GHS Classification Result

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GENERAL INFORMATION
Item Information
CAS RN 80-15-9
Chemical Name 1-Methyl-1-phenylethyl hydroperoxide
Substance ID H29-B-060
Classification year (FY) FY2017
Ministry who conducted the classification Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised Revised
Classification result in other fiscal year FY2008  
Download of Excel format Excel file

REFERENCE INFORMATION
Item Information
Guidance used for the classification (External link) GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
UN GHS document (External link) UN GHS document
Definitions/Abbreviations (Excel file) Definitions/Abbreviations
Model Label by MHLW (External link) MHLW Website (in Japanese Only)
Model SDS by MHLW (External link) MHLW Website (in Japanese Only)
OECD/eChemPortal (External link) eChemPortal

PHYSICAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Explosives Not classified
-
-
- - There is a chemical group associated with explosive properties (neighboring oxygen atoms) in the molecule, and the calculated oxygen balance of -231 is below the criteria, -200. Besides, it is estimated that one containing 90-98% does not correspond to explosives because it is classified in Organic peroxide type E in UNRTDG (UN 3107).
2 Flammable gases (including chemically unstable gases) Not applicable
-
-
- - Liquid (GHS definition)
3 Aerosols Not applicable
-
-
- - Not aerosol products.
4 Oxidizing gases Not applicable
-
-
- - Liquid (GHS definition)
5 Gases under pressure Not applicable
-
-
- - Liquid (GHS definition)
6 Flammable liquids Category 4
-
Warning
H227 P370+P378
P403+P235
P210
P280
P501
Based on a flash point of 79 deg C (closed cup) (ICSC (J) (2005)), it was classified in Category 4.
7 Flammable solids Not applicable
-
-
- - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable
-
-
- - It is classified in Organic peroxide.
9 Pyrophoric liquids Classification not possible
-
-
- - No data available.
10 Pyrophoric solids Not applicable
-
-
- - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible
-
-
- - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable
-
-
- - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Classification not possible
-
-
- - It is an organic compound which does not contain fluorine or chlorine but contains oxygen, and the oxygen is chemically bonded to the element other than carbon or hydrogen. However, the classification is not possible due to no data.
14 Oxidizing solids Not applicable
-
-
- - Liquid (GHS definition)
15 Organic peroxides Type E


Warning
H242 P411+P235
P210
P220
P234
P280
P410
P420
P501
One containing 90-98% is classified in Division 5.2, type E in UNRTDG (UN 3107) (UNRTDG 2.5.3.2.4).
16 Corrosive to metals Classification not possible
-
-
- - No data available. Besides, there is the information it may decompose violently on contact with cobalt, copper or lead alloys and mineral acids (ICSC (J) (2005)).

HEALTH HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Acute toxicity (Oral) Category 4


Warning
H302 P301+P312
P264
P270
P330
P501
Based on a report of an LD50 value of 382 mg/kg (DFGOT Vol. 3 (1992), PATTY (6th, 2012)) for rats, it was classified in Category 4.
1 Acute toxicity (Dermal) Category 3


Danger
H311 P302+P352
P361+P364
P280
P312
P321
P405
P501
There are reports of LD50 values for rats of 0.5-1.0 mL/kg (530-1,060 mg/kg) and 1.13-1.43 mL/kg (1,198-1,516 mg/kg) (both in HSDB (Access on June 2017)). One case corresponds to Category 3 or Category 4, and the other case corresponds to Category 4. By adopting the category with higher hazard, it was classified in Category 3.
1 Acute toxicity (Inhalation: Gases) Not applicable
-
-
- - Liquid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible
-
-
- - Classification not possible due to lack of data.
1 Acute toxicity (Inhalation: Dusts and mists) Category 4


Warning
H332 P304+P340
P261
P271
P312
Based on reports of LC50 values of 200 ppm (1.24 mg/L) (DFGOT Vol. 3 (1992)) and 220 ppm (1.36 mg/L) (PATTY (6th, 2012)) in 4-hour inhalation exposure tests with rats, it was classified in Category 4. Besides, because the LC50 values are higher than the saturated vapor pressure concentration (4.35 ppm), the reference value in the unit of mg/L as mist was applied.
2 Skin corrosion/irritation Category 1


Danger
H314 P301+P330+P331
P303+P361+P353
P305+P351+P338
P304+P340
P260
P264
P280
P310
P321
P363
P405
P501
As for skin sensitization tests with rabbits, there is a report that severe irritation and damages were found (DFGOT Vol. 3 (1992)), and a description that severe irritation or corrosivity were observed (PATTY (6th, 2012)), therefore, it was classified in Category 1. Besides, this substance was classified as "Skin Corr. 1B" in EU CLP classification (ECHA CL Inventory (Access on June 2017)).
3 Serious eye damage/eye irritation Category 1


Danger
H318 P305+P351+P338
P280
P310
Since this substance was classified in Category 1 for skin corrosivity/irritation, it was classified in Category 1. Besides, as for eye irritation tests with rabbits, there is a report that severe irritation and damage were shown (DFGOT Vol. 3 (1992)), a description that it was irritating to the eyes (PATTY (6th, 2012)), and a report that redness and pains caused by severe deep burns occurred (HSDB (Access on June 2017)).
4 Respiratory sensitization Classification not possible
-
-
- - Classification not possible due to lack of data.
4 Skin sensitization Classification not possible
-
-
- - Classification not possible due to lack of data. Besides, although there was a description that this substance was known as a skin sensitizer (HSDB (Access on June 2017)), it was not adopted because the details of the test method and so on were unknown.
5 Germ cell mutagenicity Classification not possible
-
-
- - It was classified as "Classification not possible" because it was not possible to classify a substance as "Not classified" according to the revised GHS classification guidance for the Japanese government. As for in vivo, a dominant lethal test with mice and a micronucleus test with the peripheral blood of mice were negative (NTP DB (Access on July 2017), HSDB (Access on June 2017)). As for in vitro, bacterial reverse mutation tests were positive (SIAP (2008), NTP DB (Access on July 2017), HSDB (Access on June 2017)).
6 Carcinogenicity Classification not possible
-
-
- - Classification not possible due to lack of data.
7 Reproductive toxicity Classification not possible
-
-
- - Classification not possible due to lack of data.
8 Specific target organ toxicity - Single exposure Category 2 (respiratory organs)


Warning
H371 P308+P311
P260
P264
P270
P405
P501
There is no information on single exposure to this substance in humans. As for experimental animals, there is a report that in a 4-hour single inhalation exposure test with rats, at necropsy, severe inflammation of the trachea and lungs was observed (PATTY (6th, 2012)). Although there is no detailed description of the dose, since the LC50 value was reported as 220 ppm (1.36 mg/L) within the guidance value range of the mist for Category 2, it is thought that the effect was observed at the dose in the range for Category 2. Therefore, it was classified in Category 2 (respiratory organs).
9 Specific target organ toxicity - Repeated exposure Category 1 (respiratory organs, haemal system)


Danger
H372 P260
P264
P270
P314
P501
No information on humans is available.
As for experimental animals, in a 3-month inhalation toxicity test (6 hours/day, 5 days/week) with rats, deaths were observed at 124 mg/m3 (converted guidance value: 0.017 mg/L), which was within the guidance value range (mist) for Category 1, and surviving animals were urgently slaughtered on the 12th day of exposure. In the same group, symptoms of irritation of the eyes and nose, dyspnea, suppression of body weight gain, decreases in the erythrocyte count, hemoglobin level and leukocyte count, ulcers and inflammation of the cornea, nasal turbinate, and stomach, atrophy of the thymus, depletion of lymphatic system tissues of the germinal centers of the lymph nodules and spleen, and decreased lipid content of the liver were observed (Environmental Risk Assessment for Chemical Substances Vol.9, Tentative Hazard Assessment Sheet (Ministry of the Environment, 2011)).
From the above, effects on the haemal system in addition to irritation of the eyes, respiratory organs and gastrointestinal tract were observed. However, among these, the effect on the eyes corresponded to the hazard class for eye irritation, and the effect on the gastrointestinal tract was considered that to be due to ingestion or stress considered to be possibly due to ingestion or stress, thus, they were not included in the target organs. Therefore, it was classified in Category 1 (respiratory organs, haemal system).
Besides, the classification was changed from the previous one since a new information source was adopted.
10 Aspiration hazard Classification not possible
-
-
- - Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 2
-
-
H401 P273
P501
From 72-hour EC50 (rate method) = 3.1 mg/L for algae (Pseudokirchneriella subcapitata) (OECD SIDS: 2008), it was classified in Category 2.
11 Hazardous to the aquatic environment (Long-term) Category 2


-
H411 P273
P391
P501
If chronic toxicity data are used, then it is classified in Category 2 due to being not rapidly degradable (BioWin), and 72-hour NOEC (rate method) = 1.0 mg/L for algae (Pseudokirchneriella subcapitata) (OECD SIDS: 2008).
If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified in Category 2 due to being not rapidly degradable (BioWin), and 96-hour LC50 = 3.9 mg/L for fish (Oncorhynchus mykiss) (OECD SIDS: 2008).
From the above results, it was classified in Category 2.
12 Hazardous to the ozone layer Classification not possible
-
-
- - No data available.


NOTE:
* A blank or "-" in a cell of classification denotes that the classification of the hazard class was not conducted.
* Hazard_statement_and/or_Precautionary_statement will show when hovering the mouse over a code of Hazard_statement_and/or_Precautionary_statement.
Hazard_statement_and/or_Precautionary_statement are also provided in the Excel file.
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government,
and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.
* Codes assigned to each of the hazard statements and codes for each of the precautionary statement are
based on the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) in United Nations.

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