GHS Classification Result
GENERAL INFORMATION
REFERENCE INFORMATION
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
GENERAL INFORMATION
| Item | Information |
|---|---|
| CAS RN | 80-46-6 |
| Chemical Name | 4-tert-Pentylphenol |
| Substance ID | H29-A-029 |
| Classification year (FY) | FY2017 |
| Ministry who conducted the classification | Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE) |
| New/Revised | New |
| Classification result in other fiscal year | |
| Download of Excel format | Excel file |
REFERENCE INFORMATION
| Item | Information |
|---|---|
| Guidance used for the classification (External link) | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
| UN GHS document (External link) | UN GHS document |
| Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
| Model Label by MHLW (External link) | |
| Model SDS by MHLW (External link) | |
| OECD/eChemPortal (External link) | eChemPortal |
| Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. |
| 2 | Flammable gases (including chemically unstable gases) | Not applicable |
- |
- | - | Solid (GHS definition). |
| 3 | Aerosols | Not applicable |
- |
- | - | Not aerosol products. |
| 4 | Oxidizing gases | Not applicable |
- |
- | - | Solid (GHS definition). |
| 5 | Gases under pressure | Not applicable |
- |
- | - | Solid (GHS definition). |
| 6 | Flammable liquids | Not applicable |
- |
- | - | Solid (GHS definition). |
| 7 | Flammable solids | Classification not possible |
- |
- | - | There is the information that it is combustible (GESTIS (Access on September 2017)), but the classification is not possible due to no data. |
| 8 | Self-reactive substances and mixtures | Not applicable |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. |
| 9 | Pyrophoric liquids | Not applicable |
- |
- | - | Solid (GHS definition). |
| 10 | Pyrophoric solids | Classification not possible |
- |
- | - | No data available. |
| 11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Test methods applicable to solid (melting point <= 140 deg C) substances are not available. |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable |
- |
- | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
| 13 | Oxidizing liquids | Not applicable |
- |
- | - | Solid (GHS definition). |
| 14 | Oxidizing solids | Not applicable |
- |
- | - | The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen. |
| 15 | Organic peroxides | Not applicable |
- |
- | - | Organic compounds containing no bivalent -O-O- structure in the molecule |
| 16 | Corrosive to metals | Classification not possible |
- |
- | - | Test methods applicable to solid substances are not available. |
| Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Acute toxicity (Oral) | Not classified |
- |
- | - | There were reports of LD50 values of > 2,000 mg/kg for rats (EPA Guideline No. 870.1100-compliant) (EPA Pesticide (2005)) and 1,830 mg/kg (HSDB (Access on August 2017)), one item corresponds to "Not classified," and another one corresponds to Category 4. By adopting the information in the EPA Pesticide of the test compliant with the guideline, and it was classified as "Not classified." |
| 1 | Acute toxicity (Dermal) | Category 4 |
 Warning |
H312 |
P302+P352
P362+P364 P280 P312 P321 P501 |
Based on a report of an LD50 value of 2,000 mg/kg for rabbits (HSDB (Access on August 2017)), it was classified in Category 4. |
| 1 | Acute toxicity (Inhalation: Gases) | Not applicable |
- |
- | - | Solid (GHS definition) |
| 1 | Acute toxicity (Inhalation: Vapours) | Not applicable |
- |
- | - | Solid (GHS definition) |
| 1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 2 | Skin corrosion/irritation | Category 1 |
 Danger |
H314 |
P301+P330+P331
P303+P361+P353 P305+P351+P338 P304+P340 P260 P264 P280 P310 P321 P363 P405 P501 |
Based on descriptions that this substance was corrosive to the skin (EPA Pesticide (2005)), and that this substance was an irritant of Category I (HSDB (Access on August 2017)), it was classified in Category 1. |
| 3 | Serious eye damage/eye irritation | Category 1 |
Danger |
H318 |
P305+P351+P338
P280 P310 |
This substance was classified in Category 1 for skin corrosion/irritation. There is a description that pain, conjunctivitis, blurring vision and acute inflammation occurred in the accidental exposure to this substance in human eyes (EPA Pesticide (2005)). It is described that in eye irritation tests with rabbits, the evaluation value was maximal 10 (maximum value 10) 24 hours after application, and that this substance is irritating to the eyes (animal species unknown) (HSDB (Access on August 2017)). Therefore, it was classified in Category 1. |
| 4 | Respiratory sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 4 | Skin sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. There is no in vivo data, and as for in vitro, there is a report that a bacterial reverse mutation test was negative (NTP DB (Access on August 2017)). |
| 6 | Carcinogenicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 7 | Reproductive toxicity | Category 2 |
 Warning |
H361 |
P308+P313
P201 P202 P280 P405 P501 |
In a developmental toxicity study with pregnant rats dosed by gavage, at or above 200 mg/kg/day, general effects such as a decrease in weight gain and a decrease in food consumption were observed in maternal animals; at 500 mg/kg/day, decreased fetal weight and skeletal malformations (bent ribs) were observed in fetuses (EPA Pesticide (2005), HSDB (Access on August 2017)). Additionally, it is described that this substance shows an estrogenic effect (EPA Pesticide (2005)). From the above, the substance was classified in Category 2 because it causes morphological defects in the fetal skeletons at the dose with general toxicity in maternal animals, and it has endocrine disruptor capabilities. |
| 8 | Specific target organ toxicity - Single exposure | Category 1 (nervous system), Category 3 (respiratory tract irritation) |
Danger Warning |
H370
H335 |
P308+P311
P260 P264 P270 P321 P405 P501 P304+P340 P403+P233 P261 P271 P312 |
As for humans, as the effects of inhalation exposure to end-use products containing this substance, the irritation-related symptoms such as irritation of the mouth/throat/nose, coughing/choking and shortness of breath and neurological effects such as dizziness, headache and blurred vision were reported though there is no information on the original source, and the details such as the frequency of exposures are unknown. (EPA Pesticide (2005), HSDB (Access on August 2017)). Therefore, it was classified in Category 1 (nervous system), Category 3 (respiratory tract irritation). |
| 9 | Specific target organ toxicity - Repeated exposure | Classification not possible |
- |
- | - |
As for humans, most of accidents are related to irritation reactions, but also neurological effects such as dizziness, headache, and vision disorders were reported (EPA Pesticide (2005), HSDB (Access on August 2017)). As for experimental animals, it is reported that in a 13-week dermal application test (6 hours/day, 5 days/week) with rats, no systematic effect was observed; as local effects, skin irritation (erythema, desquamation, eschar formation), acanthosis, acute or chronic dermatitis and inflammatory exudate on the epidermal surface at or above 10 mg/kg/day, and ulcers, etc. at 25 mg/kg/day were observed (HSDB (Access on August 2017)). As a result of consideration of the effects on the nervous system in humans, it was judged that the effects were due to a single exposure, and it was not adopted in repeated exposure. From the above, it was classified as "Classification not possible" due to lack of data. |
| 10 | Aspiration hazard | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment (Acute) | Category 2 |
- |
H401 |
P273
P501 |
From 96-hour LC50 = 1.6 mg/L for fish (Cyprinus carpio) (NLM HSDB: 2010, EPA AQUIRE: 2017, Gimeno, S., H. et al. (1998)), it was classified in Category 2. |
| 11 | Hazardous to the aquatic environment (Long-term) | Category 1 |
 Warning |
H410 |
P273
P391 P501 |
If chronic toxicity data are used, then it is classified in Category 1 due to being not rapidly degradable (non-biodegradable, average degradation rate by BOD: 0% (J-CHECK, 2013)), and 30-day NOEC (sexual maturation) = 0.0566 mg/L for fish (Pimephales promelas) (EPA AQUIRE: 2017, Panter, G. H. et al. (2006)). If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified in Category 2 due to being not rapidly degradable (non-biodegradable, average degradation rate by BOD: 0% (J-CHECK, 2013)), and 96-hour LC50 = 1.7 mg/L for crustacea (Crangon septemspinosa) (NLM HSDB: 2010, EPA AQUIRE: 2017). By drawing a comparison between the above results, it was classified in Category 1. |
| 12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | No data available. |
NOTE:
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* A blank or "-" in a cell of classification denotes that the classification of the hazard class was not conducted. * Hazard_statement_and/or_Precautionary_statement will show when hovering the mouse over a code of Hazard_statement_and/or_Precautionary_statement. Hazard_statement_and/or_Precautionary_statement are also provided in the Excel file. * Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. * Codes assigned to each of the hazard statements and codes for each of the precautionary statement are based on the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) in United Nations. |