Item | Information |
---|---|
CAS RN | 128-04-1 |
Chemical Name | Sodium dimethyldithiocarbamate |
Substance ID | H29-B-063 |
Classification year (FY) | FY2017 |
Ministry who conducted the classification | Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE) |
New/Revised | Revised |
Classification result in other fiscal year | FY2008 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
UN GHS document (External link) | UN GHS document |
Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
Model Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | eChemPortal |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Explosives | Not applicable |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. |
2 | Flammable gases (including chemically unstable gases) | Not applicable |
- |
- | - | Solid (GHS definition). |
3 | Aerosols | Not applicable |
- |
- | - | Not aerosol products. |
4 | Oxidizing gases | Not applicable |
- |
- | - | Solid (GHS definition). |
5 | Gases under pressure | Not applicable |
- |
- | - | Solid (GHS definition). |
6 | Flammable liquids | Not applicable |
- |
- | - | Solid (GHS definition). |
7 | Flammable solids | Classification not possible |
- |
- | - | No data available. |
8 | Self-reactive substances and mixtures | Not applicable |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. |
9 | Pyrophoric liquids | Not applicable |
- |
- | - | Solid (GHS definition). |
10 | Pyrophoric solids | Classification not possible |
- |
- | - | No data available. |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Test methods applicable to solid (melting point <= 140 deg C) substances are not available. |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable |
- |
- | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
13 | Oxidizing liquids | Not applicable |
- |
- | - | Solid (GHS definition). |
14 | Oxidizing solids | Not applicable |
- |
- | - | Organic compounds containing no oxygen, fluorine or chlorine |
15 | Organic peroxides | Not applicable |
- |
- | - | Organic compounds containing no bivalent -O-O- structure in the molecule |
16 | Corrosive to metals | Classification not possible |
- |
- | - | Test methods applicable to solid substances are not available. |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Category 4 |
Warning |
H302 |
P301+P312
P264 P270 P330 P501 |
Based on reported LD50 values for rats of 545 mg/kg, 900 mg/kg (EHC 78 (1988)), 1,000 mg/kg (HSDB (Access on June 2017)), and 1,832 mg/kg (EHC 78 (1988)), it was classified in Category 4. |
1 | Acute toxicity (Dermal) | Not classified |
- |
- | - | Based on a reported LD50 value of > 5,000 mg/kg for rats (HSDB (Access on June 2017)), it was classified as "Not classified." |
1 | Acute toxicity (Inhalation: Gases) | Not applicable |
- |
- | - | Solid (GHS definition) |
1 | Acute toxicity (Inhalation: Vapours) | Not applicable |
- |
- | - | Solid (GHS definition) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
2 | Skin corrosion/irritation | Category 2 |
Warning |
H315 |
P302+P352
P332+P313 P362+P364 P264 P280 P321 |
Based on a description that a product containing this substance showed irritation of human skin such as burns, rashes, itching, discoloration and redness of the skin, blister formation (EPA Pesticide (2009)), and a description that it was slightly irritating to rabbit skin (HSDB (Access on June 2017)), it was classified in Category 2. Based on the information obtained in this investigation, the category was revised. |
3 | Serious eye damage/eye irritation | Classification not possible |
- |
- | - | Classification not possible due to lack of data. Besides, there are descriptions that many agricultural chemicals of dithiocarbamate type showed eye irritation, and some part of agricultural chemicals of dithiocarbamate type (nabam (CAS RN 142-59-6), zineb (CAS RN 12122-67-7)) did not show eye irritation (both in EHC 78 (1988)). |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
4 | Skin sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. Besides, there is a description that some dithiocarbamate compounds cause sensitization (EHC 78 (1988)). |
5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. There is no in vivo data. As for in vitro, it was positive in a bacterial reverse mutation test, and negative in a mammalian cell gene mutation test (HSDB (Access on June 2017)). |
6 | Carcinogenicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. Besides, there is a description in HSDB that this substance was classified as L (Likely to be carcinogenic to humans) by EPA in 2006 (HSDB (Access on June 2017)), but this substance has been already deleted from the list of classification for carcinogenicity of pesticides by EPA (Chemicals Evaluated for Carcinogenic Potential, Annual Cancer Report (2016)). |
7 | Reproductive toxicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
8 | Specific target organ toxicity - Single exposure | Category 2 (nervous system, systemic toxicity) |
Warning |
H371 |
P308+P311
P260 P264 P270 P405 P501 |
There is no data on single exposure to this substance in humans. As for experimental animals, there was a report that in a single oral administration test with rabbits, depression of the central nervous system, reduced tactile and sensory sensitivity, and decreased food consumption were observed at or above 500 mg/kg. All cases died within 24 hours at 1,000 mg/kg or 1,500 mg/kg. There were no deaths at 500 mg/kg. It is reported that although there was no description as to whether only dead animals were involved or surviving ones were included, visceral congestion, pulmonary edema, and hemorrhages of the gastric mucosa were observed at necropsy (HSDB (Access on June 2017)). The doses at which the effects were observed correspond to the guidance value range for Category 2. Among them, pulmonary edema may be a secondary effect, and because target organs other than the nervous system cannot be identified based on other symptoms, therefore, it was classified in Category 2 (nervous system, systemic toxicity). |
9 | Specific target organ toxicity - Repeated exposure | Category 2 (nervous system, systemic toxicity) |
Warning |
H373 |
P260
P314 P501 |
No information on humans is available. As for experimental animals, there is a description that when rabbits were dosed at 100 mg/kg/day for 15 weeks (no description of administration route, within the guidance value range for Category 1 assuming an oral route), body weight gain was increased, and adynamia, changes in blood morphology, the nervous system, and cardiovascular system, and yellowing of the fur were observed (HSDB (Access on June 2017)). From the above, it was classified in Category 2 (nervous system, systemic toxicity) because the rabbit data is from the information source in List 2, assuming that it is by an oral route. |
10 | Aspiration hazard | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment (Acute) | Category 1 |
Warning |
H400 |
P273
P391 P501 |
From 96-hour LC50 = 0.0027 mg/L for crustacea (Mysidopsis bahia) (NLM HSDB: 2005), it was classified in Category 1. |
11 | Hazardous to the aquatic environment (Long-term) | Category 1 |
Warning |
H410 |
P273
P391 P501 |
Chronic toxicity data were not obtained. Due to being not rapidly degradable (non-biodegradable, average degradation rate by BOD: 2% (J-CHECK, 1993)), and acute toxicity Category 1, it was classified in Category 1. |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | No data available. |
* A blank or "-" in a cell of classification denotes that the classification of the hazard class was not conducted. * Hazard_statement_and/or_Precautionary_statement will show when hovering the mouse over a code of Hazard_statement_and/or_Precautionary_statement. Hazard_statement_and/or_Precautionary_statement are also provided in the Excel file. * Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. * Codes assigned to each of the hazard statements and codes for each of the precautionary statement are based on the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) in United Nations. |