance for the Japanese government. |
| 6 | Carcinogenicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 7 | Reproductive toxicity | Classification not possible |
- |
- | - |
In a combined repeated dose toxicity study with the reproduction/developmental toxicity screening test (OECD TG 422) with rats dosed by gavage, in the high dose group (200mg/kg/day), in which apparent general toxic effects (reduced body weight gain, effects on the liver, kidney, haemal system etc.) were observed in parent animals, a slight effect (low body weight at day 4 after birth) was observed in pups born, but no other reproductive/developmental effects were observed (JECDB (Access on August 2017), SIDS (2012)). Furthermore, in developmental toxicity tests where pregnant rats or mice were exposed by inhalation at up to 200 ppm (6 hours/day: gestation days of 6-19 (rats), gestation days of 6-16 (mice)), neither the maternal animals nor fetuses showed effects due to exposure to this substance even at the highest concentration (SIDS (2012)). From the above, both a reproduction/developmental toxicity screening test with rats by the oral route and developmental toxicity tests with rats and mice by the inhalation route resulted in negative in reproductive/developmental toxicity. However, the oral administration test is a screening test, and in the developmental toxicity tests by the inhalation route, animals were not exposed at up to the concentration at which general toxic effects appeared in maternal animals, and the dose was thought to be insufficient to conclude that it is negative, and it is not possible to classify as "Not classified" only by these results, therefore, it was classified as "Classification not possible." |
| 8 | Specific target organ toxicity - Single exposure | Category 3 (respiratory tract irritation, narcotic effects) |
Warning |
H335
H336 |
P304+P340
P403+P233 P261 P271 P312 P405 P501 |
No information was available for single exposure in humans. As for experimental animals, it was reported in a 4-hour single inhalation exposure test with rats, lacrimation, labored breathing, reduced activity, prostration, and ataxia were observed at doses of 55.0 mg/L or more, exceeding Category 2, and tremors were observed at doses of 82.6 mg/L or more (SIDS (2012), PATTY (6th, 2012)). Also it was reported that in another 4-hour single inhalation exposure test with rats, at doses of 57.0 mg/L or more, exceeding Category 2, findings indicating irritation to the mucous membranes such as rubbing of the eyes and nose, eye closure, sneezing, and lacrimation were observed within approximately 15 minutes after exposure, moreover, increased respiration, restlessness, uncoordinated movement, staggering gait, muscular weakness, cyanosis, sedation and lethargy were observed (SIDS (2012), SIDS Dossier (2012)). From the above, it was classified in Category 3 (respiratory tract irritation, narcotic effects). |
| 9 | Specific target organ toxicity - Repeated exposure | Category 2 (haemal system, liver) |
 Warning |
H373 |
P260
P314 P501 |
As for experimental animals, in a combined repeated dose toxicity study with the reproduction/developmental toxicity screening test (OECD TG 422) with rats dosed by gavage, hyaline deposits in proximal tubules and basophilic renal tubules in the kidneys which were considered to be indicative of alpha 2u-globulin nephropathy was observed at or above 10 mg/kg/day (converted guidance value: 4.7 mg/kg/day), which is within the guidance value range for Category 1, an increase in total cholesterol, centrilobular hepatocellular hypertrophy, periportal fatty degeneration of hepatocytes in the liver, etc. were observed at or above 50 mg/kg/day (converted guidance value: 23.3 mg/kg/day), which is within the guidance value range for Category 2, and decreased body weight, lower values of erythrocyte, hemoglobin, and hematocrit, an increase in platelet count, prolonged prothrombin time and activated partial thromboplastin time, increased albumin and gamma-GT, hemosiderosis in the spleen were observed at or above 200 mg/kg/day (converted guidance value: 93.3 mg/kg/day) (SIDS (2012)). Also in a 13-week inhalation toxicity study with rats (6 hours/day, 5 days/week), chronic nephrosis which is thought to be alpha 2u-globulin nephropathy at or above 0.033 mg/L (converted guidance value: 0.024 mg/L), which is within the guidance value range for Category 1 (vapour), increases in the mean absolute and relative weights of the kidneys (males only), and an increase in alveolar macrophages were observed at or above 0.36 mg/L (converted guidance value: 0.26 mg/L), which is within the guidance value range for Category 2 (vapour) (SIDS (2012)). From the above, the changes in the kidney are considered to be findings specific to male rats, and the increase in alveolar macrophages is a physiological response to foreign matter, therefore, these were not used as basis for classification. Therefore, it was classified in Category 2 (haemal system, liver). |
| 10 | Aspiration hazard | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment (Acute) | Classification not possible |
- |
- | - | No data available. |
| 11 | Hazardous to the aquatic environment (Long-term) | Classification not possible |
- |
- | - | No data available. |
| 12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | No data available. |
NOTE:
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* A blank or "-" in a cell of classification denotes that the classification of the hazard class was not conducted. * Hazard_statement_and/or_Precautionary_statement will show when hovering the mouse over a code of Hazard_statement_and/or_Precautionary_statement. Hazard_statement_and/or_Precautionary_statement are also provided in the Excel file. * Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. * Codes assigned to each of the hazard statements and codes for each of the precautionary statement are based on the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) in United Nations. |