Item | Information |
---|---|
CAS RN | 446-35-5 |
Chemical Name | 2,4-Difluoro-1-nitrobenzene |
Substance ID | H29-B-031 |
Classification year (FY) | FY2017 |
Ministry who conducted the classification | Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE) |
New/Revised | Revised |
Classification result in other fiscal year | FY2011 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
UN GHS document (External link) | UN GHS document |
Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
Model Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | eChemPortal |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Explosives | Classification not possible |
- |
- | - | Although there is a chemical group associated with explosive properties (nitro group) in the molecule, and oxygen balance of -116 is above the criteria, -200, the classification is not possible due to no data. |
2 | Flammable gases (including chemically unstable gases) | Not applicable |
- |
- | - | Liquid (GHS definition) |
3 | Aerosols | Not applicable |
- |
- | - | Not aerosol products. |
4 | Oxidizing gases | Not applicable |
- |
- | - | Liquid (GHS definition) |
5 | Gases under pressure | Not applicable |
- |
- | - | Liquid (GHS definition) |
6 | Flammable liquids | Category 4 |
Warning |
H227 |
P370+P378
P403+P235 P210 P280 P501 |
Based on a flash point data of 91 deg C (closed cup) (Sigma-Aldrich (2017)), it was classified in Category 4. |
7 | Flammable solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
8 | Self-reactive substances and mixtures | Classification not possible |
- |
- | - | There is a chemical group associated with explosive properties (nitro group) in the molecule, but the classification is not possible due to no data. |
9 | Pyrophoric liquids | Not classified |
- |
- | - | It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 480 deg C (BUA 252 (2004)). |
10 | Pyrophoric solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Test methods applicable to liquid substances are not available. |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable |
- |
- | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
13 | Oxidizing liquids | Classification not possible |
- |
- | - | It is an organic compound which does not contain chlorine but contains fluorine and oxygen, and the oxygen is chemically bonded to the element other than carbon or hydrogen (N). However, the classification is not possible due to no data. |
14 | Oxidizing solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
15 | Organic peroxides | Not applicable |
- |
- | - | Organic compounds containing no bivalent -O-O- structure in the molecule |
16 | Corrosive to metals | Classification not possible |
- |
- | - | No data available. |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Category 3 |
Danger |
H301 |
P301+P310
P264 P270 P321 P330 P405 P501 |
Based on reports of LD50 values for rats of 194 mg/kg and 200 mg/kg (BUA 252 (2004)), it was classified in Category 3. |
1 | Acute toxicity (Dermal) | Category 2 |
Danger |
H310 |
P302+P352
P361+P364 P262 P264 P270 P280 P310 P321 P405 P501 |
There is a report of an LD50 value for rats of 84 mg/kg (BUA 252 (2004)), and it corresponds to Category 2. There is a report of an LD50 value for rabbits of 207 mg/kg (BUA 252 (2004)), and it corresponds to Category 3. It was classified in Category 2 by adopting the category with higher hazard. |
1 | Acute toxicity (Inhalation: Gases) | Not applicable |
- |
- | - | Liquid (GHS definition) |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible |
- |
- | - | There is a report that in an 8-hour inhalation exposure test with rats, no death occurred at about 1.78 mg/L (274 ppm) (converted 4-hour equivalent value: 2.52 mg/L (387 ppm)) (BUA 252 (2004)), however, since it is not possible to specify the category only with this data, it was classified as "Classification not possible." Besides, since the exposure concentration is lower than 90% of the saturated vapor pressure concentration (2.17 mg/L (335 ppm)), a reference value in the unit of ppm was applied as vapor with little mist. |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
2 | Skin corrosion/irritation | Classification not possible |
- |
- | - | Classification not possible due to lack of data. Besides, this substance has high dermal toxicity, and in a skin irritation test with rabbits, animals died on an application of an undiluted solution. There is a report that as 1 mL of an undiluted solution was washed 15 minutes after application, no irritation was shown in a 14-day observation (BUA 252 (2004)). However, it was not adopted because the experimental conditions were insufficient. |
3 | Serious eye damage/eye irritation | Classification not possible |
- |
- | - | In an eye irritation test with rabbits (OECD TG 405-compliant), no effect was observed on the cornea and iris, and redness of score 2 and edema of score 1 were observed 1 hour after an application to the conjunctiva. However, they decreased after 2 days, and the irritation score (MMAS) was 4.7 (ECETOC TR48 (1998)). Similarly, there is a description that in an eye irritation test with rabbits, the irritation scores after 1, 7, 24, 48, 72 hours were 5, 2, 14, 10, 11, respectively, and slight irritation was observed (BUA 252 (2004)). On the other hand, it is also described that it was not irritating to the eyes (BUA 252 (2004)), therefore, it was classified as "Classification not possible." The category was changed by reviewing information. |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
4 | Skin sensitization | Classification not possible |
- |
- | - | There is a report that, in order to investigate the delayed type hypersensitivity skin reaction, this substance was applied to 96 volunteers, and challenge treatments were done to 30 people whose skin reaction disappeared after the introduction, and as the result, positive responses were observed in 27 of them (90%) (BUA 252 (2004)). However, the details of the results of the control group etc. are unknown, and it is not possible to conclude that this substance is positive based on this result, therefore, it was classified as "Classification not possible." |
5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
6 | Carcinogenicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
7 | Reproductive toxicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
8 | Specific target organ toxicity - Single exposure | Category 2 (nervous system, haemal system) |
Warning |
H371 |
P308+P311
P260 P264 P270 P405 P501 |
There is no information on single exposure to this substance in humans. As for experimental animals, there is a report that in a single oral dose test with rats, the methemoglobin concentration in the blood rose up to a maximum 6% at a dose of 80 mg/kg, and it decreased to less than 2% after 48 hours (BUA 252 (2004)). In addition, there are reports that in other two single oral dose tests with rats, staggering gait, crouching position, ventral or lateral position, convulsions, tremors and lacrimation were observed. Although there is no detailed description of the dosage at which these effects were observed, it is considered to be in the range for Category 1 near the LD50 values of 197 mg/kg and 200 mg/kg (BUA 252 (2004)). Moreover, there is a report that in a single oral administration in cats at 100 mg/kg, the methemoglobin concentration in the blood rose up to 8.5 to 11%; Heinz body formation and blue discoloration of the tongue were observed: they showed muscle tremors, twitching, salivation, and gasping and died within 2 hours (BUA 252 (2004)). As for the dermal route, there is a report that in a single dermal exposure test with rabbits, disturbance of the equilibrium sense, muscle tremor, twitch were observed at or above 160 mg/kg; cyanosis, an increased respiration rate, and yellow urine were observed at or above at or above 200 mg/kg (BUA 252 (2004)). Additionally, in a single dermal exposure test with rats, they showed a crouching or prone position, tremors, and convulsions and died after 2 hours to 2 days. Although there is no detailed description of the dosage at which these effects were observed, it is considered to be in the range for Category 1 near the LD50 value of 84 mg/kg (BUA 252 (2004)). By summarizing the above information, the target organs of this substance are considered to be the nervous system and haemal system. The effects on experimental animals are all observed at dosages within the range for Category 1. They correspond to Category 1 from the guidance value, however, it is the data from BUA which are an information source in List 2, and it does not satisfy the criterion 1b3) (OECDTG test and GLP compliance test). Therefore, it was classified in Category 2 (nervous system, haemal system) according to the GHS classification guidance for the Japanese government. The classification result was changed from the previous classification. |
9 | Specific target organ toxicity - Repeated exposure | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
10 | Aspiration hazard | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment (Acute) | Category 2 |
- |
H401 |
P273
P501 |
From 96-hour LC50 = 7.1 mg/L for fish (Danio rerio) (BUA vol.252: 2004), it was classified in Category 2. |
11 | Hazardous to the aquatic environment (Long-term) | Category 2 |
- |
H411 |
P273
P391 P501 |
Chronic toxicity data were not obtained. Due to being not rapidly degradable (BioWin), and acute toxicity Category 2, it was classified in Category 2. |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | No data available. |
* A blank or "-" in a cell of classification denotes that the classification of the hazard class was not conducted. * Hazard_statement_and/or_Precautionary_statement will show when hovering the mouse over a code of Hazard_statement_and/or_Precautionary_statement. Hazard_statement_and/or_Precautionary_statement are also provided in the Excel file. * Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. * Codes assigned to each of the hazard statements and codes for each of the precautionary statement are based on the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) in United Nations. |