GHS Classification Result
GENERAL INFORMATION
REFERENCE INFORMATION
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
GENERAL INFORMATION
| Item | Information |
|---|---|
| CAS RN | 156-62-7 |
| Chemical Name | Calcium cyanamide |
| Substance ID | H29-B-044 |
| Classification year (FY) | FY2017 |
| Ministry who conducted the classification | Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE) |
| New/Revised | Revised |
| Classification result in other fiscal year | FY2006 |
| Download of Excel format | Excel file |
REFERENCE INFORMATION
| Item | Information |
|---|---|
| Guidance used for the classification (External link) | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
| UN GHS document (External link) | UN GHS document |
| Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
| Model Label by MHLW (External link) | |
| Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
| OECD/eChemPortal (External link) | eChemPortal |
| Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. |
| 2 | Flammable gases (including chemically unstable gases) | Not applicable |
- |
- | - | Solid (GHS definition). |
| 3 | Aerosols | Not applicable |
- |
- | - | Not aerosol products. |
| 4 | Oxidizing gases | Not applicable |
- |
- | - | Solid (GHS definition). |
| 5 | Gases under pressure | Not applicable |
- |
- | - | Solid (GHS definition). |
| 6 | Flammable liquids | Not applicable |
- |
- | - | Solid (GHS definition). |
| 7 | Flammable solids | Classification not possible |
- |
- | - | Because there is the information that a pure substance corresponds to "Not classified" due to being not combustible, but there is a fire risk in the presence of impurity (ICSC (J) (2006)), it was classified as "Classification not possible." |
| 8 | Self-reactive substances and mixtures | Not applicable |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. |
| 9 | Pyrophoric liquids | Not applicable |
- |
- | - | Solid (GHS definition). |
| 10 | Pyrophoric solids | Classification not possible |
- |
- | - | Because there is the information that a pure substance corresponds to "Not classified" due to being not combustible, but there is a fire risk in the presence of impurity (ICSC (J) (2006)), it was classified as "Classification not possible." |
| 11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Because there is the information that a pure substance corresponds to "Not classified" due to being not combustible, but there is a fire risk in the presence of impurity (ICSC (J) (2006)), it was classified as "Classification not possible." |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Classification not possible |
- |
- | - | It contains a metal (Ca) and reacts with water (ICSC (J) (2006)), but the classification is not possible due to no data. Besides, when it contains more than 0.1% calcium carbide, impurity, it is classified in Division 4.3, PGIII in UNRTDG (UN 1403) corresponding to Category 3. In addition, because in Special Provision 38 of UNRTDG, it does not correspond to Dangerous Goods when it contains not more than 0.1% calcium carbide, impurity, a pure substance corresponds to "Not classified." |
| 13 | Oxidizing liquids | Not applicable |
- |
- | - | Solid (GHS definition). |
| 14 | Oxidizing solids | Not applicable |
- |
- | - | It is an inorganic compound not containing oxygen or halogen. |
| 15 | Organic peroxides | Not applicable |
- |
- | - | It is an inorganic compound. |
| 16 | Corrosive to metals | Classification not possible |
- |
- | - | Test methods applicable to solid substances are not available. |
| Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Acute toxicity (Oral) | Category 4 |
 Warning |
H302 |
P301+P312
P264 P270 P330 P501 |
There are three reports of LD50 values for rats of 700 mg/kg (purity 40-60%, a converted value equivalent to 100% purity: 280-420 mg/kg) (Japan Crop Protection Association (Agricultural Chemicals Times supplement "Agricultural chemicals technology information" (1992))), 765 mg/kg (purity 62-65%, a converted value equivalent to 100% purity: 474-497 mg/kg) (DFGOT Vol. 5 (1993)), and 690 mg/kg (purified products, EU SCHER (2016)), one of which corresponds to Category 3-4, and two to Category 4. By adopting the category with the larger number of cases, it was classified in Category 4. |
| 1 | Acute toxicity (Dermal) | Classification not possible |
- |
- | - | There is a report of an LD50 value for rabbits of >2000 mg/kg (purity 62%, a converted value equivalent to 100% purity: >1240 mg/kg) (DFGOT Vol. 24 (2007)), it corresponds to Category 4 or "Not classified," but since the category cannot be specified by this value alone, it was classified as "Classification not possible." The documents on the Agricultural Chemical Registration Application (2000) used in the previous classification was not used because it was not available and could not be confirmed. The classification result was changed from the previous classification due to the use of new information sources. |
| 1 | Acute toxicity (Inhalation: Gases) | Not applicable |
- |
- | - | Solid (GHS definition) |
| 1 | Acute toxicity (Inhalation: Vapours) | Not applicable |
- |
- | - | Solid (GHS definition) |
| 1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | There is a report of an LC50 value for rats of >0.155 mg/L in a 4-hour inhalation test (DFGOT Vol. 24 (2007)), but since the category cannot be specified by this value alone, it was classified as "Classification not possible." The classification result was changed from the previous classification due to the use of new information sources. |
| 2 | Skin corrosion/irritation | Category 2 |
Warning |
H315 |
P302+P352
P332+P313 P362+P364 P264 P280 P321 |
There is a report that in a skin irritation test of this substance with rabbits (in compliance with OECD TG 404), no skin irritation was observed with the dried substance, whereas the moistened substance showed mild to moderate irritation (DFGOT Vol. 24 (2007)). Also, there is a report that severe eye irritation is observed in humans (DFGOT Vol. 24 (2007)). Therefore, by judging comprehensively from these results, it was classified in Category 2. |
| 3 | Serious eye damage/eye irritation | Category 1 |
 Danger |
H318 |
P305+P351+P338
P280 P310 |
From reports that in eye irritation tests with rabbits (in compliance with OECD TG 405), necrosis of the nictitating membrane, corneal opacity and severe irritation were observed, or eye irritation such as conjunctival edema (grade 4) and erythema (grade 2), congestion of the iris (grade 2), and corneal opacity (grade 4) occurred on observation 7 days after an application (DFGOT Vol. 24 (2007)), it was classified in Category 1. Besides, there is a description that the aqueous solution of this substance is strongly alkaline (EU SCHER (2016)). In the EU CLP classification, this substance is classified in Eye Dam. 1 (ECHA CL Inventory (Access on June 2017)). |
| 4 | Respiratory sensitization | Classification not possible |
- |
- | - | No data available. |
| 4 | Skin sensitization | Category 1 |
Warning |
H317 |
P302+P352
P333+P313 P362+P364 P261 P272 P280 P321 P501 |
There is a report that this substance was positive in a modified maximization test (in compliance with OECD TG 406) with guinea pigs (EU SCHER (2016)). In addition, there is a report that a skin sensitization survey by patch test in 65 workers showed no sensitization (EU SCHER (2016)), but since it was not possible to deny the result of the animal test, it was classified in Category 1. The category was revised based on the information obtained in this survey. |
| 5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | The substance was classified as "Classification not possible" because it was not possible to classify a substance as "Not classified" according to the revised GHS classification guidance for the Japanese Government. As for in vivo, it was negative in a micronucleus test (EU SCHER (2016)). As for in vitro, it was weakly positive or negative in bacterial reverse mutation tests, negative in a mouse lymphoma test, a chromosome aberration test, and a sister chromatid exchange test with mammalian cultured cells (NTP DB (Access on June 2017), ACGIH (7th, 2001), EU SCHER (2016)). |
| 6 | Carcinogenicity | Classification not possible |
- |
- | - | In two-year carcinogenicity studies by dietary administration to rats and mice, no increased tumors associated with the administration was observed in rats (NTP TR163 (1979), ACGIH (7th, 2001), PATTY (6th, 2012)). As for mice, dose relationship was seen in hemangiosarcoma in males, however, it was not statistically significant. As for females, dose relationship was found in lymphoma or leukemia, there was a statistical significance in the high dose group, but the incidence was within background data (NTP TR163 (1979), ACGIH (7th, 2001), PATTY (6th, 2012)). Thus, neither the hemangiosarcoma in male mice nor lymphomas or leukemia in females was considered to be related to the administration of this substance, it was concluded that the test substance showed no carcinogenicity either in rats or in mice (NTP TR163 (1979), PATTY (6th, 2012)). As for classification results by other organizations, ACGIH classified it in A4 (ACGIH (7th, 2001)). From the above, it was classified as "Classification not possible." |
| 7 | Reproductive toxicity | Classification not possible |
- |
- | - | In a developmental toxicity study with pregnant rats dosed by gavage on gestational day 6-19, at 21 mg/kg/day or more where maternal toxicity (reduction in body weight gain and food consumption, a decrease in uterus weights) was observed, only a minor effect (lowered fetal body weight) was observed in the fetuses (EU SCHER (2016)). However, since there is no information on the effects on fertility and sexual function, classification was not possible due to lack of data. |
| 8 | Specific target organ toxicity - Single exposure | Category 3 (Respiratory tract irritation) |
Warning |
H335 |
P304+P340
P403+P233 P261 P271 P312 P405 P501 |
There is a description that this substance causes irritation of the mucous membranes of the nose, throat and respiratory passages, which results in coughing, tickling in the throat, rhinitis and tonsillitis (DFGOT Vol. 5(1993)). As for experimental animals, there is a report in a single inhalation exposure test with rats, respiratory disorders, tremors, poor general state and loss of body weight occurred at 5.1 mg/L of a commercial product of this substance (a converted value equivalent to 100% purity: 3.16-3.32 mg/L which is calculated from a purity of 62-65% as described in DFGOT Vol. 5 (1993)) (DFGOT Vol. 24 (2007)). However, there was no description of the exposure time, and the original literature was also a non-disclosure document and cannot be confirmed, so it was not adopted. From the above, it was classified in Category 3 (respiratory tract irritation). Besides, the documents on the Agricultural Chemical Registration Application (2000) used in the previous classification were not adopted because they were not available, and the details are unknown. Therefore, the classification result was changed from the previous classification. Besides, it is believed that this substance is transformed into cyanamide (CAS RN 420-04-2) after oral administration, and that the toxic effects observed for this substance were mainly attributable to cyanamide toxicity (EU SCHER (2016)). Since cyanamide inhibits aldehyde dehydrogenase, it is used as a liquor amount inhibitor, and there is a statement that facial flushing, decreasing blood pressure, nausea, tachycardia, dizziness, dyspnea and decreased vision may occur after ingesting alcohol (and foods including alcohol etc.) with oral ingestion of cyanamide (Ethical Pharmaceuticals 2017 (2016)). |
| 9 | Specific target organ toxicity - Repeated exposure | Category 1 (thyroid), Category 2 (liver) |
 Danger Warning |
H372
H373 |
P260
P264 P270 P314 P501 |
As for humans, this substance has an alcohol suppression effect in the same way as cyanamide. For 65 employees who worked with nitrolime which is a product containing this substance as the main ingredient and various amounts of caustic lime, determination of their exposure concentration and examination by industrial physicians were conducted. As a result, the following is reported: the total period of employment was 5-41 years (average 19 years); exposure concentrations were 0.23-8.36 mg/m3; no exposure-related adverse effects were observed; and alcohol consumption 1-7 hours after work led to moderate alcohol intolerance reactions in 6 of the 22 employees and weak reactions in 7 (DFGOT Vol. 5 (1993)). As for experimental animals, there is data on the commercial product of this substance (containing 63% of this substance). In a 7-week repeated dose toxicity test by feeding with rats, at or above 0.04% (20 mg/kg/day, 13 mg/kg/day as this substance) (converted guidance value: 10 mg/kg/day) which is within a guidance value range for Category 1, reduced body weight gain was seen, at or above 0.06% (30 mg/kg/day, 19 mg/kg/day as this substance) (converted guidance value: 19 mg/kg/day), hyperplasia of the thyroid gland was found, and at or above 0.15% (60 mg/kg/day, 47 mg/kg/day as this substance) (converted guidance value: 26 mg/kg/day) which is within a guidance value range for Category 2, bile-duct hyperplasia was observed (Environmental Risk Assessment for Chemical Substances Vol.9, Tentative Hazard Assessment Sheet (Ministry of the Environment, 2011), NTP TR163 (1979)). Besides, in a 7-week repeated dose toxicity test with mice dosed by feeding, effects on the liver (slight hyperplasia of the bile duct, vacuolated periportal hepatocytes, focal necrosis of hepatocytes) were observed at doses above the guidance value range of Category 2 (Environmental Risk Assessment for Chemical Substances Vol.9, Tentative Hazard Assessment Sheet (Ministry of the Environment, 2011), NTP TR163 (1979)). From the above, in humans, effects related to alcohol metabolism disorder rather than a direct effect of this substance are observed, and in the experimental animals, the effects on the thyroid and liver are found within the guidance value ranges of Category 1 and Category 2, respectively. Therefore, it was classified in Category 1 (thyroid), Category 2 (liver). Besides, it is believed that this substance is transformed into cyanamide (CAS RN 420-04-2) after oral administration, and that the toxic effects observed for this substance were mainly attributable to cyanamide toxicity (EU SCHER (2016)). Cyanamide is classified in Category 1 (haemal system, thyroid, liver, genetic organs (men)) in the GHS classification by Japanese government, but this substance was classified only from the data of this substance. The classification result was different from the previous classification due to the use of a new information source. |
| 10 | Aspiration hazard | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment (Acute) | Classification not possible |
- |
- | - | No data available. |
| 11 | Hazardous to the aquatic environment (Long-term) | Classification not possible |
- |
- | - | No data available. |
| 12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | No data available. |
NOTE:
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* A blank or "-" in a cell of classification denotes that the classification of the hazard class was not conducted. * Hazard_statement_and/or_Precautionary_statement will show when hovering the mouse over a code of Hazard_statement_and/or_Precautionary_statement. Hazard_statement_and/or_Precautionary_statement are also provided in the Excel file. * Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. * Codes assigned to each of the hazard statements and codes for each of the precautionary statement are based on the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) in United Nations. |