GHS Classification Result
GENERAL INFORMATION
REFERENCE INFORMATION
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
GENERAL INFORMATION
| Item | Information |
|---|---|
| CAS RN | 80-51-3 |
| Chemical Name | 4,4'-Oxybisbenzenesulfonylhydrazide |
| Substance ID | H29-B-030 |
| Classification year (FY) | FY2017 |
| Ministry who conducted the classification | Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE) |
| New/Revised | Revised |
| Classification result in other fiscal year | FY2010 FY2006 |
| Download of Excel format | Excel file |
REFERENCE INFORMATION
| Item | Information |
|---|---|
| Guidance used for the classification (External link) | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
| UN GHS document (External link) | UN GHS document |
| Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
| Model Label by MHLW (External link) | MHLW Website (in Japanese Only) |
| Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
| OECD/eChemPortal (External link) | eChemPortal |
| Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Explosives | Not classified |
- |
- | - | Although there is a chemical group associated with explosive properties (sulfonyl hydrazides) in the molecule, and oxygen balance of -116 is above the criteria, -200, it is classified in Division 4.1 in UNRTDG (UN 3226, self-reactive substance, solid, type D). It does not correspond to explosives, hazard class with the highest precedence. |
| 2 | Flammable gases (including chemically unstable gases) | Not applicable |
- |
- | - | Solid (GHS definition). |
| 3 | Aerosols | Not applicable |
- |
- | - | Not aerosol products. |
| 4 | Oxidizing gases | Not applicable |
- |
- | - | Solid (GHS definition). |
| 5 | Gases under pressure | Not applicable |
- |
- | - | Solid (GHS definition). |
| 6 | Flammable liquids | Not applicable |
- |
- | - | Solid (GHS definition). |
| 7 | Flammable solids | Classification not possible |
- |
- | - | There is the information that it is not combustible (ICSC (J) (1998)) and combustible (ACGIH (7th, 2001)). Due to conflicting data, the classification is not possible. |
| 8 | Self-reactive substances and mixtures | Type D |
 Danger |
H242 |
P370+P378
P403+P235 P210 P220 P234 P280 P411 P420 P501 |
There is a chemical group associated with explosive properties (sulfonyl hydrazides) in the molecule, and the name of the substance is clearly mentioned in Table 2.4.2.3.2.3 in UNRTDG , and it is classified in Division 4.1 in UNRTDG (UN 3226, self-reactive substance, solid, type D). |
| 9 | Pyrophoric liquids | Not applicable |
- |
- | - | Solid (GHS definition). |
| 10 | Pyrophoric solids | Not classified |
- |
- | - | Because it is classified in Division 4.1 in UNRTDG (UN 3226, self-reactive substance, solid, type D), it does not correspond to pyrophoric solids, hazard class with the highest precedence. |
| 11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | No data available. |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable |
- |
- | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
| 13 | Oxidizing liquids | Not applicable |
- |
- | - | Solid (GHS definition). |
| 14 | Oxidizing solids | Classification not possible |
- |
- | - | It is an organic compound which does not contain fluorine or chlorine but contains oxygen, and the oxygen is chemically bonded to the element other than carbon or hydrogen (S). However, the classification is not possible due to no data. |
| 15 | Organic peroxides | Not applicable |
- |
- | - | Organic compounds containing no bivalent -O-O- structure in the molecule |
| 16 | Corrosive to metals | Classification not possible |
- |
- | - | Test methods applicable to solid substances are not available. |
| Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Acute toxicity (Oral) | Not classified |
- |
- | - | The following three items of data are reported as LD50 values for rats: 1,000 to 2,000 mg/kg (SIDS (2007)), > 2,000 mg/kg (JECDB (Access on June 2017)), and 2,300 mg/kg (ACGIH (7th, 2001)). One value corresponds to Category 4, another value corresponds to "Not classified" (Category 5 in UN GHS classification), and the third value corresponds to "Not classified" (Category 5 in UN GHS classification or "Not classified"). By adopting the category to which the largest number of cases corresponds, it was classified as "Not classified." |
| 1 | Acute toxicity (Dermal) | Classification not possible |
- |
- | - | Although there is a report of an LD50 value of > 200 mg (ACGIH (7th, 2001)) for rabbits, it is not possible to specify the category to which the LD50 value corresponds only from this data, and the classification was not possible. |
| 1 | Acute toxicity (Inhalation: Gases) | Not applicable |
- |
- | - | Solid (GHS definition) |
| 1 | Acute toxicity (Inhalation: Vapours) | Not applicable |
- |
- | - | Solid (GHS definition) |
| 1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 2 | Skin corrosion/irritation | Not classified |
- |
- | - | Based on the reports on skin irritation tests with rabbits that it was not irritating to the skin (ACGIH (7th, 2001)), and that it was slightly irritating to the skin (SIDS (2007)), it was classified "Not classified" (Category 3 in UN GHS classification). |
| 3 | Serious eye damage/eye irritation | Category 2B |
Warning |
H320 |
P305+P351+P338
P337+P313 P264 |
Based on the reports on eye irritation tests with rabbits that it was slightly irritating to the eyes (ACGIH (7th, 2001)), and that it was irritating (SIDS (2007)), it was classified in Category 2B. |
| 4 | Respiratory sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 4 | Skin sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | The substance was classified as "Classification not possible" because it was not possible to classify a substance as "Not classified" according to the revised GHS classification guidance for the Japanese government. As for in vivo, a mouse bone marrow micronucleus test was negative (ACGIH (7th, 2001), SIDS (2007)). As for in vitro, a bacterial reverse mutation test and a chromosomal aberration test with mammalian cultured cells were positive (JECDB (Access on June 2017), ACGIH (7th, 2001), SIDS (2007), HSDB (Access on June 2017)). |
| 6 | Carcinogenicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 7 | Reproductive toxicity | Classification not possible |
- |
- | - | In a combined repeated dose toxicity study with the reproduction/developmental toxicity screening test with rats by oral administration (OECD TG 422), and in a reproduction/developmental toxicity screening test with rats by oral administration (OECD TG 421), reproductive development effects were not observed at up to the dose of 45 mg/kg/day in the former and at up to the dose of 30 mg/kg/day in the latter (SIDS (2007), JECDB (Access on June 2017)). However, since these are the results of screening tests, it was not classified as "Not classified" for this hazard class, and it was classified as "Classification not possible." |
| 8 | Specific target organ toxicity - Single exposure | Category 2 (nervous system) |
 Warning |
H371 |
P308+P311
P260 P264 P270 P405 P501 |
As for single oral dose tests with rats, there are reports that tiptoe gait, paralytic gait, etc. were observed at 1,000 mg/kg, which is equivalent to Category 2 (JECDB (Access on June 2017)), and that mild paralysis of hind limbs was also observed at the same 1,000 mg/kg (SIDS (2007)). Therefore, it was classified in Category 2 (nervous system). |
| 9 | Specific target organ toxicity - Repeated exposure | Category 2 (nervous system, haemal system, liver, kidney) |
Warning |
H373 |
P260
P314 P501 |
No information on humans is available. As for experimental animals, it is reported that in a 28-day repeated oral dose toxicity test with rats dosed by gavage, a decrease in grip strength, an increase in protein in the urine, an increase in rod nucleus neutrophils, an increase in inorganic phosphorus, a decrease in glucose, and an increase in kidney weights, etc. were observed at or above 30 mg/kg/day (converted guidance value: 9.3 mg/kg/day) within the guidance value range for Category 1, and decreases in hematocrit value and hemoglobin level, increases in reticulocytes and segmented leukocytes, a decrease in lymphocytes, increases in total cholesterol, triglycerides and urea nitrogen, a decrease in chlorine, an increase in the liver weight, perilobular fatty changes, centrilobular hypertrophy of hepatocytes, increased microgranuloma in the liver, fatty degeneration of the proximal tubular epithelium in the kidney, degeneration of nerve fibers in the sciatic nerve, extramedullary hematopoiesis and congestion in the spleen, and atrophy of muscle fibers in the gastrocnemius muscles were observed at or above 100 mg/kg/day (converted guidance value: 31.1 mg/kg/day) within the guidance value range for Category 2, a paralytic gait, diarrhea, deterioration of general conditions, fatty degeneration of the proximal tubular epithelium in the kidney, a decrease in hematopoietic capacity and congestion in the femoral bone marrow, decreases in secretory granules and atrophic changes in the organs and tissues of the whole body were observed at 200 mg/kg/day (converted guidance value: 62.2 mg/kg/day) (JECDB (Access on June 2017)). Besides, regarding the same study, the finding in the liver is not adopted as an effect for the target organ in SIDS (2007). In addition, it is reported that in a combined repeated dose toxicity study with the reproduction/developmental toxicity screening test with rats dosed by gavage (OECD TG 422), increases in spleen and kidney weights were observed in males at or above 15 mg/kg/day (converted guidance value: 7 mg/kg/day) within the guidance value range for Category 1, an increase in liver weight, decreased function in sensory and motor function tests in the open field were observed at 45 mg/kg/day (converted guidance value: 21 mg/kg/day), which is within the guidance value range for Category 2 (SIDS (2007)). From the above, effects on the nervous system, liver, spleen, haemal system, and kidney were observed. As for the effect on the nervous system, only a decrease in grip strength was seen at the dose within the guidance value range for Category 1, and the pathological histology findings were observed at the dose within the guidance value range for Category 2. Therefore, it was classified in Category 2 (nervous system, haemal system, liver, kidney). By reconfirming the reference, the classification was changed. |
| 10 | Aspiration hazard | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment (Acute) | Category 2 |
- |
H401 |
P273
P501 |
From 48-hour EC50 = 2.9 mg/L for crustacea (Daphnia magna) (Results of Aquatic Toxicity Tests of Chemicals conducted by Ministry of the Environment in Japan (Ministry of the Environment, 2017), OECD SIDS: 2006), it was classified in Category 2. |
| 11 | Hazardous to the aquatic environment (Long-term) | Category 1 |
 Warning |
H410 |
P273
P391 P501 |
If chronic toxicity data are used, then it is classified in Category 1 due to being not rapidly degradable (non-biodegradable, a degradation rate by BOD: 2% (J-CHECK, 1994)), and 72-hour NOEC (rate method) = 0.059 mg/L for algae (Pseudokirchneriella subcapitata) (Results of Aquatic Toxicity Tests of Chemicals conducted by Ministry of the Environment in Japan (Ministry of the Environment, 2017)). If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified as "Not classified" due to being not rapidly degradable (non-biodegradable, a degradation rate by BOD: 2% (J-CHECK, 1994)), and 96-hour LC50 >6.6 mg/L for fish (Oryzias latipes) (limit test, Results of Aquatic Toxicity Tests of Chemicals conducted by Ministry of the Environment in Japan (Ministry of the Environment, 2017), OECD SIDS: 2006). From the above results, it was classified in Category 1. |
| 12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | No data available. |
NOTE:
|
* A blank or "-" in a cell of classification denotes that the classification of the hazard class was not conducted. * Hazard_statement_and/or_Precautionary_statement will show when hovering the mouse over a code of Hazard_statement_and/or_Precautionary_statement. Hazard_statement_and/or_Precautionary_statement are also provided in the Excel file. * Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. * Codes assigned to each of the hazard statements and codes for each of the precautionary statement are based on the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) in United Nations. |