GHS Classification Result

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GENERAL INFORMATION
Item Information
CAS RN 74-95-3
Chemical Name Dibromomethane
Substance ID H29-B-066
Classification year (FY) FY2017
Ministry who conducted the classification Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised Revised
Classification result in other fiscal year FY2008  
Download of Excel format Excel file

REFERENCE INFORMATION
Item Information
Guidance used for the classification (External link) GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
UN GHS document (External link) UN GHS document
Definitions/Abbreviations (Excel file) Definitions/Abbreviations
Model Label by MHLW (External link) MHLW Website (in Japanese Only)
Model SDS by MHLW (External link) MHLW Website (in Japanese Only)
OECD/eChemPortal (External link) eChemPortal

PHYSICAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Explosives Not applicable
-
-
- - There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases (including chemically unstable gases) Not applicable
-
-
- - Liquid (GHS definition)
3 Aerosols Not applicable
-
-
- - Not aerosol products.
4 Oxidizing gases Not applicable
-
-
- - Liquid (GHS definition)
5 Gases under pressure Not applicable
-
-
- - Liquid (GHS definition)
6 Flammable liquids Not classified
-
-
- - It is not combustible (ICSC (J) (2013)).
7 Flammable solids Not applicable
-
-
- - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable
-
-
- - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not classified
-
-
- - It is not combustible (ICSC (J) (2013)).
10 Pyrophoric solids Not applicable
-
-
- - Liquid (GHS definition)
11 Self-heating substances and mixtures Not classified
-
-
- - It is not combustible (ICSC (J) (2013)).
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable
-
-
- - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable
-
-
- - Organic compounds containing no oxygen, fluorine or chlorine
14 Oxidizing solids Not applicable
-
-
- - Liquid (GHS definition)
15 Organic peroxides Not applicable
-
-
- - Organic compounds containing no bivalent -O-O- structure in the molecule
16 Corrosive to metals Classification not possible
-
-
- - No data available.

HEALTH HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Acute toxicity (Oral) Classification not possible
-
-
- - Classification not possible due to lack of data. As an LD50 value for rats, >1,000 mg/kg was reported (SIAP (2013), PATTY (6th, 2012)), and this corresponds to Category 4 or "Not classified." However, since classification cannot be determined based on this value alone, it was classified as "Classification not possible."
1 Acute toxicity (Dermal) Classification not possible
-
-
- - Classification not possible due to lack of data.
1 Acute toxicity (Inhalation: Gases) Not applicable
-
-
- - Liquid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Category 4


Warning
H332 P304+P340
P261
P271
P312
Based on a report of an LC50 value of 40,000 mg/m3 (5,640 ppm) (converted 4-hour equivalent value: 28.3 mg/L (3,978 ppm)) for rats in a 2-hour inhalation exposure test (HSDB (Access on May 2017)), it was classified in Category 4. Besides, a reference value in the unit of ppm was applied as vapour with little mist because the exposure concentration was lower than 90% of the saturated vapour pressure concentration (46,535 ppm). The category was changed from the previous classification.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible
-
-
- - Classification not possible due to lack of data.
2 Skin corrosion/irritation Category 2


Warning
H315 P302+P352
P332+P313
P362+P364
P264
P280
P321
Based on the description that it showed moderate to severe irritation in skin irritation tests with rabbits (SIAP (2013)) and the description that it showed mild irritation (PATTY (6th, 2012)), it was classified in Category 2. Based on the information obtained in this investigation, the category was revised.
3 Serious eye damage/eye irritation Category 2


Warning
H319 P305+P351+P338
P337+P313
P264
P280
Based on the description that it showed moderate irritation in eye irritation tests with rabbits (SIAP (2013)), it was classified in Category 2. Based on the information obtained in this investigation, the category was revised.
4 Respiratory sensitization Classification not possible
-
-
- - Classification not possible due to lack of data.
4 Skin sensitization Classification not possible
-
-
- - Classification not possible due to lack of data.
5 Germ cell mutagenicity Classification not possible
-
-
- - Classification not possible due to lack of data. There is no in vivo data, and as for in vitro, it was positive in a bacterial reverse mutation test and a mammalian cell chromosome aberration test (SIAP (2013)).
6 Carcinogenicity Classification not possible
-
-
- - Classification not possible due to lack of data. Besides, there was a report that in a 2-year inhalation study with male rats which were exposed at up to 150 ppm, no oncological changes related to exposure were observed in the gross pathological examination (PATTY (6th, 2012)).
7 Reproductive toxicity Category 2


Warning
H361 P308+P313
P201
P202
P280
P405
P501
There is a report that in a reproductive and developmental toxicity screening test with rats dosed by gavage, at 500 mg/kg/day where depressed body weight gain and lower food conversion efficiency were seen in maternal animals, increased pre-coital intervals and a reduction in the litter size were observed as reproductive effects (SIAP (2013)), therefore, it was classified in Category 2. Besides, based on the new information source after the previous classification, the classification became possible this time.
8 Specific target organ toxicity - Single exposure Category 3 (Narcotic effects)


Warning
H336 P304+P340
P403+P233
P261
P271
P312
P405
P501
There is no information on a single exposure to this substance in humans. As for experimental animals, there is a report that in a 4-hour single inhalation exposure test with rats, impaired spontaneous motor activity, bradypnea, abnormal gait, and tremors were seen at 21.4 to 22.3 mg/L, which was greater than the values corresponding to Category 2, and most of the animals fell into a deep coma within 3 hours, but no mortalities occurred, and there were no findings that seemed to be toxic effects on autopsy (SIAP (2013)). In addition, there is a description that the vapor of this substance can cause anesthesia (PATTY (6th, 2012)). Therefore, it was classified in Category 3 (narcotic effects). Besides, there is a report that disorders in the central nervous system occurred in experimental animals (no description of the species) by the inhalation of 17-20 mg/L (2,400-2,800 ppm) (PATTY (6th, 2012)) though it was not adopted as evidence of the classification for the central nervous system since the exposure time was not described, and the category could not be specified.
9 Specific target organ toxicity - Repeated exposure Classification not possible
-
-
- - Classification not possible due to lack of data.
There is a report that in a 13-week inhalation toxicity test (6 hours/day, 5 days/week) with rats, an increase of liver weight was observed in females at 75 ppm (converted guidance value: 0.38 mg/L) or above which was within the guidance value of Category 2 (PATTY (6th, 2012)). Since the observed effect was only weight increase, it was not adopted as evidence of the classification.
10 Aspiration hazard Classification not possible
-
-
- - Classification not possible due to lack of data. Besides, the kinematic viscosity is calculated to be 0.392 mm2/sec (25/20 deg C) from the numerical data (viscosity: 0.980 mPa*s (25 deg C), density: 2.4969 g/cm3 (20 deg C)) listed in HSDB (Access on May 2017).

ENVIRONMENTAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 3
-
-
H402 P273
P501
From 96-hour LC50 = 45 mg/L for fish (Oncorhynchus mykiss) (OECD SIDS: 2011), it was classified in Category 3.
11 Hazardous to the aquatic environment (Long-term) Category 3
-
-
H412 P273
P501
Chronic toxicity data were not obtained. Due to being not rapidly degradable (BioWin), and acute toxicity Category 3, it was classified in Category 3.
12 Hazardous to the ozone layer Classification not possible
-
-
- - No data available.


NOTE:
* A blank or "-" in a cell of classification denotes that the classification of the hazard class was not conducted.
* Hazard_statement_and/or_Precautionary_statement will show when hovering the mouse over a code of Hazard_statement_and/or_Precautionary_statement.
Hazard_statement_and/or_Precautionary_statement are also provided in the Excel file.
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government,
and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.
* Codes assigned to each of the hazard statements and codes for each of the precautionary statement are
based on the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) in United Nations.

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