GHS Classification Result
GENERAL INFORMATION
REFERENCE INFORMATION
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
GENERAL INFORMATION
| Item | Information |
|---|---|
| CAS RN | 109-09-1 |
| Chemical Name | 2-Chloropyridine |
| Substance ID | H29-B-023 |
| Classification year (FY) | FY2017 |
| Ministry who conducted the classification | Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE) |
| New/Revised | Revised |
| Classification result in other fiscal year | FY2009 |
| Download of Excel format | Excel file |
REFERENCE INFORMATION
| Item | Information |
|---|---|
| Guidance used for the classification (External link) | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
| UN GHS document (External link) | UN GHS document |
| Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
| Model Label by MHLW (External link) | MHLW Website (in Japanese Only) |
| Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
| OECD/eChemPortal (External link) | eChemPortal |
| Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. |
| 2 | Flammable gases (including chemically unstable gases) | Not applicable |
- |
- | - | Liquid (GHS definition) |
| 3 | Aerosols | Not applicable |
- |
- | - | Not aerosol products. |
| 4 | Oxidizing gases | Not applicable |
- |
- | - | Liquid (GHS definition) |
| 5 | Gases under pressure | Not applicable |
- |
- | - | Liquid (GHS definition) |
| 6 | Flammable liquids | Category 4 |
Warning |
H227 |
P370+P378
P403+P235 P210 P280 P501 |
From a flash point data of 64 deg C (unknown method) (GESTIS (Access on June 2017)), it is estimated that the result corresponding to Category 4 will be obtained in the prescribed test method. |
| 7 | Flammable solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
| 8 | Self-reactive substances and mixtures | Not applicable |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. |
| 9 | Pyrophoric liquids | Not classified |
- |
- | - | It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 585 deg C (GESTIS (Access on June 2017)). |
| 10 | Pyrophoric solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
| 11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Test methods applicable to liquid substances are not available. |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable |
- |
- | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
| 13 | Oxidizing liquids | Not applicable |
- |
- | - | The substance is an organic compound containing chlorine (but not fluorine or oxygen) which is chemically bonded only to carbon or hydrogen. |
| 14 | Oxidizing solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
| 15 | Organic peroxides | Not applicable |
- |
- | - | Organic compounds containing no bivalent -O-O- structure in the molecule |
| 16 | Corrosive to metals | Classification not possible |
- |
- | - | No data available. |
| Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Acute toxicity (Oral) | Category 3 |
 Danger |
H301 |
P301+P310
P264 P270 P321 P330 P405 P501 |
Based on a report of an LD50 value for mice of 100 mg/kg (NTP TOX83 (2017)), it was classified in Category 3. |
| 1 | Acute toxicity (Dermal) | Category 2 |
Danger |
H310 |
P302+P352
P361+P364 P262 P264 P270 P280 P310 P321 P405 P501 |
Based on a report of an LD50 value for rabbits of 64 mg/kg (NTP TOX83 (2017)), it was classified in Category 2. |
| 1 | Acute toxicity (Inhalation: Gases) | Not applicable |
- |
- | - | Liquid (GHS definition) |
| 1 | Acute toxicity (Inhalation: Vapours) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 2 | Skin corrosion/irritation | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 3 | Serious eye damage/eye irritation | Classification not possible |
- |
- | - | Classification not possible due to lack of data. Besides, as for information sources other than those in the list, there is a report that in an eye irritation test with rabbits, severe conjunctivitis and moderate corneal opacity occurred and persisted even after 48 hours, but the conjunctivitis diminished to only a trace of a lesion after 7 days (Gehring P.J. et al., Toxicology and Applied Pharmacology, 11, 361-371, 1967). |
| 4 | Respiratory sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 4 | Skin sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | The substance was classified as "Classification not possible" because it was not possible to classify a substance as "Not classified" according to the revised GHS classification guidance for the Japanese government. As for in vivo, a micronucleus test with mouse peripheral blood was negative (NTP DB (Access on June 2017), NTP TOX83 (2017)), and as for in vitro, a bacterial reverse mutation test was positive (NTP DB (Access on June 2017), NTP TOX83 (2017)). |
| 6 | Carcinogenicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 7 | Reproductive toxicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 8 | Specific target organ toxicity - Single exposure | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 9 | Specific target organ toxicity - Repeated exposure | Category 2 (haemal system, liver, genetic organs (men)) |
 Warning |
H373 |
P260
P314 P501 |
No information on humans is available. As for experimental animals, 3-month repeated oral dose toxicity tests by drinking water with rats and mice were conducted, and the following is reported: As for rats, an increase in the kidney weight and spleen congestion at or above 10 ppm (male: 1 mg/kg/day, female: 1 mg/kg/day), and an increase in total protein/albumin and the liver weight at or above 30 ppm (male: 3 mg/kg/day, female: 3 mg/kg/day) were observed, and both doses were within the guidance value range for Category 1; decreases in the erythrocyte counts/the hemoglobin amount/the hematocrit value, an increase in the reticulocyte counts, the hepatocyte cytoplasmic vacuolization of the liver, hematopoietic cell proliferation in the spleen, and bone marrow hyperplasia were observed at or above 300 ppm (male: 25 mg/kg/day, female: 27 mg/kg/day), suppression of weight gain, emaciation, clear cell focus of the liver, and a decrease in the epididymal sperm counts were observed at 1000 ppm (male: 65 mg/kg/day, female: 70 mg/kg/day), and these doses were within the range of the guidance value of Category 2; as for mice, an increase in the liver weight was observed at or above 10 ppm (male: 1.5 mg/kg/day, female: 1.2 mg/kg/day) within the guidance value range for Category 1, centrilobular hypertrophy in the liver was seen at or above 300 ppm (male: 41 mg/kg/day, female: 38 mg/kg/day) within the guidance value range for Category 2, and decreases in the erythrocyte counts/the hemoglobin amount/the hematocrit value and an increase in the kidney weight was found at 1000 ppm (male: 110 mg/kg/day, female: 92 mg/kg/day) near the upper limit of the guidance value range for Category 2 (NTP TOX83 (2017)). From the above, findings of anemia and findings associated with anemia, effects on the liver, and effects on sperm were observed, and it was classified in Category 2 (haemal system, liver, genetic organs (men)). The classification was changed because the new information source was obtained. |
| 10 | Aspiration hazard | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment (Acute) | Classification not possible |
- |
- | - | No data available. |
| 11 | Hazardous to the aquatic environment (Long-term) | Classification not possible |
- |
- | - | No data available. |
| 12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | No data available. |
NOTE:
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* A blank or "-" in a cell of classification denotes that the classification of the hazard class was not conducted. * Hazard_statement_and/or_Precautionary_statement will show when hovering the mouse over a code of Hazard_statement_and/or_Precautionary_statement. Hazard_statement_and/or_Precautionary_statement are also provided in the Excel file. * Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. * Codes assigned to each of the hazard statements and codes for each of the precautionary statement are based on the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) in United Nations. |